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Imidazole-1-Sulfonic Acid Dimethyl Amine

    • Product Name Imidazole-1-Sulfonic Acid Dimethyl Amine
    • Alias 1-(Dimethylamino)sulfonylimidazole
    • Einecs 629-695-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    305237

    Cas Number 51642-41-6
    Molecular Formula C5H9N3O2S
    Molecular Weight 175.21 g/mol
    Appearance White to off-white solid
    Melting Point Approx. 160 °C (decomposes)
    Solubility In Water Soluble
    Purity Typically ≥ 98%
    Storage Temperature Room temperature, keep dry
    Synonyms N,N-dimethylimidazole-1-sulfonamide
    Boiling Point Decomposes before boiling

    As an accredited Imidazole-1-Sulfonic Acid Dimethyl Amine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Imidazole-1-Sulfonic Acid Dimethyl Amine, 25 grams, packaged in a sealed amber glass bottle with secure screw cap and safety labeling.
    Shipping Imidazole-1-Sulfonic Acid Dimethyl Amine is shipped in tightly sealed containers to prevent moisture absorption and contamination. It is typically transported as a solid or in solution, labeled according to chemical safety regulations. Ensure storage in a cool, dry place, with appropriate hazard labels during shipping to comply with international transport standards.
    Storage Store Imidazole-1-Sulfonic Acid Dimethyl Amine in a tightly sealed container, in a cool, dry, and well-ventilated area, away from moisture, heat, and incompatible substances such as oxidizing agents. Avoid exposure to direct sunlight. Ensure appropriate labeling, and handle with suitable personal protective equipment. Keep away from food, drink, and animal feeding areas.
    Application of Imidazole-1-Sulfonic Acid Dimethyl Amine

    Applications of Imidazole-1-Sulfonic Acid Dimethyl Amine in Industrial Manufacturing

    Imidazole-1-Sulfonic Acid Dimethyl Amine serves as a key intermediate in several advanced chemical processing industries. Our production facility ensures purity, batch traceability, and consistent supply for customers implementing this compound in stringent and large-scale manufacturing environments.

    1. Pharmaceutical Intermediate for Antifungal Drug Synthesis

    This material is primarily used as a building block in the synthesis of azole-based antifungal active pharmaceutical ingredients (APIs). During the multi-step process, it introduces a sulfonic acid function that enhances water solubility and improves downstream drug loading, making it a critical precursor in triazole and imidazole derivative formations. Pharmaceutical manufacturers employ it for both pilot and commercial manufacturing stages, where reproducibility in large-scale fermentation and crystallization is vital.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP and EP monographs for azole APIs
    • Good Distribution Practice (GDP) for pharmaceutical raw materials
    • FDA 21 CFR Part 210/211 (current Good Manufacturing Practice)

    Typical usage ratio

    • 0.8–2.2 molar equivalents in API synthesis, adjusted according to target azole structure and impurity profile requirements.

    Downstream process integration

    • Added during the heterocycle construction stage, before final purification and salt formation; inclusion monitored by in-process HPLC or NMR analytics.

    Final product types

    • Fluconazole, Itraconazole bulk API
    • Topical antifungal finished dosage forms (creams, suspensions)
    • Tablet-grade granules for oral antifungal drugs
    • API intermediates for contract manufacturing organizations (CMOs)

    2. Corrosion Inhibitor Component for Water Treatment Formulations

    Major chemical treatment formulators apply this compound as a corrosion inhibitor component in closed water circulation systems, especially in power plant and industrial chiller environments. Its presence disrupts electrochemical corrosion paths and provides synergetic protection when used alongside polycarboxylates or phosphate esters, extending equipment service life under varying pH and temperature conditions.

    Industry compliance standards

    • ASTM D3946—Standard Practices for Industrial Water Treatment
    • ASME BPVC Section VIII for pressure vessel operation
    • REACH registration for industrial additives (EU)
    • ISO 9001:2015 for quality management in water chemical manufacturing

    Typical usage ratio

    • 30–100 mg/L in recirculating water, dosage fine-tuned according to system metallurgy and make-up water TDS.

    Downstream process integration

    • Batch-blended with dispersants and antiscalants, dosed into main make-up water tank, with online dosing pumps controlled by system corrosion sensors.

    Final product types

    • Pre-mixed liquid corrosion inhibitor concentrates
    • Powdered inhibitor sachets for mobile maintenance kits
    • Multi-component water treatment blends for industrial cooling circuits
    • OEM additive packages for facility management providers

    3. Electroplating Bath Additive for Metal Surface Passivation

    Electroplating and surface protection manufacturers select this intermediate as an additive in specialized passivation baths, notably for zinc and nickel coatings. The compound forms protective organometallic complexes on metal surfaces, reducing oxidation rates and improving product shelf life especially under storage humidity fluctuations. Its rapid reaction rate with activated metal ions ensures production lines sustain consistent coating quality and reduces surface defect rate.

    Industry compliance standards

    • ISO 12683—Electroplated coatings—Process control
    • RoHS restrictions on plating bath compositions
    • EN 1706 for structural metal components
    • Manufacturing process validation under ISO/TS 16949 (automotive suppliers)

    Typical usage ratio

    • 0.5–1.5% by weight in plating bath solutions, adjusted based on desired passivation layer thickness and substrate composition.

    Downstream process integration

    • Dosed directly into the plating bath following primary cleaning; monitored using ion-selective electrodes or UV-VIS absorbance, with batch records for each lot.

    Final product types

    • Anti-corrosion passivated fasteners and bolts
    • Coated electrical connectors for telecom panels
    • Plated automotive underbody components
    • Precision electronic housings against atmospheric corrosion

    4. Resin Catalyst in Epoxy Formulation for Electronics Encapsulation

    Electronic resin compounders integrate this chemical as a functional catalyst for the production of high-durability epoxy resins. It enables controlled curing kinetics, resulting in void-free encapsulation for sensitive circuit assemblies and microelectronic modules. The amine-sulfonic acid structure imparts enhanced dielectric stability and reduces micro-cracking in underfill and potting applications subjected to thermal cycling.

    Industry compliance standards

    • UL 94 flammability certification for potting resins
    • IEC 61249-2-21 for halogen-free laminates
    • RoHS Directive (EU) for electronics production
    • JIS C 5018 for encapsulant QC in Japanese electronics manufacturing

    Typical usage ratio

    • 0.2–0.7 phr (parts per hundred resin), depending on targeted cure time, temperature profile, and resin molecular weight.

    Downstream process integration

    • Blended as a curing agent during resin mixing under controlled moisture and temperature; automated dosing applied in resin delivery lines for SMT assembly operations.

    Final product types

    • LED chip encapsulation compounds
    • Potting resins for automotive and power electronics
    • Underfill formulations for BGA and CSP chips
    • Protective coatings for microelectronic sensors

    5. Auxiliary Agent in Specialty Textile Dye Formulations

    Advanced textile chemical producers utilize Imidazole-1-Sulfonic Acid Dimethyl Amine as an auxiliary agent in dye bath formulations for acrylic and polyamide fiber dyeing. It modifies dye solubilization and bath pH buffering, leading to improved dye uptake rate, levelness, and shade reproducibility across large lot productions. Particularly in continuous and jet dyeing processes, the improved migration control supports consistent color strength on performance apparel and technical textiles.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for restricted substances in textiles
    • ZDHC MRSL for auxiliary chemicals
    • ISO 105-C06 washing fastness protocols
    • GOTS v6.0 for processing chemicals in organic textiles

    Typical usage ratio

    • 0.1–0.6 g/L in bulk dye solutions, fine-tuned based on fiber type, dye class, and targeted shade depth.

    Downstream process integration

    • Pre-dissolved in dye liquor before addition to textile machines; inline pH and dye bath conductivity sensors used for process monitoring.

    Final product types

    • Sportswear and outdoor technical fabrics
    • High-colorfastness automotive seat covers
    • Home textile fabrics requiring allergen control certification
    • Colored yarns for high-speed knitting applications
    Free Quote

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    Certification & Compliance
    More Introduction

    Imidazole-1-Sulfonic Acid Dimethyl Amine: Direct from the Manufacturing Floor

    Getting to know a chemical from a catalog is nothing like handling it every day on the plant floor. Our work with Imidazole-1-Sulfonic Acid Dimethyl Amine goes back years. We’re not a trading house or a distributor who scans containers and relabels sacks; we’re the people feeding measured quantities of precursor into vessels, adjusting pressure, and refining each batch so it matches the standards chemists expect.

    Our Production Approach and Model Details

    Batch consistency does not happen by accident. Work begins by sourcing high-purity starting materials that have proven reliable across dozens of runs—there’s no shortcut here. Each production cycle uses a proprietary sequence matched with careful temperature control because sulfonating imidazole isn’t forgiving if shortcuts creep in. After the intermediate forms, we introduce dimethyl amine under conditions that minimize byproducts, using a tried-and-true agitation protocol to coax out the best yield. Each run builds on experience. Our model, ISADMA-38M, represents the latest refinement of this process. It’s not just a label; it’s a tally of persistent adjustments—every reclaimed reaction, every filter swap, every analysis to check for legacy impurities.

    Product purity has real consequences, especially in organic syntheses where side products can stall a reaction. Our ISADMA-38M keeps assay tolerances tight, with batch documentation checked by plant staff on every shift. We won’t bottle something that leaves residue on our own glassware, so end-users rarely see issues in scale-up or pilot programs. Water content, residual halides, or off-odor hints get traced back and fixed before anything ships. We’d rather hold up an order than force a downstream QC complaint.

    Physical Profile and Storage Experience

    On our site, Imidazole-1-Sulfonic Acid Dimethyl Amine shows as a crystalline material or, depending on storage, a dense free-flowing powder. High humidity on the packing line can influence caking, so our facility maintains a strict dry zone. Staff learned the hard way that open bags left by new hires absorb atmospheric moisture fast. These details impact how a chemist might weigh it inside a fume hood—clumps or static charge can throw off a balance. In our storage, containers are double sealed, and silica packs go inside every drum. Unplanned downtime taught us moisture control pays off—a few careless days and an entire lot loses its sharp powder characteristics, then customers call asking why the product doesn't behave.

    The color of each batch says a lot. Our QC office expects a pale white-to-off white—any sign of yellowing means someone has skipped a temperature hold or reused fouled glassware. We’ve tested the upper limits of stability ourselves under lab heat and normal storage. Shelf life measured in years comes down to clean bottling and packaging straight from the dryer, not magic stabilizers. Each time we see a returned drum with discoloration, it’s usually due to improper warehouse conditions, not an intrinsic flaw in the material itself.

    Usage in the Field: Our Practice and Listening to Chemists

    Adoption of Imidazole-1-Sulfonic Acid Dimethyl Amine across sectors tells us how versatile it has become. Synthetics laboratories seek out our product for its performance as a sulfonating agent or as an intermediate. Peptide chains and N-heterocycle coupling steps can hinge on the fine points of its purity. We’ve picked up feedback from formulators who need predictable results batch after batch. There’s direct pride in knowing that downstream, researchers trust every bottle we send.

    Pharma groups favor our ISADMA-38M during innovative heterocycle formation and sulfonation. Each gram precisely weighed can turn into weeks of patentable work. Lower impurity loads minimize false positives during screens and safety tests—this was a key point brought up during a site audit by an external team. It’s gratifying to see our matches for melting point and elemental analysis data reported back in published papers and internal project memos. When issues crop up, formulators often send us their run notes or observation logs. We have staff chemists liaise directly, reviewing temperature curves and recommending minor changes for reproducibility, based on deep familiarity with our lots. If a problem pops up, we track down the contributing factor and make the necessary adjustment—having a direct line of communication with specialists keeps us sharp.

    In environmental testing and analytical projects, our product’s stability and solubility have made it a mainstay. Dilutions to specific molarities come off smoothly, and colorimetric responses hold benchmark values. Our glassware and pipetting routines have been fine-tuned to prevent contamination, and we share tips for customers battling similar issues. Sometimes users ask if surface area changes after grinding—our experience says careful homogenization during milling keeps results consistent, but we always suggest retesting solutions after long storage as a precaution.

    Differences Compared to Other Products: Behind the Manufacturing Lines

    Not every Imidazole-1-Sulfonic Acid Dimethyl Amine on the market comes out of a reactor built for flexibility. We’ve sampled products from competitor catalogs and traced recurring complaints from chemists using alternatives—off-odors, inconsistent melting points, particle size variation, or trace contamination from ambiguous syntheses. Unlike large resellers or commodity traders who buy surplus lots, we never mask origin or blend stocks. In the plant, every bag, drum, or flask can be traced to a real operator and a logged batch record.

    A critical distinction is batch-to-batch reproducibility. Other producers running uncontrolled or semi-manual lines often see fluctuating output. We’re in a position to guarantee performance, whether for gram-scale pilot reactions or multi-kilogram campaigns, because every kilo arises from the same validated method. Labs seeking regulatory clearances have come to us when faced with certification headaches from untraceable sources. Customizations, like minor changes to particle size or moisture targets, are done based on direct end-user dialogue, not paperwork passed between middlemen.

    We also get reports about lingering sulfurous odors or strange residues with some competitor material. Tracking these down, our facility found they most often come from shortcuts in the acid introduction step, or from storing intermediates in partially cleaned tanks. Our procedures—cleaning protocols after every batch, precise venting before amine addition—ward off these pitfalls. The cost is in labor and time, but the upside is true reliability. We avoid masking faults with over-dilution or post-process blending. Any irregular drum on our floor gets sampled again and, if necessary, reprocessed. No one wants a call from a customer angry about failed syntheses or ghost peaks in their chromatography.

    Real Solutions to Real Challenges

    Ask any production chemist, and they’ll say the devil is in the details. In our case, process safety and environmental controls remain ongoing priorities. Amine handling introduces risk—everything from gassing off in humid weather to minor exposure from cracked seals. Over time, we’ve reworked our lines with sealed transfer systems, personal protective protocols for staff, and real-time airflow checks in the charging bay. Failures in these steps can mean personnel injury or off-spec goods. Chasing root causes and integrating fixes right in the plant is part of our daily rhythm.

    Packaging has posed another long-term lesson. One year, a run of drums sent to Southeast Asia returned clumped despite passing our own checks. A local agent had stored them in a poorly ventilated, high-heat warehouse for a month before delivery. That experience led us to team with shippers who understand the “do not stack” and “dry zone only” labeling. We started adding a second layer of bag lining and batch-tracking on every container, with advice notes inside the shipment. Every season, we rebrief staff and customers to expect modest appearance variations but screen for moisture pickup as the main red flag.

    Another headache appears with cross-contamination, a real risk at plants that swing between products. Our team focuses on dedicated reactor lines and closed-loop transfer. Filters, seals, and glassware that touch sulfonic acid intermediates go through system-level washing procedures—not just a rinse. We track cleaning logs, and if a residue gets noticed during the morning check, we halt operation, swap the fitting, and rerun everything. Batch failures sting, but leaving open the possibility for customer complaints costs more in the long haul.

    Feedback Loop: Listening and Improving

    Over the years, direct end-user feedback has shaped our approach to Imidazole-1-Sulfonic Acid Dimethyl Amine. One team sent in polaroids of their crystallizations, noting slight streaking in product purity bands above a certain weight. We replicated their method, adjusted the drying step, and saw improvements not just in their yields but others’ as well. These tweaks carry forward, and every incoming complaint or suggestion turns into a chance for us to refine our steps. We take pride in the fact that our operating manual reads more like a living document shaped by scientists at the bench—not just those of us in the plant.

    Reliability keeps researchers coming back. Regular customers usually notice if we make even minor changes to the energy input or crystallization profile. We flag every planned tweak to our endpoints, and batch samples go to a test panel for evaluation. Technical bulletins include observations from both our process staff and outside labs using the same lot. This dialog prevents gaps between what process engineers imagine and what end-users experience. Across different fields, from pharma to analytical testing labs, this communication loop helps steer how we approach incremental improvements.

    Commitment to Compliance and Safety

    As manufacturers, we stay alert to updated guidelines on chemical handling, safer processing, and reporting. Local authorities conduct regular checks, and compliance records are not hypothetical paperwork on a shelf—we live with these audits. Every minor spill gets logged; every container movement gets recorded. When new standards emerge, our first task is mapping out gaps and retraining operators day to day.

    Some of our customers seek cleanroom-grade batches or want documentation to satisfy regulatory filings abroad. For these orders, we build custom records and back up every claim with chromatograms, MS data, and third-party analysis. Over time, these efforts smooth the path for us and for labs needing to demonstrate provenance or satisfy their own certification programs.

    Worker safety isn’t a line item—it’s central to operations. Gowning stations stand beside production lines, neutralization pits handle accidental spills, and we run annual drills for containment. Our team meets weekly to review incident logs and near-misses, making improvements or fine-tuning emergency procedures if needed. This investment means not only fewer disruptions but lower insurance costs and better morale among staff. Every improvement to our site safety ends up benefiting our customers through fewer defects and more dependable output, batch after batch.

    The Manufacturer’s Perspective: Trust through Process, Not Promises

    Manufacturing Imidazole-1-Sulfonic Acid Dimethyl Amine takes sustained attention to detail and a readiness to admit mistakes. Suppliers who shortcut, dilute standards, or outsource every critical process end up with unpredictable goods—a risk downstream chemists can’t afford. Our production site’s logic isn’t built just on maximizing numbers but on building a reputation among people in the know.

    Real-world chemistry is messy and often unforgiving. Tweaking a single temperature probe or swapping a faulty impeller changes the outcome, and we see those effects directly on product characteristics. Over time, our in-house protocol has taken shape through listening, repetition, and learning rather than copying literature procedures. Each batch happens under watchful eyes, with over a decade of accumulated know-how behind it.

    We know our customers demand more than a spec sheet copy-pasted from a supplier in another timezone. Every decision, from solvent source to filter grade, is made to ensure you get a reliable, high-purity intermediate ready for whatever technical challenge you bring. Feedback is never ignored or lost, and every improvement becomes part of tomorrow’s manufacturing run. In this business, trust is hard earned and easily lost. Our routine is to honor the spirit of scientific rigor you expect, not just the black-and-white marks on a delivery slip.