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Methyl Caffeate

    • Product Name Methyl Caffeate
    • Alias Methyl 3,4-dihydroxycinnamate
    • Einecs 249-197-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    730336

    Chemical Name Methyl Caffeate
    Molecular Formula C10H10O4
    Molar Mass 194.18 g/mol
    Iupac Name methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
    Cas Number 3118-71-2
    Appearance Pale yellow solid
    Solubility Soluble in methanol, ethanol, and DMSO
    Melting Point 151-153°C
    Boiling Point Unknown
    Pubchem Cid 5280534
    Synonyms Caffeic acid methyl ester
    Smiles COC(=O)/C=C/C1=CC(=C(C=C1)O)O
    Category Phenolic ester
    Source Often derived from plant sources

    As an accredited Methyl Caffeate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging for Methyl Caffeate contains 25 grams in a sealed amber glass bottle with a secure screw cap and product labeling.
    Shipping Methyl Caffeate should be shipped in tightly sealed containers, protected from light and moisture. It is typically transported at room temperature, following standard chemical safety protocols. Ensure labeling per regulatory guidelines, and handle with care to avoid spills or exposure. Consult the Safety Data Sheet (SDS) for detailed shipping and handling instructions.
    Storage Methyl Caffeate should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. It should be kept in a tightly sealed container, protected from moisture and incompatible substances such as strong oxidizers. For optimal stability, refrigeration is recommended, and the storage area should be designated for chemicals to prevent contamination.
    Application of Methyl Caffeate

    Applications of Methyl Caffeate in Industrial Manufacturing

    Methyl Caffeate is a specialty intermediate used across multiple industrial fields, chosen for its antioxidant properties and functional ester characteristics. Below, we detail verified downstream markets, specific compliance standards, application ratios, processing stages, and target end products utilized by major customers in each segment.

    1. Pharmaceutical Intermediates for API Synthesis

    Active pharmaceutical ingredient (API) manufacturers use Methyl Caffeate as a starting block or reaction intermediate in synthesizing certain active compounds where the caffeic acid backbone is required. The compound enters as an esterified phenolic moiety, facilitating controlled downstream hydrolysis, amidation, or substitution, depending on the synthetic route. Companies involved in research-phase drug development utilize its structure for building anti-inflammatory or antimicrobial molecules, and clinical trial supply production requires strict regulatory compliance.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF Pharmacopeial monographs (if final API is listed)
    • EU Guidelines EudraLex Volume 4 (GMP for API manufacturing)
    • 21 CFR Parts 210/211 (FDA cGMP for finished pharmaceuticals)

    Typical usage ratio

    • 5–25 mol% relative to core reaction scheme, based on process optimization data for desired intermediate; adjusted via pilot batch yield and impurity profiling

    Downstream process integration

    • Charged to reactor as an esterifying or acylating intermediate during step-growth or reductive amination sequences
    • May undergo transesterification or direct coupling as part of target molecule construction
    • Used in early or mid-stage step for API synthesis, followed by downstream purification (crystallization or chromatography)

    Final product types

    • Small-molecule anti-inflammatory drug substances
    • Intermediary bulk drugs containing caffeic acid derivatives
    • Reference standards for analytical labs
    • Active ingredient samples for R&D and clinical supply

    2. Cosmetic Antioxidant Additive

    Industrial-scale cosmetic ingredient formulators include Methyl Caffeate into skincare and haircare bases for its proven radical scavenging properties. Manufacturers blend the ester into emulsions or solutions, relying on its phenolic structure to limit oxidative degradation in creams, lotions, and serums. Strictly, EU and ASEAN guidelines require verified purity, non-irritancy, and substantiated function prior to use in large-batch cosmetic production.

    Industry compliance standards

    • EU Regulation (EC) No 1223/2009 (Cosmetics Regulation)
    • ASEAN Cosmetic Directive
    • ISO 22716 (Cosmetic GMP guidelines)
    • Regional Ingredient Reporting/INCI registration

    Typical usage ratio

    • 0.05–0.5% by weight in anti-aging creams or antioxidant serums; total content adjusted for formulation pH and compatibility with emulsifiers

    Downstream process integration

    • Added during oil or water phase preparation before final emulsification
    • Solution blending occurs in closed mixing tanks at controlled temperature
    • Compatibility checks performed with natural extracts and common actives (e.g., Vitamin C, E)

    Final product types

    • Facial serums and ampoules
    • Anti-photoaging day/night creams
    • Protective hair conditioners and styling gels
    • Hand and body lotions for oxidative stability

    3. Food & Beverage Natural Antioxidant Preservative

    Large-volume food ingredient manufacturers employ Methyl Caffeate as a natural phenolic antioxidant preservative in specific beverage and processed food categories requiring shelf-life extension with clean-label ingredients. Applied under controlled dosing, its use ensures minimal impact on sensory parameters while extending product freshness and reducing oxidation of polyunsaturated fats and flavors. Compliance is subject to region-specific food additive lists and maximum allowable intake thresholds established by food safety authorities.

    Industry compliance standards

    • GB 2760-2023 (China Food Additive Standards)
    • EU Regulation (EC) No 1333/2008 (EU Food Additive Framework)
    • FDA 21 CFR 172 Subpart F (Food Additives, Antioxidants and Preservatives)
    • HACCP and ISO 22000 (Food Safety Management)

    Typical usage ratio

    • 10–80 ppm; dosage based on fat content & desired antioxidant effect, validated by storage testing in finished foods or beverages

    Downstream process integration

    • Dosed into formulation tanks with other micro-ingredients before pasteurization or UHT processing
    • Integrates during mixing stages for emulsified or fat-rich products (e.g., dairy beverages, sauces)
    • Homogenized to ensure uniform dispersion, followed by filtration and bottling

    Final product types

    • Plant-based beverages and functional drinks
    • Sauces, dressings, and ready meals with extended shelf life
    • Margarines and fat spreads
    • Processed snack coatings requiring clean-label antioxidants

    4. Polymer Stabilizer in Biodegradable Plastics

    Bioplastic compounders leverage the antioxidant capability of Methyl Caffeate in biodegradable resin systems such as polylactic acid (PLA) or polyhydroxyalkanoates (PHA). Its phenolic ester structure interrupts thermo-oxidative chain degradation during extrusion or injection molding. Adoption remains subject to polymer-grade quality control and food-contact safety approval if used in packaging solutions, requiring validation by migration testing.

    Industry compliance standards

    • EN 13432 (Compostable and Biodegradable Plastics Standard, EU)
    • FDA 21 CFR 177.1630 (Polymer Additives, U.S. Regulation)
    • ISO 14021 (Environmental Labels and Declarations)
    • Migration testing per EU 10/2011 for food contact plastics

    Typical usage ratio

    • 0.1–0.4% by weight in resin blends; trialed at pilot scale to ensure migration compliance for packaging use

    Downstream process integration

    • Dry-blended with resin pellets before extrusion or direct metered feed at compounding stage
    • Monitored for thermal stability during screw processing or film blowing
    • Residue tests carried out on molded articles for regulatory approval

    Final product types

    • Compostable food trays and cutlery
    • Biodegradable films and bags
    • Injection-molded parts for disposable packaging
    • PLA-based functional containers with improved heat resistance
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    Certification & Compliance
    More Introduction

    Methyl Caffeate: Reliable Delivery of Precision Chemistry

    Manufacturing Methyl Caffeate stems from the need for purity and traceable sourcing in many downstream industries. As a chemical manufacturer, we see the demand for high-purity methyl ester derivatives rise with applications in fine chemical synthesis, flavor production, pharmaceutical intermediates, and advanced material development. Our Methyl Caffeate carries a CAS number for identification and comes as a refined, off-white to light brown crystalline powder, providing unmatched clarity in application.

    Purity stands out far more than paperwork. We watch laboratories and production lines wrestle with contamination issues that stem from loose controls upstream in the supply chain. By processing our raw caffeic acid in-house, maintaining dedicated extraction and esterification lines, and running full spectral analyses batch-by-batch, we've built in assurance against those hard-to-trace adulterants that sometimes slip into less disciplined operations. Each lot passes a full set of HPLC, NMR, and mass spectrometry checks before it even leaves our loading docks. This adds peace of mind for formulators who depend on consistency from one drum to the next.

    Our engineers adjust the esterification parameters—catalyst selection, solvent phase, reaction temperature, and purification route—depending on the end-market requirements. Methyl Caffeate for dietary supplement intermediates, for example, undergoes an additional decoloration and comprehensive solvent removal. These steps require continuous maintenance on our filtration and crystallization infrastructure. Our in-house maintenance team tracks every filter and column regeneration with real-world logs, not just digital records.

    Some buyers have asked about particle size because minor differences can affect both reactivity and flow behavior. While certain producers cut corners on grinding, relying on a simple milled feed, our batches undergo multistage size reduction and air classification up to four times per lot. This has proven important for formulators who disperse Methyl Caffeate in high-value resin or spray-drying systems, where caking or uneven feeding can slow production schedules. It takes years of building a process map to stick to expected micron size distribution under variable ambient conditions.

    Concerns about batch-to-batch performance rarely come up after customers transition to our material. That’s the result of decades working with the full feedback loop—listening to teams on plant floors, lab benches, and QC labs, then closing gaps with incremental improvements. The color, odor, and bulk density of each lot reflect the upstream care put into the extraction of the base caffeic acid and the downstream packaging choices. Every variant receives a unique code that traces to both incoming botanical source and outgoing batch specifics.

    Chemical research teams and industrial manufacturers have different requirements. For scale-up pilots or high-purity active development, our 99% Methyl Caffeate works best. Material scientists and larger volume blenders lean toward our 97% technical grade, which still tracks impurity profiles under strict limits. During the move to larger drums or intermediate bulk containers, we adapted the packaging setup—replacing old liners with inert, anti-static bags, reviewing seals to protect from minor humidity bumps, and running accelerated stability evaluations on every new closure. All of this came from direct user audits and trial shipments, not just theory.

    Beyond Standard Grades—Addressing Real-World Needs

    Over the past few years, requests for environmentally sensitive manufacturing methods have increased. Clients express concern about the residual solvents used in the synthesis route, exposure to potential halogenated compounds, and waste stream management. As a manufacturer, we control cradle-to-gate process validation, so we've moved to greener catalyst systems and switched to reusable solvent loops where feasible. Detection limits for residual methanol, dichloromethane, or acetic acid have been set far below international standards, and we provide open, audited results upon request.

    Material scientists sometimes approach us for custom modifications—argument over batch size, unique counter-ions needed for downstream processing, or replacement of traditional esterification reagents with more biobased alternatives. Our technical support works directly on these edge cases, often spending weeks running non-routine syntheses or separating newly discovered side-products.

    By maintaining on-site analytical labs, we have real-time visibility into contaminants and can intervene at any synthesis step. Our ability to reprocess, recrystallize, or neutralize off-spec material is not something built into every factory, and our teams have learned to prevent avoidable losses. These routine check procedures reduce customer complaints related to off-odors or subtle reactivity shifts.

    Compared to simple caffeine derivatives or other methyl esters available in the open market, Methyl Caffeate distinguishes itself via its functional groups and resulting physical behavior. Research by both our partners and third parties points to increased radical scavenging activity, potential for aromatic ring substitutions in medicinal chemistry, and a taste-aroma profile favored in beverages. Many off-the-shelf methyl esters lack these specific hydroxyl and methoxy substitutions, making their reactivity or biological effects notably distinct. In food and beverage application trials, Methyl Caffeate produces a more stable, consistent flavor note and resists breakdown better during extended processing.

    The path from raw material to packed Methyl Caffeate is neither automatic nor universally standardized. We invest heavily in training operators to spot issues not visible in digital control screens. Variations in feedstock appearance, seasonal differences in raw caffeic acid, and even local temperature or humidity shifts can play a role during reaction or purification. From time to time, during annual maintenance, operators have found unexpected deposits in the condenser lines—by reviewing and adapting our protocol, we’ve minimized these occurrences and reduced the risk of batch spoilage. Human knowledge, built over years, balances out gaps technology cannot yet fill.

    Pharmaceutical developers stress the need for reliable documentation. We support this by keeping an auditable chain of custody from farm to finished drum. Every sample matches back to a digital library of corresponding analysis, covering not just purity but trace element scans and potential pesticide residues from botanical sources. This comes directly from conversations with our early partners: one flagged a trace heavy metal that eluded standard review, and our team now checks for those elements permanently.

    We also help customers evaluate alternative applications with technical support, including shared runs at their sites. In some research cases, partners use our material as a reference compound to check for cross-reaction in complex matrices. In others, they blend Methyl Caffeate into antioxidant systems or photo-labile formulations and check for color stability or migration rates. By working hands-on with these teams, our technical staff can adjust future batches or offer small-lot variants with alternate particle sizes, blend ratios, or purification steps.

    Experience-Driven Process Improvement

    Every time a new regulation appears, we review its impact on downstream users. Regulations over residual solvents, allowed botanical sources, and composition reporting all shape the focus of our process engineers and regulatory team. Feedback from customers shows they appreciate being able to track regulatory updates in plain language and see immediate changes in documentation or reporting when new laws arrive.

    Many queries cover compatibility with specific process solvents or co-ingredients. We send small samples with full documentation and run joint lab-scale tests if unusual impurities or interactions could emerge. Customers in food, personal care, and specialty chemicals often discover Methyl Caffeate presents fewer incompatibility issues than more common methyl esters or caffeine derivatives, due mainly to its well-characterized side-chains and neutral pH handling. Years of side-by-side dissolution and reactivity trials provide real-world assurance that doesn’t show up in a typical product listing.

    In flavors and fragrances, Methyl Caffeate provides a complex aromatic profile with a hint of deep roast and subtle sweetness. Beverage companies have tested it for flavor enrichment, preservation, or to mask bitter or metallic notes. Blenders also use it to create unique flavor backbones, often exploring synergies with fruit or botanical extracts. Each batch remains consistent from pilot scale to commercial runs, thanks to our checks on both chemical and organoleptic standards.

    Traditional caffeine-based ingredients often present challenges related to bitterness or overheating during storage or blending. Methyl Caffeate sidesteps many of these, giving producers a tool to experiment with new formats—cold brewing, specialty syrups, and even topical personal care systems seeking natural antioxidant content. As interest in clean-label and ingredient transparency grows, producers want to see detailed information on every load: we offer digital access to certificates, chain-of-custody, and supply chain declarations.

    Long-Term Relationships, Not Short-Term Transactions

    Working as a chemical manufacturer means viewing each order as an ongoing commitment rather than a finished transaction. Some clients ask us to store material for extended periods with special handling requirements, particularly for high-value product lines where shelf stability means everything. In these cases, we've invested in specialized ambient and cooled storage, use desiccants, and periodically sample stored lots to monitor any degradation or change in bulk properties.

    Dealers and traders sometimes seek out our material when supply disrupts from competing regions or less regulated operators. Over the years, we've had to adjust shipping procedures, pack design, and transit documentation to satisfy both customs requirements and the practical realities—hot summers, port dwell times, or container swaps. These adjustments rely as much on experience as on written protocols.

    Some partners engage in multi-year supply contracts, working closely with our teams to develop optimized ordering and delivery schedules. This ongoing relationship allows their R&D groups to influence the process: a slight shift in particle size, modified drying temperature, or customized drum internal surface finish can translate to measurable improvements in plant efficiency. We've seen cases where this flexibility made the difference during supply crunches or quick reformulation cycles.

    Challenges do arise, particularly in aligning differing regulatory labels, international hazard classifications, or preferred documentation styles. Our compliance group works hands-on with client regulatory staff to resolve these, often providing translated documentation or referencing country-specific regulations. The resulting paperwork may seem thick, but it means all parties trust the same numbers and safety standards.

    Comparing Methyl Caffeate With Other Esters and Caffeic Derivatives

    Methyl Caffeate sits in a unique spot among phenolic acid derivatives. Other esters, such as ethyl or isopropyl versions, show lower water solubility, distinct volatility, and noticeably different thermal stability. Our R&D team gathers feedback from formulators who have tested alternate esters in beverage stabilization or antioxidant systems. In almost every instance, switching to Methyl Caffeate resulted in improved process stability, easier incorporation, and a more balanced taste.

    Compared to pure caffeic acid, the methyl ester form offers greater ease of handling, less sensitivity to minor environmental variations, and less rapid oxidative breakdown. This becomes especially evident in spray drying or thermal processing environments. Powder flow, dispersibility, and shelf life extend considerably simply by moving from acid to ester form.

    Adulteration is less common with Methyl Caffeate than with bulk caffeic acid, but we’ve discovered a few forms cut with unrelated methyl esters or even caffeine. Routine testing, both at incoming and outgoing stages, catches these before any material enters our production lines. Our chemists maintain a digital and physical archive of reference spectra, supporting detection of unusual peaks even when source materials change from season to season.

    Every year, industry groups meet to compare data and swap feedback about new applications for caffeate derivatives. Our technical staff shares lab notes and real production data, showing that pharmaceutical groups and specialty chemical developers often rely on Methyl Caffeate’s dual hydroxyl functionality and specific aromatic profile. These same teams come back for further technical collaboration, providing long-term insights that guide our manufacturing upgrades.

    Supporting Downstream Innovation

    Some of the most promising work with Methyl Caffeate comes directly from our partners' R&D teams. We provide small sample kits for pilot synthesis, working with universities, start-ups, and established companies. Together we run side-by-side comparisons with alternative antioxidants, solubilizers, or intermediates. This open, collaborative approach brings both unexpected discoveries and practical improvements in cost, process efficiency, or finished product quality.

    Our production teams gain new insights from these direct collaborations—maybe a gumminess issue in new granulation processes, or subtle color drift after long thermal holds. Each feedback loop provides actionable data. Over time, our process teams incorporate better grinding, advanced drying, or improved micro-filtration methods directly into our workflow. The result is that our Methyl Caffeate enables partners to keep pushing the innovation envelope, with fewer unplanned troubleshooting cycles.

    One growing segment includes personal care and cosmeceuticals, where Methyl Caffeate’s antioxidant and gentle aromatic profile offer an alternative to harsher phenolic compounds. Quality-focused formulators have asked for extra transparency into our synthesis and packaging processes. Responding to their audits, we created full process flow diagrams, released information on all excipient and packaging contact layers, and provided detailed trace potential allergen information. This level of access builds the long-term trust that large volume buyers need.

    We do not chase every passing trend, but maintain focus on engineered reliability and user-driven customization. When a new need emerges—a larger lot, a novel application, or a unique impurity spec—our teams reach out to labs, manufacturing, and logistics, all under one roof. Over time, this hands-on, collaborative approach has enabled us to deliver both standard and custom Methyl Caffeate with full confidence in reproducibility and regulatory acceptance.

    A Commitment Grown From Experience

    Years of direct engagement with real-world processing challenges fuel our insistence on analytical transparency, traceable raw materials, and strong communication. Every adjustment—whether in grinding, purification, packaging, or documentation—reflects a lesson learned not from theory, but from close work with plant operators and production partners. Our staff views every finished drum shipped not only as a product, but as a visible result of every handshake, audit, and troubleshooting session along the way.

    Looking forward, we focus on adapting our systems to new regulatory requirements, evolving customer expectations, and the subtle process variations that only show themselves after years in the field. As technical demands on flavor, pharmaceutical, or functional ingredient formulators grow ever more complex, we continue investing in training, equipment, and hands-on collaboration. Methyl Caffeate remains a unique chemical bridge—connecting proven chemical foundations with the shifting real-world needs of innovation-driven industries. Through every change, our role as the manufacturer centers on reliability, honest communication, and persistent improvement built on experience.