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Methyl 2,4-Dichlorophenylacetate

    • Product Name Methyl 2,4-Dichlorophenylacetate
    • Alias Methyl 2,4-dichlorophenylacetate
    • Einecs 254-646-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    363910

    Chemicalname Methyl 2,4-Dichlorophenylacetate
    Casnumber 4091-39-8
    Molecularformula C9H8Cl2O2
    Molecularweight 219.07
    Appearance Colorless to pale yellow liquid
    Boilingpoint 144-146°C at 17 mmHg
    Density 1.34 g/cm3
    Solubility Insoluble in water; soluble in organic solvents
    Purity Typically ≥98%
    Flashpoint 140°C
    Synonyms 2,4-Dichlorophenylacetic acid methyl ester

    As an accredited Methyl 2,4-Dichlorophenylacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g amber glass bottle with a secure screw cap, labeled "Methyl 2,4-Dichlorophenylacetate, ≥98% purity," and hazard warnings.
    Shipping Methyl 2,4-Dichlorophenylacetate should be shipped in tightly sealed containers, protected from moisture and direct sunlight. It must comply with applicable regulations for hazardous chemicals. Transport in accordance with local, national, and international guidelines, ensuring appropriate labeling and documentation. Avoid exposure to heat or incompatible materials during transit. Handle with proper safety precautions.
    Storage **Methyl 2,4-Dichlorophenylacetate** should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from direct sunlight and sources of heat or ignition. Keep away from incompatible substances such as strong oxidizers and bases. Store at room temperature, and ensure appropriate chemical labeling. Use secondary containment to prevent leaks or spills.
    Application of Methyl 2,4-Dichlorophenylacetate

    Applications of Methyl 2,4-Dichlorophenylacetate in Industrial Manufacturing

    Methyl 2,4-Dichlorophenylacetate serves as a critical intermediate across specialist chemical manufacturing sectors, particularly where halogenated aromatic compounds are essential for producing advanced downstream products. With established performance in controlled syntheses, this material integrates into regulated and audited workflows in the agrochemical, pharmaceutical, and specialty additive industries.

    1. Agrochemical Active Ingredient Synthesis

    Agrochemical manufacturers frequently use Methyl 2,4-Dichlorophenylacetate during the synthesis of selective herbicide actives and certain fungicidal intermediates. This ester functions at the initial couplings for aryl-acetate frameworks, supporting process controls that ensure active purity and residue compliance. Midstream workflows within most commercial agrochemical sites employ this intermediate, given its compatibility with chlorination and alkylation process steps. The focus remains on producing APIs compliant with regulation for crop protection chemistry.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • European Union Regulation (EC) No 1107/2009 for plant protection products
    • US EPA FIFRA pesticide registration criteria
    • China GB 2763 maximum residue limits for pesticides

    Typical usage ratio

    • 10-25% by weight in core actives synthesis, adjusted per required dose and conversion efficiency within crop protection active ingredient pathways.

    Downstream process integration

    • Introduced at the condensation or esterification step to build the dichlorophenyl acetyl moiety needed for downstream chlorination and chain extension.

    Final product types

    • Selective herbicide active ingredients (e.g., dichlorophenyl-type herbicides)
    • Pre-emergent fungicide core intermediates
    • Ready-to-use crop protection formulation concentrates
    • Dispersible granules deployed in field application

    2. Pharmaceutical Intermediate for Non-Steroidal Anti-inflammatory Drugs (NSAIDs)

    Methyl 2,4-Dichlorophenylacetate enters pharmaceutical manufacturing as an advanced intermediate for constructing arylacetic acid-based NSAIDs, such as selective COX inhibitors. Production workflows use this raw material during the assembly of the dichlorophenyl segment, which forms the pharmacophore of several established APIs. Plant environments maintain strict process validation, and documentation supports traceability from raw material intake through to batch finished goods release. All synthesis incorporates validated process analytical technologies for in-process control.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF monographs for arylacetic acid derivatives
    • EU EudraLex Volume 4 GMP Guidelines
    • China Pharmacopoeia (ChP) for intermediate validation

    Typical usage ratio

    • 20-35% by weight in reaction mixture, adjusted for yield optimization and impurity profiling in non-steroidal anti-inflammatory API synthesis.

    Downstream process integration

    • Charged during the Friedel–Crafts acylation or esterification steps to deliver the dichlorophenylacetate motif, followed by hydrolysis and amination for API construction.

    Final product types

    • Bulk NSAID APIs (e.g., diclofenac analogues)
    • Intermediates for pain relief pharmaceuticals
    • Finished oral and topical formulations
    • Export-quality pharmaceutical custom synthesis stock

    3. Fine Chemical Intermediate for Dyes and Pigment Manufacture

    Producers in the colorant sector apply Methyl 2,4-Dichlorophenylacetate as a substrate to assemble specialty pigment molecules based on halogenated aromatics. The ester provides a stable entry point for constructing complex azo and anthraquinone dyes that meet regulated color fastness and migration requirements for the plastics, textiles, and coatings industries. Downstream workflows utilize the compound for high-purity dye synthesis, where batch traceability and process reproducibility are under tight statistical process control.

    Industry compliance standards

    • ISO 14001:2015 Environmental Management Systems for pigments
    • EN 71-3:2019 Safety of Toys (migration of certain elements in pigments)
    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (for colorants)
    • OEKO-TEX® Standard 100 (for textile auxiliary chemicals)

    Typical usage ratio

    • 5-18% by weight, based on coupling agent excess and dye assembly scale in pigment synthesis operations.

    Downstream process integration

    • Supplied to coupling or substitution process units as the core component for dichlorophenyl dye build-up, downstream of primary aromatic assembly.

    Final product types

    • Specialty azo and anthraquinone pigments
    • High-stability plastic masterbatch colorants
    • Solvent and water-based industrial dyes
    • Textile disperse dyes for polyester applications

    4. Intermediate for Halogenated Aromatic Polymer Additives

    Manufacturers of high-performance polymers and resins implement Methyl 2,4-Dichlorophenylacetate in the synthesis of halogenated aromatic additives that impart thermal and UV stability. The compound is introduced in controlled batch reactors as an intermediate in the production of flame-retardant or stabilizer molecules. These additives are subsequently formulated into engineering plastics and high-durability coating systems used in electrical, automotive, and building materials sectors, where compliance with additive migration and resistance parameters is mandatory.

    Industry compliance standards

    • UL 94 Standard for Safety of Flammability of Plastic Materials
    • EN 13501-1 Reaction to Fire Classification
    • ASTM D3801 Standard Test Method for Flame Retardancy
    • RoHS Directive 2011/65/EU (for restricted substance levels in electronics)

    Typical usage ratio

    • 2-10% by weight in additive precursor preparations, margin adjusted per performance and integration requirements in polymer compounding.

    Downstream process integration

    • Dosed during the formation of halogenated aromatic segments for plastic additive molecules, prior to incorporation in final resin or masterbatch compounding lines.

    Final product types

    • High-thermal stability polyolefin additives
    • Halogenated flame-retardant masterbatches
    • UV-stabilized coatings for industrial panels
    • Engineering plastics for electronics and automotive parts
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    Certification & Compliance
    More Introduction

    Methyl 2,4-Dichlorophenylacetate: A Manufacturer’s Perspective on Quality and Distinction

    Unveiling Our Take on Methyl 2,4-Dichlorophenylacetate

    Rolling up our sleeves in the chemical plant year after year, we know a few things about methyl 2,4-dichlorophenylacetate. This product, which reflects the grit and precision of every technician here, has built a solid reputation in pharmaceutical synthesis and specialty chemical manufacture. In our process lines, it starts as a raw aromatic precursor and emerges as a finely tuned ester, which delivers reliable performance batch after batch.

    You can spot real value only with hands-on experience. Generic catalog descriptions won’t give you the full story. This isn’t about clever marketing. We face the smells of chloroaromatic chemistry daily. The workers and engineers who run those reactors watch for subtleties day and night. Impurity levels, residual solvents, particle size—all these factors stack up to influence downstream use, not just paperwork.

    Specifications and Quality Through Real-World Practice

    Crafting methyl 2,4-dichlorophenylacetate takes more than a clean recipe. Our chemists obsess over the GC purity and HPLC fingerprint, confirming that synthetic byproducts don’t sneak through the cracks. Most shipments consistently show over 99% purity. Every batch is weighed against these standards, not because a customer demanded it, but because we have seen how even slight deviations can ripple through further processing—whether it is acylation, hydrolysis, or reduction.

    Physical characteristics matter, too. The product lines churn out a white to off-white crystalline solid, typically tailored to a melting point range of about 38–42°C. We filter with precision, never leaving excess fines or sticky residues behind. Customers in pharma and agrochemical research rely on this: if the product clumps or varies in color, it jams up their own operations or throws analytical signals off. Clean, consistent batches reduce hassle in downstream applications, cutting back on unnecessary troubleshooting.

    Solubility is often reported as an afterthought. Not for us. We focus on cleanliness at the end stage, leaving no trace of unreacted alcohols, acids, or stoichiometric residues behind. When our customers dissolve it in ethanol, methanol, or simple acetones, they waste less time with filtration or recrystallization. Lab folks talk about “trickiness” in solubility, but that is usually caused by poor control over raw material sources. We maintain our own supply chain checks on chloride sources and phenylacetic inputs, so batch-to-batch consistency makes itself clear in the flask.

    Usage in Real Applications

    Most buyers don’t want empty assurances—they want proof grounded in practice. In pharmaceutical intermediates, methyl 2,4-dichlorophenylacetate shows its value as a reliable penultimate in a variety of synthetic routes. Process chemists appreciate its ability to anchor halogenated side chains while resisting unwanted side reactions. For contract manufacturers—the ones with hard customer timelines—our product slashes rework and reduces the headache of failed columns or odd HPLC peaks.

    Agrochemical labs prize the molecule for similar reasons. They draw on its dual chlorine atoms for targeted functionalization, using the ester as a handle for further adjustment of biological activity. We’ve worked beside researchers tweaking novel herbicide or fungicide candidates. For them, a clean ester with tight melting range and predictable reactivity keeps projects off the rocks, whether they are synthesizing for field trials or regulatory studies.

    We have found our customers in specialty polymers and advanced materials as well. They experiment with ring-substituted aromatics for their dye chemistry or resins. Here too, trace impurities lurking in a poorly managed batch can scuttle a whole run. Keeping product characteristics tight isn’t about ticking boxes, it’s about standing behind material that does what you expect, every time the truck lands at your dock.

    Distinct Pathways: How Our Process Sets This Product Apart

    Not every sample you scoop from a drum of methyl 2,4-dichlorophenylacetate will perform the same—regardless of what the label or accompanying papers say. This truth is born from our years of wastewater management, catalyst recycling, and hard-won quality control. You could make this ester by various routes, but some leave hard-to-purge residuals or a haze of unknowns on your chromatograms.

    We insist on using thoroughly dried and high-purity phenylacetic acid derivatives. Taking shortcuts with wet solvents or low-grade starting materials leads to trace chlorides or esters that linger, causing cloudiness in solution or color shifts at scale. We keep reaction times carefully optimized: neither overcooked, risking over-chlorination, nor rushed, which leaves excess unreacted substrate poking through on analysis.

    Most of the large-volume material on the open market is prepared for bulk synthesis where price, not purity, is the driver. We built our process lines around high demand from pharmaceutical and agro R&D firms, so we guard against heavy metal contamination from catalysts and aggressively filter off trace silica before shipment. Our decision to keep these steps tight is rooted in experience—we have seen entire customer programs derailed by micro-level contamination that standard supplier audits overlook.

    Comparing with Alternatives: Beyond the Numbers

    Some folks ask why they shouldn’t just swap in a generic ester or a competitor’s dichlorophenylacetate. The answer shows up in yield drops, unexpected purification steps, and a parade of analytical outliers. When customers tried other sources, they often reported sticky residues, odd color fades after storage, or mysterious side peaks in their NMR spectra. We hear those stories, too.

    There’s a belief among some buyers that a phenylacetic acid ester is a commodity. Our engineers argue otherwise. The way halogenation is managed, and the way we scrub out by-products, means our methyl 2,4-dichlorophenylacetate gives line operators fewer headaches—less rework, more predictable crystallization, fewer sticky messes in the vessel. That isn’t marketing. It’s what we see in the lab and on the plant floor.

    We see the knock-on effects in custom pharmaceutical synthesis schedules. A single failing batch or misbehaving intermediate spills days of lost time and unplanned overtime. Avoiding that expense and keeping projects on the rails is worth more to most production managers than chasing last-gram price differences.

    Regulatory Confidence and Safety Practices from Direct Experience

    Because we deal directly with regulatory audits, we know the level of scrutiny involved. Our operations meet not only internal specifications but also comply with all standard regulatory thresholds. Batches come with full traceability. We run concurrent environmental controls to keep solvent residues below limits, and we’ve installed inline sensors to track airborne halogen levels for worker safety.

    By working alongside analytical teams, we ensure consistent batch certification. Our transparency on residual solvents, elemental impurities, and all relevant data comes from years of navigating both government and customer audits. We’ve watched what happens when noncompliance sneaks into a chain of custody.We share everything we know up front. Our approach comes from making mistakes, learning, and refusing to let small gaps turn into big risks.

    Tackling Real-World Problems: Our Commitment to Solutions

    Methyl 2,4-dichlorophenylacetate production isn't immune to problems. Raw material volatility and global transport disruptions can throw even carefully maintained supply chains off-balance. In years past, we’ve had to scramble when phenylacetic acid imports dried up or when a critical catalyst was backordered for weeks. These moments train you to keep strong supplier relationships, deep inventories, and backup transport options at the ready.

    Energy use also shapes our daily conversations. Many manufacturers chase unit cost by neglecting solvent recycling or temperature minimization. We’ve invested heavily to keep solvent loops closed and emissions low. This isn’t pure altruism—energy savings reduced our plant’s monthly spend, and solvent recovery cuts annual costs while shielding the team from unnecessary exposure. Every new increment in efficiency pushes us a little closer to sustainable, profitable operations.

    Disposal of waste bromides and chlorinated by-products has kept us working closely with local regulators. Rather than send these streams off for incineration, we’re working toward chemical recovery and reuse. Small steps—like recapturing mother liquors, reprocessing off-grade batches, and developing in-house neutralization—build resilience and keep production smooth even when the outside environment gets rough. We learned early that handling your own waste is the only way to guarantee what leaves your fence meets your standards.

    Quality by Those Who Live and Breathe It

    When you buy methyl 2,4-dichlorophenylacetate from a manufacturer who runs every pump, every jacketed reactor, you’re getting more than material. You tap into the lessons collected from years of daily batch work. Each specification is rooted in experience—what we saw on failed pilot runs, what knocked a customer’s downstream column out of spec, or what cost us precious hours when a dryer failed.

    Customers who share their real-life problems with us sharpen our own processes. Not all feedback is glowing. Sometimes a customer catches micro-level issues with filtration or detection limits we hadn’t considered. Instead of reading paperwork, we listen to complaints with fresh ears. Some of our best process adjustments came from phone calls about sticky residues or inconsistent melting, not from academic study. This keeps us honest, and drives our open-door policy on plant visits and sample requests.

    Product Differentiation: Not Just a Commodity

    We don’t see methyl 2,4-dichlorophenylacetate as a faceless bulk product. The tightness of impurity control and consistency is why customers return—especially in high-value, time-sensitive programs. Our batch-to-batch reproducibility isn’t just tracked on paper; it’s verified in daily output runs and spot checks. Unexpected color changes or odd physical properties don’t make it out the door. We simply would not pay for substandard feedstocks ourselves, so we won’t sell them.

    Customers have told us that some suppliers find ways to swap in lower grade methyl esters to chase unit costs down. Those shortcuts might pass a quick export inspection, but not the forensic scrutiny of a process chemist. Introducing poorly controlled by-products or solvent residues into a repeat synthesis often brings knock-on costs that dwarf any up-front savings. We’ve cleaned up enough customer process streams to know the reality behind bulk market deals.

    Supporting Your Process, Not Dictating It

    Every plant floor looks a little different, and unexpected hiccups happen. If our methyl 2,4-dichlorophenylacetate ever gives you trouble—whether solubility issues in a new solvent system or interaction with a new catalyst—our team stands ready to help analyze the root cause. Our technical staff spend more hours with customers than at their desks. If a customer’s pilot line goes sideways, we’re not above running side-by-side tests to troubleshoot together.

    We prioritize open access to supporting analytical data: batch certificates, GC and HPLC traces, and source documentation are all shared by default, not hidden until someone asks. Customers appreciate this approach, because waiting days for clarification can stop a batch in its tracks. Fixing a problem in real time, by phone or email, often prevents a minor issue from turning into lost productivity.

    Looking Ahead: More Than a Product, a Partnership

    Markets change. Chemistries change. What doesn’t change is our approach: hands-on, detail-focused, and invested in each batch. As regulatory bodies set ever-tighter requirements on manufacturing standards for pharmaceutical and fine chemical building blocks, running a facility that delivers consistency becomes even more important. We invest each year in better detection methods, training for operators, and flexibility in our production lines.

    We also know that customers will always push for better. Sometimes a customer wants an alternate grade with an even tighter impurity profile or a different crystallization habit. Rather than push back, we work alongside them to trial new process tweaks, evaluate alternative suppliers for raw materials, and adjust specs as science evolves. This collaborative cycle lets both sides avoid future problems and stay ahead of looming regulatory or market shifts.

    Reliability, Integrity, and Shared Purpose

    We believe that the difference between just another drum of methyl 2,4-dichlorophenylacetate and one we ship boils down to how it’s made and who stands behind it. No shortcuts—every unit produced carries the weight of hard-earned trust. That trust shapes every conversation with customers, every analytical run in our QC lab, and every troubleshooting call to a buyer wrestling with a new scale-up. We share this experience openly, knowing that the next challenge—be it process drift or a new regulatory hurdle—will be easier if we solve it together.

    This is what we’ve learned from living the process, not just selling into it. The value we deliver grows out of this experience, every day, batch by batch.