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Methyl Benzenesulfonate

    • Product Name Methyl Benzenesulfonate
    • Alias Benzenesulfonic acid, methyl ester
    • Einecs 208-892-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    178323

    Chemical Name Methyl Benzenesulfonate
    Molecular Formula C7H8O3S
    Molar Mass 172.20 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 273 °C
    Melting Point −36 °C
    Density 1.245 g/cm³
    Solubility In Water Slightly soluble
    Cas Number 80-18-2
    Iupac Name Methyl benzenesulfonate
    Flash Point 126 °C
    Refractive Index 1.524
    Odor Characteristic, aromatic
    Vapor Pressure 0.021 mmHg at 25 °C
    Stability Stable under normal conditions

    As an accredited Methyl Benzenesulfonate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Methyl Benzenesulfonate is packaged in a 500g amber glass bottle with a secure screw cap and hazard labeling.
    Shipping Methyl Benzenesulfonate should be shipped in tightly sealed containers, protected from moisture and incompatible substances. The packaging must comply with local and international transport regulations for hazardous chemicals. Ensure proper labeling, ventilation, and cushioning to prevent leaks or breakage, and transport with care to avoid exposure or environmental contamination.
    Storage Methyl Benzenesulfonate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition, moisture, and incompatible substances such as strong bases or oxidizers. It should be kept away from heat, direct sunlight, and protected from physical damage. Use appropriate chemical storage cabinets and clearly label all containers for safety.
    Application of Methyl Benzenesulfonate

    Applications of Methyl Benzenesulfonate in Industrial Manufacturing

    Methyl Benzenesulfonate serves as a specialized intermediate in select chemical transformations that require controlled alkylation, sulfonation, or methylation. As a direct manufacturer, we supply this compound to downstream sectors with clearly defined industrial practices, ensuring traceable quality and compliance at every stage of large-scale synthesis and formulation.

    1. API Intermediate in Pharmaceutical Synthesis

    Within active pharmaceutical ingredient (API) manufacturing, this compound acts as an efficient methylating agent during the multi-step synthesis of specific antihypertensive and antineoplastic drug molecules. Process engineers integrate it at defined steps where clean conversion, low by-product profile, and reproducible downstream reactions are critical for batch-to-batch consistency and regulatory approval.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU EudraLex Volume 4 GMP Guidelines
    • 21 CFR Parts 210/211 (US FDA GMP for Pharmaceuticals)
    • Pharmacopoeia specifications (e.g., USP, EP, JP)

    Typical usage ratio

    • 0.8–1.3 molar equivalents per API precursor substrate, adjusted according to the desired methylation degree and process yield optimization

    Downstream process integration

    • Introduced during mid-stage or late-stage methylation, generally after selective protection and prior to purification by crystallization or HPLC; engineers add under controlled temperature and pH to ensure selectivity

    Final product types

    • Beta-blocker APIs (e.g., metoprolol intermediate)
    • Cancer therapy molecules (e.g., methanesulfonate group-bearing drugs)
    • Antiviral compound intermediates
    • Raw materials for generic pharmaceutical synthesis

    2. Agrochemical Herbicide Intermediate

    In agrochemical production, manufacturers employ this molecule as a sulfonating agent to modulate chemical structure and biological activity in the synthesis of advanced herbicide and safener actives. Its controlled reactivity supports the creation of specific sulfonate functional groups, crucial for the performance of post-emergence selective herbicides used in cereal and broadleaf agriculture.

    Industry compliance standards

    • FAO/WHO Specification for Pesticide Ingredients
    • ISO 9001 Quality Management Systems for Agrochemical Synthesis
    • REACH Regulation (EC) No 1907/2006 (Europe)
    • China GB 2763 Maximum Residue Limits for Pesticides

    Typical usage ratio

    • 2–5% by weight relative to primary agrochemical substrate, based on target sulfonation pattern and plant tolerance requirements

    Downstream process integration

    • Fed into the sulfonation reactor post-nitration, under continuous agitation and solvent management; process incorporates real-time titration and phase separation to maximize yield of the sulfonated intermediate

    Final product types

    • Sulfonylurea herbicides (e.g., metsulfuron-methyl)
    • Phenylsulfonate-based herbicides
    • Synthetic safeners for herbicide formulations
    • Custom pre-formulated technical concentrates

    3. Dye and Pigment Intermediate

    Producers of high-performance dyes employ this compound as a key alkylation agent to introduce methylsulfonate moieties onto aromatic structures, resulting in colorfast, water-soluble dye precursors and pigment dispersants. The process is integral to the controlled manufacturing of textile and inkjet dyes with tailored solubility and absorption profiles.

    Industry compliance standards

    • OEKO-TEX® Standard 100
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals)
    • EN 71-3 (Safety of Toys – Migration of Certain Elements)
    • ISO 14001 Environmental Management System

    Typical usage ratio

    • 3–6% by weight of target chromophore compound; dosage depends on desired hydrophilicity and sulfonate group density

    Downstream process integration

    • Added during the alkylation or sulfonation stage after coupling reactions, typically at elevated temperature and controlled pressure; engineers monitor conversion rate and color properties during batch monitoring

    Final product types

    • Reactive dyes for cotton and viscose textile applications
    • Water-soluble azo pigments
    • Dispersing agents for pigment concentrates
    • Printing ink colorants for industrial and office use

    4. Electrolyte Additive for Battery Electrochemistry

    In the energy storage sector, researchers and manufacturers utilize this sulfonated ester as a specialty additive to improve the anodic stability and conductivity of electrolytic solutions in advanced battery chemistries. The compound integrates with solvent blends to enhance ion transport and thermal tolerance in high-performance lithium and sodium ion batteries.

    Industry compliance standards

    • IEC 62660-2 (Lithium-ion traction battery safety)
    • GB/T 31485 (China automotive battery safety)
    • UN 38.3 Transport Regulation for Battery Components
    • ISO 9001:2015 for Battery Raw Material Production

    Typical usage ratio

    • 0.5–2% wt/wt of total electrolyte solution; level adjusted based on cell voltage, cycle life, and electrolyte composition targets

    Downstream process integration

    • Dosed into solvent mixing tanks shortly before lithium salt dissolution and cell assembly; QC teams verify additive dispersion via electrochemical impedance and NMR prior to electrode dipping or injection filling

    Final product types

    • Lithium-ion battery electrolytes for automotive and storage sectors
    • Sodium-ion cell electrolytes
    • Electrolyte blends for power banks and consumer electronics cells
    • Prototype chemistries for solid-state and polymer batteries
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    Certification & Compliance
    More Introduction

    Methyl Benzenesulfonate: What Experience Teaches Us About Consistency and Value

    Bringing Real Industry Practice to Methyl Benzenesulfonate Production

    For any manufacturer devoted to specialty sulfonates, few products demand deeper attention than Methyl Benzenesulfonate. After decades standing behind stainless vessels and through lab screens, patterns emerge from every run and shipment. This compound—also known in the trade as methylbenzenesulfonic acid methyl ester—delivers functionality and reliability for partners far outside our plant gates. With a well-established CAS number, clear performance, and years of customer feedback, our daily work with this chemical goes well past formulaic listing; we build every batch from experience meeting practical expectations.

    Our process uses a direct sulfonation reaction with high-purity methylating agents. The approach yields a clear-to-pale-yellow liquid, exhibiting high purity by area normalization (minimum 99.5%). Residual moisture and acidity stay low, commonly below industry thresholds. The batch-to-batch repeatability—crystallinity, color, and by-products—shows up as much in the reaction as in decades of debugged procedures. The result remains a standard methyl ester, strong and dependable, ready for large-scale reactions or sensitive lab work.

    Where Methyl Benzenesulfonate Earns Its Place

    The main channel for Methyl Benzenesulfonate centers on organic synthesis. Few sulfonates occupy the same balance between reactivity, stability, and processability. Common uses emerge in methylation reactions, as strong alkylating agents, and in the preparation of specialty intermediates for the pharmaceutical and agrochemical sectors. Familiar pathways in the laboratory—methylations, substitutions, protection steps—take advantage of the compound’s clarity and low tendency to by-product formation. Operators working in glassware note the ease of handling, limited residue, and absence of color drift, even across long campaigns.

    Byway applications also surface where selectivity and mild processing conditions rank high on the checklist. Synthetic chemists and process engineers appreciate the low volatility, manageable by-product stream, and clean phase separation—qualities supporting safe scale-up and continuous processing. The thermal and hydrolytic stability helps avoid complications during prolonged exposure, making it a reliable workhorse over extended campaigns.

    Measuring the Difference: What Sets Methyl Benzenesulfonate Apart

    Not every sulfonate or alkylating ester matches the behaviors of Methyl Benzenesulfonate. In our own workflows—especially on the pilot and commercial scale—the distinctions stand out through yield, purity, and operational safety. Compare methyl with ethyl or propyl benzenesulfonates: methyl versions run more fluid and predictable, causing fewer filter or transfer complications. Removal from reaction mixtures requires less effort, with reduced fouling and clogging. Lower molecular weight translates directly to lower viscosity and easier handling, especially in cold-room conditions.

    Among alkylators, methyl benzenesulfonate delivers higher reactivity in methyl transfer reactions compared with longer-chain counterparts. This speed reduces side product formation and shortens reaction times, especially in tightly controlled batch operations. Substituting toluene-based sulfonates or other benzenesulfonate esters shows frequent setbacks in selectivity, with more waste or separate purification steps needed. We have tested many of these alternatives side-by-side; methyl benzenesulfonate stands out again for cleaner chromatographic profiles and lower residual odor.

    Another differentiator matters less in the textbook than on the shop floor: storage and shelf life. Methyl benzenesulfonate handles exposure and temperature swings much better than its larger homologs or analogs. Storage tanks stay cleaner, risk of polymer formation drops, and the sensitivity to light or humidity stays manageable over months, not just days. This cuts down re-processing, keeps maintenance teams free for higher-value work, and makes inventory oversight more forgiving.

    Technical Evolution: Responding to Supply and Demand Challenges

    Industry cycles rarely wait for perfect conditions. Customers push lead times shorter and purity requirements higher, and disruptions in raw material supply—whether from regional weather events or changing regulatory landscapes—can throw off planning. From time in the seat, we have seen clear trends: manufacturers who cling too tightly to fixed traditions risk running slow or inconsistent batches. Constant monitoring for off-odors, color picks, and trace contaminants allows us to adjust the feedstock ratios and process conditions based on lot-by-lot analytics. These tweaks, informed by QC records dating back decades, have helped prevent rejects and ensure our partners avoid shutdowns.

    Shifts in demand also ask for flexibility in reactor scheduling and logistics. Running a versatile plant—capable of jumping between batch and semi-continuous operations—gives us an edge in meeting variable customer demand without building up stale inventory. Larger customers may require IOQ and validation support, traceability, or chemistry-to-delivery timing rarely satisfied by traders or tollers. We have invested in in-house analytics, automatic batch tracking, and customer QA matching to close these gaps, all in the service of delivering each kilogram exactly as ordered.

    Committing to Quality From Raw Material to Delivery

    Meeting and exceeding customer expectations for Methyl Benzenesulfonate relies on more than chemistry. Reliable supply begins at the procurement stage. Early checks on raw material origin, documentation, and handling eliminate headaches later. We qualify each source for phenylsulfonic acid, methylating agents, and catalysts—not just by paperwork, but by pilot batch runs under actual production settings. Each new source submits samples for our analytics lab, where GC-MS, NMR, and titrimetric analysis serve as the mainstays. This hands-on approach prevents off-grade material from entering the regular process flow.

    In production, our operators follow a multi-point process control approach. Temperature, feed rates, and pressure undergo close tracking, and deviations give real-time alarms. By building historical process profiles for every vessel and shift team, problems get spotted early—sometimes days before analytical data shows an issue. Maintenance crews check heat exchangers, seals, and pumps on a rolling schedule, further tightening process reliability.

    Packaging remains the last—but not least—point of control. Methyl Benzenesulfonate can react aggressively with moisture and some metals, so we rely on lined drums and nitrogen blanketing throughout loading and storage. Logistics teams handle labeling in strict compliance with global and region-specific shipping standards. In some cases, we offer special handling for temperature-sensitive customers, sending small-batch high-purity product in sealed ampoules or containers.

    Meeting Regulatory and Application Demands Head-On

    Changing global regulations influence every aspect of the specialty chemicals business. Methyl Benzenesulfonate attracts ongoing attention for its reactivity and niche toxicity profile. As manufacturers, we face requirements for data transparency, environmental controls, and reporting not only in our home country but in every place where partners operate. Meeting these regulatory challenges takes a multi-layered approach.

    We maintain up-to-date registration with all applicable chemical management frameworks, including region-specific filings, hazard declarations, and environmental impact records. Safety Data Sheets receive continuous updates, keeping pace with global hazard communication standards. Waste streams are processed internally, using scrubbing and neutralization units to capture emissions and reduce wastewater loads. Downstream users often share their own application needs or regulatory guidance, and we provide supporting documentation on request—never as an afterthought.

    Trace impurities, especially suspected mutagenics and environmental hazards, undergo routine screening. Routine third-party audits reinforce internal controls. Keeping open lines with regulatory bodies and industry groups allows us to reduce disruptions, avoid supply delays, and make sure the product flows smoothly from our tanks to customer reactors, with no compliance hang-ups along the way.

    Working Directly With Users: Building Solutions Instead of Offering Promises

    Whether serving a pharmaceutical innovator or a midsized agrochemical operation, our support for customers does not stop at shipment. Early collaboration with R&D groups, scale-up teams, and supply chain managers builds lasting business. Technical personnel on our team routinely troubleshoot process questions: solubility in unfamiliar solvents, compatibility with new reagents, and sometimes help writing scale-up protocols that describe safe addition or remediation. If someone in the field runs into bottlenecked effluent or crystallized residue, we invite process samples back for analysis, then modify recommendations based on measured outcomes.

    Feedback loops work both ways. End-users flag rising interference with trace impurities, evolving production specs, or need for particular physical forms—liquid, crystalline, or stable solution. Instead of running a fixed product slate, we adjust material or packaging. This approach means less downtime, less process scrap, and stronger relationships built on shared problem-solving.

    Managing Risk and Ensuring Continuity

    Every specialty chemical—Methyl Benzenesulfonate included—carries risk, whether obvious or hidden. The raw chemistry can lead to splashing, vapors, or residue, with each new transfer or reaction requiring basic but non-negotiable protection. Over years of loading, sampling, and filling, the procedures earn a kind of muscle memory in the plant. Standard PPE, tested ventilation, and real response drills keep the operation tight and the teams confident.

    Outages or disruptions in utility supply—water, steam, power—pose concrete threats. Back-up systems and regular stress tests ensure that these failures never reach the customer. Our supply chain logistics lean hard on local and regional partners. Regular drills and scenario planning, shaped by past shipping delays and border issues, keep the material moving even when storms or emergency events impact the area. By sharing these concerns openly with partners, we have created redundancies and backup shipping channels which keep their lines running.

    Supporting Green Chemistry and Future Application Needs

    Sustainability challenges do not let specialty manufacturers off the hook. Methyl Benzenesulfonate often enters into multi-step synthesis routes, with customers and regulators both asking about waste minimization, atom efficiency, and end-of-life impacts. On our side, process improvements have cut volatile organic compound emissions and lowered the need for harsh neutralization steps. We continue to invest in catalyst recovery, solvent recycling, and greener methylating agents. Pilot work on continuous-flow reactors shows growing promise for reducing environmental footprint without trading off quality.

    Our experience echoes a bigger trend in industry: real sustainability needs collaboration. We keep a direct dialog with leading users, academic partners, and technology consortia. If new downstream applications need altered profile—lower impurity, different polymorph, or flexibility in reactant concentration—we customize production runs and participate in test trials, sharing data and observations all along the way. By staying active in pre-competitive research and knowledge sharing, the industry advances together.

    Long-Term Consistency: Lessons Learned, Benefits Delivered

    After many years working in chemical plants, tracking hundreds of production runs, and keeping test results logged by hand and by computer, a few truths become clear about Methyl Benzenesulfonate. The chemical delivers best where experience guides production, where every drum and every kilo gets checked and handled by well-trained teams, not just algorithms and order forms. Differences over competitors—consistency in fill, ease of handling, low by-product—come directly from deep familiarity with feedstocks, equipment, logistics, and the unglamorous daily realities of specialty chemicals.

    Steady quality pays for itself across many links in the chain. Less waste during synthesis means less downtime, less spent material, and fewer headaches for frontline operators. Low color and odor profiles translate into easier quality approval, smoother downstream purification, and happier customers at every point, from first trial to hundreds of repeat orders. We have seen the direct payoff: smoother processing, lower rejection rates, and more reliable performance benchmarks compared to traders or resellers with only surface exposure.

    Methyl Benzenesulfonate stands as a proven choice in sulfonate chemistry. Through decades of production, direct customer support, and ongoing improvement against real modern challenges, our commitment stays the same. Reliability and deep knowledge translate not only into better chemical yields, but into trusted relationships, shared technical progress, and long-term mutual gain.