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Hydantoin

    • Product Name Hydantoin
    • Alias Imidazolidine-2,4-dione
    • Einecs 200-543-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    143511

    Cas Number 461-72-3
    Molecular Formula C3H4N2O2
    Molar Mass 100.08 g/mol
    Appearance White crystalline powder
    Melting Point 221-224°C
    Solubility In Water Slightly soluble
    Density 1.44 g/cm³
    Boiling Point Decomposes
    Ph Neutral (in aqueous solution)
    Chemical Structure Imidazolidine-2,4-dione
    Odor Odorless
    Stability Stable under normal conditions
    Synonyms Glycolylurea; 2,4-Imidazolidinedione

    As an accredited Hydantoin factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Hydantoin is packaged in a 500g amber glass bottle with a secure screw cap, labeled with hazard symbols and handling instructions.
    Shipping Hydantoin should be shipped in tightly sealed containers, protected from moisture and incompatible substances. It does not require special hazardous labeling under most regulations, but standard chemical shipping guidelines apply. Ensure packaging is secure to prevent leaks during transit, and store in a cool, dry place away from strong acids or bases.
    Storage Hydantoin should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of moisture and incompatible substances such as strong oxidizers. Protect from light and keep away from heat or open flame. Properly label storage containers and ensure storage areas are secure and compliant with chemical safety regulations.
    Application of Hydantoin

    Applications of Hydantoin in Industrial Manufacturing

    Hydantoin plays a decisive role in several specialized manufacturing sectors thanks to its unique chemical structure and reactivity. As a direct manufacturer, we support high-volume industrial processors by enabling the production of precise end products with secure compliance, tailored formulations, and well-established process steps. The following sections outline concrete, real-world applications implemented by global industry leaders.

    1. Biocidal Active Ingredient for Water Treatment

    Industrial operators in municipal and pool water treatment deploy hydantoin derivatives, mainly bromochlorodimethylhydantoin (BCDMH) and dichlorodimethylhydantoin (DCDMH), as broad-spectrum antimicrobial agents. Facilities choose these compounds for controlled, long-acting disinfection with measured halogen release, specifically targeting bacteria, algae, and pathogens in recirculating and wastewater systems. Operations must balance release rate, residual management, and corrosion control. The raw material undergoes on-site blending with halogen donors and buffer agents, followed by solid-form processing into tablets or granules for incremental dosing in distribution reservoirs and pipe networks.

    Industry compliance standards

    • US EPA FIFRA regulations for biocidal formulations
    • EN 15030: Chemicals used for treatment of water intended for human consumption
    • Regulation (EC) No 528/2012 (EU Biocidal Products Regulation)
    • NSF/ANSI Standard 60: Drinking Water Treatment Chemicals

    Typical usage ratio

    • 0.5–1.5 mg/L of available halogen, based on water contamination levels and contact time; formulation adjusted seasonally or by water throughput volume

    Downstream process integration

    • Introduced in solid or granular form through inline feeders during secondary water treatment or recirculating loop stabilization
    • Final dose determined by automated monitoring and dosing controls

    Final product types

    • Swimming pool sanitizer tablets
    • Cooling tower biocide tablets
    • Industrial process water disinfectants
    • Municipal water stabilizer compounds

    2. Pharmaceutical Intermediate for Anticonvulsant APIs

    Pharmaceutical producers synthesize several key APIs, such as phenytoin and certain barbiturates, starting from high-purity hydantoin. The molecule functions as a heterocyclic backbone, undergoing alkylation and substitution reactions under GMP guidelines. Precision control during reflux, crystallization, and scale-up ensures both chemical yield and impurity management. Downstream routes adapt the crystallographic properties of hydantoin for optimal synthetic accessibility, culminating in bulk API used in tablet and injectable forms for epilepsy therapies.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP–NF Monographs for hydantoin derivatives and APIs
    • EDQM Guidelines for starting materials (CEP application)
    • US FDA 21 CFR Part 211 (Finished Pharmaceuticals)

    Typical usage ratio

    • 1.0 molar equivalent hydantoin per target API; adjusted based on yield optimization and reaction scaling

    Downstream process integration

    • Charged to reactor in initial API synthesis step
    • Undergoes sequential condensation and substitution before purification and API isolation

    Final product types

    • Phenytoin sodium API
    • Mephenytoin API
    • Barbital and phenobarbital intermediates
    • Finished anticonvulsant drugs

    3. Preservative in Personal Care and Cosmetic Manufacturing

    Industrial formulation plants use hydantoin derivatives such as diazolidinyl urea and DMDM hydantoin as antimicrobial preservatives in a wide range of water-based personal care and cosmetic items. Manufacturers value consistent formaldehyde release at low concentrations for effective microbial control over product life cycles. Each production batch incorporates the preservative during emulsification or cold blending, relying on stringent GMP monitoring and extensive micro-biological QC for regulatory compliance.

    Industry compliance standards

    • EU Cosmetic Regulation EC No 1223/2009, Annex V (Europe)
    • US FDA 21 CFR Part 700 (Cosmetics)
    • ASEAN Cosmetic Directive
    • ISO 22716:2007 (Cosmetic GMP)

    Typical usage ratio

    • 0.1–0.6% by weight of total formulation, not to exceed jurisdictional maximums

    Downstream process integration

    • Added during post-heating process step before packaging
    • Uniformly dispersed in lotions, shampoos, and creamy bases by mechanical agitation

    Final product types

    • Shampoo and conditioner blends
    • Emulsified creams and lotions
    • Makeup removers
    • Skin cleansers and facial masks

    4. Intermediate for Agrochemical Synthesis

    Agrochemical manufacturers employ hydantoin as a stable, low-toxicity intermediate for producing selective herbicides and plant growth regulators. Synthesis steps utilize condensation and cyclization to convert it into functional pyrimidine and triazine derivatives as demanded for broadacre and horticultural applications. Downstream flow involves reaction with chlorinating agents and alkyl halides in controlled reactor environments guided by QS principles. Manufacturers precisely measure and monitor residual content to comply with pesticide-specific technical requirements.

    Industry compliance standards

    • FAO/WHO Specification for Agricultural Pesticides
    • US EPA Pesticide Registration (40 CFR Part 158)
    • REACH Regulation (EC) No 1907/2006—Intermediate Registration
    • China GB2763 Maximum Residue Limits for Pesticides

    Typical usage ratio

    • Batch reaction employs 1–1.2 molar equivalents hydantoin per final herbicidal product; adjusted by catalyst and temperature

    Downstream process integration

    • Incorporated at the initial building block stage of active ingredient synthesis
    • Undergoes further substitution and ring modification before technical concentration and formulation

    Final product types

    • Selective herbicide active concentrates
    • Plant growth regulator technical material
    • Seed dressing formulations
    • Pyrimidine-based fungicide precursors

    5. Epoxy Resin Curing Agent for Industrial Coatings

    Epoxy resin formulators adopt hydantoin-based amine derivatives as specialized curing agents, enabling control over pot life, hardness, and chemical resistant properties in industrial floor coatings and anti-corrosive paints. Process engineers dose the compound at the resin blending or final cross-linking stage where amine-hydantoin adducts react with epoxy oligomers. Strict batch records, scale-dependent mixing, and physical QC drive production, especially for architectural and heavy-duty protective coatings in infrastructure and utility markets.

    Industry compliance standards

    • ASTM D2486 (Scrub resistance of coatings)
    • ISO 12944 (Paints and varnishes—Corrosion protection of steel structures)
    • REACH compliant usage of amine adducts
    • China HG/T 4567-2013 Epoxy Curing Agents

    Typical usage ratio

    • 20–30 phr (parts per hundred resin), depending on targeted cure time and hardness requirements; fine-tuned for specific end-use

    Downstream process integration

    • Integrated at the final resin blending line or directly before application
    • Co-polymerized under controlled temperature and humidity

    Final product types

    • 2K epoxy floor coatings
    • Pipe and tank linings
    • Heavy-duty anti-corrosion paints
    • Protective industrial varnishes
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    Certification & Compliance
    More Introduction

    Hydantoin: Dependable Chemistry Backed by Craftsmanship

    Understanding Hydantoin from the Manufacturer’s Floor

    Hydantoin comes from a legacy of practical chemistry. Our plant has been working with this compound for decades, and we’ve seen the full range of uses take shape—from stabilizing personal care products to supporting industrial applications. Our commitment to the best possible quality starts at sourcing, but the real work takes place in the reactor halls and on the quality control benches, where every batch tells its own story. We put precision into every step, trusting in experience built over years.

    Models and Specifications—A Practical Approach

    Different customers walk through our doors with unique questions about hydantoin. Some ask about the basic white crystalline powder, looking for high assay and controlled moisture content. Others look for technical grades suited for further transformation—like halogenation or formulations involving specialty disinfectants. We’ve kept our focus on the following core product lines:

    We do not chase after exotic varieties with every possible functional group, focusing instead on reliability and reproducibility across lots.

    Application Insight—We’ve Seen the Trends

    Hydantoin enters so many industries because it resists hydrolysis and displays comforting stability under regular storage. The personal care world uses hydantoin derivatives as antimicrobials and preservatives. The water treatment sector uses these related compounds for disinfection, especially brominated and chlorinated analogs (notably DBDMH and DCDMH) that stem from our foundational hydantoin chemistry.

    The agricultural sector values hydantoin as a starting point for protective agents and plant growth regulators. Material science teams like it for synthesis, where hydantoin’s carbonyl structure works as a building block for specialized polymers. Lab teams working in academia and industrial research see it as a solid intermediary with a track record for predictable reactivity.

    In our own experience supplying fine chemicals to multinational clients and domestic customers alike, quality stakes rarely waver. We hear that impurities—no matter how trace—can upend entire production lines or invalidate batch runs of pharmaceuticals and cosmetics. This keeps our production and QC teams up at night, so we stick to robust process controls and regular instrument calibration. The product meets USP, EP, or relevant standards each time, or it doesn’t leave the facility.

    Comparing Hydantoin to Other Chemistry—What Sets It Apart

    Many newcomers ask why hydantoin finds a home in places where urea, imidazolidinone, or imide chemistry could show up. The answer comes from both structure and reliability. Hydantoin’s imide group forms a stable ring that resists breakdown better than straight-chain amides or open-chain ureas. This resilience matters in high-stress synthetic steps, where sidereactions cost time and money. It also matters in formulations left on the shelf, exposed to air and humidity.

    Chlorinated or brominated hydantoins outcompete older formulations—like simple sodium hypochlorite—in both shelf life and handling. Pool and spa professionals, as well as water treatment plants, notice the difference whenever changing sources. Hydantoin-based disinfecting tablets tolerate heat, shipment, and uneven storage much better without caking or breaking apart prematurely.

    The cosmetic and personal care industry appreciates that properly produced hydantoin, unlike some traditional preservatives, maintains compatibility with more sensitive ingredients. Many aldehydes and quaternary ammonium types cause skin irritation or reactions with oils and fragrances. Our team receives repeat business from formulators chasing cleaner labels, looking to push shelf life further without sacrificing gentleness.

    Quality as a Priority: Perspective from the Floor

    Manufacturing hydantoin carries risks you can’t always see in a specification sheet. The route to pure, high-quality hydantoin runs through tricky reaction stages and requires precise temperature control and staged crystallization. We’ve learned the hard way that low-grade raw inputs or slipshod cGMP adherence quickly create impurities—especially biuret, glyoxal, and heavier byproducts—that pass chemical testing but pop up as haze, odor, or solubility issues for customers. Those batches never reach our warehouse.

    Ten years ago, a process review showed us the importance of regular equipment replacement. Even minor corrosion in a crystallization vessel introduces metal ions that nobody wants in a pharmaceutical supply chain. Regular ICP-MS screening and use of passivated steel have become part of our prevention routine. Data show that batches with tighter metal limits have consistently higher customer satisfaction ratings, especially from buyers making pharmaceuticals or skin-contact goods.

    Responsible Sourcing and Sustainable Practices

    Sourcing for hydantoin starts with urea and glyoxylic acid, two bulk chemicals with volatile pricing and uncertain supply outside of responsible regions. Our purchasing team works directly with primary producers—international and local—eschewing unreliable traders and shadow brokers. Shipping only starts after each supplier batch passes our defined set of checks, which looks beyond general purity: we care about absence of volatile chlorinated organics and other residues from less-vigilant plants upstream.

    Sustainable manufacturing isn’t just a slogan. Our process design team recycles wash liquors to minimize water waste and energy usage, and manages spent byproduct streams securely rather than chasing lowest-cost disposal. This approach has earned repeat visits from downstream auditors, including multinationals concerned about supply chain transparency. They want to see that behind the certificate, every kilogram tracks back to a batch number, raw supplier, and operator signature. We invest in full digital batch records for this reason—if a recall ever became necessary, nobody wants to scramble for paper logs and faded signatures.

    Safety, Handling, and Real-World Considerations

    Concerns about hydantoin’s handling have matured over the decades. The pure base form comes with relatively low toxicity and manageable dusting. We train our operators to avoid inhaling powders and work in well-ventilated spaces, using local exhaust as a matter of course. The bigger challenges come in the chlorinated and brominated derivatives, where stability cuts both ways: they release active halogen slowly, but poor packaging or moisture ingress can trigger unwanted reactions.

    We package hydantoin and its analogs only in new, food-contact certified drums or heavy-duty bags with multiple moisture barriers. While a trading house might cut corners on packaging materials, our technical managers sign off on each purchase to block leaks and losses. Customers in hot or humid regions appreciate seeing shipments arrive in spec, without the caking or yellowing that indicates mishandling or extended warehouse time.

    Transportation also requires real-world solutions. We have a direct relationship with bulk shippers who certify their containers and provide cleaning logs. Some customers require special anti-static liners or short-chain alkane flushing after unloading, which we accommodate in scheduling. These steps look small, but they have saved us and our customers countless headaches and insurance claims.

    Traceability and Documentation—Beyond Paperwork

    Paperwork in the chemical industry often gets a poor reputation—just signatures and rubber stamps. In reality, traceability protects both us and the buyer. Each batch reflects not only chemical analysis but a flow of responsibility: which production line, which shift, which reactor load. Problems become rare after thousands of runs, but our digital system lets us pull up everything from raw input certificates to spectrographic analyses within minutes.

    Buyers, particularly multinationals and regulated markets, increasingly ask for tighter documentation linking batch origin, environmental impact, and operator training logs. Our willingness to invest in transparency paves the way for repeat business, as customers know they can count on not just a safe product but a verified, reproducible one. Any claims around “pharmaceutical grade” or “cosmetic grade” get paired with evidence, so every incoming and outgoing shipment can pass regulatory and supplier audits without fuss.

    Commitment to Innovation—Lessons from Years in the Industry

    Chemistry evolves, and hydantoin’s role keeps shifting with new knowledge. Our R&D group stays closely linked to the shop floor, not housed in a detached office. Projects include alternative routes using renewable feedstocks and research into minimizing byproduct formation, echoing customer calls for cleaner, more responsible chemistry.

    Our process engineers keep looking for ways to minimize steps and energy input. We’ve experimented with in situ glyoxal preparation to reduce imported precursor dependency, seeing promising results that both cut costs for large-volume production and make the supply chain more robust. Pilots take time, but sticking close to customers’ future specifications keeps us ahead of regulatory changes.

    Customer feedback guides our R&D—requests for better solubility, different particle sizes, and lower residuals. Collaboration goes both ways, with some customers bringing us challenges from their end users or R&D labs. We treat these as opportunities, usually running joint pilot batches instead of taking guesses from afar.

    Market Realities and Shifting Demand

    Trends come and go in chemical manufacturing. Hydantoin’s demand remains steady, but the mix of buyers—personal care, pool & spa, pharma, and agrochemicals—changes in response to season, regulation, and broader market cycles. Our ability to meet these shifts comes from robust stock control and real communication between plant, warehouse, and sales.

    Years ago, a spike in disinfectant demand during a waterborne outbreak tested supply chain stress points. Our policy of keeping safety stock, investing in bulk storage, and refusing to rely on “just in time” deliveries paid off. While some competitors ran dry, our teams pulled overtime, packaging late into the night to get shipments out. This would not have been possible without a flexible manufacturing culture capable of switching between product grades as needed.

    A recent regulatory shift against formaldehyde-releasing preservatives brought new demand from personal care brands and forced us to step up technical consultation to allay transition worries. Our experience taught us long ago that sudden surges can strain less-prepared plants, especially those without rigorous process control at every step. Our customers stayed supplied, and our own team gained insights about emerging concerns and technical requirements.

    Long-Term Partnerships and Customer Success

    Partnerships with customers look different every day. Sometimes support means sharing technical sheets and advice, other times it means delivering emergency shipments when overseas supply chains falter. We have built several long-standing relationships with both big buyers and regular smaller customers. Our commitment means nobody gets left out in a crunch.

    For new buyers unfamiliar with hydantoin, we provide samples with analytic support—not just a product, but results of particle-size analysis, GC-MS impurity profiles, and full written records from production to dispatch. We also invite site visits because seeing is believing; more than one skeptical procurement officer became a partner after walking the floor, speaking with shift operators, and examining our batch logs.

    Repeat customers, especially in regulated sectors, return because we solve problems, not just ship merchandise. Whether the solution requires custom packaging, tweaks to granulation, or adjustments to specification for borderline applications, our production and technical teams offer straightforward feedback and workable timelines.

    Tackling Industry Challenges—Transparency and Adaptation

    Chemical manufacturers face challenges beyond the chemistry itself. Regulatory scrutiny, sustainability concerns, and ever-tightening quality specifications shape the way we do business. Hydantoin, with its diverse applications and high visibility in regulated end-products, sits squarely at the center of these waves.

    We address transparency demands through traceable supply chains and consistent record-keeping, offering customers not just product but confidence. Sustainability measures, including water recycling and renewable energy investments, reduce both cost over time and environmental impact. We believe that responsible business wins repeat customers and lets us weather supply chain disruptions.

    Our approach to adaptation means building a team that knows its craft, investing in continuous operator training, and welcoming feedback at every level—from the warehouse loader flagging a packaging issue to the QC analyst tracking trace metals. This culture of openness allows us to spot problems before they reach the customer and incorporate new industry requirements ahead of deadline.

    Looking Ahead—Why We Stand Behind Our Hydantoin

    Hydantoin plays a role in keeping water safe, protecting crops, and preserving goods on store shelves. Every kilogram shipped speaks for the many hands and hearts that have contributed to its journey—from raw materials to finished product. This work brings pride, not just profit. Our plant operates with the understanding that reputation is built batch by batch, shipment by shipment.

    As regulatory and market landscapes shift, our roots in hands-on, careful manufacturing position us to support long-term partners and new customers alike. Innovation, trust, and accountability remain at our core. Hydantoin’s versatility keeps us nimble and ready to serve evolving needs, while our history of direct engagement and commitment to honesty ensures that every customer interaction reflects both experience and respect for their business and reputations.