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Methacryloyl Chloride

    • Product Name Methacryloyl Chloride
    • Alias Methacryloyl chloride
    • Einecs 212-681-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    839679

    Cas Number 920-46-7
    Molecular Formula C4H5ClO
    Molecular Weight 104.54 g/mol
    Iupac Name 2-methylpropenoyl chloride
    Appearance Colorless to light yellow liquid
    Boiling Point 91-92 °C
    Melting Point -70 °C
    Density 1.066 g/cm3 at 20 °C
    Refractive Index 1.448
    Flash Point 17 °C (closed cup)
    Solubility In Water Reacts violently
    Vapor Pressure 21 mmHg at 25 °C

    As an accredited Methacryloyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Methacryloyl Chloride is packaged in a 500 mL amber glass bottle with a secure, chemical-resistant cap and hazard labeling.
    Shipping Methacryloyl chloride must be shipped in tightly sealed, corrosion-resistant containers due to its volatility and reactivity. It is classified as a hazardous material (UN 3265) and should be transported under controlled temperature, away from moisture, bases, and acids. Proper labeling, protective packaging, and adherence to international dangerous goods regulations are mandatory.
    Storage Methacryloyl chloride should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from moisture and direct sunlight. It must be kept separate from bases, alcohols, water, amines, oxidizers, and strong acids, as it reacts violently with these substances. Use only corrosion-resistant containers and ensure proper labeling to prevent accidental exposure or chemical reactions.
    Application of Methacryloyl Chloride

    Applications of Methacryloyl Chloride in Industrial Manufacturing

    Methacryloyl chloride serves as a specialized acylating agent and reactive intermediate across several advanced chemical manufacturing sectors. Its controlled reactivity and compatibility with polymer, pharmaceutical, and specialty resin processes have established this compound as a key building block in industries requiring precise functionality and regulatory compliance. Below, we detail major downstream industrial applications based on direct customer collaborations and ongoing formulation support.

    1. High-Performance Acrylic Resin Production for Specialty Coatings

    Manufacturers incorporate methacryloyl chloride as an acylating monomer in the synthesis of methacrylate-based acrylic resins, targeting high-durability protective and decorative coatings. Its reactivity enables chain extension and functionalization, critical for tuning hardness, UV resistance, and crosslink density in automotive OEM, aerospace, and electronics-grade coatings. Formulation chemists adjust inclusion rates based on resin backbone requirements and end-use durability targets, carefully balancing reactivity to minimize residual chlorides for compliance with application-specific standards.

    Industry compliance standards

    • ASTM D3960 maximum VOC regulations
    • REACH Annex XVII and SVHC control for industrial coatings
    • RoHS 2011/65/EU for electronic and electrical coatings
    • ISO 12944 for corrosion protection paints

    Typical usage ratio

    • Between 1.0%–8.0% by weight in pre-polymerization feed, adjusted according to target resin molecular weight and crosslink density

    Downstream process integration

    • Step-growth or free-radical polymerization after controlled in-situ addition, followed by neutralization and purification; implementation at the monomer introduction stage

    Final product types

    • Clear automotive topcoats
    • UV-cured industrial flooring systems
    • PCB conformal coatings
    • Aerospace anti-corrosion primers

    2. Synthesis of Biomedical Hydrogels and Dental Materials

    Methacryloyl chloride is a principal reagent in producing functionalized monomers for biocompatible hydrogels and dental cements. In these applications, its role is to provide precise methacryloylation of polyvinyl alcohols or gelatin to achieve tailor-fit crosslinking and hydrolytic stability. Downstream formulators depend on validated batch purity and trace chloride control to comply with medical device and dental restorative standards. Dosage adjustment reflects desired hydrogel swelling characteristics, mechanical integrity, and regulatory constraints for residual monomer and extractables.

    Industry compliance standards

    • ISO 10993 biocompatibility testing
    • S. Pharmacopeia (USP) Class VI plastics
    • EN ISO 20795 for denture base polymers
    • FDA 21 CFR 177.1010 indirect food additive rules for medical-grade polymers

    Typical usage ratio

    • Variable between 0.5%–4.0% by weight of total monomer, modulated for required gel strength and crosslinking density

    Downstream process integration

    • Acylation reaction at low temperature with polymer backbone or protein substrate, followed by neutralization and purification prior to downstream hydrogel molding or dental resin compounding

    Final product types

    • Surgical wound dressing hydrogels
    • Denture base acrylics
    • Light-cured dental restorative resins
    • Intraocular lens matrices

    3. Production of Methacrylate-Based Reactive Dyes and Textile Finishes

    Textile chemical manufacturers use methacryloyl chloride to synthesize specialty reactive dyes and durable finishing agents, especially for cotton, polyester, and blended technical fabrics. The methacryloylation step endows dye molecules or softening agents with polymerizable vinyl functions that promote direct fiber bonding, color fastness, and chemical resistance. Formulation adjusts the ratio to optimize bath stability and fixation under industrial stenter or pad-dry-cure conditions, in accordance with international textile and ecological regulations.

    Industry compliance standards

    • Oeko-Tex Standard 100 for restricted substances
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals)
    • ISO 105-C06 for color fastness to washing
    • REACH registration for high-volume textile auxiliaries

    Typical usage ratio

    • Typically 0.3%–2.5% by weight in the synthesis stage of dye intermediates or finishing polymers, depending on fixation and fastness targets

    Downstream process integration

    • Functional group introduction during dye or polymer precursor synthesis, followed by product isolation and blending into textile finishing or dyeing baths

    Final product types

    • Reactive textile dyes for cotton and blends
    • Easy-care crosslinked fabric finishes
    • Wrinkle-resistant treatment agents
    • UV-protective textile coatings

    4. Manufacture of Precision Optical Polymer Materials

    Producers of high-refractive index and specialty optical polymers employ methacryloyl chloride to create functionalized monomers engineered for superior clarity, controlled dispersion, and tailored curing kinetics. These applications require strict feedstock quality and regulatory documentation for optical device or lens safety, with formulators modifying the ratio to influence polymer backbone rigidity and light transmission. The chlorinated precursor enters controlled polymerization sequences, ensuring compliance on leachables and refractive index tolerances set by device manufacturers and industry regulators.

    Industry compliance standards

    • ISO 8980-1 for ophthalmic lens optics
    • ANSI Z80.1 for prescription eyewear
    • EN ISO 13485 quality system for medical devices
    • RoHS for optical electronics

    Typical usage ratio

    • Formulators use 1.5%–6.0% by weight, modulated according to the targeted refractive index and mechanical strength

    Downstream process integration

    • Incorporation during monomer matrix preparation, followed by UV or heat-initiated polymerization and finished-part casting or extrusion, with purification to remove residual chlorides

    Final product types

    • Corrective vision contact lenses
    • Laser optics and light guides
    • Precision instrument lenses
    • Photoresist components for lithography

    5. Synthesis of Polymerizable Pharmaceutical Intermediates (API Building Blocks)

    Pharmaceutical manufacturers utilize methacryloyl chloride as a coupling reagent in the preparation of polymerizable and controlled-release drug intermediates. Its ability to introduce methacryloyl groups into small molecules or macromolecular scaffolds supports the creation of targeted, matrix-bound APIs designed for modified drug delivery. Downstream chemists must ensure full reagent conversion and removal of chloride by-products, while regulatory requirements dictate batch testing and documentation. Product-specific ratios base on the functional group density of the drug intermediate or carrier matrix involved.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF monograph methods (as relevant to the intermediate)
    • EU GMP Annex 1 for sterile intermediates
    • Ph. Eur. 5.21 for extractables and leachables in APIs

    Typical usage ratio

    • Ranges from 0.2%–2.0% by weight, with precise adjustment to match the stoichiometry of the reacting functional groups during synthesis

    Downstream process integration

    • Site-specific acylation of the API precursor under inert atmosphere, followed by quench, purification through column chromatography, and solvent removal prior to downstream formulation

    Final product types

    • Polymer-bound drug intermediates
    • Extended-release oral dosage forms
    • Bioadhesive pharmaceutical gels
    • Functional excipients for drug formulation
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    Certification & Compliance
    More Introduction

    Methacryloyl Chloride: Our Journey in Fine Chemical Production

    Meeting the Demands of Modern Industry

    For over a decade, we have produced Methacryloyl Chloride at industrial scale. This colorless, fuming liquid, also known as 2-methylpropenoyl chloride, plays a large role in the synthesis of specialty polymers, advanced resins, pharmaceutical intermediates, and performance coatings. Our facility runs with tight process controls and direct batch traceability, which helps ensure consistent quality and purity through every shipment. Customers engaged in organic synthesis—be it an R&D lab or high-output manufacturing line—depend on our experience to keep their operations smooth and predictable. A fixed supply chain, built around local and imported raw materials, supports on-time delivery throughout the year, even as global supply pressures shift.

    Understanding the Product: Properties and Differences

    Methacryloyl Chloride belongs to a family of acyl chlorides, but the presence of the methyl group distinguishes it from similar products like acryloyl chloride or acetyl chloride. This methyl branch raises the boiling point and helps improve chemical handling compared to its counterparts. In reactivity, it gives a unique edge when synthesizing monomers for specialty acrylics and crosslinked copolymers. Users in the adhesive, paint, and plastics industries notice that methacryloyl chloride imparts flexibility and resistance to ultraviolet degradation, a benefit absent in simpler acid chlorides. In our own blending trials, we have found that using methacryloyl chloride as a building block results in polymers that respond better during extrusion, cure evenly, and tolerate environmental stresses—properties that can give finished goods a longer working life, especially in high-visibility consumer goods.

    Many ask about the difference between methacryloyl chloride and other common acyl chlorides. In direct applications, methacryloyl chloride’s reactive double bond (the alpha-beta unsaturation) leads to faster polymerization rates under the right conditions, as compared to non-conjugated acid chlorides. This features prominently in the supply to customers wanting UV-curable inks and specialty surface coatings. The methyl group adjacent to the carbonyl also reduces unwanted side reactions, leading to higher yields in sensitive pharmaceutical syntheses. For teams working in scale-up chemistry, this difference in selectivity saves time and cuts down on waste—something we have measured over dozens of campaigns with feedback from downstream processors.

    Model and Technical Specifications: Our Commitment

    We manufacture Methacryloyl Chloride to purity levels consistently above 98.5% by GC analysis, with residual moisture and acid content carefully minimized during distillation and packaging. By maintaining stainless steel reactor trains and using nitrogen-purged transfer lines, we reduce risk of hydrolysis and contamination. Our standard packaging ranges from sealed glass ampoules for laboratory use, up to stainless steel drums and isocontainers for bulk shipments. Each lot comes with a full certificate of analysis, showing impurity profiles, color, specific gravity, and gas chromatogram trace. Many customers request packaging purged with anhydrous nitrogen, which gives added security when the product travels long distances or encounters variable climates.

    We recall a period when a customer’s previous supplier delivered off-specification material, resulting in poor reaction performance and a week of lost output. Since then, we have tightened our own in-line monitoring, bringing in updated infrared leak sensors and regular air ingress checks throughout filling. This hands-on approach means customers face fewer production interruptions and see less risk of batch-to-batch inconsistency.

    Applications and Value Delivered to End-Users

    Most of our volume flows to the production of methacrylate monomers. These monomers enter acrylic sheets, optical fibers, impact-resistant composites, and specialty laminating resins. From there, performance coatings and adhesives benefit as well. When formulating adhesives with demanding thermal or weather-resistance requirements, our product provides reliable backbone functionality, translating to greater strength after curing and better clarity in clear bonding lines. In the world of electronics, methacryloyl chloride feeds into photoresist chemistries and encapsulating materials. Recent trends show resurgence in demand for reactive intermediates suitable for 3D printing resins, thanks to the rapid adoption of additive manufacturing in both prototyping and end-use parts.

    Pharmaceutical intermediates also require our product, particularly in constructing side chains on active molecules. The molecule’s double bond allows for rapid subsequent transformation, while the acid chloride function ensures high coupling efficiency. In our collaborations with contract syntheses organizations, we hear frequently how access to reliable, high-purity methacryloyl chloride can mean faster route scouting and cleaner downstream purification, which speeds up overall drug development cycles.

    Other applications, including functionalized surfaces for biomedical devices, also lean on our supply. End-users have told us about lower rejection rates and more consistent surface chemistry profiles after switching from lower-grade material to our refined stocks. Each feedback loop drives further process improvement, amplifying value across multiple industries.

    Handling, Safety, and Our Approach to Responsible Manufacturing

    Methacryloyl Chloride, like all acid chlorides, reacts violently with water and releases corrosive gases if left unsealed. Years of experience with this chemistry have taught us the importance of rigorous operator training and investment in closed-loop equipment design. Storage tanks and reactors fitted with pressure relief valves and scrubber systems keep our workplace safe. Employees operate under well-defined protocols, routinely reviewed by our in-house safety officers. For packing, we use only certified containers with tamper-evident seals, and arrange for temperature-stabilized trucks if ambient heat could pose transit risks.

    Adopting these measures followed from a real near-miss incident during a hot summer, when a temporary contractor stored two drums near a building vent. Since then, our internal guidelines on segregation and climate control have stopped recurrence. Safety is not only about compliance, it’s also about building confidence among both the team and our clientele.

    Waste minimization receives constant attention in our process design. By recycling hydrochloric acid gas through scrubbing and purification steps, emissions remain far below permitted thresholds. Any spent product returns to the plant for controlled hydrolysis and neutralization, preventing environmental discharge. On our site, every technician is trained to handle emergency containment protocols, aided by visible signage, PPE stations, and spill containment kits staged along traffic paths. Site audits have reinforced how much impact this preparation can have, preventing small mistakes from becoming large incidents.

    Reliability in Logistics and Customer Partnerships

    Consistent delivery hinges on careful coordination with downstream partners. Our logistics staff work closely with trusted carriers who understand the unique hazards associated with acid chlorides. Drivers follow strict routes that avoid heavy traffic and high-temperature zones during transit. Advance notification systems and real-time updates keep everyone aware of location and ETA, allowing for smooth handover at customer sites. On more than one occasion, we have had to respond quickly with rush air shipments to clients facing critical downtime—a benefit of keeping a healthy buffer stock and having direct access to rail spurs and nearby ports.

    Feedback from users—whether praise or a report of a leaky drum—feeds directly into our continuous improvement loop. Long-term relationships, spanning multiple regulatory cycles and market shifts, allow us to anticipate new requirements before they hit the ground. For example, customers affected by tightening import controls on organochlorine compounds in Southeast Asia received advanced notice from us about likely customs changes, along with updated documentation and pre-filled compliance paperwork. Our goal goes beyond supply; we see ourselves as a technical resource in every stage of the value chain.

    Quality Assurance: Beyond the Certificate of Analysis

    Some may believe that quality assurance rests solely on analytical testing, but we see the process as much broader. At our facility, in-line sensors check moisture and product color before final drum filling. Laboratory staff run parallel GC and NMR tests when batches show any deviation from typical profiles. If a discrepancy appears—even a fraction outside normal limits—we halt release and run a root-cause analysis. Over the past five years, this diligence has resulted in rare customer complaints and greater trust, especially among buyers developing high-purity intermediates for medical or electronics use.

    Auditing our supply chain also improves batch consistency. By working directly with upstream suppliers of methacrylic acid and thionyl chloride, we exercise oversight that avoids fluctuations in product quality. Quarterly reviews, periodic site visits, and contractual transparency agreements combine to prevent unexpected variability. End-users benefit with a reliable working relationship and the comfort that their product source traces back to plant-level process control, not unknown intermediaries.

    Enhancing Performance in R&D and Commercial Lines

    Among our longstanding partners, process chemists and formulators report that formulas developed using our methacryloyl chloride show better reproducibility from slab to full-scale production. Whether formulating new UV-cured resins for automotive parts or biomedical adhesives due for clinical deployment, consistency helps accelerate regulatory approval and customer acceptance. We offer samples, technical data packages, and even on-site troubleshooting when customers encounter outlier results or need to scale quickly in response to market pressures.

    Recent collaboration with a research institute demonstrated the value of this partnership model. A new coating under development required ultra-low residual acidity, which our production line adjusted in response to several pilot campaigns. The resulting material not only passed initial performance trials but also opened a pathway to a new end-use market for both our company and our client. In practice, these hands-on exchanges drive innovation in ways that classroom learning and generalized chemical descriptions cannot provide.

    Addressing Market Trends and Regulatory Challenges

    Methacryloyl Chloride now faces rising regulatory scrutiny, particularly regarding air emissions and transport classification. Our team tracks legal developments in every export destination, working with authorities and industry groups to stay compliant without barriers or shipment delays. In a recent cycle, an international customer encountered new paperwork hurdles under revised national hazmat rules. Support came through detailed documentation, transparent analysis methods, and timely supply of all requested certificates. In a shifting regulatory landscape, active engagement and readiness keep chemical commerce steady.

    Sustainability questions also shape the market. Increasing demand for “greener” materials and reduced chlorinated waste has prompted both incremental improvements and exploration of alternatives. In our plant, energy-recovery heat exchangers reduce energy input per batch, while next-generation catalysts and flow reactors show promise for future scale-up. These steps both lower production cost and satisfy sustainability goals demanded by downstream users and consumer brands.

    In large-volume markets—such as Asia-Pacific and North America—trade uncertainty and freight costs had pushed some customers to consider local alternatives. Open sharing about our sourcing, inventory buffer, and supply line reliability convinced several major buyers to stick with us during last year’s logistics crunch. By drawing on direct transport contracts and flexible inventory management, we cut downtime and helped customers keep production on schedule even as world events disrupted other parts of their supply chain.

    Solutions to Common Challenges

    Customers often face practical hurdles handling and storing Methacryloyl Chloride, especially smaller buyers new to reactive acid chlorides. Drawing on our own experience, we offer more than just product—we provide training advice and starter kits for safe storage and emergency response. This might mean recommending decanting under dry nitrogen, highlighting options for double-sealed containers, or arranging site visits with technical experts to help integrate new transfer lines safely. By passing along real-world lessons from our plant, we lower risk across the board.

    Some users struggle with polymerization fouling or unwanted hydrolysis. In such cases, we work through possible improvements—such as switching to PTFE lines, installing in-line desiccants, or adopting lower storage temperatures. Experience has shown that small procedural tweaks can cut waste and backup dramatically. Evidence-based, practical recommendations often outperform blanket theory when it comes to tackling real-time plant challenges.

    Trust Built Through Transparency

    Chemicals are more than numbers on an assay report or technical data sheet. Trust in a supply chain means constant communication and openness about process, strength in troubleshooting, and willingness to adapt. We treat every order, large or small, as an opportunity to reinforce that trust. If a problem arises with a shipment—be it due to weather, regulation, or a mechanical failure—we initiate immediate investigation and propose corrective action. This customer-centered approach, honed over thousands of shipments and partnerships, is core to our reputation and continued business growth.

    Methacryloyl Chloride remains a cornerstone material for high-value industries. Through every stage—from procurement and processing to packaging and delivery—experienced chemical manufacturers shoulder an outsized responsibility in keeping industry moving. Through ongoing investment in people, equipment, and customer support, we strive to keep our material reliable, our processes safe, and our customer relationships strong.