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Methyl 2-Chlorophenylacetate

    • Product Name Methyl 2-Chlorophenylacetate
    • Alias Methyl o-chlorophenylacetate
    • Einecs (EINECS) 220-829-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    916715

    Chemical Name Methyl 2-Chlorophenylacetate
    Cas Number 16617-34-0
    Molecular Formula C9H9ClO2
    Molecular Weight 184.62 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 255-257°C
    Melting Point -4°C
    Density 1.22 g/cm3
    Refractive Index 1.531
    Purity Typically ≥98%
    Solubility Slightly soluble in water; soluble in organic solvents
    Smiles COC(=O)CC1=CC=CC=C1Cl
    Flash Point 108°C
    Storage Temperature Store at 2-8°C
    Synonyms Methyl (2-chlorophenyl)acetate

    As an accredited Methyl 2-Chlorophenylacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Methyl 2-Chlorophenylacetate, 100g, supplied in a sealed amber glass bottle with chemical-resistant screw cap and detailed safety label.
    Shipping Methyl 2-Chlorophenylacetate is typically shipped in tightly sealed, chemical-resistant containers to prevent leakage and contamination. It should be transported according to local and international regulations for the shipment of chemicals, avoiding extreme temperatures and direct sunlight. Proper labeling and documentation, including hazard identification, are required for safe and compliant shipping.
    Storage Methyl 2-chlorophenylacetate should be stored in a cool, dry, well-ventilated area away from sources of heat, ignition, and direct sunlight. Keep the container tightly closed when not in use and protect from physical damage. Store separately from strong oxidizing agents and acids. Use appropriate, clearly labeled chemical containers, and ensure compliant with local regulations on chemical storage.
    Application of Methyl 2-Chlorophenylacetate

    Applications of Methyl 2-Chlorophenylacetate in Industrial Manufacturing

    Methyl 2-Chlorophenylacetate serves as a key intermediate across several chemical synthesis sectors. Its unique reactivity profile supports precise formulation requirements in custom manufacturing, ensuring repeatable results in regulated industrial contexts. Our facility tailors specifications for downstream production, guaranteeing compliance and optimal batch performance.

    1. Pharmaceutical Intermediate Manufacturing

    As a core intermediate, Methyl 2-Chlorophenylacetate enables efficient synthesis of active pharmaceutical ingredients, especially in producing anti-inflammatory drugs and certain antihistamines. Its chemical structure provides a controlled pathway for esterification, crucial for consistent molecular assembly. Manufacturers integrate this material to achieve strict purity thresholds dictated by international pharmacopeias, particularly when scaling up for regulated drug manufacturing. Secure handling protocols and validated supply chain documentation form integral parts of the delivery process.

    Industry compliance standards

    • ICH Q7 GMP Guidelines for Active Pharmaceutical Ingredients
    • USP-NF, EP, JP Monograph Adherence (as applicable)
    • U.S. FDA 21 CFR Part 210/211
    • Controlled Substance Precursor Regulation (where required)

    Typical usage ratio

    • 0.15–0.45 molar equivalents per API batch, with adjustments based on target molecule and scale

    Downstream process integration

    • Reacts in early-stage condensation or acylation, typically within multi-step synthesis under monitored temperature and pH
    • Acts as a rate-limiting substrate, fed into reactors via automated dosing systems
    • Integrated in pre-formulation for pilot and commercial production runs

    Final product types

    • Non-steroidal anti-inflammatory drug (NSAID) intermediates
    • Second- and third-generation antihistamine precursor chemicals
    • Custom small-molecule APIs for contract manufacturing partners

    2. Agrochemical Synthesis

    Producers in the crop protection industry utilize Methyl 2-Chlorophenylacetate to construct advanced pesticide actives, including specific herbicide and fungicide molecules. The ester function allows for targeted esterification steps, facilitating high-yield transformations under tightly controlled batch processing conditions. Adherence to REACH and FAO/WHO requirements is strictly maintained, ensuring safe integration into agrochemical formulations that undergo regional registration.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • FAO/WHO Specifications for Agricultural Pesticides
    • ISO 9001:2015 Quality Management System
    • National Agrochemical Registration Guidelines (EPA, EU, China ICAMA, etc.)

    Typical usage ratio

    • 5–18% mass fraction per synthesis batch, adjusted in line with the desired active compound and processing yield targets

    Downstream process integration

    • Introduced at the initial derivatization or coupling stage for synthesis of target crop protection active ingredients
    • Undergoes controlled reaction with various nucleophiles in jacketed batch reactors
    • Feeds into spray-drying or microencapsulation units for final formulation

    Final product types

    • Selective herbicide actives for cereal and broadleaf weed management
    • Specialty fungicide precursors used in fruit and vegetable protection
    • Bespoke insecticide intermediates for global contract manufacturing

    3. Fragrance and Flavor Chemical Production

    Specialty fragrance ingredient manufacturers depend on Methyl 2-Chlorophenylacetate as a building block for aromatic ester and alcohol synthesis. Its aromatic scaffold enables fine-tuning of olfactory and taste profiles while meeting IFRA standards. Typical processes take advantage of its reactivity under mild transesterification and hydrolysis, enabling efficient downstream isolation and purification for use in both consumer and industrial fragrance applications.

    Industry compliance standards

    • IFRA Standards for Fragrance Materials
    • FCC (Food Chemicals Codex) and FEMA GRAS for flavor components
    • EU Regulation (EC) No 1334/2008 on Flavourings
    • ISO 9235:2013 for Aroma Chemicals

    Typical usage ratio

    • 0.8–3% of total batch weight, variable based on formulation goal and target sensory intensity

    Downstream process integration

    • Introduced as a reactive intermediate in fragrance molecule assembly lines
    • Participates in transesterification and subsequent distillation for purity control
    • Direct addition to compounding reactors under inert atmosphere for controlled synthesis

    Final product types

    • Aromatic esters for fine fragrance formulations
    • Flavoring alcohols and ketone intermediates
    • Solubilized aroma compounds for home care and personal care products

    4. Specialty Chemical and Fine Organic Synthesis

    Methyl 2-Chlorophenylacetate finds consistent demand in the synthesis of specialty organics, particularly as an intermediate in the creation of dyes, plasticizers, and specialty coatings. Suppliers to electronics and polymer sectors incorporate it for proficient control of chain-length and functional group incorporation. Precision in batch dosing, coupled with systematic in-process analytical testing, provides tangible benefits in both yield and quality, especially for applications subject to international safety and chemical registration directives.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 for Industrial Chemicals
    • ISO 14001:2015 for Environmental Management
    • IECQ QC 080000 for Hazardous Substance Process Management (electronics)
    • US EPA TSCA Listing Requirements (where applicable)

    Typical usage ratio

    • 1.2–7% of process mass, with adjustments for color strength, polymer target properties, or end-user specified performance criteria

    Downstream process integration

    • Integrated into multi-step synthesis as a coupling reagent or chain starter
    • Metered addition to stirred tank reactors for advanced polymer modification
    • Feeds into in-line granulation or milling equipment where end-use dictates particle size

    Final product types

    • Intermediates for high-performance dyes in textile and plastics
    • Specialized plasticizer compounds for flexible polymers
    • Intermediate chemicals used in electronics-grade specialty coatings
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    Certification & Compliance
    More Introduction

    Methyl 2-Chlorophenylacetate: Reliable Quality from a Trusted Manufacturer

    The Journey from Raw Material to Finished Product

    In our facility, we have been making Methyl 2-Chlorophenylacetate for years, focusing on consistency, high-quality output, and full control over the raw material inputs. Our engineers follow strict synthesis protocols that pay close attention to every step, down to purification and packaging. We know the substance starts as 2-chlorophenylacetic acid and methanol, and through careful esterification, we produce a clear, colorless liquid or sometimes a pale crystalline solid if cooled. The final product runs through several checks—purity, moisture content, and residual solvents are measured batch by batch, and any deviations from the set range get addressed before shipment.

    For us, quality isn't just a claim stamped on a drum; it shows up in how the batches look, how they respond under the GC, and how our repeat customers report outcomes. We see this detail play out on the shop floor: careful weighing, temperature controls, fraction collection, and, at times, a second distillation. Every step means something when the end user depends on a chemical that behaves exactly as intended in every formulation.

    Specifications That Matter in Real-World Production

    We produce Methyl 2-Chlorophenylacetate with a typical assay above 99 percent by GC. Water content comes in consistently below 0.2 percent, which matters for anyone who needs a reliable solvent profile in downstream synthesis. The final product flows smoothly, has a faint, sweetish odor, and shows a boiling point that matches published literature values, usually around 240 degrees Celsius at ambient pressure.

    In the lab, our chemists regularly check refractive index and specific gravity, and we stay ready with batch records going back several years for traceability. Each shipment comes in well-sealed, internally-lined drums or FIBCs that arrive securely, with clear labeling and documentation. After years of shipping both domestically and overseas, we've seen the importance of securing every drum during loading to avoid contamination. Loose seals or small leaks do more than damage the batch—they can bring a process to a complete stop on the client’s side.

    Distinguishing Methyl 2-Chlorophenylacetate from Other Intermediates

    In our experience, Methyl 2-Chlorophenylacetate finds its main use as a building block in pharmaceutical and agrochemical synthesis. The chlorine atom at the ortho position provides a unique handle for further functionalization, which is very different from standard phenylacetates or methyl esters missing that substituent. This placement opens pathways for Grignard reactions and selective hydrolyses, giving chemists more control in elaborate synthetic steps.

    For customers who come to us looking for plain methyl phenylacetate, we make it clear this molecule is not a direct substitute. Methyl 2-Chlorophenylacetate has different electron density across the aromatic ring, so it reacts in a noticeably distinct way in Friedel-Crafts acylations or when forming heterocycles. Those subtle differences spell success or frustration for downstream yields. There is no one-size-fits-all in synthetic chemistry, and we’ve learned that end-users recognize quickly if they’re using the wrong intermediate for their process.

    Applications and Value for Fine Chemical Synthesis

    We make this chemical for clients pushing forward in pharmaceutical research, specialty fragrance design, and, sometimes, custom catalysts. The majority of requests we get involve protection, derivatization, or further chlorination. In each case, the methyl ester functionality provides a balance between reactivity and stability, making it easier to manipulate without losing integrity during shipping or short-term storage.

    Our technical advisors have worked alongside customer R&D teams to troubleshoot challenges like incomplete conversions, product crystallization, or odd side reactions. We listen carefully to these problems. Sometimes a process must be changed, such as the drying method, either by slight modification in the nitrogen flow or switching to a higher-vacuum line for distillations. We’ve invested in pilot-scale reactors and analytical equipment because these small process changes can have outsized effects on yield and product quality. This hands-on approach comes directly from years in the field, not just from reading a textbook.

    Meeting the Needs of Industrial Clients

    Our buyers appreciate that we understand the everyday reality of chemical handling. Scale-up isn’t just about formula translation; it’s about drum integrity, batch traceability, and repeatable purity. A drum leaking in the warehouse or during ocean transit isn’t a small matter. We use high-quality gasket seals that hold up under temperature cycling and movement. All batch records travel with every order so anyone receiving the material knows what they're getting.

    We see requests for samples when clients shift formulas, sometimes due to new regulations or changing customer needs. We’re prepared to offer documentation such as CoAs and analytical spectra because industrial users want assurance. We also keep a close eye on regulatory updates—REACH compliance, for example, can require detailed changes in labeling, batch documentation, and even transportation. Staying prepared means less downtime for everyone.

    Difference in Performance and Synthetic Reliability

    Consistency in how Methyl 2-Chlorophenylacetate reacts—and how cleanly it dissolves—can make or break a process. Some other manufacturers cut corners at the purification stage, leading to yellowish tints, higher residual acid, or trace water. We’ve had new customers come to us when their old supply led to unpredictable reaction times or incomplete conversions. We respond by offering technical support, a sample vial, and a clear chain of custody for every order.

    Purity also links to process safety. Higher methyl ester purity often means fewer side products after saponification. For some of our buyers, who use automated reactors, even a fraction of a percent in impurity means fouled lines or unexpected halogenation. It isn’t just lab work at stake—sometimes there’s a forty-liter reactor with a full charge running overnight, and that’s real money and real risk.

    Working Directly with Manufacturing Expertise

    We often get questions from clients interested in how the manufacturing site operates. As the manufacturer, we believe direct communication makes troubleshooting better and more cost-effective than through multiple trading intermediaries. Our technical managers have actual production experience, not just sales training, so they catch issues early, like subtle shifts in product odor, increased viscosity, or shelf-life changes.

    We support regular audits at our site, providing access to records, protocols, and the actual production system when needed. This level of transparency helps companies meet quality guidelines for ISO auditing, as well as satisfy their own clients’ due diligence investigations. Working directly with us means fewer chances for error or miscommunication. When we receive questions about how a certain batch was produced, we pull up process logs and answer within the same day in most cases, because the records are ours—not lost somewhere in a supply chain.

    Addressing Downstream Waste and Safety Concerns

    Our shop knows that the halogen content in intermediates creates unique disposal and wastewater concerns. Over the years, we’ve built on-site treatment and recovery systems to minimize what goes down the drain and to capture any fugitive chlorinated vapors. Solvent recovery is also a top priority. Every liter of spent solvent reused in-house translates to lower cost for end-users and less environmental impact globally.

    We regularly work with industrial users who ask about regulatory compliance—especially around handling, storage, and trace halogen content in effluent. Our staff goes through annual training on hazardous materials handling and change management procedures to cut the risk of reportable incidents. Some companies use fluoride or bromine compounds instead, but due to local regulations or disposal costs, chlorinated intermediates like Methyl 2-Chlorophenylacetate strike the strongest balance between reactivity, safety, and long-term environmental impact.

    Real-World Examples and Client Challenges

    Examples from our own production line often help new users understand why precise specification matters. For one pharmaceutical project, the client needed minimal trace acid content due to sensitivity in their catalyst step. We shifted to a deeper vacuum cut, lengthened the fraction collection window, and solved the conversion issue on their end. In another case, a specialty fragrance producer found that product from a different supplier contained trace toluene, ruining their batch scent. By running one extra QC check on our end, we demonstrated to the client exactly what was missing in their prior supply.

    These aren't just isolated situations. Our largest agrochemical buyers care about consistent lot-to-lot performance because a failed synthesis can mean missing a growing season. We keep reserves of prior batches and reference samples so repeat orders match the original, even if their delivery shifts to the next year. Our traceable system underwrites these guarantees, and it stems from long practice in batch control, not just paperwork.

    Supporting Clients with Knowledge and Adaptability

    We encourage technical questions. Some users ask if Methyl 2-Chlorophenylacetate is compatible with unusual solvents or if it regenerates cleanly after certain transformations. We draw from a list of in-house pilot trials and decades of customer feedback, rather than relying solely on theory. Not every intermediate plays well with every process, and sometimes a small change in formulation, like solvent swap or quenching agent tweak, fixes an intractable process stall.

    Adapting to unexpected challenges is part of life at our plant. Equipment upgrades, new purification resins, or incremental process tweaks come from real challenges, not arbitrary decisions. In the past, we’ve worked through odd color formation and particulate contamination by re-examining upstream raw materials, not just bolting on more filtration. Hands-on response time often makes the difference for our buyers facing tight deadlines.

    Supplying More Than Just a Molecule

    As a chemical manufacturer, our responsibility extends past simply filling an order. We deliver a product that slots into complex downstream syntheses, where every variable matters. Many of our buyers keep open communication because they know they’ll get more than a bag or a drum. They receive updated technical support, access to experienced staff, and the assurance that the same material can be made again next year—or changed, if their regulatory landscape does.

    We keep a network of long-term customers because we solve problems, not just move product. If a compliance audit flags a small data gap, we back it up by supplying in-house measurement records or, if needed, running a new characterization. Batch reproducibility should not be left to chance, so we invest in equipment and training that ensure each lot of Methyl 2-Chlorophenylacetate meets the same tough standards. Our clients expect this—and so do we.

    Integrating Sustainability and Compliance into Operations

    Our site management team runs regular internal reviews to track how waste minimization, emission reduction, and process safety integrate into the operation. The growing importance of sustainability in specialty chemicals means every batch gets tracked for yields, solvent recovery, and effluent disposal. Regulatory shifts sometimes challenge the way a product is made, prompting us to test new bases, acids, or processing times to align with updated safe handling protocols.

    We partner with analytical labs and environmental groups to keep raw materials and finished products within customer and regulatory guidelines. Keeping accurate batch records, documenting resin and catalyst origins, and facilitating periodic audits help everyone track supply chain risk. Problems get tackled directly and fast—no waiting weeks for a slow response.

    Why Direct Sourcing From a Manufacturer Makes a Difference

    Feedback from our clients confirms that the reliability of direct sourcing matters. A distributor or broker can't fix a scale-up issue or missing documentation after the order ships. As an actual manufacturer, we stand behind our chemistry with real solutions—technical records, process advice, and transparent communication. We prepare documentation to help support downstream registration or compliance, and we genuinely listen to feedback, whether for a kilo sample or a multi-ton shipment.

    Being involved in the process means that any challenges, from scale-up to impurity management, are addressed quickly. One client’s process produced a persistent haze in their final product; after reviewing our production logs and sharing sampling protocols, we found the contaminant originated upstream, outside our facility. Sharing this information honestly allowed everyone to correct the issue without finger-pointing or delay.

    Staying Ahead in a Changing Industry

    Chemical manufacturing continues to evolve, with tighter specifications, more complex downstream pathways, and tougher environmental standards each year. We stay competitive by investing in lab instrumentation, training our workforce, and refining process steps for both efficiency and safety. The people who make the product know the stakes are real; when batch purity slips, or a shipment arrives late, it's not a theoretical problem—it’s a headache for the user, which we all aim to avoid.

    Methyl 2-Chlorophenylacetate may seem like just another intermediate out of context, but for our team, it represents a direct link between upstream chemistry and the breakthroughs our customers pursue. Solid communication, visible records, and fast response make us a preferred partner for those who depend on high-integrity manufacturing at every stage. Each new project is a reminder that careful, experienced handling beats simple transaction every time.