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Methyl 5-Chloroanthranilate

    • Product Name Methyl 5-Chloroanthranilate
    • Alias MCA
    • Einecs 252-255-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    517296

    Cas Number 2836-92-4
    Molecular Formula C8H8ClNO2
    Molecular Weight 185.61 g/mol
    Iupac Name Methyl 5-chloro-2-aminobenzoate
    Appearance White to off-white crystalline powder
    Melting Point 86-90 °C
    Boiling Point 322.9 °C at 760 mmHg
    Solubility Soluble in organic solvents such as ethanol and methanol
    Purity Typically ≥98%
    Smiles COC(=O)C1=CC(=CC=C1N)Cl

    As an accredited Methyl 5-Chloroanthranilate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of Methyl 5-Chloroanthranilate is supplied in a sealed amber glass bottle with a screw cap and chemical safety labeling.
    Shipping Methyl 5-Chloroanthranilate should be shipped in tightly sealed, chemical-resistant containers, clearly labeled per regulatory requirements. It must be protected from moisture and incompatible substances, and handled according to Hazard Class guidelines. Transport should comply with local, national, and international regulations for hazardous chemicals, ensuring secure, upright placement and temperature control if required.
    Storage Store Methyl 5-Chloroanthranilate in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and direct sunlight. Keep container away from incompatible substances, such as strong oxidizers. Use appropriate chemical storage cabinets if available. Ensure proper labeling and restrict access to trained personnel. Handle using appropriate personal protective equipment.
    Application of Methyl 5-Chloroanthranilate

    Applications of Methyl 5-Chloroanthranilate in Industrial Manufacturing

    Methyl 5-Chloroanthranilate is a specialty intermediate with targeted applications in fragrance compounding, agrochemical synthesis, pharmaceutical manufacturing, and fine chemical production. As a direct manufacturer, we support industrial partners by supplying consistent, high-purity raw materials compliant with leading regulations, to meet the rigorous technical and process demands of end-use sectors. Below we outline key application scenarios, highlighting regulatory context, practical dosage, downstream integration, and the types of products our clients produce using this ingredient.

    1. Fine Fragrance and Aroma Formulations

    This compound serves as an integral building block in creating sophisticated floral and fruity notes for use in high-grade perfumery compositions. Industrial perfumers utilize its unique olfactory profile to create signature accords for luxury fragrances and compounded aromas. Due to its structure, the material also acts as a modifier in specialty blends, requiring careful dosing to balance intensity and stability in final scent profiles.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards
    • EU Cosmetic Regulation EC No. 1223/2009 (for fragrance ingredients in cosmetic products)
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) for import and use in the EU
    • U.S. Food and Drug Administration (CFR 21, Subpart C, § 700.13 Fragrance allergens labeling if applicable)

    Typical usage ratio

    • 0.01–0.5% of total fragrance oil formula, with concentration adjusted based on target intensity, fragrance family, and compatibility with other aroma chemicals

    Downstream process integration

    • Added during the compounding stage of bulk fragrance oil production; solubilization and blending occur under controlled temperature and agitation to ensure homogeneous distribution before stabilization and filtration

    Final product types

    • Fine perfumes (EDP, EDT, parfum concentrates)
    • Cosmetic and personal care fragrances (body mists, deodorants, creams)
    • Home and air care aroma oils (diffuser refills, scented candles)

    2. Flavor Ingredient for Food and Beverage Applications

    Methyl 5-Chloroanthranilate contributes a distinctive grape-like and fruity flavor, making it a niche compound in flavor house manufacturing, especially for soft drinks, candy, and confectionery. Industrial formulators use the material for flavor modulation, with careful attention to regional food additive regulations and typical dosages to ensure safety and flavor authenticity in mass-market consumables.

    Industry compliance standards

    • U.S. Food Chemical Codex (FCC) guidelines when used as a flavoring agent
    • EU Regulation (EC) No 1334/2008 on flavorings and certain food ingredients with flavoring properties
    • Japan Food Sanitation Act (when used in imported flavor formulations for the Japanese market)
    • Generally Recognized as Safe (GRAS) status review by FEMA (Flavor and Extract Manufacturers Association) where applicable

    Typical usage ratio

    • 2–20 ppm in finished beverage or confectionery products; formulated level depends on intensity required and regional maximum limits as defined by local food authorities

    Downstream process integration

    • Incorporated at the blending stage of flavor compound production; dissolved in ethanol or propylene glycol as carrier solvent and introduced post-emulsification but prior to spray drying or liquid compounding for finished flavor delivery

    Final product types

    • Grape-flavored soft drinks and sodas
    • Chewing gum and hard candy flavor pastes
    • Baked goods and dessert pre-mixes with fruit notes

    3. Pharmaceutical Intermediates for Active Ingredient Synthesis

    Our material is used as a critical intermediate in the multi-step synthesis of several APIs (active pharmaceutical ingredients), particularly in areas where derivatives of anthranilates facilitate medicinal applications such as anti-inflammatory or anti-allergic drugs. Manufacturer partners rely on precise quality and lot traceability throughout production, implementing in-process controls in accordance with regulatory demands for cGMP manufacturing.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) for intermediate quality reference (if incorporated into a USP monograph product route)
    • European Pharmacopoeia (Ph. Eur.) standards for intermediates and APIs
    • FDA Drug Master File (DMF) system for supplier qualification

    Typical usage ratio

    • Used at a stoichiometric ratio according to target synthesis scale, commonly ranging from 0.5–1.2 eq relative to the main reactive substrate, with adjustments based on yield optimization in process development

    Downstream process integration

    • Charged into reaction vessels at the defined stage of pharmaceutical synthesis, following initial activation or protection steps; typically utilized during acylation, esterification, or functional group modification, then processed through extraction, purification, and isolation

    Final product types

    • Small molecule APIs used in anti-histamine or anti-inflammatory drugs
    • Advanced pharmaceutical intermediates for custom synthesis
    • Reference standards for medicinal chemistry research

    4. Agrochemical Synthesis – Herbicide and Pesticide Intermediates

    Methyl 5-Chloroanthranilate is employed as a key intermediate in the industrial fabrication of specific chloro-substituted herbicide actives and growth regulators. Agrochemical production facilities incorporate this input in closed-system reactions that require traceable purity, environmental compliance, and documentation aligned with national pesticide product registrations.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products (where applicable)
    • EPA Pesticide Registration (U.S. Code of Federal Regulations, 40 CFR Part 158)
    • REACH and Biocidal Products Regulation (in the EU)
    • GB 3796-2015 (China National Standard for Pesticide Technical Material)

    Typical usage ratio

    • 1–1.5 molar equivalent based on downstream conversion route, with batch scale and conversion efficiency dictating mixture strength

    Downstream process integration

    • Introduced into closed reactors during the active ingredient synthesis phase, typically following initial halogenation or amidation, then subjected to further functionalization to yield the final agrochemical compound

    Final product types

    • Selective herbicide technicals
    • Growth regulator actives
    • Pesticide formulation intermediates for large-scale crop protection products

    5. Specialty Dye and Pigment Intermediates

    This material provides a chlorinated aromatic unit that dye manufacturers use in the design of specialty anthraquinone and azo dye intermediates. The compound’s reactivity facilitates the formation of chromophores for high-performance dyes that meet strict industrial and environmental benchmarks for textiles, plastics, and inkjets. Process controls emphasize purity control to reduce side reaction by-products during condensation or cyclization steps.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (for finished textile dye safety)
    • REACH Annex XVII for substances of concern in dyes and pigments
    • ISO 9001:2015 Quality Management (for dye and pigment manufacturers)
    • ZDHC (Zero Discharge of Hazardous Chemicals) guidelines for textile chemicals

    Typical usage ratio

    • 5–30% as a key intermediate component relative to other coupling partners, with specific ratios determined by desired color strength and process scale in dye chemistry

    Downstream process integration

    • Added during the intermediate synthesis step (such as diazotization or coupling), then carried forward through filtration, drying, and finishing to yield dye components for industrial coloration recipes

    Final product types

    • Textile dye intermediates (anthraquinone series, azo dyes)
    • Plastics and fiber colorants
    • High-resolution pigment dispersions for inkjet and printing applications
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    Certification & Compliance
    More Introduction

    Methyl 5-Chloroanthranilate: A Closer Look at Craftsmanship and Purity

    Our Experience Shaping Methyl 5-Chloroanthranilate

    Producing Methyl 5-Chloroanthranilate starts with a chemistry that doesn’t tolerate shortcuts. Any batch that leaves our site carries the fingerprints of years we’ve spent refining process control, safety, and purity. Our team has learned that anyone can blend materials, but building trust among expert formulators takes steadfast attention to every variable, and a willingness to quietly push for tangible improvements. In hands-on synthesis, each step becomes non-negotiable—meticulous raw material selection, steady reaction temperatures, precise moisture management, and full accountability for waste handling. Over the years, demanding customers in flavors, fragrances, and intermediates have made us take every spec personally, because one off-smelling drum stains a relationship. We don’t ship what doesn’t meet our bar, period.

    Technical Details and Nuance in Production

    We manufacture Methyl 5-Chloroanthranilate to meet the needs of formulation chemists who can spot the difference between “pure enough” and “right every time.” The model we produce uses a process that never accepts vague color metrics or rough purity ranges. Years ago we learned the hard way that even trace organics or solvent residues show up in final evaluations. Current production involves multi-stage purification, including fractional distillation and repeatedly washing reactants. We routinely analyze lots using GC-MS, and our batch records can track any bottle back to the exact conditions it was formed under. For us, methylating clean 5-chloroanthranilic acid with high-quality methanol isn’t just a textbook pathway. It’s a set of decisions about reagents, pressure, and timing, shaped by knowing which mistakes cost the end user time and money.

    Why Specifications Matter in Real Use

    Methyl 5-Chloroanthranilate matters to flavor and fragrance creators because even subtle shifts in quality turn up in sensory evaluation. That lesson came early in our company’s story, when a batch that looked and smelled fine proved inconsistent under panel testing. The pain of seeing an entire project delayed for weeks comes back every time we sign off on a shipment. For our standard grade, assay by GC consistently exceeds 99 percent. Water content is tightly controlled below 0.2 percent. The finished product is a clear, almost colorless to pale yellow liquid, but our most demanding clients check not just appearance but trace acid value and impurity profile. For new applications, we work directly with partners to go beyond the spec sheet—sharing full chromatograms, providing retention samples, and welcoming third-party verification. We never treat these numbers as marketing points; quality gets tested in the real world, not on paper.

    End-Use Applications We See in Industry

    Methyl 5-Chloroanthranilate holds a special appeal in both industrial and specialty markets. In flavors, it’s the foundation for grape, berry, and herbal profiles. Large beverage brands and boutique flavorists alike rely on that signature, slightly green-fruity nuance. Fragrance blenders value it for its long-lasting, mellow floral note—often rounded by pairing it with esters and musks. Synthetic intermediates based on our product show up in agrochemicals, pharmaceutical research, and materials science. Because we’ve worked directly with downstream engineers, we’ve seen how even half a percent impurity can trigger pigment fading, odor off-notes, or regulatory headaches. That’s why we share not just specs but practical performance guidance.

    How Methyl 5-Chloroanthranilate Compares

    Methyl 5-Chloroanthranilate differs from other anthranilate derivatives in ways that matter for real-world use. Compared to standard methyl anthranilate, our product offers a uniquely soft yet persistent aromatic impression—less candy-sweet, more nuanced green. Chloro substitution at the 5-position introduces a subtle modification in volatility and persistence, which translates to longer shelf-life in fragrance blends and bolder top notes in flavorings. Other methylated analogues might work at a pinch, but formulating with them often means chasing minor differences with masking agents or rebalancing a blend. On the analytical side, Methyl 5-Chloroanthranilate provides a more predictable impurity profile when sourced using modern purification methods. This saves our customers rounds of re-qualification, especially when supplying products to regulated environments or consumer brands with tight tolerances.

    Lessons Learned from Customer Feedback

    Direct conversations with customers changed how we view quality control. Over the years, a few common requests have re-shaped our protocols. Many in the flavor industry pressed for shorter lead times, so we invested in scalable synthesis and modular purification to cut turnaround. Fragrance specialists demanded tighter color control, so we adopted new handling and storage methods that preserve freshness. A handful of pharmaceuticals partners needed documentation down to impurity origin, which led us to expand our tracking and digital record-keeping. Frequently, customers want to know storage stability—especially in high-humidity regions. Every feature came from a real need or a past complaint; every specification has a story behind it.

    Addressing Regulatory and Purity Concerns

    Regulatory reviews often focus on trace contaminants and ingredient traceability. We take this personally. From the start, our batches undergo full-regime screening—checking for residual solvents, unreacted starting material, and compliance with global purity standards. Any container moving to an export market carries full CoA documentation traceable to production day. In-house stability testing under accelerated conditions validates shelf-life claims, keeping surprises out of the customer’s warehouse. Where end users need kosher, halal, or pharmaceutical-grade assurances, we tailor documentation bundles and can host customer audits on request. Every time a new region sets new standards, we respond by updating process and paperwork—not because a certification logo looks nice, but because we know how upstream consistency prevents downstream headaches.

    Reliable Sourcing—Not Hype

    True reliability doesn’t hide behind sales talk. It comes from predictable outcomes, robust quality checks, and open conversations. We learned this after seeing what happens when a global customer received sub-par material from elsewhere and scrambled to recalibrate entire systems. That memory influences every batch we release. We’re not interested in being the lowest bidder. Our aim is long-term supply continuity: uninterrupted access to consistent product, backed by intimate understanding of chemical behavior throughout shipping, storage, and mixing. When a partner’s process changes or a regulation tightens, our technical team talks directly with their staff to ensure a good fit. Bulk lots carry the same care as small orders; our responsibility doesn’t stop at the warehouse door.

    Solving Storage and Handling Challenges

    Over the years, our technical service engineers have seen the gamut of storage mishaps and transport surprises. Customers have stored drums without full sealing or exposed contents to extended temperature swings, only to discover a subtle loss in aroma quality or a shift in composition. In our own facility, we implement nitrogen blanketing and maintain climate-controlled warehousing. The importance of minimizing headspace contact and preventing microbial ingress became clear through experience, not theory. We share these lessons candidly with end users, because we both gain when surprises get managed before they happen in the field. For bulk customers, we support custom packaging—stainless, HDPE, or lined steel—matched to end-use timelines and shipment size.

    Continuous Process Improvement

    Making Methyl 5-Chloroanthranilate better each year comes from listening, not guessing. Early on, our process favored yield above all else, but incompatibility issues in downstream blending made clear that purity trumped all. We switched solvents, re-engineered reaction vessels, and invested in digital controls to automate the parameters we learned matter most: pH, pressure, and exact addition timing. Every improvement ties back to feedback from technical staff and operators who use our product every day. In our experience, steady progress beats flashy innovation—incremental tweaks over years produce a lot less drama and a lot more reliability on the blending floor. Because our customers often scale new products in short runs, we support pilot batch customization and small-lot trialing alongside bulk shipments, giving partners room to experiment without risking project budgets.

    Transparency About Raw Materials and Upstream Sourcing

    Our raw material traceability dates back to our earliest production runs. Before any new source joins the supply list, we validate every supplier through site audits and trial lots. After an incident with a contaminated input years ago, we started demanding full microanalysis and trace impurity checks from every upstream vendor. If supply chains shift—due to price, logistics, or regulatory disruption—we notify partners ahead of any material change. This approach isn’t about box-checking; we’ve learned the expensive lesson that an upstream slip can echo for months through the value chain. By keeping partner labs and purchasing managers informed, we shrink risk and speed up problem-solving if anything unexpected appears on a chromatogram. Some competitors still change raw sources behind closed doors. Our team sees long-term trust as worth more than a short-term margin.

    Rigorous Analytical Verification

    Each batch of Methyl 5-Chloroanthranilate undergoes more than a single purity check. We run full-spectrum analysis—GC-MS, HPLC, IR, and wet chemistry—on every lot. Every year, we upgrade our detection protocols and retrain staff in emerging contaminants, because new insights keep surfacing from finished-product testing across markets. As trace-level thresholds tighten in food and cosmetic law, our specs now include even minor byproducts and residuals that once went unmonitored. Tight controls on water content and pH preserve performance in moisture-sensitive blends. We routinely validate findings through third-party labs—especially for clients introducing final goods to new geographies. This openness makes for honest conversations about what matters in a real-world setting, not perfection for its own sake.

    Supporting Innovation in Applications

    The science behind Methyl 5-Chloroanthranilate continues to surprise us. In recent years, we’ve partnered with customers experimenting in new beverage categories, complex natural/flavor hybrids, and next-generation scent carriers. Sometimes, clients bring unexpected hurdles—delayed releases, aggressive blending partners, or off-beat delivery systems. Those moments push us to rethink what our product can do. We share new analytical data and collaborate to tweak functional groups or blend ratios, always focusing on stability and regulatory fit as much as sensory payoff. In return, customers tell us which performance quirks show up on the shelf or in real-world applications, feeding that feedback into the next production cycle.

    Eco-Conscious Production: Not Just Marketing

    Environmental concerns motivate much of our process design. We run closed-loop solvent systems, minimize wash-water, and reclaim as much reaction heat as practical. Years ago, our waste management protocols exceeded local regulation, driven by the knowledge that trace emissions upstream show up downstream. Staff training centers on safe handling for both people and planet. Clients in food and pharma markets want answers on everything from Energy Use to Life Cycle Analysis, and we work openly to supply the data and verify it where feasible. For partners seeking to green-label their finished goods, we share process data openly so claims stand up under scrutiny. These steps didn’t come overnight; each one stemmed from repeated requests and hard-won experience, not a single round of optimization.

    Realistic Outlook on Cost and Value

    Anyone who uses or sources Methyl 5-Chloroanthranilate knows market price fluctuates with energy, raw materials, logistics, and regulation. While commodity vendors chase every cent, we have chosen to focus on total cost-in-use for our partners: a predictable batch that reduces troubleshooting, regulatory rework, and reformulation delays. Longstanding clients tell us they value certainty above marginal savings. Recent volatility in chemical supply only underscored the need for steady partners. Our purchasing team manages risk through diversified sources and built-in inventory, so spikes in global transport or temporary bottlenecks don’t cascade into late shipments or missed deadlines for customers.

    Long-Term Partnerships and Knowledge Sharing

    Our technical support and commercial teams don’t treat project completion as the end of the story. Many partners circle back for help scaling new applications, adapting to regulatory updates, or meeting new consumer trends. We welcome shared lab work, joint plant trials, and pilot-order feedback. If a performance issue or outlier appears, we treat it as a chance to improve on both sides. Open communication matters—our most successful partnerships started as simple troubleshooting conversations, not high-stakes negotiations. In every interaction, we strive for collaborative problem-solving and practical outcomes that make both products and processes stronger.

    Conclusion: Methyl 5-Chloroanthranilate, Built on Craft, Feedback, and Trust

    Methyl 5-Chloroanthranilate reflects decades of applied insight, quiet upgrades, and honest feedback from partners across industries. Those selecting ingredients for foods, fragrances, or specialty chemicals rely on more than a name or a number; they depend on reliability shaped by experience, transparency, and adaptability. Our progress rested on real needs—shaped by field failures, panel taste-offs, and demands from regulatory audits—not hopes or standard formulas. Years of close work with customers taught us production is never just about molecules; it’s about knowledge, trust, and a continuous willingness to improve together. We look forward to seeing what our product—and our partnerships—achieve in the years ahead.