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Methyl 4-Hydroxycinnamate

    • Product Name Methyl 4-Hydroxycinnamate
    • Alias Methyl p-coumarate
    • Einecs 240-242-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    837464

    Cas Number 3943-89-3
    Molecular Formula C10H10O3
    Molecular Weight 178.18 g/mol
    Iupac Name methyl (2E)-3-(4-hydroxyphenyl)prop-2-enoate
    Appearance White to off-white crystalline powder
    Melting Point 124-126 °C
    Boiling Point 340.4 °C at 760 mmHg
    Solubility In Water Slightly soluble
    Smiles COC(=O)C=CC1=CC=C(C=C1)O
    Pubchem Cid 5280457
    Synonyms Methyl p-coumarate, p-Coumaric acid methyl ester
    Refractive Index 1.573
    Density 1.206 g/cm³
    Storage Conditions Store at room temperature, protected from light and moisture
    Flash Point 139.6 °C

    As an accredited Methyl 4-Hydroxycinnamate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Methyl 4-Hydroxycinnamate is packaged in a 25g amber glass bottle with a secure screw cap, labeled with safety and identification details.
    Shipping Methyl 4-Hydroxycinnamate should be shipped in well-sealed, labeled containers, protected from light and moisture. Handle as a chemical product, following standard safety protocols. Transport in compliance with local and international regulations, including any applicable hazardous material guidelines. Ensure appropriate documentation accompanies the shipment to guarantee safe, legal delivery.
    Storage Methyl 4-Hydroxycinnamate should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and moisture. The container should be tightly closed and made of compatible material, such as glass or high-density plastic. It should be kept away from sources of ignition, strong oxidizers, and incompatible substances. Proper labeling and precautionary signage are recommended.
    Application of Methyl 4-Hydroxycinnamate

    Applications of Methyl 4-Hydroxycinnamate in Industrial Manufacturing

    Methyl 4-Hydroxycinnamate finds consistent demand across multiple chemical manufacturing sectors due to its well-defined properties and compatibility with strict industry controls. As the direct producer, we serve global industrial partners who apply this raw material for precise downstream synthesis and formulation processes.

    1. UV Absorbers in Personal Care Formulations

    Personal care manufacturers employ Methyl 4-Hydroxycinnamate as a UV-protective intermediate, primarily during the production of sunscreen agents and daily skincare lines. It gives targeted ultraviolet filtering effects, fitting into the regulated design of photo-stable formulations. Integration in these applications involves deep collaboration with compliance teams to ensure all inclusion levels and process steps align with international safety and quality benchmarks.

    Industry compliance standards

    • EU Cosmetic Regulation (EC) No 1223/2009
    • US FDA 21 CFR 700-799 Cosmetics
    • China GB/T 34834-2017 Sunscreen Cosmetic Safety Assessment
    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals

    Typical usage ratio

    • 0.1% – 1.5% by weight of formulation, adjusted following in-vitro SPF testing and formulation base type

    Downstream process integration

    • Introduced during pre-mix of the oil phase; requires dispersion with controlled heating to fully dissolve before emulsion or gel blending. Batch QC sampling verifies full incorporation to meet filter performance metrics.

    Final product types

    • Sun protection lotions and creams
    • Daytime facial moisturizers
    • UV-blocking makeup bases
    • Hair care sprays with UV defense labeling

    2. Pharmaceutical Intermediate for Antioxidant Synthesis

    API manufacturers use Methyl 4-Hydroxycinnamate as a well-characterized intermediate in the production of select antioxidant agents, particularly for topical and semi-solid drug delivery. Its phenolic structure supports the formulation of actives for oxidative stress control, and process parameters focus on purity retention. Validated protocols under cGMP environments require traceability for every lot used in the synthesis sequence.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP) monographs for antioxidants where applicable
    • WHO Technical Report Series, Annex 2 Quality Control

    Typical usage ratio

    • Intermediate feed: stoichiometric amounts as determined by API molecular pathway, usually 0.5–2.8 mmol per batch depending on scale

    Downstream process integration

    • Dosed into the reactor at the early condensation or esterification stage. Reaction monitored for complete transformation. Residue analysis ensures absence in final API per Q7A documentation.

    Final product types

    • Finished antioxidant topical pharmaceuticals
    • Precursor intermediates for dermatological actives
    • Bulk substances for further semi-synthetic modification

    3. Food Additive Synthesis for Flavor Compounds

    The flavor and fragrance industry utilizes Methyl 4-Hydroxycinnamate as a starting material for the synthesis of spice and vanilla-type additives. Its molecular structure supports both esterification and transesterification routes, producing food-grade aroma enhancers under strictly documented process flows. Facilities adopting this material operate under global food safety management and additive purity protocols.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius General Standard for Food Additives
    • 21 CFR 172 – US FDA Food Additives Permitted for Direct Addition
    • ISO 22000 Food Safety Management System
    • EU Regulation (EC) No 1334/2008 on Flavourings

    Typical usage ratio

    • Added at 0.02% – 0.15% w/w (200–1500 ppm), ratio refined by batch size and targeted aroma intensity, with finished product testing for sensory and regulatory compliance

    Downstream process integration

    • Mixed into flavor precursor reactors following solvent charging and catalyst addition; esterification temperature and timeline established through internal SOPs, with residual content tracked to meet global food additive limits

    Final product types

    • Liquid and powder flavor concentrates
    • Spice blend bases for processed foods
    • Baked goods aroma enhancers
    • Confectionery additive syrups

    4. Intermediate for Agrochemical Synthesis

    Agrochemical synthesis facilities select Methyl 4-Hydroxycinnamate for its role as a building block in the creation of growth-regulating substances and certain plant protective agents. Strict process controls and formulation secrecy demand valid COA traceability and documented impurity profiles. Synthesis routes integrate this material for further transformation, with downstream agencies requiring proof of guideline adherence and safe handling records.

    Industry compliance standards

    • FAO Specification and Evaluations for Agricultural Pesticides
    • OECD Principles of Good Laboratory Practice (GLP)
    • REACH Annex VIII for industrial use of chemical intermediates
    • US EPA Registration (40 CFR Part 180) where applicable

    Typical usage ratio

    • 0.05 mol – 2.0 mol per processing batch, adjusted by the final active ingredient synthesis route and crop regulatory approvals

    Downstream process integration

    • Charged at the intermediate formation stage prior to alkylation or reduction; process follows validated master batch records with in-process HPLC monitoring, supporting traceability through subsequent conversion steps

    Final product types

    • Plant growth regulator formulations
    • Intermediate chemicals for herbicide or fungicide production
    • Seed treatment additive bases

    5. Chemical Intermediate in Polymer Additive Manufacturing

    Plastics and coatings producers use Methyl 4-Hydroxycinnamate as a precursor for UV-stabilizing additives and cross-linking agents. The material’s integration improves weather-resistance in finished plastics and surface coatings. Facility protocols schedule precise charging with focus on maintaining additive purity and batch reproducibility, as required by advanced manufacturing contracts for automotive, packaging, and electronics markets.

    Industry compliance standards

    • EN ISO 9001 Quality Management for Manufacturing
    • ASTM D2565 Practice for Xenon-Arc Exposure of Plastics
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)

    Typical usage ratio

    • 0.2% – 1.2% by polymer mass, adapted according to polymer type (e.g., PVC, PET) and desired photostability index

    Downstream process integration

    • Pre-polymerization addition to monomer or masterbatch mixing; downstream extrusion or molding steps ensure uniform dispersion; finished component analyzed by UV stability and mechanical property tests

    Final product types

    • UV-resistant plastic films and sheets
    • Outdoor polymer profiles for construction
    • Protective surface coatings for automotive and consumer goods
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    Certification & Compliance
    More Introduction

    Methyl 4-Hydroxycinnamate: Practical Applications and Everyday Value in Chemical Manufacturing

    Introduction to Methyl 4-Hydroxycinnamate

    In the landscape of fine chemical production, Methyl 4-Hydroxycinnamate stands out for its versatility. This phenylpropanoid ester brings together a unique structural profile with excellent reactivity, offering both complexity and dependability in a single molecule. Our plant handles this compound from raw feedstock to tightly controlled, finished form, always driven by hands-on experience and a deep understanding of how chemistries behave in practice, not just theory.

    Understanding the Chemistry: What Makes This Molecule Special?

    Methyl 4-Hydroxycinnamate, sometimes referred to by its CAS number 3943-09-9, belongs to the class of methyl esters derived from hydroxycinnamic acids. Following the tried-and-true synthetic pathways, our chemists produce this compound with high purity, minimizing by-products that could complicate downstream processes. The molecule itself offers a valuable aromatic ring with a hydroxy group at the para position, paired with an ester functional group. This combination leads to a balance of stability and reactivity, which many other esters can't match.

    Specifications That Matter in Manufacturing

    On the shop floor, experience shows that real-world outcomes depend on specifications, not buzzwords. We focus on purity levels above 99%, verified by HPLC and GC where suitable, and regularly check for residual solvents and trace metals. Consistent melting points and established solubility curves make for predictable behavior in both lab and plant settings. This reproducibility eliminates wasteful rework and keeps batch records straightforward, especially when audited for compliance.

    Moisture content is a constant battle in many facilities. With carefully monitored drying, we keep water levels below 0.5%, a detail that pays off in reaction setups where side reactions can cost a day’s output. In organics, color matters too—not just for aesthetics, but as a quick visual check for oxidation or cross-contamination. We take pride in batches with clear, pale-yellow appearance, a practical indicator of both clean handling and proper storage.

    Application Experience Across Industries

    Demand for Methyl 4-Hydroxycinnamate comes from different directions. In cosmetics and personal care, the molecule plays a key role in UV-absorbing formulations, standing up to repeated testing where stability under light and temperature shifts is critical. Our own trials confirm that even after weeks under UV aging, our material keeps its integrity and doesn’t drift in color or texture.

    As a manufacturer, we see the bulk of inquiries from flavor and fragrance houses. Here, Methyl 4-Hydroxycinnamate bridges spicy, sweet, and slightly woody notes, without the sharpness that some free acids bring. In food applications, our biggest ongoing challenge is compliance with tight residue limits and clear allergen declarations. To address this, we follow strict segregation approaches during synthesis and packaging, keeping cross-contamination well below regulatory thresholds.

    Researchers also value this ester as an intermediate in more complex syntheses. Its robust methyl ester group can undergo a range of transformations: reductions for alcohol production, hydrolyses for acid recovery, and O-alkylations for functional extensions. These reactions are usually smooth at scale when starting from a clean, crystalline batch—something that shortcuts with impure material will rarely deliver.

    Why Choose Methyl 4-Hydroxycinnamate Over Alternatives?

    Plenty of esters jostle for attention in the market. After years of batch testing and performance trials, we’ve noticed clear differences that matter outside of spreadsheets. Simple methyl cinnamate, for example, lacks the hydroxy group, which means it misses out on both antioxidant properties and certain UV absorption profiles. Our customers in skincare and sunscreens report stronger photo-protection and longer shelf stability by sticking with the para-hydroxy variant. Food technologists confirm that subtle flavor nuances are easier to dial in, without drifting into bitterness.

    In organic synthesis, the hydroxy function on the aromatic ring lets the chemist link, extend, or protect the molecule in precise ways. This flexibility reduces time wasted on lengthy precursor steps or messy protection group strategies. In real-world labs, cleaner starting material saves man-hours and reduces solvent usage—a benefit that’s measurable in both productivity and waste streams.

    Production Insights: How We Keep Quality Consistent

    Maintaining robust quality means focusing on process, not just testing the final product. Our reactors handle small to mid-scale batches, allowing us to respond quickly to seasonal demand shifts. Digital monitoring at every stage catches early signs of deviations. For example, we found that minor tweaks in esterification temperature improved both yield and color consistency, shaving several hours off post-processing time.

    We store raw phenols and cinnamic acid derivatives under nitrogen to prevent color changes that customers find frustrating. Filtration methods have evolved—from gravity-driven setups to vacuum-assisted lines—because real-world feedback from our own teams highlighted how easily fine particulates can impact clarity and downstream compatibility. Feedback isn't just paperwork; it’s the difference between an easy filtration step and a recurring blockage that stops a full shift in its tracks.

    Packaging counts too. By using moisture-barrier liners and small batch drums, we trim product degradation during shipping, especially in humid months. Customers tell us they notice the difference: open up a drum at destination and the product still carries the fresh, mild scent typical of a high-grade ester, without musty notes or caking.

    Sustainability and Sourcing

    Chemical manufacturing has a real impact on the environment. For Methyl 4-Hydroxycinnamate, we source feedstocks from regional suppliers with proven records in sustainable farming. By avoiding the cheapest, least traceable options, we've cut back on inconsistent raw material quality. Local procurement also keeps transport distances short, limiting greenhouse gas emissions and supporting responsible land use.

    In our waste handling, solvent recovery comes standard. Still, experience keeps teaching that small, unmonitored leaks can undermine months of progress. Every new technician goes through hands-on training, not just classroom reading, walking through collection points and learning to spot the warning signs. The investment pays off: even routine plant maintenance becomes an opportunity to tighten up environmental safeguards.

    Spill response drills are more than formality. We design for containment at every stage, starting from bulk solvent storage to final blending. By closing loops on wastewater and keeping a strict watch on vented organics, we've been able to show auditors a real decrease in emissions year over year. Operating this way brings peace of mind and helps preserve both community trust and the ongoing right to operate.

    Regulatory Compliance: Meeting Evolving Standards

    Every region has its own rules about chemical ingredients, food additives, and cosmetic actives. Navigating this maze without shortcuts is the only way to keep products on shelves and avoid shipment holds. For Methyl 4-Hydroxycinnamate, we prepare full documentation for every batch, including traceable lot numbers and certificates detailing purity, analytical results, and residual solvent content.

    Years spent submitting data to regulatory agencies have shown that anticipating questions prevents costly delays. When authorities ask about trace processing aids or secondary reaction products, we already have the profiles and method outlines ready. Our internal audits map directly to customer documentation needs—for example, knowing that a fragrance customer in Europe needs full IFRA/REACH paperwork, while a North American food customer wants FDA GRAS references. That attention to detail creates trust, and trust keeps partnerships steady through tough market cycles.

    Practical Solutions to Common User Pain Points

    Repeated complaints in the wider market target poor color consistency, mild contamination, and solubility hiccups. We see the root cause tracking back to cost-cutting in purification or lapses in storage. Rather than chasing margins, our teams revisit each process after big setbacks. We’ve replaced some filter media and even shelving units when they proved difficult to clean or led to unnoticed cross-overs.

    On the technical side, customers sometimes report handling issues—material clumping under moisture, slow dissolving in alcohols, or variable crystal sizes. By working directly alongside formulating chemists, we’ve dialed in drying cycles and sieving steps that match these downstream expectations. This dialogue reduces time burned on reprocessing and means fewer emergency rushes.

    Some large scale users prefer bulk shipments to minimize handling costs. We double-wrap pallet loads and use tamper-evident seals to reassure warehouse managers. It’s not about ticking a box; customers know at a glance that their order hasn’t been tampered with, streamlining inward checks and saving on rejected loads.

    In shipping to humid climates, we recommend (and supply) desiccant packs with each drum, sharing best practices drawn from our own export routes. Each year’s crop of customer field reports gives us actionable ideas—everything from drum venting tips to improved label adhesives in wet warehouses. These small adjustments, learned through accumulated experience, prevent product loss and hassle at the receiving end.

    Research Trends and Product Enhancements

    Interest in natural and nature-identical ingredients is growing, especially across Europe, North America, and Asia-Pacific. Our technical staff keeps up with published studies on phenylpropanoid esters, and we maintain our own in-house stability trials to make sure our methyl 4-hydroxycinnamate aligns with these trends. Studies point to its efficacy in antioxidant blends and its gentle impact in cosmetic trials, with fewer reported sensitivities than harsher phenolics. We adapt our purification steps accordingly, using column chromatography or recrystallization to achieve the desired safety margins.

    We also work with R&D partners testing novel derivatizations. Sometimes customers push for even milder odor profiles or higher UV absorption. This prompts us to tune our processes and adopt modern catalytic methods, shifting away from older acid-catalyzed reactions that risk introducing color bodies or residual acidity. These improvements take time, but they pay off as formulation hurdles fall away and batch-to-batch consistency increases.

    Customer Support and Knowledge Sharing

    Years in this business teach that no two customers use an ingredient in the exact same way. We invite technical questions early, bringing plant managers and formulators into three-way conversations to find the real-world solutions that save time and frustration. Sometimes, an unexpected lab result leads us to review a drying parameter or track an unexpected contaminant back to a supplier’s change in drum lining. Support is more than an email address—it means involvement at every step and honest feedback both ways.

    Our documentation practices sprang from repeated requests for extra details. After producing a run flagged for off-standard color, we rolled out a revised sample retention program. Now, teams can compare current production to past batches, learning from subtle differences that even our best QC checks might have missed before. This kind of living archive creates confidence in our claims and helps root out root causes.

    We also encourage customer visits. Seeing the plant in operation, meeting the staff who handle and pack the material, and watching real samples move through the process helps buyers make informed decisions—not just based on price, but on the predictability and transparency of the operation behind the product.

    Looking Forward: Meeting New Market Expectations

    New regulations and trends push us to rethink the basics year after year. Shifts in consumer demand push for “clean label” ingredients and tighter traceability. We don’t just add buzzwords to packaging; ongoing investment goes into analytical upgrades and refining our internal controls. It takes hands-on effort to stay ahead, but this approach shapes a reliable supply chain in the long run.

    Looking ahead, we’re expanding our batch sizes and improving solvent recycling to reduce both costs and carbon footprint. Teams search for new ways to increase purity and reduce handling stress on the powder, so end-users receive a product that behaves as expected even under tough conditions. The simple fact is that quality, consistency, and responsive support stem from years in the field, not shortcuts or one-size-fits-all solutions.

    We invite partners to bring us their toughest problems and lean on our experience. Methyl 4-Hydroxycinnamate isn’t just a line on a product list—it’s the result of careful stewardship, collaboration, and endless small improvements, each of which builds confidence on every order, large or small.