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L-Hydroxybutanedioic Acid Disodium Salt

    • Product Name L-Hydroxybutanedioic Acid Disodium Salt
    • Alias disodium-malate
    • Einecs 208-534-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    927156

    Product Name L-Hydroxybutanedioic Acid Disodium Salt
    Cas Number 6106-24-7
    Molecular Formula C4H4Na2O5
    Molecular Weight 178.05 g/mol
    Appearance White crystalline powder
    Solubility Soluble in water
    Ph 1 Solution Approximately 7.0-9.0
    Melting Point 210-215°C (decomposes)
    Synonyms Disodium L-malate, L-Malic acid disodium salt
    Storage Conditions Store in a cool, dry place, tightly closed

    As an accredited L-Hydroxybutanedioic Acid Disodium Salt factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Sealed in a 100g amber glass bottle, the L-Hydroxybutanedioic Acid Disodium Salt is clearly labeled with hazard and product information.
    Shipping L-Hydroxybutanedioic Acid Disodium Salt is securely packaged in sealed containers to prevent moisture absorption and contamination. It is shipped at ambient temperature unless specified otherwise, with clear labeling for chemical safety. Handling complies with standard hazardous chemical transport regulations to ensure safe and efficient delivery.
    Storage Store L-Hydroxybutanedioic Acid Disodium Salt in a tightly sealed container, protected from moisture and light. Keep at room temperature, ideally between 15-25°C (59-77°F), in a well-ventilated, dry area. Avoid exposure to strong acids or bases. Ensure proper labeling, and store away from incompatible substances. Follow all relevant safety protocols and local regulations for chemical storage.
    Application of L-Hydroxybutanedioic Acid Disodium Salt

    Applications of L-Hydroxybutanedioic Acid Disodium Salt in Industrial Manufacturing

    As a primary manufacturer of L-Hydroxybutanedioic Acid Disodium Salt, we supply key industrial users requiring precise material quality for regulated applications. Detailed below are four major downstream sectors and their specific integration of this raw material in advanced manufacturing environments.

    1. Pharmaceutical Intermediate in Stereospecific Synthesis

    Our L-Hydroxybutanedioic Acid Disodium Salt supports major pharmaceutical groups in synthesizing chiral intermediates for active pharmaceutical ingredients (APIs), particularly where stereochemical control and enantiopurity affect drug safety and activity. Chemists leverage this salt in processes such as asymmetric hydrogenation or as a resolving agent, optimizing selectivity for medicines targeting CNS, cardiovascular, and metabolic diseases. We deliver high-purity, traceable lots to comply with international drug regulatory standards, supporting both pilot and large-scale API manufacture.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) relevant monographs for intermediates
    • European Pharmacopoeia (Ph. Eur.) compliance for synthesis materials
    • FDA 21 CFR Part 211: cGMP for Finished Pharmaceuticals

    Typical usage ratio

    • 0.5% to 2.0% w/w as a resolving or chiral agent in intermediate-stage reactions; chemists adjust ratio based on target API structure and batch volume.

    Downstream process integration

    • Integrated during chiral resolution or as a complexing agent in the synthesis stage before downstream isolation or purification steps.

    Final product types

    • Bulk pharmaceutical intermediates
    • Chiral building blocks for proprietary APIs
    • Generic API precursor substances

    2. Food Additive Component in pH Correction and Buffering

    The disodium salt of L-Hydroxybutanedioic Acid is incorporated in food manufacturing as a buffering agent, contributing to controlled acidity in beverage formulations, gelled desserts, and bakery improvers. Major food processors reference global additive codes and food safety authorities for ingredient traceability. Our batches are produced under strict HACCP and FSSC 22000-certified protocols to manage contamination risk and uphold multi-market regulatory acceptance.

    Industry compliance standards

    • Codex Alimentarius INS No. 386
    • EU Commission Regulation (EC) No 1333/2008: Food Additives
    • U.S. FDA 21 CFR § 182.1180 (Generally Recognized As Safe)
    • GB 2760—Chinese Food Additive Standard

    Typical usage ratio

    • 0.05% to 0.3% w/w in ready-to-drink beverages or food matrices, with adjustment for acidulant system strength and desired final pH range.

    Downstream process integration

    • Added during blending or solution preparation before thermal treatment to assure stable pH throughout shelf life.

    Final product types

    • Soft drinks
    • Fruit preparations and jams
    • Instant dessert powders
    • Baked goods with controlled fermentation

    3. Electroplating Complexant in Surface Finishing Chemicals

    L-Hydroxybutanedioic Acid Disodium Salt serves as a complexing agent in specialized electroplating bath formulations. Metal finishing manufacturers use it for stabilizing metal ion concentrations, managing pH stability, and reducing unwanted precipitation in copper, nickel, and tin-plating lines. Our rigorous control of trace metals and particle size distribution ensures process stability and deposition uniformity in high-volume industrial finishing plants supplying automotive and electronics sectors.

    Industry compliance standards

    • ISO 9001:2015 for chemical quality management
    • RoHS—Restriction of Hazardous Substances Directive
    • Automotive Quality Management (IATF 16949)
    • REACH Registration, Evaluation, Authorization and Restriction of Chemicals—EU chemical safety regulation

    Typical usage ratio

    • 1.0 to 5.0 g/L in plating bath solutions; ratio adjusted for metal ion concentration and substrate type.

    Downstream process integration

    • Charged into bath makeup during initial solution formulation and maintained via analytical control during continuous operation.

    Final product types

    • Decorative and functional plated parts
    • Connector pins and printed circuit boards
    • Automotive and household hardware

    4. Analytical Reagent for Clinical and Biotechnology Laboratories

    Commercial laboratories and diagnostics kit producers include high-purity L-Hydroxybutanedioic Acid Disodium Salt as a buffering substance or calibration standard for quantitative assays, particularly in metabolic analysis related to organic acid profiling. Our facilities guarantee batch-to-batch consistency and full documentation to meet traceability needs for labs operating under ISO and GMP guidance, ensuring reliable calibration and minimal interference with analyte detection.

    Industry compliance standards

    • ISO 17025:2017—Testing and Calibration Laboratories
    • CLSI GP27-A3—Quality management for laboratory chemical reagents
    • Good Laboratory Practice (GLP) Principles (OECD)
    • 21 CFR Part 820: Quality System Regulation for Medical Devices (for in-vitro diagnostics manufacturing)

    Typical usage ratio

    • 0.1 to 1.0% w/v in analytical reagent formulations; determined by specific assay parameter and desired buffer capacity.

    Downstream process integration

    • Dissolved into analytical standard or buffer reagent preparations prior to kit assembly or calibration solution bottling.

    Final product types

    • Biochemical assay kits
    • Calibration standards for laboratory instruments
    • Manual and automated metabolic screening kits
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    Competitive L-Hydroxybutanedioic Acid Disodium Salt prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

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    Certification & Compliance
    More Introduction

    L-Hydroxybutanedioic Acid Disodium Salt: Experiences from Our Production Floor

    What L-Hydroxybutanedioic Acid Disodium Salt Brings to the Table

    L-Hydroxybutanedioic Acid Disodium Salt stands as a staple ingredient in our daily operation. This compound, known to many in research circles as Disodium malate, emerges from rigorous control of raw materials and process integrity. Every batch we produce reflects a history of constant investment in purification steps and precision monitoring. Anyone who has worked with organic acid salts quickly learns that not all salts behave in the same way even if chemistry books group them together.

    In hands-on manufacturing, this salt consistently shows advantages over monosodium or other substituted salts. Our mainstay model follows the chemical formula C4H4Na2O5, matching a high purity content routinely above 99%. Key endpoints like pH stability and tight control of trace metal content remain crucial for downstream use, particularly where end-users count on straightforward, clean reactions that won’t get thrown off by excess chloride or residual magnesium.

    How It’s Different: Our Take After Years in the Plant

    Chemists in product development might see a list of organic acid salts and imagine they could swap one for another. Years of large-batch work quickly teach you otherwise. For one, L-Hydroxybutanedioic Acid Disodium Salt does not introduce the solubility headaches some alternatives bring. In cold fermentors or ambient mixing tanks, it dissolves without clumping, meaning daily operations don’t hinge on intense agitation or special order mixers.

    From the outset, we said goodbye to tedious filtration steps common with certain calcium or potassium variants. Product yield stays better, cleaning downtime shortens, and nothing about its behavior requires us to recalibrate pH sensors or fight erratic foaming after adding buffers. Once, we tried introducing a monosodium equivalent — experience showed precipitation in applications crucial to food and biopharmaceutical sectors. That risk remains much lower with the disodium form and our QC inspectors confirm that stability on every shipment.

    Application Know-How: Voices from the Lab and the Loading Dock

    On the production line, application diversity becomes clear. Food formulators count on this compound to regulate taste and acid balance in beverages, jams, and bakery mixes. Our end-users tell us the disodium version integrates especially well where sodium contribution must stay precise and acidity control sharp. Compared to sodium tartrate or citrates, L-Hydroxybutanedioic Acid Disodium Salt offers a tart profile that sits between mellow and aggressive, allowing for delicate flavor work in premium mixes.

    Chemical synthesis labs draw on its chelating functions without facing the side reactivity some monoesters introduce. In our catalysts division, scientists rely on the predictable dissociation of the disodium salt to neutralize reaction mixtures or buffer the pH shifts common in fine chemical manufacturing. The lack of strong odor and low hygroscopicity means warehouse teams move the product with fewer storage worries. We recall problems in early storage days with other dicarboxylates—sticky handling on humid days led to lumps, requiring double labor to break up the stockpile. Product design updates on our line now keep dustiness down and free-flowing properties up, no clumping noted even through summer.

    Every so often, a customer asks why not use citric acid salts or plain sodium malate. Years of troubleshooting reveal the difference: citrates can skew metal reactivity, shifting outcomes in fermentation batches. Monosodium malate, meanwhile, swings the pH downward with less buffering room, a detail critical in microbiology media or complex process streams in biotech. Trace inspection rounds in our QC lab reveal less residual acidity with our disodium formulation. Across a thousand lots, trends show reduced compounding errors during scale-up, saving hours for both us and our partners.

    Addressing Consistency: Tactics on the Plant Floor

    Consistency year to year forms the backbone of our operation. We start from high-grade butanedioic acid, pushing lots past pharmaceutical checkpoints even though most output serves food and industrial needs. Fresh sodium hydroxide batches—never recycled caustic—cut down on the residual ions that can destabilize downstream blends. The final product passes through custom crystal growth reactors built by our engineering team, avoiding off-form particles that could throw off packing or feeding rates for automated lines.

    Continuous process monitoring gives operators real-time data, reducing the margin for batch deviations. Our team invests in in-line spectroscopy instead of relying solely on endpoint titration, which helps pinpoint variations before shipping. Pack-out feedback loops mean we hear about every caked valve or stuck auger—lessons hard-won after early missteps with bulk container shipments. Bulk powder flows through anti-static-lined totes, meeting customer demand for smooth integration with their gravity-fed processes.

    We measure caking resistance by humid chamber cycling, ensuring powders sustain their loose consistency through summer and winter. In bulk orders, product moves directly from crystal dryer to packing house, reducing air exposure and keeping moisture uptake well below action limits. Dust management comes from decades spent refining airflow and extractor settings—an obsession for some, a relief for everyone working in proximity.

    Quality Matters: From Sampling to Shipment

    Stable product quality means attention to detail long before packaging. Each lot gets a microbial test panel to rule out background contamination—a necessity in food and pharma use. Our test logs run back more than a decade, mapping every complaint or customer spec request. Chromatographic checks for organic purity appear obsessive to some, but a few early runs with “almost pure” precursors taught us the value of clean input streams.

    Our customers’ formulations leave little margin for error. Inequalities in pH, even by a fraction, can translate to failed bench runs and lost weeks. We run duplicate checks on both initial and post-transfer samples, matching results before labeling. Each drum carries a QR-coded trace statement that field techs can scan and cross-reference against lab reports, removing any guesswork during spot checks on arrival.

    Once, we fielded a cluster of inconsistent flavor results from a series of bakery trials. After tracing back, the flaw stemmed from third-party drums repacked by a distributor who cut corners. That turned into a policy: direct shipments from our plant or certified depots only, eliminating the risk of cut-in supply chains.

    Environmental and Safety Priorities from an Operator’s View

    Manufacturing L-Hydroxybutanedioic Acid Disodium Salt brings environmental pressures of its own. Runoff streams and air emissions offer little flexibility in today’s regulatory climate. Our site management team mapped a wastewater recirculation loop years before regulations turned strict, dropping total water demand while capturing nearly all sodium residues for reprocessing. Small adjustments—like recycling rinse water to neutralize incoming acid—save cost and keep our compliance numbers simple.

    Inhalation risks and dust control remain key. Instead of issuing more PPE, we spent years sealing dust points in hoppers, modifying belt covers, and overhauling our pneumatic conveyors. These front-end investments paid off—recordable incidents dropped, and long-tenured operators now train new hires on best practices that actually work. Storage tanks and silos connect to filtered vent lines, catching stray particulates long before off-site limits become an issue. Once, we faced community complaints after a pressure release vented fine powder—today, real-time monitors set off alerts before levels climb.

    Our long-term goal focuses on greener processing aids and more energy-efficient crystallization. Each year, technical staff reviews possible process swaps, weighing new solvent systems or heat recovery options. No silver bullet exists yet, but incremental gains stack up over time. Occasional pilot runs with lower-carbon precursors suggest a promising path. We actively work with specialty logistics partners tested for environmental track records, ensuring freight doesn’t undercut plant improvements.

    Market Reality: Why Our Approach to L-Hydroxybutanedioic Acid Disodium Salt Sets a Bar

    Price pressure and margin strain never truly go away, even as the product matures in global markets. We face routine speculation about switching to lower-purity grades or incremental filler use. Operations experience on the ground disagrees: long-term reliability comes out ahead when customers calculate rework, warranty claims, or downstream troubleshooting. Customers return and ask for direct-from-plant supply rather than gray-market variants. Our contract partners report less variability in process outcomes and lower non-conformance rates.

    Sometimes, unexpected sources flood the market with low-grade material. Laboratory tests reveal hidden sulfate or minor organic residues, which might not show in bulk but surface during sensitive steps—crystal formation in biotech media, or shelf-life stability in functional beverages. Instead of chasing those markets, we reinforce audits and stick to published specs that match claimed purity, not just by certificate but by back-to-back analytical results. Experience taught us that stability and transparency win out in the end, especially as manufacturers further up the chain ramp up automation and data-integrity requirements.

    Market feedback from respected food technologists and bioprocess engineers weighs heavier in our strategy meetings than pricing chatter. Quality conversations lead to concrete improvements—a tweak to an anti-caking step here, an extra purification there. By listening and responding to field challenges, we clear up real pain points, like dissolving speed in cold tanks or pH drift during high-throughput runs. Customer loyalty grows from this open loop. If someone tells us a blend’s off after a drum change, we check historical runs and retrain packing teams where needed.

    Why Specifications Mean More Than Just Numbers

    In an on-the-ground operation, numbers like purity, moisture content, and particle size mean more than regulatory compliance. They tie directly into customer processes—affecting taste profiles, yield curves, stability in sensitive buffers, or the performance of catalysts downstream. We keep records on every spec deviation found in customer blends, updating plant systems to fend off repeats. A key finding through years: slightly uneven particle distribution triggers dosing errors, especially in high-speed automated filling. By redesigning sieves and adjusting dryer cycles, we noticed a drop in customer complaints and a measurable boost in output consistency.

    Tight sodium content control grew into a priority after biotech partners flagged drift in fermentation outcomes. By refining our NaOH dosing protocols and switching to newer sensors, discrepancies shrank. The lesson reminds us that control of input quality builds lasting trust.

    Small specs—like limiting insoluble residue to below 0.03%—come directly from feedback with juice manufacturers and pharmaceutical labs. Even a hint of grit creates processing problems in clear drinks or injectable solutions. Our operators document sieve checks and share findings with process engineers, keeping real improvements at the front of the operation rather than stashing them in reports.

    Keeping Pace with Demand: Output Strategies in Practice

    Seasonal swings impact both supply and logistics. We anticipated bottlenecks after holiday order surges at food plants, adapting batch sizes and logistics contracts in response. Our planning team monitors not just sales, but weather forecasts and global shipping updates to avoid delays. Higher demand never means dropping corners on quality—it often means double-checking packaging stocks or bringing in trusted temps to maintain standards during peak runs.

    As volume grows, automation steps in. Each filler, packer, and loader receives regular simulation runs, stress-testing the system before full-scale outputs ramp up. Warehouse expansion followed real storage constraints, with new racking connecting seamlessly to outbound lanes. We moved away from hand augmenting bags and toward automated stacking, lightening the physical load on staff.

    Shipping reliability remains a watchpoint. Users face tighter production windows, and late arrivals on our side can set back entire schedules. Delivery partners with experience in chemical logistics help minimize surprises. Shipments follow tamper-evidence protocols, reducing risk of post-departure contamination or accidental switching, an important safeguard for sensitive end-use cases.

    Supply Chain: From Sourcing to Customer Floor

    Sourcing raw materials carries its own set of risks. Our team vets every supplier in person, running test batches with trial shipments before scaling up. If a new source introduces stray ions or trace contaminants, corrective action starts immediately at intake—long before it can affect downstream output.

    Through years of sourcing, relationships build with reliable vendors who support our technical data and offer traceability. We keep backup options vetted, ready to step in if geopolitical issues or freight tie-ups challenge main lanes. Lab staff keep tabs on supply chain health, suggesting new audits whenever downstream customers raise a flag.

    Partnership with logistics experts ensures temperature and humidity controls stay intact all the way to the final destination, a non-negotiable detail for stable powder performance. Our network works with geographic redundancy, guarding customers from risk of isolated weather events or port delays. Lessons from storms and strikes shape inventory planning, so the unexpected becomes a rare event, rather than a recurring setback.

    Listening and Improving Every Season

    Improvement doesn’t come from chance—it evolves through active feedback loops with customers, team members, and technical partners. Every issue log, no matter how minor, receives review at quarterly meetings. Real results come from immediate process tweaks, technician retraining, and updating control systems.

    Customer feedback ranges from straightforward troubleshooting to creative application requests—like alternative bulk container types or new blending sequences for novel beverage launches. Rather than dismiss “small” requests, we see them as clues to better handling and happier partnerships.

    Internally, operator suggestions drive constant adaptation, from simplified bagging methods to ergonomic refinements on the plant floor. Crew leads help document workarounds and short-term fixes, providing raw data for longer-term upgrades.

    Looking Forward: What the Experience Means

    Producing L-Hydroxybutanedioic Acid Disodium Salt in a modern manufacturing setting combines technical discipline with a responsibility to those who rely on our product—formulators, lab techs, bulk handlers, and end users alike. Every drum that leaves our site carries not just a spec number, but the sum of lessons learned through collaboration and letting production realities guide improvement. Our reputation grows not from the chemical’s formula, but from real-world results: cleaner product, predictable performance, and trusted consistency wherever chemistry needs precision and safety.