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Maleamic Acid

    • Product Name Maleamic Acid
    • Alias 2-Butenedioic acid (2Z)-, monoamide
    • Einecs 249-388-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    860232

    Cas Number 626-48-2
    Molecular Formula C4H5NO3
    Molar Mass 115.09 g/mol
    Appearance White to off-white crystalline solid
    Melting Point 160-163°C
    Solubility In Water Soluble
    Density 1.59 g/cm³
    Boiling Point Decomposes before boiling
    Iupac Name 2-(carbamoyl)acrylic acid
    Synonyms 2-Aminosuccinic acid, Maleamic acid; Maleic acid monoamide

    As an accredited Maleamic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Maleamic Acid is packaged in a 500g high-density polyethylene bottle with a tight-sealing cap and clear hazard labeling.
    Shipping Maleamic Acid should be shipped in tightly sealed containers, protected from moisture and direct sunlight. It must be handled with care, stored at room temperature, and kept away from incompatible substances, such as strong oxidizers. Follow all relevant regulations for chemical transport and include proper hazard labeling and documentation during shipping.
    Storage Maleamic acid should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from moisture, heat, and incompatible substances such as strong oxidizing agents. Protect it from physical damage and direct sunlight. Use appropriate chemical-resistant containers and ensure proper labeling. Follow all relevant safety guidelines and local regulations for safe storage and handling.
    Application of Maleamic Acid

    Applications of Maleamic Acid in Industrial Manufacturing

    Maleamic acid supports advanced synthesis requirements across select chemical manufacturing sectors. Our direct process chain ensures authentic supply for downstream producers, supporting strict traceability and formulation consistency. Explore practical deployment and integration details across key industrial segments.

    1. Synthesis of Specialty Polymeric Resins

    In the preparation of specialty copolymer resins for coatings and adhesives, maleamic acid functions as a reactive monomer, introducing controlled amide functionality into resin backbones. Processors utilize its precise reactivity to adjust curing profiles, adhesion characteristics, and solvent resistance without introducing halogenated compounds. Its defined purity profile minimizes unwanted by-products during polycondensation and imide-forming reactions.

    Industry compliance standards

    • REACH (Regulation (EC) No 1907/2006) for chemical safety in Europe
    • TSCA (Toxic Substances Control Act, USA) compliance for raw material use
    • ISO 9001:2015 certified quality management for resin manufacturing
    • VOC regulations for low-emission architectural and industrial coatings

    Typical usage ratio

    • 5-20% (w/w) of total monomer content in base resin formulations; dosage fine-tuned to target molecular weight and crosslink density of the finished resin

    Downstream process integration

    • Dosed during the pre-polymer formation phase, often reacted in solvent or melt state with additional acrylic or styrenic monomers, before imidization and curing stages

    Final product types

    • High-performance industrial adhesives
    • Powder coatings for automotive and electronics
    • Corrosion-resistant epoxy-modified resins
    • Specialty binder systems for metal and wood panels

    2. Fine Chemical Intermediate in Agrochemical Synthesis

    Maleamic acid serves as a versatile intermediate in the multistep synthesis of active ingredients for crop protection formulations. Its selective amide functionality allows downstream producers to build complex heterocyclic structures, especially for new-generation herbicides and plant growth regulators. Manufacturers rely on its high assay and low ion content for sensitive catalytic transformations during scale-up and validation stages.

    Industry compliance standards

    • EU Plant Protection Product Regulation (EC) No 1107/2009
    • ISO 17025 for analytical and QC traceability in fine chemical labs
    • FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act, USA) for agrichemical raw material traceability
    • Good Manufacturing Practices (GMP) for active substance production

    Typical usage ratio

    • 0.5-2.5 mol equivalents relative to partner synthons in API precursor steps; adjusted for desired yield and purity controls

    Downstream process integration

    • Fed into the second or third step of multi-component reactions—typically amidation or cyclization phases—under controlled temperature and pH

    Final product types

    • Active herbicide molecules (imidazolinone class)
    • Plant growth regulator intermediates
    • Precursor chemicals for biocide formulations
    • Stabilized pesticides for seed treatment

    3. Curing Agent in Advanced Epoxy Formulations

    Epoxy systems producers use maleamic acid as a modifier or secondary curing agent for two-component resin systems, targeting applications demanding fine-tuned thermal properties and increased chemical resistance. It acts via amide-imide transition, introducing controlled network flexibility while reducing post-cure yellowing. Quality-controlled supply minimizes contamination and downstream gel time deviations, critical for high-end composite applications.

    Industry compliance standards

    • RoHS (Restriction of Hazardous Substances Directive)
    • ISO 14001 for environmental management in composite manufacturing
    • ASTM D1763 for epoxy resin curing agents
    • UL 94 for flammability rating of cured systems

    Typical usage ratio

    • 1-8% (w/w) relative to base epoxy resin; optimized for specific pot life and exotherm profiles based on workpiece dimensions

    Downstream process integration

    • Added with mixing or post-preblend stage with hardener; cured at 60–140°C depending on formulation and targeted glass transition temperature (Tg)

    Final product types

    • Epoxy prepregs for aerospace applications
    • High-gloss composite panels
    • Chemical-resistant industrial coatings
    • Potting compounds for electronic assemblies

    4. Intermediate in Pharmaceutical API Synthesis (Non-Clinical Tier)

    In the manufacture of specific non-clinical pharmaceutical intermediates, maleamic acid functions as a precursor for imide and heterocyclic motifs critical in the synthetic chain of some investigational APIs. Operators leverage its defined melt point and reactivity for reproducible batch-to-batch control, essential in kilo-scale GMP pilot studies and early candidate validation.

    Industry compliance standards

    • ICH Q7 for GMP in active pharmaceutical ingredient production
    • EU Pharmacopoeia monographs where applicable
    • US FDA 21 CFR Part 210/211 (as referenced for chemical intermediate handling)
    • ISO 9001:2015 for supplier audit traceability

    Typical usage ratio

    • 0.2–1.0 eq. relative to nucleophilic partner; quantity refined during process validation for impurity profiling and isolation yield

    Downstream process integration

    • Introduced in early intermediate coupling or ring-closing step under inert atmosphere, followed by controlled crystallization and purification

    Final product types

    • Non-clinical pharmaceutical intermediates for route scouting and scale-up
    • Fine chemicals for further functional group interconversion
    • Building blocks for investigational new drug (IND) candidates

    5. Building Block in Dyes and Pigment Manufacture

    Manufacturers of specialty dyes and high-performance pigments incorporate maleamic acid as a key building block during the synthesis of azo and imide pigment classes. Its highly selective amide reactive site enables concise synthesis steps with high chromophore integrity, supporting robust color consistency for sensitive textile and plastic coloration applications. Feedstock undergoes rigorous quality monitoring to avoid unwanted by-products, directly impacting finished colorant batch reproducibility.

    Industry compliance standards

    • OEKO-TEX Standard 100 (for textile colorants)
    • ISO 18314 for analytical QC of colorants
    • REACH Annex XVII for restricted substances in pigments
    • EN 71-3 for toy safety regarding colored plastics

    Typical usage ratio

    • 5–15% (w/w) as precursor in pigment or dye-forming reactions; adjusted according to color intensity and targeted molecular structure

    Downstream process integration

    • Enter the dye synthesis pathway during azo-coupling or imidization after diazotization, commonly step 2 or 3 of a 4-step process

    Final product types

    • Disperse dyes for polyester textiles
    • Imide-based organic pigments for automotive and plastics coatings
    • Color masterbatch concentrates
    • High-purity colorants for inkjet and digital printing
    Free Quote

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    Certification & Compliance
    More Introduction

    Maleamic Acid: Practical Experience and Real-World Value

    Understanding Maleamic Acid from the Production Floor

    Producing maleamic acid day in and day out gives a direct line of sight into what goes right and wrong in the market’s expectations. Out here, there’s little room for wrapping things in marketing lingo or masking limitations with stock phrases. Asking about maleamic acid takes the discussion to the heart of what real users—whether in polymer chemistry, intermediates manufacturing, or fine chemicals—actually care about: purity, reactivity, and consistency. The raw material flow, the small hurdles in crystallization, and the challenge of batch-to-batch reproducibility separate a manufacturer’s reality from the image a catalog might promise.

    Direct handling of materials and tight process controls have shown that true value in maleamic acid—CAS number 618-46-2, chemical formula C4H5NO3—comes from controlling moisture content, preventing yellowing, and keeping trace impurity levels low. Depending on the production scheme, finished lots can vary in color, granule size, and shelf stability. These differences matter, not just in a technical sheet, but in the ultimate yield and performance for the end user.

    Quality Built from Experience, Not Just Instrument Readouts

    Real-world production routines demand more than just running reactors to specification. Over the years, equipment fouling and filter clogging showed how easy it becomes for a batch to drift out of spec, even with the best feedstocks. Experience pushed continuous improvements in reflux temperatures, acid addition rates, and filtration points. Because every gram leaving the plant affects subsequent formulations for customers, process intent always aligns with application needs—polyamide resins, corrosion inhibitors, and beyond.

    By standing at the reactor rather than behind a sales desk, small differences become huge. Some batches may show foaming or unexpected crystallization behavior, which often traces back to ambient humidity or drum storage time rather than just miscalculation. True learning comes from seeing which lots run clean in high-throughput extrusion plants versus those that throw unwanted color or require remedial adjustments down the supply line. Quality isn’t just a checkbox here; it is monitored by eye, by smell, by routine laboratory backup, and by a keen record of how that batch performed in actual customers’ processes.

    More Than Purity: The Importance of Robust Physical Properties

    Purity, typically above 99 percent by HPLC or titration, only tells part of the story. Packing, handling, and consistent melting behavior separate reliable product from commodities prone to cause headaches during scale-up or formulation. An uneven batch from poorly controlled reaction steps leads to clogging filters, irregular particle flow, or worse, unpredictable chemistry.

    Granulation size matters for end-users dosing into extrusion equipment. Free-flowing product in dry powder or crystalline form beats lumpy or caked stock every time. Our focus stays on minimizing clumping through careful control of both water content and cooling rates during precipitation. Moisture variation changes not only the apparent weight but also affects dissolution and residual activity—especially when used as an intermediate for polyimide synthesis. End-users avoid surprises when we enforce consistent conditioning from batch to batch, often running extra steps that others may skip to save time.

    Applications: Bridging Chemistry With User Needs

    Over the years, real feedback from on-site technical visits and repeated user complaints has led to more fine-tuned grades of maleamic acid. The differences go beyond numbers—high-purity, low-residual maleamic acid remains the backbone for specialty coatings, thermosetting plastics intermediates, and wire enameling resins. For those pushing performance limits in polymer chemistry, every small impurity impacts polymerization rates and final material flexibility or toughness.

    In our role, heavy demand comes from companies developing polyimide films, epoxy modifiers, and corrosion inhibitors. Even the trace amount of phthalic anhydride contamination or excess water content changes downstream reactivity, affecting not only physical properties but also color stability of the final product. Getting these impurities under control means fewer headaches for others in the supply chain, something that only a manufacturer with hands-on experience can truly appreciate.

    For instance, polyimide resins require strict consistency in precursor purity and physical form. Variable lots result in finished films with color drift or reduced flexibility. Years of chasing the “why” behind uneven film properties has taught us that every single point of inconsistency in maleamic acid ripples through a user’s whole value stream. That’s why excess moisture control, fine powder sizing, and a rapid-response feedback loop for unexpected behavior remain standard practices here.

    Comparisons That Matter: Maleamic Acid Versus Alternatives

    Many buyers treat maleamic acid as just another chemical intermediate, but the reality inside a plant looks different. Maleic anhydride, maleic acid, and their amide derivatives each bring unique reactivity and handling issues. Maleamic acid stands out for its amide and carboxylic acid functional groups, giving precise control in stepwise polymerization or multi-step organic syntheses. Directly, compared to maleic anhydride, maleamic acid introduces both an amide and an acid group, offering unique selectivity and pH responsiveness in downstream transformations.

    Some users consider going upstream to maleic acid, but the cost and hazards of direct amination prove more trouble than they are worth. Maleic anhydride hydrolysis and subsequent neutralization also risk introducing byproducts that complicate purification or affect performance in sensitive systems. Our continuous upgrades to purification equipment and batch protocols are a response to these realities, learned from cumulative user trials rather than textbook comparison.

    Technical managers often chase convenience, but skipping forward to maleamic acid—already synthesized and preconditioned—saves time, reduces overall process risk, and improves safety. For niche applications like advanced polymer precursors or specialty resin systems, those small process improvements matter. It’s not just about hitting a specification but ensuring every lot actually performs the same in a customer’s plant, no surprises.

    Physical Handling and Safety: In the Shoes of Workers

    Inside the manufacturing space, daily exposure to powdered chemicals raises practical and ethical questions. Dust control, worker protection, and clear labeling are not optional extras—they arise from first-hand observation. Keeping particle size consistent isn’t only about performance; it’s also about minimizing operator exposure. We’ve seen how even a minor adjustment in drying cycles or sifting equipment prevents dust clouds that stick to filters and linger in the workspace. Health and safety habits come from observing how even a small spill or poorly labeled drum stops production and puts someone at risk.

    Handling instructions matter most when based on direct plant trials. Proper grounding, antistatic procedures, and correct load sizes during transportation limit both product loss and unnecessary exposure. Repeatedly, older packaging methods led to compromised bags and material loss; switching to lined fiber drums with tamper-evident closures has saved not only raw product but also built a safety culture among workers. There’s a direct connection between the right product form, packaging, and minimal occupational hazards—a lesson cemented only through years of hands-on experience.

    Customer Feedback and Continuous Learning

    Every request for investigation, every complaint about a blocked process line, every sample sent back for retesting—those moments drive most changes in our technical approach. We do not just ship drum after drum and wait for reports. Often, closer work with partners reveals their actual pain points—polymer yellowing, residual moisture, or reaction time variation can point directly to microscopic detail lost in routine quality checks. In reality, improvements come not just from equipment upgrades but by openly addressing real loss points.

    Regular batch reviews go beyond simply matching analytical data. Sample lots are held for extended storage, retested for color and flow, and compared to earlier batches. Close failures or “borderline” lots are tracked, and their process parameters adjusted, so learning builds from one campaign to another. Simple changes in agitation rate or vacuum pressure, only picked up after repeated user feedback, can mean the difference between trouble-free application and avoidable rework at the customer’s plant. That insight doesn’t arise from remote speculation but from every production run and every field report handled personally.

    Ways Forward: Solutions From Inside the Plant

    The market asks for tighter controls, increased transparency, and reliable documentation with every shipment. Old practices that worked at a small scale prove risky when demand jumps or users’ spec sheets change without notice. Rather than chase after standards, manufacturers improve by listening to repeat buyers, testing every suggested tweak, and feeding that learning right back into the daily operation.

    Solving moisture variation came from investing in modular drying units, after older forced-air driers left too much batch-to-batch uncertainty. Keeping trace contaminants low has brought new purification columns and solvent recovery loops, allowing for leaner production lines that still deliver cleaner product. Subtle but critical adjustments in pH neutralization stop unwanted hydrolysis side products and make filtration trouble-free. Each one of these technical upgrades results from confronting daily operational hurdles and troubleshooting sample failures, tuning control parameters over hundreds of campaigns, not by following any one-size-fits-all recipe.

    Another real difference comes through direct collaboration with users. By regularly running evaluation samples under end-use conditions, problems rarely found in the lab reveal themselves quickly. Storage stability, caking behavior, and color stability all become visible when a batch spends time in a real warehouse, rides transport in summer heat, or mixes into an actual production run. Every trial sent out with batch samples means taking responsibility for how that material behaves, not just for what’s measured on an assay.

    Real-World Results, Not Just Theoretical Promise

    Technical literature describes maleamic acid in the language of carboxyl and amide reactivity, stepwise condensation, and functional group manipulation. From a manufacturer’s perspective, those qualities translate into day-to-day flexibility for researchers, process chemists, and developers working on robust resins, corrosion-resistant coatings, or high-performance polymers. Many new applications develop by open communication with users—sharing sample histories, troubleshooting coloration issues, and exploring new forms or blends driven by next-generation product requirements.

    Direct access to production records and real performance feedback shows which delivery forms and conditioning methods save headaches for all parties. Adjusting particle size, testing alternative drying techniques, and running advanced impurity screens, even when not strictly required, come directly from learning how material behaves down the supply chain. This approach shortens troubleshooting cycles for customers, encourages knowledge sharing, and builds long-term trust that every lot going out will predictably do its job.

    In practical terms, consistent raw material means less downtime, fewer filter cleanings, and more predictable process windows for buyers. These are not abstract benefits—they show up as real cost savings and reliability in operations both large and small. While “specialty” can mean many things in a catalog, real specialty handling flows from technical focus refined batch after batch, driven by users who demand more from their intermediates than just purity numbers on a page.

    Pushing Boundaries: Keeping Up With New Demands

    The future brings both new hurdles and new opportunities. Increasing demand for high-performance polymers puts more pressure on consistency and traceability, not less. Tighter requirements from downstream partners call for granular lot records, batch-to-batch stability, and faster response to technical queries. Each technical specification presents both a challenge and an avenue to build trust.

    By investing in up-to-date spectroscopic and chromatographic tools, we keep a close eye on contaminants and small shifts in composition that would otherwise go unnoticed. No instrument or procedure, though, replaces seeing batches run through end-use equipment, reviewing trial failures, and tracing the difference back to a single variable in our own process. For emerging segments—conductive polymers, smart resins, green chemistry intermediates—technical partnerships with users matter as much as the raw analytical results. Building proficiency in compliance and sustainability also comes from real cooperation with customers facing stricter standards and new certification requirements.

    Shaping a reliable maleamic acid offering does not start or stop with manufacturing input alone. Feedback, failure analysis, hands-on trials, and willingness to revisit core assumptions all play their part. As regulations shift and user profiles expand into electronics, advanced elastomers, and life science intermediates, new investments in both human skill and technical resources become necessary. In this environment, the manufacturer’s willingness to learn, adapt, and innovate keeps the material dependable, batch after batch, order after order.

    Building On Real Results, Not Promises

    For many, maleamic acid’s story ends at the point of delivery. To us, it starts at the reactor, covers every quality decision, and extends through to how the batch performs in the most demanding polymerization runs or specialty resin processing. The discipline forcing each step—reducing batch variation, eliminating known impurities, and responding openly to every customer observation—remains the difference between plant-floor reliability and catalog promises that fade under pressure.

    What ultimately matters is not a lab-read number or a catalog entry, but the knowledge that every lot received will behave predictably and offer peace of mind. That’s a promise built on learning, collaboration, and years of cumulative feedback—not vague commitments, but on-the-ground improvements made real each day. By holding tight to those principles, the reliability of maleamic acid continues to earn its place wherever end-use requirements exact the highest standards.