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Methyl 4-Amino-2-Methoxybenzoate

    • Product Name Methyl 4-Amino-2-Methoxybenzoate
    • Alias mfcd00017357
    • Einecs 242-729-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    868194

    Name Methyl 4-Amino-2-Methoxybenzoate
    Synonyms Methyl 4-amino-2-methoxybenzoate; Benzoic acid, 4-amino-2-methoxy-, methyl ester
    Cas Number 1193-68-0
    Molecular Formula C9H11NO3
    Molecular Weight 181.19 g/mol
    Appearance White to light yellow crystalline powder
    Melting Point 98-102°C
    Boiling Point 335.5°C at 760 mmHg
    Solubility Slightly soluble in water, soluble in organic solvents
    Purity Typically ≥ 98%
    Storage Conditions Store in a cool, dry place, tightly closed container
    Smiles COC(=O)C1=CC(=C(C=C1)N)OC
    Inchi InChI=1S/C9H11NO3/c1-12-9(11)6-3-4-7(10)8(5-6)13-2
    Density 1.22 g/cm3 (estimated)
    Hazard Statements May cause skin and eye irritation

    As an accredited Methyl 4-Amino-2-Methoxybenzoate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with screw cap, labeled "Methyl 4-Amino-2-Methoxybenzoate, 25 grams," with safety warnings and lot number.
    Shipping Methyl 4-Amino-2-Methoxybenzoate is typically shipped in tightly sealed containers to prevent contamination and moisture exposure. It should be stored at room temperature, away from direct sunlight and incompatible materials. During shipping, proper labeling and documentation are required to comply with regulations for handling and transporting laboratory chemicals safely.
    Storage Methyl 4-Amino-2-Methoxybenzoate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible substances such as oxidizers. Protect from moisture and acids. Handle using appropriate personal protective equipment. Ensure clearly labeled storage to prevent contamination or accidental misuse.
    Application of Methyl 4-Amino-2-Methoxybenzoate

    Applications of Methyl 4-Amino-2-Methoxybenzoate in Industrial Manufacturing

    Methyl 4-Amino-2-Methoxybenzoate functions as a critical intermediate for several industrial sectors. This compound’s reactivity and chemical profile facilitate its use in diverse downstream manufacturing processes where purity, reliability, and traceability are essential.

    1. Pharmaceutical Synthesis: Active Pharmaceutical Ingredient (API) Intermediate

    Major pharmaceutical companies use this compound as a key intermediate in the synthesis of analgesic and anti-inflammatory APIs, such as benzoic acid derivatives. Process chemists integrate it into multi-step organic syntheses, leveraging its amine and methoxy functionalities for subsequent modifications. Facilities employing GMP-compliant synthesis protocols employ batch or continuous stirred reactors for transformations involving this ester, ensuring traceability through validated analytical methods. Frequent in non-steroidal anti-inflammatory drug (NSAID) pipelines, the quality of this intermediate directly affects overall yield, purity, and batch consistency in high-volume production.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • USP <857>, <621> for chromatography and identity testing
    • FDA 21 CFR Parts 210/211 for finished pharmaceuticals
    • European Pharmacopoeia monographs for intermediates (where applicable)

    Typical usage ratio

    • Often 0.5–2.0 molar equivalents per target API batch, precise loading based on reaction stoichiometry and process optimization for yield/purity targets

    Downstream process integration

    • Early-stage inclusion after initial coupling or acylation steps; enters downstream amidation, hydrolysis, or functional group exchange reactions in multi-step syntheses

    Final product types

    • NSAID intermediates
    • Analgesic active pharmaceutical ingredients such as mefenamic acid derivatives
    • Anti-inflammatory compounds
    • Compound libraries for drug discovery

    2. Veterinary Pharmaceuticals Production

    Contract manufacturers and in-house veterinary pharmaceutical plants use this substance as a building block for synthesizing veterinary active agents, particularly carboxylic acid-based anti-infectives and antiparasitics. Its reactivity provides an entry point for functional modification through amination or methoxylation, supporting multicomponent synthesis routes in large-scale animal health formulations. Production lines must consistently control purity, impurity profiles, and batch uniformity due to regulatory requirements on residual solvents and intermediates.

    Industry compliance standards

    • VICH GL32: Stability Testing of New Veterinary Drug Substances and Medicinal Products
    • US FDA CVM Guidance for Industry 98: Residual Solvents in New Animal Drugs
    • EU Regulation (EC) No 470/2009 for veterinary medicinal product residues
    • ISO 9001:2015 for quality management in API manufacturing

    Typical usage ratio

    • Between 1.0–1.5 equivalents per target molecule, depending on the synthetic transformation and desired output. Adjustments made for conjugation efficiency in large-batch regime.

    Downstream process integration

    • Introduced as a starting scaffold in semi-batch reactor trains; integrated prior to heterocycle formation, chlorination, or alkylation steps required by veterinary intermediate specifications.

    Final product types

    • Benzamide-based antiparasitic APIs
    • Intermediate compounds for veterinary injectable solutions
    • Veterinary anti-inflammatory drugs
    • Animal oral tablet pre-blends

    3. Fine Chemical Synthesis: Dye and Pigment Intermediate

    Dye and pigment manufacturers select this compound for its functional groups, which offer utility in producing azo, anthraquinone, and benzoic acid dye intermediates. During the production of specialty dyes for plastics, textiles, and inks, it acts as a foundation for diazotization and coupling reactions. Industrial plants require tight color index control, minimal byproduct formation, and compliance with chemical inventory tracking, particularly for exports to regulated jurisdictions such as the EU.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006—Substance Registration
    • OEKO-TEX® Standard 100 for textile chemical safety (where applicable)
    • GHS/CLP Classification, Labelling, and Packaging Regulation
    • ISO 14001:2015 for Environmental Management Systems

    Typical usage ratio

    • Ranges 5–15% by weight of starting feedstock in dye intermediate synthesis, dependent on pigment color strength and solubility profile in the target application

    Downstream process integration

    • Fed into diazotization units after raw material dissolution; undergoes coupling and further functionalization before isolation of final dye intermediates

    Final product types

    • Colorant intermediates for high-performance plastics
    • Reactive dyes for cotton and polyamide textiles
    • Specialty pigment dispersions for industrial inks
    • Coloring formulations for coatings

    4. Agrochemical Intermediate Manufacturing

    Producers of agrochemical actives, including herbicidal benzoate esters and fungicidal compounds, employ this ester as a central intermediate. Its functionalized aromatic scaffold enables downstream manufacturing teams to construct target molecules by introducing additional substituents. Applied in both pilot plant and industrial production, the raw material must meet stringent internal material specifications for agrochemical use due to strict downstream registration and environmental safety standards.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Guidelines for the Testing of Chemicals (Environment, Health and Safety Division)
    • Pesticide Registration Manual—US EPA Office of Pesticide Programs
    • ISO 17025:2017 for laboratory analysis and traceability

    Typical usage ratio

    • 5–10% of total batch mass for protected benzoic acid-based synthesis; the precise quantity determined by downstream conversion rate and impurity tolerance

    Downstream process integration

    • Charged into the synthesis reactor as a precursor to esterification, nitration, or halogenation sequences; involved in multi-step process up to active crop protection agent

    Final product types

    • Intermediate ingredients for systemic herbicides
    • Precursors for fungicidal benzoates
    • Custom pesticide actives for cereals and vegetables
    • Stabilized intermediates for market-registered agrochemical formulations

    5. Fragrance and Flavor Ingredients Base

    Industrial fragrance and flavor formulators utilize this ester as a specialty ingredient for custom aroma molecules. Through selective hydrolysis and subsequent chemical transformation, it supports synthesis of fine aromatic molecules used in personal care products and food-grade flavors. Facilities must operate within strict contamination control, with careful isolation steps and extensive analytical verification prior to downstream blending into finished fragrances or flavors.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards and Compliance Code
    • FEMA GRAS (Flavor and Extract Manufacturers Association Generally Recognized as Safe) listings
    • ISO 9001:2015 for process and QC management
    • US FDA 21 CFR Part 172 for food additive safety (applicable for flavor applications)

    Typical usage ratio

    • Below 2.5% in base formulations when applied as an upstream intermediate; varies by the aroma or flavor strength required in final downstream processing

    Downstream process integration

    • Hydrolyzed and functionally modified in jacketed batch reactors; post-processing includes fractional distillation and preparatory chromatography for high-purity aroma molecules

    Final product types

    • Aromatic intermediates for perfumery
    • Blending agents for fine fragrance bases
    • Precursor molecules for flavor chemicals in beverage and confectionery industries
    • Specialty aroma compounds for personal care product manufacturers
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    Certification & Compliance
    More Introduction

    Methyl 4-Amino-2-Methoxybenzoate: Trusted Chemical Performance from a Direct Manufacturer

    Fresh Insight Into Methyl 4-Amino-2-Methoxybenzoate

    Producing methyl 4-amino-2-methoxybenzoate means working directly with hands-on chemical processes, not just packaging someone else's product. Decades of technical trials shape every batch that leaves our site. Our team—proud to hold the title of the original manufacturer—knows this chemical inside out. Its CAS number confirms its core identity, but what matters most is the assurance built into every order: from sourcing raw materials with traceable origins, to consistent purification methods, to the finished powder you receive. We spot-check every lot for purity using HPLC and NMR—not because clients ask, but because anything less feels lazy. Solid experience and reliable results remain unmatched in this industry.

    What Makes This Compound Matter?

    Methyl 4-amino-2-methoxybenzoate is more than just a chemical name. Chemists across pharmaceutical, agrochemical, and specialty fine chemical fields recognize its backbone as a crucial intermediate. Over the years, collaborations with research institutes and pilot-scale innovators have illuminated its utility: it's a key building block in synthesizing active pharmaceutical ingredients and advanced intermediates. Users rely on its capabilities for acylation, coupling, or further functionalization. Our long-term customers share stories about R&D breakthroughs that started from trials with our material. First-hand experience with scale-up shows predictable response under varied synthetic conditions, making it a pragmatic choice both at the bench and in kilo-lab settings.

    How Model and Specifications Shape Results

    Quality begins with fine control over every synthesis parameter and doesn’t stop after filtration. Our current production model centers on a multi-step process, with rigorous control of temperature, pH, and solvent handling. The crystalline powder you unpack meets typical purity thresholds of 99%, often with trace residual solvents below thresholds detectable by standard GC methods. Melting point falls in a narrow range, and color consistency is checked alongside solubility indices in organic media. Years of production feedback led us to refine drying techniques, ensuring powder flows well and re-dissolves fully during use. Handling characteristics mean laboratories avoid clumps and save time in weighing.

    Each customer project brings its own specification requests—sometimes higher purity, sometimes detailed impurity profiles, or larger lots for one-pot reactions. We fill those requests using scalable batch reactors and flexible purification columns. Our track record across thousands of batches demonstrates robust reproducibility, something repeated audits have confirmed. Lab managers have told us they appreciate never seeing dust or off-notes in odor. Every lot comes packaged with a certificate of analysis, but most partners trust their results on the bench even more than paper records. We see batch consistency as the foundation of effective collaboration.

    Addressing Usage Nuances On the Production Line

    Production realities rarely make headlines, but practical chemistry thrives here. One facility manager once summed it up: "It just works, every batch." We take pride in that. Formulators seeking reliable aromatic amine intermediates for esterification reactions return to our product because it releases consistently across different reaction platforms. Whether facing pressure reactors or open-air glassware, users report smooth incorporation and stable reaction kinetics. Most downstream applications favor its profile for avoiding side reactions, especially in multi-component coupling frameworks. Material losses from filtration remain minimal—an overlooked detail until chemists run the numbers on pilot yields. Over time, knowledge gleaned from real-world feedback made tweaks possible: crystals stay manageable, no sticking to vessel walls, no fingerprint residue from microdust.

    Many production users have commented on the comfort provided by our extensive MSDS resources and technical support. One example: a university lab with a challenging amidation found it easier to optimize yield when working with our granular material versus less refined powders. Simple points matter when you're chasing time and tight budgets. The learning loop between lab, pilot, and full-scale sets the groundwork for practical innovation—never theoretical, always informed by what actually transpires on the factory floor.

    Authentic Distinction: Setting Our Product Apart

    Comparing one supplier's methyl 4-amino-2-methoxybenzoate to another's, differences soon become clear, especially after extended use. We work at root cause: not only checking key analyte levels but examining trace impurities born of side reactions in earlier steps. The strict solvent regime and evaporation cycles protect both purity and consistency. Those who have tried others describe erratic behavior in batch reactions; by contrast, we measure each variable to precision and tweak if even small shifts start to show up in QA timelines. Long-term stability tests of our samples show no appreciable degradation under standard packaging and climate conditions. Others may ship earlier generations of the compound, with off-spec coloration or marginally higher residuals, but trusted labs quickly recognize the distinction through performance metrics. Raw testing aside, repeat orders show real-world approval—those with the highest volume needs return for reliability, not lowest price alone.

    The human side matters. We keep open communication with process teams, responding to “what-ifs” and troubleshooting requests. Sometimes the technical answer points to a slight tweak in intermediary storage; other times, adjusting stirring speed smooths out a reaction bottleneck. We also incorporate feedback about bottle size, protection against moisture incursion, and labeling standards. This adaptability has encouraged new partnerships among R&D teams rolling out the next generation of pharmaceutical syntheses. We listen to end users and integrate what they need, not just what batch specifiers assume. It’s this agility—rooted in mutual respect and years of hands-on practice—that brings our methyl 4-amino-2-methoxybenzoate to the preferred status in many lab storerooms.

    Speaking from Real-World Experience

    Direct knowledge of the chemistry, not marketing spin, shapes our worldview. Plant-based synthesis has evolved since we established our first production line; we've swapped outdated methods for steps with better yields and fewer byproducts. Our biggest lessons came from scaling up: grams to kilograms to multi-ton, watching for hidden risks each step of the way. Cooling lines fail, crystal growth throws a curveball, test tubes overheat—problems are a fact of life, and solutions only come from rolling up sleeves. Documentation isn't an afterthought; it’s the backbone of reproducibility, compliance, and customer trust. We revise SOPs based on feedback and field trials. Some changes shrink energy use or waste, which both lowers costs and improves working conditions. It’s a mindset of continuous, experience-driven improvement.

    Our technical teams have solved more than a few puzzles for outside partners, often with fast turnaround. For example, when a batch doesn't dissolve as expected, we trace it down to changes in upstream feedstock, catch it on the analytics, fix it, and document the solution. It helps reach consistent performance year after year. Customers have called us to discuss side-by-side comparisons with off-the-shelf versions: clarity, particle size, behavior in solvents, and aftertaste in sensitive APIs. Facts from these hands-on tests outshine expectation or advertising language. The field trusts us because we've got the data—and if we don’t, we run the extra test. That’s how reputation builds, slowly and with steady attention to real results.

    Supporting Compliance and Safety With Open Communication

    All chemicals require thoughtful management, and ours is no exception. We’re upfront about safety notes drawn from years shipping to labs and industrial sites worldwide. Each employee in our packaging and transport division gets trained to handle the minor quirks associated with aromatic amines: dust controls, spill containment, and PPE basics. Every container ships fully sealed, with labeling reflecting regional regulations and universal GHS conventions. Team members preparing paperwork engage with every shipment, ready to clarify handling or storage questions raised by receiving chemists. More than once, we’ve caught labeling errors ahead of customs holdups. It’s easier to prevent a problem than resolve a miscommunication after the fact.

    On the internal safety front, process engineers regularly review hazard assessments and update them when a customer’s unique requirement raises a new question. We draw on the full library of empirical safety data and not just theoretical models. Sharing these insights keeps our partners prepared and avoids unpleasant surprises. Some users adopt custom secondary containment or ventilation based on suggestions from our experience—many have gone on to improve their own in-plant policies as a result. We reinforce what matters based on things we’ve seen work—or fail—under real conditions. This approach has fostered a community across technical teams, where trading practical safety tips is just part of ongoing collaboration.

    Recognizing Practical Challenges and Offering Real Solutions

    No production campaign ever runs perfectly—sometimes deliveries need to hit tighter windows, or specific particle sizes support new downstream chemistry. Each of these realities calls for close feedback and tweaks. Once, a customer hit a bottleneck dissolving an older batch of methyl 4-amino-2-methoxybenzoate; their solubility was off by enough to threaten critical reaction timing. Our technical manager organized a pickup, ran fresh analysis, and found a subtle bottleneck with micro-clumping during drying. With the root cause identified, we put in a small tweak to the drier ramp and returned a flawless run in the next cycle. It took only days, but saved the customer’s R&D process from expensive downtime. This sort of challenge can’t be solved by a go-between; it calls for direct line-of-sight from process engineer to manufacturing floor.

    Lab and plant teams trust us because we know the entire arc, from synthesis route selection to blending, packing, and even end-use. Our technical leadership maintains close ties with global quality standards. Projects come in with very different needs: sometimes it’s the purity, other times it’s minimizing a specific side product to support an ultra-pure pathway. By keeping our process adaptable and our analytical team close to the pulse, we help scientists scale up or troubleshoot—faster than would be possible with a remote vendor.

    Real differences between our product and others emerge in these one-to-one conversations. We don’t hide behind “one size fits all” claims. If your method benefits from tighter particle size control, or from extra screening for trace metals, both can be built into your order. Downstream users cite the benefits in tablet manufacturing, where uniform mixing prevents problems. More sophisticated use cases—for instance, in peptide coupling or novel photochemical pathways—highlight the need for total absence of certain synthetic route impurities. Upgrading our routes, checking batch history, or making a lab-scale pilot before full order: these aren’t “extra services,” they form the backbone of what reliable chemical manufacturing should look like.

    Engaging With the Future: Ongoing Responsiveness to New Demands

    Markets keep moving. Regulations tighten, applications diversify, and the importance of trusted, traceable source material grows. Early in our company’s history, we learned to pay attention not only to today’s project but also to where research and industry were heading. This meant constant upgrading of analytic sophistication and ever-tighter process control—including automated monitoring and digital data logs for every batch. Our process chemists keep pace with ICH guidelines and contribute to international standard-setting conversations, supporting regulatory teams when they’re generating new dossiers or compliance documentation. We see regulations not only as hurdles, but pathways to better product quality and end-user confidence.

    Future applications in the pharmaceutical industry, as well as new uses developing in catalysis and organic electronics, stretch the way we evaluate our product's relevance. We actively encourage feedback from early-stage research teams: they often spot needs ahead of full commercialization, such as tighter trace impurity limits, custom particle morphology, or solvent profiles that work better for green chemistry. Building partnerships with educational consortia and research parks helps us stay at the edge, always ready to move beyond standard routines when a client’s creativity triggers something new. Responsiveness isn’t just business development; it’s the essential ingredient for keeping pace with top-tier science.

    Building Trust Through Consistency and Open Dialogue

    At the root of every successful supplier partnership is trust. Consistency in methyl 4-amino-2-methoxybenzoate, as with any specialty chemical, starts with strict attention to detail and ends with open feedback loops between technical teams. We prioritize honesty—owning up to issues, inviting third-party inspections, and sharing learnings from both successful and challenging batches. This transparency forms the basis of long-term customer relationships, as we align our production targets with your standards in both specifications and timelines.

    We also recognize that material supply is only as good as its traceability and after-sales support. Whether it’s reviewing historical COAs for regulatory filings, updating packaging formats in response to new shipping regulations, or preparing detailed impurity profiles ahead of a big production run, we bring experience to the table—earned, not guessed. In an industry where a single out-of-specification element can result in a cascade of production delays or regulatory issues, attention to trace detail delivers value far beyond the chemical itself. Customers come back not simply for a product, but for the confidence that comes from a supplier who shares their drive for technical excellence and process reliability from order intake to final delivery and follow-up.

    Conclusion: More Than a Product, a Partnership in Applied Chemistry

    Every gram of methyl 4-amino-2-methoxybenzoate rolling off our production line reflects commitment—from procurement, through synthesis, purification, and rigorous QA, to how it’s shipped, stored, and finally used by end customers. Detail-driven manufacturing means less risk for researchers and producers relying on dependable inputs. Real-world challenges kept us sharp, shaping practical improvements batch by batch. Scientists and process engineers across sectors repeatedly share one underlying need: a partner who understands not just the compound, but how people use it, what can go wrong, and how genuine solutions require experience and agility. We bring that to every lot, every conversation, every day. Through collective expertise, shared stories, and a focus on results, we work to deliver not only a chemical but a reliable foundation for innovation. Where tested performance, robust communication, and long-term collaboration come together, success follows. That's what sets true manufacturing apart: pride in craftsmanship, respect for fact, and enduring trust.