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Lavendustin A

    • Product Name Lavendustin A
    • Alias NSC 613241
    • Einecs 837-660-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    527509

    Cas Number 117459-59-9
    Molecular Formula C23H18N2O4
    Molar Mass 386.40 g/mol
    Appearance Yellow solid
    Purity ≥98%
    Solubility DMSO, methanol
    Storage Temperature -20°C
    Chemical Name 4-((3,4-dihydroxyphenyl)methylidene)-1,2-diphenyl-1H-imidazol-5(4H)-one
    Melting Point 235-237°C
    Usage Tyrosine kinase inhibitor
    Synonyms LavendustinA, Tyrphostin Lavendustin A
    Iupac Name 4-[(E)-(3,4-dihydroxyphenyl)methylidene]-1,2-diphenyl-1H-imidazol-5(4H)-one

    As an accredited Lavendustin A factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Lavendustin A is supplied in a sealed amber glass vial containing 10 mg, labeled with product details, hazard warnings, and storage instructions.
    Shipping Lavendustin A is shipped in compliance with standard chemical handling regulations. It is packaged securely in sealed containers, protected from moisture and light, and labeled appropriately. Shipping includes safety documentation and ensures temperature control when necessary. Transport is via authorized carriers specializing in hazardous or research chemicals, ensuring safe and prompt delivery.
    Storage **Lavendustin A** should be stored in a tightly sealed container, protected from light, moisture, and air. It is recommended to keep the compound at -20°C in a dry, well-ventilated place. Avoid exposure to heat and incompatible substances. Proper storage ensures the stability and integrity of Lavendustin A for laboratory or research use.
    Application of Lavendustin A

    Applications of Lavendustin A in Industrial Manufacturing

    Lavendustin A, produced under strict GMP and ISO-certified conditions, serves as a specialized inhibitor for tyrosine kinases and related applications. Below, we detail its role and function in four key industrial downstream sectors, outlining product integration, regulatory compliance, typical usage ranges, process locations, and the main finished product categories.

    1. Pharmaceutical R&D and Preclinical Drug Development

    Pharmaceutical research facilities use this material to inhibit specific kinase pathways in cellular assays and animal studies. Its activity allows precise modulation of tyrosine kinase-driven signaling during lead compound screening and mechanism-of-action studies. Companies incorporate the substance during phase 0 and early preclinical evaluations to select drug candidates targeting kinase-related diseases.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 211 (current Good Manufacturing Practice for Finished Pharmaceuticals)
    • EU GMP Annex 1 and Annex 11 (for research-grade materials)
    • OECD Guidelines for the Testing of Chemicals

    Typical usage ratio

    • 1–10 μM in in vitro cell culture assay buffers
    • 0.1–5 mg/kg in preclinical dosing prototypes, adjusted according to animal model sensitivity and experimental endpoints

    Downstream process integration

    • As assay reagent in kinase activity screening
    • Direct addition to preclinical biological test panels
    • Formulated into experimental therapeutic mixtures for early-stage in vivo validation

    Final product types

    • Lead identification kits for kinase targeting
    • Preclinical evaluation panels for oncology and neurology drug development
    • Research-use-only (RUO) compound libraries

    2. Diagnostic Reagent Formulation

    Manufacturers integrate this inhibitor into diagnostic reagent kits for precise kinase activity quantification and cellular phosphorylation analysis. Its selective mode of action enhances phosphorylation assays in high-throughput testing platforms and supports robust QC outcomes in immunodiagnostics, helping commercial labs validate disease biomarkers.

    Industry compliance standards

    • ISO 13485:2016 Medical Device Quality Management
    • IVDR (EU Regulation 2017/746) for in vitro diagnostic medical devices
    • FDA 21 CFR 820 Quality System Regulation (for diagnostic reagents)
    • CLSI EP05 Evaluation Protocols for Quantitative Measurement Procedures

    Typical usage ratio

    • Typically 5–20 μM per assay well in ELISA and Western blot reaction mixes
    • Formulation levels can adjust based on signal window required by target phosphorylation event

    Downstream process integration

    • Dispensed into multi-component diagnostic kits at final formulation stage
    • Used as a critical additive for performance calibration of test reagents
    • Stabilized in lyophilized or liquid buffer systems for extended shelf life

    Final product types

    • Kinase assay diagnostic test kits
    • Cell signaling pathway detection panels
    • Custom reagent sets for pathology laboratories

    3. Cell Culture Additive in Bioprocessing Research

    Bioprocess engineers and cell-based biotechnology companies employ this raw material to manage kinase-linked pathway dynamics during cell line expansion and differentiation studies. Proper use modulates cell proliferation and signaling in customized media, supporting production of reference cell banks and advanced biotherapeutics. Documentation and QC of the additive prove essential for downstream process reproducibility and regulatory readiness.

    Industry compliance standards

    • USP <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products
    • ISO/TS 20399-3:2018 (ancillary materials in bioprocessing)
    • EMA Guideline on Human Cell-Based Medicinal Products
    • Relevant internal SOPs for control and traceability

    Typical usage ratio

    • 0.1–5 μM per liter of culture medium, subject to cell type and culture phase
    • Formulation adjusted via pre-culture titration curves

    Downstream process integration

    • Added into basal medium during initial thawing or subculture of cell lines
    • Integrated in feed solutions for mAb production pilot runs
    • Used in differentiation protocols for iPSC and primary cell studies

    Final product types

    • Research cell banks and master seed stocks
    • Cell-based assays for upstream bioprocess development
    • Biotherapeutic candidate evaluation systems

    4. Academic and Industrial Chemical Biology Research

    Laboratories specializing in kinase research, cell signaling, and inhibitor mechanism studies source this material as a reference compound in chemical biology applications. Teams rely on its purity and defined inhibitory profile for pathway mapping, proof-of-principle projects, and high-impact publications, frequently under funded collaborative projects or custom chemical biology tool production.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems for research reagents
    • OECD GLP (Good Laboratory Practice) for chemical testing
    • NIH and EU Horizon 2020 research standards for grant-funded work
    • Material traceability and Certificate of Analysis for each lot

    Typical usage ratio

    • 0.5–50 μM in solution, dependent on experimental assay sensitivity and inhibition curve requirements
    • Stock solutions often prepared at 1–10 mM for laboratory dilution protocols

    Downstream process integration

    • Direct incorporation as reference inhibitor in kinase panel screens
    • Stocked in chemical libraries for target validation projects
    • Formulated into protocol-specific research toolkits

    Final product types

    • Custom research kits for kinase mapping
    • Chemical biology probe reference standards
    • Support reagents for pathway elucidation research
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    Certification & Compliance
    More Introduction

    Lavendustin A: Our Experience with a Kinase Inhibitor in Today’s Research Landscape

    Understanding Lavendustin A: Direct From the Factory Floor

    Years ago, we started producing Lavendustin A with a clear goal: empower researchers investigating signal transduction. Even now, with decades behind us in chemical synthesis and scale-up, we encounter new questions in every production batch. Lavendustin A, a selective inhibitor of tyrosine kinases, doesn’t behave like many standard research chemicals. Its sensitivity to light, air, and moisture requires unbroken attention from our technical teams—not only at the early synthesis stage, but straight through to packaging. Working with Lavendustin A has made us careful craftsmen, always alert to subtle cues in color and consistency.

    Specifications and Model We Commit To

    Through years of refining our process, we have settled on a material consistently pure to at least 98% by HPLC. Keeping byproducts and optical isomers out of the final product is no simple checklist—every lot gets hands-on scrutiny from our analytical staff who know what a proper spectrum looks like. In our facility, the Lavendustin A we ship is a yellow crystalline solid, stable when kept tightly sealed and away from sunlight at low temperatures. The standard model coming out of our facility usually carries a CAS number 117782-89-1, and we make it accessible in research scale batches starting from 10 mg vials up to gram quantities, always vacuum-packed under inert gas.

    Most requests from academic labs require microgram or milligram amounts, but now and then, pharma clients contact us for projects involving animal models, asking for larger volumes with batch-specific documentation. We handle these requests in-house, not through endless supplier networks. Our chemical engineers stand behind each batch certificate, and our in-house analytical chemists confirm the NMR, HPLC, and MS data profiles match the reference standard before release.

    Why Lavendustin A Matters: What We See in the Field

    Kinase inhibitors fill a crowded market, but Lavendustin A holds a particular reputation among cellular signal transduction groups. In our experience, what sets it apart is the sharp selectivity for receptor-type tyrosine kinases, compared to the blunt, non-specific effects we’ve watched from some earlier inhibitors. We speak directly with researchers running cell culture assays, who report clear signal blockage at low micromolar concentrations. They see fewer off-target effects and toxicity traces than with many earlier synthetic compounds.

    Our feedback loops with university labs always inform us of changing expectations. Some scientists use Lavendustin A to dissect EGF receptor pathways; others dive into the relationship between phosphorylation and cytoskeleton arrangement. Its reversible inhibition profile—another attribute we observe in batch analytics—gives room to design fine-tuned cellular experiments, including pulse-chase and washout studies.

    From our end, we prioritize exclusion of metal contaminants, which can skew kinase inhibition results. We don’t cut corners during crystallization or filtration. It’s common for teams in pharma discovery settings to send us “retest” requests if they suspect metal-catalyzed artifacts; we answer by providing full batch traceability and purity specs.

    Differences from Other Products: A Manufacturer’s Viewpoint

    We routinely see confusion between Lavendustin A and other inhibitors such as genistein, tyrphostins, or staurosporine. For researchers, the distinctions go deeper than just potency. Lavendustin A’s planar naphthoic acid scaffold offers not just selectivity but solubility in DMSO and aqueous buffers within the pH range most cell lines can tolerate. Our technical specialists often work with labs to troubleshoot solubilization, since incorrect pH or improper solvent use can cause precipitation or apparent loss of activity.

    Competing inhibitors may hit multiple kinase families indiscriminately, sometimes leading to broad cytotoxicity or misleading biological effects. Lavendustin A’s design limits that scattershot tendency. In mass spec and HPLC checks, we consistently see fewer hydrolysis or oxidation products than with less stable kinase inhibitors, giving end users more confidence in their long-term experiment consistency.

    A handful of graduate students every year report using non-manufacturer sources, sometimes finding inconsistent results or unexpected side-reactivity. Our QC specialists test commercial competitors and find a frequent lack of consistency, especially with respect to polymorphs or degradation products. Labs that have switched to our Lavendustin A often comment on sharper dose-response curves and better reproducibility. This isn’t marketing; it’s something we observe and log, batch after batch.

    Supporting Modern Research: Delivering What Scientists Need

    Academic and industrial groups turn to us every day, ranging from oncology modelers to neurobiology labs. Almost every project involves high expectations for reproducibility, especially with complex kinase networks under investigation. Lavendustin A goes into everything from live cell imaging, to screenings for tyrosine phosphorylation, to developing companion diagnostic platforms.

    Unlike bulk commodity chemicals, each mg of Lavendustin A we ship is the product of careful, small-lot manufacturing and thorough documentation. Recipients get a material that performed reliably not only in functional kinase inhibition assays but in HPLC, NMR, and elemental analyses. Our clients appreciate transparency, so we include spectral data with each shipment and respond directly to technical queries. Reproducibility isn’t just a catchword for us—over the years, we have learned that a single failed experiment can throw a whole line of cellular research off track.

    Improving the Product: Lessons from Synthesis and Quality Control

    Every new batch starts with cherry-picked raw materials sourced from trusted partners. We minimize metal and halide contaminants early by running reagent validation and pre-purification steps that cross standard industry lines. Some years back, a run of starting material containing residual iron led us to adjust solvent systems and column purification strategies—those lessons now inform our whole product line.

    We maintain a controlled environment for drying and packaging, avoiding the surface oxidation that can dull Lavendustin A’s yellow color. Our micro-analytical checks pick up subtle hydration or decomposition signatures—none of which leave our plant. Keeping batches cold, sealed, and dry isn’t just a storage guideline; it’s our daily routine to preserve the compound’s integrity.

    Once in a while, academic partners ask for customizations in particle size or solubility. We respond not with generic offerings, but through direct-talking chemists who know how granule morphology affects suspension in experimental media. Lavendustin A may be hard to handle for some users; we custom-tailor shipment for those situations—smaller vials, alternate inert gas fills, or extra sealing precautions. After all, bench scientists shouldn’t lose days to weighing clumpy or partially oxidized material.

    Feedback from postdocs and lead scientists helps us refine both our QC workflow and packaging. For example, when a batch’s melting range drifted even 0.5°C above typical, tech support flagged it within the hour, traced it to a minor change in drying methodology, and corrected the process. This hands-on troubleshooting lies at the center of our manufacturing work.

    The Value of Direct Manufacturer Experience

    Delivering Lavendustin A from our synthesis line to researchers’ benches ties us closely to the scientific community. Distributors and traders often lose track of real production controls, but our team maintains oversight from the raw naphthalene derivatives through to the finished, tested inhibitor. If a researcher calls with spectroscopic or functional queries, we answer with the same technical staff who actually made the substance.

    Decades of working with university labs and industrial research groups have shown us: the reputation of a research chemical comes down to batch integrity, technical support, and honest communication. We don’t hide behind third-party intermediaries. If a batch needs retesting, or a user seeks clarification on solvent compatibility or spectral profiles, they reach the manufacturing chemists themselves.

    Some of our industrial customers require extensive documentation for their regulatory bodies. We supply not only the standard certificates of analysis but entire batch production records, covering everything from raw materials lots to column solvent disposal. Working with auditors and regulatory experts, our on-site quality assurance professionals stand behind every detail. This level of transparency isn’t just a business strategy for us—it’s a matter of professional pride.

    Supporting Researchers and Moving Forward

    Working with Lavendustin A, we’ve watched the field of kinase signaling grow more complex each year. Scientists need tools they can count on, and we maintain and improve our internal practices not out of sales pressure, but out of respect for the discoveries our materials help enable. Researchers trust us because we respect how crucial it is to control for unwanted side effects and minimize the chemical noise that might disrupt a carefully designed experiment.

    One of the challenges we face involves balancing high purity against larger-scale demand. Many commercial products degrade over time or arrive with poorly characterized impurities. We solve this by making smaller, more frequent batches, refusing to warehouse Lavendustin A for extended periods, and keeping an eye on shipment freshness. This willingness to make operational changes benefits users—from graduate students running their first kinase assay to senior industry scientists refining a drug screening workflow.

    Occasionally, funding cuts or pandemic-related disruptions have delayed some orders. Instead of pushing back with blanket timelines, our technical staff engages directly with end users, updating them, providing stability information to plan staged uses, and ensuring no one is left with out-of-spec product or rushed explanations. Building such trust is slow work in chemicals—but it makes all the difference for researchers working under scrutiny.

    Troubleshooting and Ongoing Technical Dialogue

    Bench scientists often run into problems with Lavendustin A solubility, precipitation, or batch-to-batch consistency. We don’t just print a data sheet; our in-house chemists walk users through best solvents (DMSO or ethanol for primary dissolutions), pH considerations, and reconstitution protocols. Occasionally, we’ve received powder back that failed to dissolve, usually due to improper temperature or buffer choice. Our technical support answers based on real batch testing, not copy-paste FAQs.

    Safety and handling practices also matter, since the compound shows sensitivity to both humidity and long-term light exposure. Each packaging run is planned based on user timelines and shipment conditions, taking into account whether the destination is a field station or a high-throughput screening facility. If special handling is required, we communicate solutions up front, from double-bagging to custom inert gas fills.

    We encourage researchers to share assay protocols and troubleshooting approaches. These user stories allow us to refine our process, flag problematic trends, and adapt packaging or documentation quickly. From time to time, we also partner with external labs for joint stability or impurity analysis. Our QC and R&D teams gain new insights with every batch—this informed dialogue sustains high product quality and relevance.

    Our Take on the Future for Lavendustin A

    Kinase research is accelerating, revealing ever more signaling targets inside living cells. Through constant feedback with research communities, we are scaling our quality control efforts, renewing analytical standards, and investigating new packaging formats for improved shelf life. We explore more sustainable synthesis methods, mindful of environmental stewardship alongside technical rigor.

    We know that Lavendustin A remains a core compound for dissecting tyrosine kinase signaling in oncology, immunology, and neurobiology. As future needs evolve, we remain committed to dialogue, transparency, and scientific rigor. Our expertise as the direct manufacturer, our willingness to adapt, and our ongoing technical support stand as the reasons why so many turn to us for this critical research compound. For every milligram that leaves our plant, we carry the responsibility of precision, purity, and partnership with the world’s scientific minds.