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Methyl 3-Chlorobenzoate

    • Product Name Methyl 3-Chlorobenzoate
    • Alias methyl-3-chlorobenzoate
    • Einecs 212-611-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    220391

    Cas Number 618-37-1
    Molecular Formula C8H7ClO2
    Molecular Weight 170.59 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 243-244 °C
    Density 1.26 g/cm3
    Refractive Index 1.544
    Purity Typically ≥98%
    Solubility Insoluble in water; soluble in organic solvents
    Flash Point 108 °C
    Smiles COC(=O)C1=CC(=CC=C1)Cl
    Synonyms m-Chlorobenzoic acid methyl ester
    Storage Temperature Store at room temperature

    As an accredited Methyl 3-Chlorobenzoate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Brown glass bottle containing 100 grams of Methyl 3-Chlorobenzoate, tightly sealed with a screw cap and labeled with hazard warnings.
    Shipping Methyl 3-Chlorobenzoate is typically shipped in tightly sealed containers, protected from moisture and direct sunlight. It is transported as a stable, non-hazardous chemical under normal conditions but should be handled with care to avoid spills or inhalation. Standard chemical shipping regulations and labeling requirements must be followed.
    Storage Methyl 3-Chlorobenzoate should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area away from heat sources and direct sunlight. It should be isolated from incompatible substances such as strong oxidizers. Proper labelling is essential, and access should be restricted to trained personnel. Store at room temperature and avoid moisture exposure to maintain stability.
    Application of Methyl 3-Chlorobenzoate

    Applications of Methyl 3-Chlorobenzoate in Industrial Manufacturing

    As a specialized manufacturer, we supply methyl 3-chlorobenzoate for downstream partners using this intermediate in high-value, process-driven industries. Our production processes and technical support align to the strict requirements of your application sectors. Explore how this raw material integrates into advanced manufacturing workflows.

    1. Pharmaceutical Intermediate for Active Pharmaceutical Ingredient (API) Synthesis

    Methyl 3-chlorobenzoate functions as a key intermediate in the multi-step synthesis of select pharmaceuticals, particularly in the creation of anti-inflammatory agents, antihistamines, and other APIs featuring substituted benzoic acid cores. Pharmaceutical formulators rely on precise purity and controlled input levels to ensure compliance with process controls and minimize side reactions during chlorination, alkylation, or amidation steps. Downstream API producers use this material in batch or continuous synthesis lines for high-quality generic and specialty medicines.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU Guidelines for APIs (EudraLex Volume 4 Part II)
    • US FDA 21 CFR Part 211 – cGMP for Finished Pharmaceuticals
    • Chinese Pharmacopoeia (for relevant APIs)

    Typical usage ratio

    • Employed at 0.6–2.2 molar equivalents relative to the primary amine or alcohol substrate; precise ratio adjusted for API yield, impurity control, and process efficiency

    Downstream process integration

    • Loaded directly to reactor during the early or intermediate condensation phase, typically following solvent charging and prior to the addition of coupling agents or bases required for further benzoate functionalization

    Final product types

    • NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
    • Antihistamine compounds
    • Certain anticonvulsant APIs with aromatic benzoic backbones
    • Custom synthesized pharmaceutical actives for clinical research

    2. Agrochemical Synthesis for Herbicide and Fungicide Intermediates

    Downstream agrochemical formulators use methyl 3-chlorobenzoate as an intermediate to build specialty herbicides and fungicides, especially where a chlorinated benzoic base is required for bioactivity modulation. The material enters as a core building block during early process steps and provides strong chemical stability throughout downstream halogenation and esterification reactions. Consistent quality and tight specification control safeguard finished agrochemical regulatory dossiers.

    Industry compliance standards

    • FAO/WHO Specification Guidelines for Plant Protection Products
    • ISO 17034 Reference Material Producer requirements
    • REACH Regulation (EC) No 1907/2006 for agrochemical intermediates
    • China Institute for the Control of Agrochemicals, Ministry of Agriculture (ICAMA) technical regulations

    Typical usage ratio

    • Commonly dosed at 1.0–1.8 moles per mole of target halogenation or ring modification substrate; adjusted for process yield and desired chlorination selectivity

    Downstream process integration

    • Charged during the initial condensation or acylation steps, typically before introduction of further chlorinating agents or alkyl functional groups and subsequent formulation into technical-grade actives

    Final product types

    • Precursor intermediates for selective herbicides
    • Fungicide technical concentrates
    • Safener additive intermediates
    • Custom agrochemical actives for contract synthesis applications

    3. Dye and Pigment Intermediate Manufacture

    Dye and pigment manufacturers employ this material to introduce specific chlorine-substituted aromatic rings in the synthesis of specialty azo dyes, disperse dyes, and pigment compounds. Stable reactivity and minimal color body contamination are essential for high chroma, batch-to-batch color consistency, and downstream dispersibility, especially in textile and plastic coloration. The raw material’s integration occurs at early diazotization or acylation phases, supporting downstream refinement for pigment-grade output.

    Industry compliance standards

    • OEKO-TEX Standard 100 limitations for aromatic amines and halogenated dye precursors
    • EU REACH Annex XVII restrictions for dye intermediates
    • ZDHC (Zero Discharge of Hazardous Chemicals) Manufacturing Restricted Substances List
    • GB/T 23912-2009 (Chinese textile dye quality control standard)

    Typical usage ratio

    • Added at 0.8–1.25 moles per mole of coupling or condensation partner, variable depending on pigment depth and finished dye intensity targets

    Downstream process integration

    • Enters mixing tanks with base aromatic nitriles, followed by controlled temperature and pH adjustments during coupling or cyclization before final filtration and milling

    Final product types

    • Chlorinated azo and anthraquinone dyes
    • Specialty disperse dyes used in polyester coloration
    • Pigment yellow and green grade intermediates
    • Textile and plastic colorant dispersions

    4. Synthesis of Specialty Fragrance and Flavor Ingredients

    Manufacturers in the aroma chemical sector utilize methyl 3-chlorobenzoate to produce fine fragrance building blocks and select synthetic flavoring aldehydes. This material provides halogenated aromatic structure essential for certain musk and balsamic notes. Producers add it under strictly regulated process control, ensuring minimal residuals and compliance with food and fragrance safety regulations.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards for use in fragrances
    • US FDA 21 CFR Part 172 Permitted Flavoring Substances
    • EU Regulation (EC) No 1334/2008 for flavoring substances
    • ISO 9001 Quality Management System certification for aroma ingredient production

    Typical usage ratio

    • Used at 0.4–1.0 mole per mole of aldehyde or alcohol precursor, fine-tuned for downstream note strength and purity requirements in finished compounds

    Downstream process integration

    • Fed at the esterification, reduction, or Grignard reaction stage for targeted aroma intermediate build-up, with in-line GC/HPLC monitoring of chlorinated residue content

    Final product types

    • Musk and balsamic fragrance intermediates
    • Synthetic aldehyde and aromatic flavor bases
    • Blended essential oil bases for perfumery
    • Processed flavor blends for beverage and confectionery industries

    5. Polymer Additive and Monomer Synthesis

    Producers of specialty polymers and engineering resins incorporate this material to introduce functionalized aromatic rings or halogen substituents into monomer systems, enhancing flame retardancy or modifying reactivity profiles. The input of this intermediate in the upstream monomer stage supports targeted customization in end-use thermoset or thermoplastic materials, particularly for electronics enclosures and automotive applications.

    Industry compliance standards

    • UL 94 Flammability Standards for polymer formulations
    • IEC 62321 Standard for evaluation of certain substances in electrotechnical products
    • ISO 9001:2015 Quality Management Systems for plastics manufacturing
    • RoHS Directive 2011/65/EU for hazardous substance control in electrical and electronic equipment

    Typical usage ratio

    • Commonly introduced at 0.3–0.9 mole fraction in co-polymer or specialty monomer batches, modified for targeted performance, molecular weight control, and additive compatibility

    Downstream process integration

    • Added at the initial monomer formulation stage, typically before initiator charging and polymerization, ensuring uniform aromatic structure incorporation

    Final product types

    • Flame-retardant thermoset resins
    • Engineering-grade thermoplastics with halogen content
    • Speciality co-polymers for electronics and automotive components
    • Additive masterbatches for polymer processing lines
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    Certification & Compliance
    More Introduction

    Methyl 3-Chlorobenzoate: Reliable Performance from a Trusted Chemical Manufacturer

    Our Commitment to Quality and Consistency

    Methyl 3-Chlorobenzoate has become a backbone material across fine chemical synthesis and industrial applications. As a long-standing manufacturer, we appreciate the unique role this compound plays in driving progress for customers involved in pharmaceuticals, agrochemicals, and specialty chemicals. Watching hands-on chemists rely on our product in their daily operations, our responsibility extends beyond delivering a bulk commodity. Each batch we produce is a result of disciplined process control, scrupulous raw material selection, and strict analytical verification.

    The confidence customers place in our material comes from years spent refining our operation. We draw from time-tested experience: minimizing potential contaminants, eliminating lot-to-lot variation, owning the supply chain from precursor handling to the final packaging. Methyl 3-Chlorobenzoate leaves our facility in a colorless to pale yellow liquid state with >99% purity on a dry basis. Every shipment comes with a detailed certificate of analysis based on validated HPLC and GC methods. Our own hands, not those of third parties, are accountable for meeting specifications.

    Specifications Built for Reliable Results

    Through decades of process optimization, our technical team established parameters that optimize both safety and ease-of-use. Our current lot of Methyl 3-Chlorobenzoate, commonly recognized by CAS 618-37-7, features a molecular weight of 170.59 g/mol. As a colorless to pale yellow liquid (or sometimes low-melting solid), it delivers a sharp, aromatic odor typical of aromatic esters with a halo substituent.

    Key specifications reflect both purity and handling convenience: water content by Karl Fischer titration holds well below 0.1%, residual starting materials and byproducts fall under 0.2%, and chloride content is monitored closely to meet downstream reaction tolerances. Our process ensures low residual acidity, which inhibits undesired side reactions in sensitive transformations. In typical storage, the material shows little tendency to degrade or polymerize, even during protracted warehousing.

    Pack sizes range from laboratory quantities (as small as 250 g bottles) up to industrial drums and isotanks for continuous manufacture. Each package lot includes tamperproof seals, anti-static liners, and traceable QR codes for full accountability. Our logistics partners operate clean, temperature-stable warehouses to safeguard every shipment.

    Production Experience Shapes Consistency

    Many years of batch manufacturing have underscored the importance of granular control and documentation. Small fluctuations in raw materials, reaction temperature, or vacuum level, even for a few hours, create variations that shorten shelf life or compromise product safety. We maintain GMP-style control over every step: starting from chlorination of benzoic acid derivatives, through esterification, to meticulous fractional distillation.

    Our synthesis pathway avoids copper catalysts, mercury contamination, or corrosive byproducts, which translates directly to lower metal and non-metal impurities. Each batch record undergoes daily review, and sampling throughout the process ensures final product matches the chromatographic fingerprints established by our reference standards. When we say Methyl 3-Chlorobenzoate from our factory, we are referring to a fingerprinted single-source material—not a rebranded or intermediated commodity.

    Practical Uses and Industry Feedback

    This ester stands out in the toolkit of synthetic chemists for a reason. The methyl group on the carboxylate confers stability during storage, but releases cleanly under mild saponification or transesterification, lending utility for downstream modifications. The meta-chloro position modifies electronic effects, enabling selective activation in cross-coupling or nucleophilic aromatic substitution reactions. Whether entering Suzuki or Heck coupling workflows, the reactivity closely matches the expectations required for scale-up and commercial manufacturing.

    Our clients in pharmaceutical development cite predictability in crystallization, purification, and yield—essential when scaling from gram to metric ton. Formulation scientists appreciate the absence of color-forming impurities and low odor carry-through, which minimizes by-product signature in high-purity active ingredient synthesis. Agrochemical teams note that our product dissolves smoothly in standard reaction solvents such as toluene, methyl ethyl ketone, and acetonitrile, sparing technicians hours of troubleshooting.

    Environmental control forms part of every customer’s audit. Waste streams from our process generate little halogenated residue, simplifying handling for those customers needing to neutralize or incinerate spent materials. Analytical labs frequently compare our standard to both European and Chinese reference samples, reporting better spectral cleanliness and less drift in DSC and TGA stability testing.

    Meeting the Demand for Reliability and Safety

    For production lines running around the clock, lost time translates directly into lost revenue. We prioritize uninterrupted supply: vertical integration across precursor synthesis, in-house storage for seasonality buffering, and a logistics network including sea, rail, and air options. Bulk users benefit from scheduled deliveries or on-call backup for urgent spike needs. Our process minimizes off-specification lots, but in rare cases, our quality assurance policy allows full traceability and rapid corrective action—never passing replacement risk onto the end user.

    Safety receives equal attention. Methyl 3-Chlorobenzoate, while generally manageable under standard solvent handling precautions, still merits respect. Our technical advisors routinely share documented hazard data, correct PPE usage guides, and best practices for ventilation and accidental exposure response. Technical documents are updated based on new regulatory requirements or customer audits, forming a living reference library for our commercial partners. Waste minimization guidance and container recycling are part of our long-term stewardship program.

    How This Product Differs from Other Benzoate Esters

    Most buyers have experience with a range of aromatic esters. Methyl 3-Chlorobenzoate stands apart from both the ortho and para isomers—not only in chemical structure but functionally as well. The meta-chloro group enhances resistance to hydrolysis compared to methyl benzoate alone. It also shows a distinct NMR and MS signature, allowing for easier analytical confirmation and intermediate tracking.

    Other chlorinated variants, like methyl 2-chlorobenzoate, tend to cyclize or react less selectively, introducing more side-products in Suzuki or Ullmann coupling processes. The 4-chloro form, on the other hand, often leads to downstream reactivity profiles less suited for certain pharmaceutical scaffolds. The meta chloro on our product creates an electronic field tuned for both electrophilic and nucleophilic aromatic chemistry—a feature chemists use in regioselective derivatizations or ring-opening reactions.

    We have seen clients replace methyl para-chlorobenzoate with our product specifically to improve yields in palladium-catalyzed cross-couplings, citing fewer by-products and a more predictable reaction profile. In dye intermediates and specialty fragrance synthesis, the subtler scent and narrower GC profile of our methyl 3-chlorobenzoate allow for sharper fraction recovery and improved downstream quality.

    While lower grade, technical methyl benzoate occasionally enters bulk markets from unspecialized plants, our 3-chloro derivative targets customers demanding consistency. Purity and low heavy metal content have consistently ranked as the driving factors in customer retention—feedback that contributes directly to continuous upgrades in our plant operation.

    Continuous Improvement through Feedback Loop

    Direct conversation with end users informs the way we work—not abstract market research or third-party data. Our product managers meet regularly with process engineers, formulation scientists, and regulatory experts across Europe, North America, and Asia. We’ve adapted filtration and packaging processes based on client laboratory validation. For example, one major partner highlighted a filtration bottleneck using a previous product from another supplier. By tweaking crystallization rates and particle distribution, we delivered a grade with reduced clogging and faster throughput.

    Another customer needed bulk lots with consistently low residual solvents for an API pathway under FDA scrutiny. Joint validation and root cause analysis identified a source of methyl chloride formation in a condenser. Changing to upgraded seal materials and a new vacuum control protocol directly improved both our own yields and customer product performance. These are the hands-on events that define a responsible manufacturer, not spreadsheet optimization by intermediaries.

    Instead of formal questionnaires, we encourage informal lab visits and active plant tours. Chemists have run their intended syntheses on-site, evaluating our batches before full delivery. Lessons from these encounters feed into process control protocols and enable us to spot incremental improvements—adding up to major advances in product stability and safety over years, not weeks.

    Regulatory Focus and Traceability

    Changing chemical regulation across continents places accelerating pressure on manufacturers; traceability and transparency have moved from buzzwords to baseline practice. Auditors from both private and public agencies regularly access our supply chain records—detailing not just container labels, but raw material supplier performance, energy usage per lot, and transport manifest histories from dock to gate.

    REACH registration in the European Union and similar compliance in the US, Japan, and Korea require not only technical but process-driven documentation. Our system allows customers real-time access to batch records and material safety data through encrypted web portals. If a concern arises over regulatory limits, such as residual halide or process impurity, we supply full primary records, not post-hoc summaries. Each year, industry partners inspecting our facility report improved document clarity and traceability compared to bulk producers without a visible production management record.

    Pricing, Flexibility, and Customer Value

    Many users ask about price stability in a volatile market for commodity aromatics. Our direct-from-manufacturer model bypasses multiple distribution layers; this reduces markups and buffers cost spikes seen among resellers. Volume arrangements support both seasonal buyers and continuous manufacturers. While we reject rush practices that harm quality, our scheduling team works closely with purchasing managers to adjust for changing production rates or project launches.

    Flexibility shapes our customer response. For custom derivatives—such as isotopic labeling or alternative ester substitutions for research use—our R&D bench chemists evaluate feasibility on a case-by-case basis, then invite partners to pilot small-scale runs. Special solvent cuts, custom labeling, and just-in-time delivery protocols stem directly from user requests, not catalog templates. We handle hazardous goods paperwork and shipping certifications directly, down to the final destination, rather than passing responsibility down the chain.

    Future Directions and Sustainability

    Long-term reliability means thinking ahead, not just meeting today’s order list. Our investment in closed-loop distillation and advanced waste processing reduces solvent emissions and simplifies spent acid recycling. Facility modernization extends to energy management: process heating now increasingly draws from combined heat-and-power and solar installations. Green chemistry principles guide process development for all new derivatives; fewer toxic reagents, reduced solvent handling, and better operator ergonomics.

    We’re also seeing the emergent push for biobased feedstocks in laboratory and pilot lines. Our technical teams monitor new routes to methyl 3-chlorobenzoate that start from lignin or other renewable aromatic resources. While commercial scale remains a challenge, laboratory trials have produced promising yields in both enzymatic chlorination and renewable alcohol esterification. When customers call asking if their product can qualify for a “green” portfolio, our team lays out facts rather than empty slogans.

    Many of our bulk customers request life-cycle data to keep pace with retailer and consumer expectations. We produce a full chain-of-custody emission and waste report for each lot, verified by third-party auditors. Carbon tracking and reduction are not only regulatory steps—a growing proportion of end-users expect it as minimum practice for new supplier approvals.

    Summary and Outlook

    Our experience as a manufacturer extends beyond producing a reagent; it’s about building a partnership based on technical experience, supply reliability, and transparency. Methyl 3-Chlorobenzoate carries a reputation for being dependable in demanding organic synthesis. We improve our process each year based on feedback from users at the bench and in the plant, transforming real-world challenges into tangible upgrades in quality and performance.

    We take pride in what goes out our gates because, for us, every lot represents more than a molecule—it’s the outcome of expertise, accountability, and an ongoing conversation with the industries that put chemistry to real-world work. For those who need answers, process details, or simply a reliable supply line, our team stands ready to discuss challenges and deliver practical solutions, batch after batch, year after year.