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Methyl 2-Methoxybenzoate

    • Product Name Methyl 2-Methoxybenzoate
    • Alias methyl o-anisate
    • Einecs 228-165-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    661262

    Iupac Name Methyl 2-methoxybenzoate
    Molecular Formula C9H10O3
    Molar Mass 166.18 g/mol
    Cas Number 606-45-1
    Appearance Colorless to pale yellow liquid
    Boiling Point 262-263 °C
    Melting Point 21-23 °C
    Density 1.16 g/cm3
    Solubility In Water Poorly soluble
    Refractive Index 1.535-1.537
    Flash Point 122 °C
    Smiles COC(=O)C1=CC=CC=C1OC

    As an accredited Methyl 2-Methoxybenzoate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100g, sealed with screw cap, white label showing "Methyl 2-Methoxybenzoate," CAS number, lot, and hazard symbols.
    Shipping Methyl 2-Methoxybenzoate is shipped in tightly sealed containers, protected from light and moisture. The packaging complies with chemical safety standards to prevent leaks or spills. During transit, it is handled as a non-hazardous material but kept away from strong oxidizers. Shipping documentation includes proper labeling and safety data sheets.
    Storage Methyl 2-methoxybenzoate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidizing agents. It should be kept at room temperature, and care should be taken to avoid moisture ingress. Properly label the container and ensure it is handled by trained personnel.
    Application of Methyl 2-Methoxybenzoate

    Applications of Methyl 2-Methoxybenzoate in Industrial Manufacturing

    Methyl 2-Methoxybenzoate, manufactured under stringent quality controls at our facility, is valued across multiple specialized industrial sectors. As a key functional ester, it finds consistent deployment in manufacturing workflows that require reliable performance, substrate compatibility, and compliance with ever-evolving regulatory demands. Below we outline its most established downstream applications, focusing on documented industrial practices.

    1. Fragrance Intermediate in Aroma Chemical Synthesis

    This compound plays a precise role as an interstitial building block for complex fragrance molecules, especially in the synthesis of floral and fruity base notes. Its usage answers the demand for refined aromatic structures in high-end perfumery and fine fragrance manufacturing. Producers select this ester during key reaction stages for introducing methoxybenzoyl moieties, directly impacting odor longevity and stability in finished formulations.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards (latest amendment)
    • REACH registration under EC No. 1907/2006
    • European Cosmetics Regulation (EC) No 1223/2009
    • ISO 9235:2013 — Aromatic Natural Raw Materials Documentation

    Typical usage ratio

    • Ranges from 0.2% to 3% by weight in fragrance compositions; formulators adjust percentage based on desired olfactive impact and interaction with other volatile components.

    Downstream process integration

    • Enters during esterification or acylation steps in flavor-aroma synthesis, and subsequently during final compounding and blending before product dilution.

    Final product types

    • Fine perfumes
    • Fragrance oil concentrates
    • Scented consumer goods (soaps and personal care bases)
    • Specialty aroma chemicals

    2. Pharmaceutical Intermediate for Antihistamine Synthesis

    As a selected intermediate, Methyl 2-Methoxybenzoate is critical in multi-step pharmaceutical syntheses, particularly for certain first and second-generation antihistamines. Its structure allows nucleophilic substitution and targeted transformations under controlled conditions, aligning with GMP mandates for traceable chemical provenance and impurity control throughout active pharmaceutical ingredient (API) manufacturing.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • EU GMP Part II
    • USP–NF (United States Pharmacopeia–National Formulary)
    • European Pharmacopoeia monographs (Employed as an unlisted intermediate, not a direct API)

    Typical usage ratio

    • Usually reacts in equimolar or slight molar excess (1.0 – 1.15 eq.) as dictated by multistep process yield and downstream impurity specifications.

    Downstream process integration

    • Introduced during early synthetic stages, including benzoylation or amidation, serving as a protected intermediate before further functionalization and final salt formation.

    Final product types

    • Bulk antihistamine APIs (e.g., mequitazine, and related compounds)
    • Tablet and capsule-grade intermediates
    • Oral suspension ingredient bases (non-direct excipient)

    3. Fine Chemical Synthesis for Photoinitiators

    Industrial photoinitiator manufacturing—critical to UV-cured coatings and inks—requires aromatic ester intermediates for constructing efficient radical-generating systems. The stability and electron-donating character of Methyl 2-Methoxybenzoate facilitate condensation and addition reactions, supporting tailored molecular designs in photopolymer chemistry at scale.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • REACH Annex XVII substance restrictions (European Market)
    • GHS (Globally Harmonized System) chemical handling for specialty chemicals
    • Customer-specific technical and purity standards (≥99% GC-purity, low moisture)

    Typical usage ratio

    • 0.5–1.5 equivalents relative to primary core substrates, optimized for condensation balance, reaction efficiency, and target initiator structure.

    Downstream process integration

    • Added at initial synthesis stage in liquid-phase or solvent-assisted batch reactors, often followed by purification before downstream functionalization into finished photoinitiators.

    Final product types

    • Photoinitiators for UV-curable adhesives and coatings
    • Photoresists for printed circuit board (PCB) manufacturing
    • Inkjet and screen-printing ink curing systems

    4. Intermediate in Agrochemical Synthesis

    The compound functions as a metabolic blocking group or coupling agent in the synthesis of select benzoic acid ester agrochemicals. Its presence increases process flexibility and allows adaptable synthetic routes to target crop protection chemicals, especially where methoxy-functionalized aromatic frameworks are necessary for desired biological activity or environmental stability.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • EU Regulation (EC) No 1107/2009 concerning the placing of plant protection products on the market
    • ISO 17025 laboratory accreditation for analytical QC
    • National agrochemical registration dossiers (conformity assessment, e.g., US EPA Subpart N)

    Typical usage ratio

    • 0.3–1.0 molar equivalents, selected based on the downstream reaction pathway, isolation efficiency, and targeted product yield.

    Downstream process integration

    • Activated during intermediate formation in multi-step synthesis, specifically in Friedel–Crafts acylation, followed by conversion to crop-active benzoate derivatives.

    Final product types

    • Selective herbicide actives
    • Fungicidal benzoate formulations
    • Plant growth regulator precursors
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    Certification & Compliance
    More Introduction

    The Versatility and Value of Methyl 2-Methoxybenzoate in Today’s Market

    Direct from the Manufacturer: Our Perspective on Production, Quality, and Application

    Years of hands-on experience in our chemical manufacturing facility have taught us that attention to detail matters – not just in the finished product, but from the first synthesis step to the final packaging. That’s especially true with an ester like Methyl 2-Methoxybenzoate. Popular among demanding industries, this compound stands out because the market asks for high purity, low odor, and traceable consistency. Our experience brings us face-to-face with many forms of benzoic acid derivatives, but methyl 2-methoxybenzoate continues to carve out its niche. For customers looking to differentiate between options, insight into what truly sets it apart can make all the difference in downstream results.

    Understanding the Product Model and Specifications

    We are not out to flood the market with variations that compromise clarity for users. The methyl 2-methoxybenzoate we produce arrives as a clear, practically colorless liquid. In our lines, the compound formula stays reliable — C9H10O3 — supported by a molecular weight consistent with reference literature (166.18 g/mol, for those logging numbers). We run every batch through gas chromatography-mass spectrometry, measuring purity above 99.0%. Higher purity translates to better reaction yields and fewer surprises in formulation steps further down the line. Our product typically holds a refractive index at 20°C around 1.540, and a boiling point crossing 265°C, facts we confirm by repeated laboratory checks rather than relying on vendor-provided paperwork.

    Solubility is a conversation starter between many customers and our technical support. As a benzoate ester, methyl 2-methoxybenzoate dissolves easily in common organic solvents like ethanol, ether, and benzene, letting us support formulators working both with aromatic blends and specialty fine chemicals. Water solubility sits low, which plays to its strengths in oil-based matrices, personal care emulsions, or in select agrochemical carriers.

    From a visual and olfactory perspective, methyl 2-methoxybenzoate brings a faint, slightly sweet note – a detail that pleases perfumers and confounds those who expect sharp chemical odors. We find that customers in the fragrance and flavor world often specify strict color and odor thresholds. Our batches hold steady thanks to a closed-system distillation process that keeps byproducts well below critical aroma detection levels.

    Applications That Benefit from Precision Manufacturing

    We see methyl 2-methoxybenzoate as a workhorse among intermediates. In our experience, many buyers come from the pharmaceutical, fragrance, and specialty chemicals fields. The compound works as a building block for higher-value esters and aromatic ethers. Pharmaceutical teams use it as an intermediate in synthesizing more complex organics, where reliable reactivity counts. Our product finds a steady audience in industrial fragrance operations, serving as a fixative or modifier that adds a sophisticated sweet-balsamic undertone, especially in floral and fantasy blends.

    Research and development teams pay close attention to the trace impurity profile of every batch. In-house, we handle every synthesis with a constant review for residual methoxybenzoic acid and methyl benzoate, since even trace levels shift the outcome for downstream processes. Consistency matters not just for regulated applications but also for small-batch specialty developers, who rely on predictable performance at each trial scale.

    Comparisons: Methyl 2-Methoxybenzoate Versus Related Benzoate Esters

    Our catalog includes several esters, providing a unique vantage point to discuss how methyl 2-methoxybenzoate lines up against its peers. The most frequent point of confusion comes with methyl salicylate (wintergreen oil). Both compounds carry a methyl ester backbone and a methoxy substitution, but the location of the methoxy group dramatically alters both performance and olfactory profile. Methyl salicylate smells sharp and minty; methyl 2-methoxybenzoate is smoother and closer to heliotrope, making it the preferred option where gentler nuances are valued.

    The physical and chemical stability of methyl 2-methoxybenzoate offers advantages in heat-sensitive applications. Formulators who work with methyl benzoate or ethyl benzoate often encounter volatility issues. Our ester, featuring a slightly higher molecular weight and lower vapor pressure, delivers slower release in controlled-release systems and holds up in post-reaction storage. We supply samples and side-by-side application data to demonstrate these performance differences, since paper specifications rarely do justice to such real-world outcomes.

    A technical question surfaces around reactivity. Laboratory-scale syntheses prove that methyl 2-methoxybenzoate tolerates gentle alkalinity without immediate hydrolysis, a vital property for customers running multi-step syntheses under basic conditions. Substituted methyl benzoates often crack under similar stress, generating waste and complicating isolation. In our hands, the signature resilience of methyl 2-methoxybenzoate has made it a staple in benches pushing the limits of tandem reactions.

    Quality Control that Springs from Real Experience

    Years back, quality assurance in chemicals meant ticking boxes and keeping paperwork tight. Now, every kilogram of methyl 2-methoxybenzoate leaving our plant represents a lineage of tight process control and batch-level analytics. By sticking close to American and European pharmacopeia guidelines, we ensure our product never drifts toward grey zones, even as supply costs and raw material pools fluctuate across Asian markets. We invest in revalidation cycles, spot impurity checks, and feedback loops with longtime customers, who are quick to report inconsistencies that disrupt sensitive research timelines.

    We handle in-house synthesis of methyl 2-methoxybenzoate from benzoic acid derivatives, using methylation methods fine-tuned for low energy use and efficient solvent recovery. Tracking raw material sources and documenting every batch offers practical insurance against unplanned contamination – a lesson learned long before current regulatory climates demanded it. Downstream, we store and ship product only in chemical-grade, lined containers, since inferior packaging leeches color and odor, especially for esters that react to sunlight or humidity.

    No ingredient clears all hurdles forever. On rare occasions, we catch minor deviations in refractive index or color from batch to batch. Rather than masking or blending, we isolate, retest, and either downgrade or reprocess as needed. Most customers recognize that this hands-on culling protects their formulations and prevents problems long before these reach market shelves or research publications.

    Meeting Regulatory and Documentation Demands in Global Trade

    Supply chain managers, importers, and regulatory affairs teams increasingly request more than just a certificate of analysis for every kilogram. In recent years, we have adapted by adopting transparent batch-level documentation. For the plant, this means keeping process logs, maintaining traceability from raw material to finished drum, and making certain that our safety data sheets reflect evolving international classification systems. Suppliers who fail to keep paperwork in sync with product shipments risk customs clearance delays and, for customers, the headaches of rejected receipt. By correlating laboratory data with shipping logs, our batches of methyl 2-methoxybenzoate move efficiently through global channels, saving both sides time and frustration.

    As a manufacturer, we watch regulatory landscapes. There’s always a possibility of new scrutiny – particularly around residual solvents or historical byproducts. Keeping lines open with compliance consultants and monitoring chemical inventories allows us to anticipate requests rather than react when a shipment sits idle at port. In recent projects, documentation requests for allergenic potential or environmental impact assessments reached us from customers in Europe and North America. We responded by performing expanded impurity screening, keeping our process clear of flagged contaminants and adjusting our reports, so clients can trace our assurances back to primary analytical data rather than third-hand summaries.

    Practical Solutions for Consistency and Product Improvements

    Feedback from the field has always driven our approach. Problems with off-color or off-odor lots sometimes trace back to seemingly minor details – a line cleaning skipped or a storage drum outstaying its welcome under direct sunlight. Our solution has been to impose short storage intervals, excluding any stock held beyond a six-month finished goods window. In daily operations, this means close coordination between production planners and logistics, matching order flow with actual demand to minimize holding time. While this can pinch lead times, the payoff in product stability is visible with every batch review, and customers have come to appreciate why a manufacturer’s direct hand matters.

    We also recognize the sustainability expectations rising from every sector. While the core feedstocks for methyl 2-methoxybenzoate aren’t yet bio-based at commercial scale, our site invests in solvent reclamation and waste minimization. Closed-loop solvent systems and centrifugal separations let us recapture over 85% of used process solvents. The direct upshot is less vented waste, fewer emissions, and a supply chain that answers not only today’s calls for green chemistry, but regulatory shifts that can arrive with little warning.

    Improvements extend to packaging as well. Our longstanding customers recall previous generations using metal drums with questionable linings; over time, we observed off-odors and traces of metal leaching. We shifted packaging to high-density polyethylene and multi-layer barrier drums. The difference appears in lower reject rates – especially for customers who rely on ultra-low odor thresholds in finished cosmetic and fragrance goods.

    Serving Industrial, Academic, and Specialty Markets

    The biodiversity of our customer base for methyl 2-methoxybenzoate keeps us sharp. Academic labs often order just a few grams for experimental synthesis, checking each data point against published spectra and retention times. Industrial giants move metric tons, chasing down cost improvements in high-throughput lines. Specialty fragrance houses want only the creme de la creme in odor quality, pressing for custom distillation cuts to maximize purity. Each of these users brings priorities, and each demands a different calibration of our skillset.

    Where academic researchers request reference samples, we back up every lot with raw analytical scans rather than stripped-down summaries. Industrial users value predictable scale logistics and on-time delivery, and our direct-to-end user shipment model trims days from order schedules. Once we found fragrance developers struggled with a specific batch’s woody note; we solved it by cross-referencing gas chromatography runs and adjusting the separation curve to target a narrower purity window.

    Product developers pursuing unique use cases have, on occasion, invited us to demonstrate the solubility curve, the volatility window, or the reactivity profile alongside other methyl benzoates. By inviting these chemists to witness pilot batches or view time-lapse stability studies, we’ve built trust that reaches beyond what any spec sheet or material database offers. These collaborations often help us zero in on previously unnoticed product quirks, supporting further process refinements.

    Looking Ahead: Evolving Expectations and the Road to Reliability

    Chemical manufacturing, as any old hand will admit, is as much about discipline as it is about flexibility. We learned early not to chase every passing trend, but instead to stay rooted in fundamentals – reliable sourcing, consistent synthesis, clean handling, and detailed tracking. The requests that customers bring today for methyl 2-methoxybenzoate reflect not just their own trust in this compound, but also the cumulative reputation that builds over hundreds of batches and years of practical learning. Navigating between aging infrastructure, rising compliance requirements, and calls for greener supply practices, our team stays ready to adapt and refine.

    We see methyl 2-methoxybenzoate as a good example of an unsung backbone molecule in many modern innovations, from better-tolerated therapies to more enticing sensorial experiences in consumer goods. Successful manufacture relies on never underestimating the detail that separates standard from exceptional. By prioritizing performance data, direct user feedback, and hard-won lessons from the plant floor, we keep pace with expectations – and sometimes, outstrip them.

    End users, whether they mix at the bench or in thousand-liter reactors, return for product that performs the same way every time. That trust rests not on slogans, but on day-in, day-out decisions in production and quality assurance. Methyl 2-methoxybenzoate stands as a testament to what careful synthesis, transparent testing, and practical improvements deliver – and, in our view, the lesson carries across every product in the catalog for those willing to dig deeper.