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Hexyl Isothiocyanate

    • Product Name Hexyl Isothiocyanate
    • Alias Hexyl mustard
    • Einecs 211-740-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    377644

    Cas Number 629-08-3
    Molecular Formula C7H13NS
    Molecular Weight 143.25 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 198-200 °C
    Density 0.966 g/mL at 25 °C
    Refractive Index 1.4860-1.4900 at 20 °C
    Flash Point 75 °C (closed cup)
    Solubility In Water Insoluble
    Odor Pungent, mustard-like

    As an accredited Hexyl Isothiocyanate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Hexyl Isothiocyanate 100 mL is packaged in an amber glass bottle with a secure screw cap and hazard labeling.
    Shipping Hexyl Isothiocyanate should be shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It must be labeled as a hazardous material, handled with care, and transported according to local, national, and international regulations. Suitable for ground or air freight, ensure safety measures against leaks and exposure during transit.
    Storage Hexyl Isothiocyanate should be stored in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and direct sunlight. Keep the container tightly closed when not in use. Store separately from oxidizing agents, acids, and strong bases. Use appropriate chemical-resistant containers and ensure proper labeling. Avoid storing near food or incompatible substances to prevent hazardous reactions.
    Application of Hexyl Isothiocyanate

    Applications of Hexyl Isothiocyanate in Industrial Manufacturing

    Hexyl Isothiocyanate serves as a specialized intermediate across selective sectors within chemical processing, pharma synthesis, and flavor compound development. Our manufacturing facility supports downstream partners with material consistency, regulatory guidance, and process-specific integration to help scale operations efficiently and compliantly.

    1. Pharmaceutical Synthesis for Active Pharmaceutical Ingredients (APIs)

    Hexyl Isothiocyanate is a key building block in the synthesis of certain pharmaceutical intermediates, particularly in the production of sulfur-containing heterocyclic compounds. Its reactivity allows precise incorporation into target molecules under controlled conditions, primarily during the early synthetic stages. Pharmaceutical manufacturers rely on our material for medicines requiring isothiocyanate-derived structures, used in anti-cancer and anti-infective drug classes. High purity and traceability are prioritized during every batch we supply to the pharmaceutical sector.

    Industry compliance standards

    • Good Manufacturing Practice (ICH Q7, EU GMP, US FDA cGMP)
    • Applicable local Drug Master File (DMF) and registration dossiers
    • USP/EP/JP monograph requirements for intermediates (if applicable)
    • ICH Q3C/Q3D guidelines for residual solvents and elemental impurities

    Typical usage ratio

    • Functioning as a reactant at 0.05–0.5 molar equivalents relative to base structure
    • Adjustment based on desired alkyl chain content and target molecule yield

    Downstream process integration

    • Employed during primary or secondary step of multistage organic synthesis
    • Introduced after initial ring or backbone construction, under controlled temperature and inert atmosphere
    • Often followed by purification and crystallization before API isolation

    Final product types

    • Antineoplastic intermediates (e.g., thiocarbamate-based drugs)
    • Sulfur-heterocycle containing anti-infective APIs
    • Research and reference standards for pharmaceutical R&D

    2. Agrochemical Active Ingredient Production

    Manufacturers of crop protection compounds use Hexyl Isothiocyanate in the synthesis of specific fungicides and pesticides, targeting a range of fungal and bacterial threats in commercial agriculture. The unique aliphatic isothiocyanate scaffold permits precise modification of active molecules, enhancing the selectivity and degradation profile of the final agrochemical product. Our technical support addresses relevant safety protocols and quality parameters for high-volume batch operations.

    Industry compliance standards

    • FAO/WHO Guidelines for pesticide manufacturing
    • OECD Principles of Good Laboratory Practice
    • REACH registration for raw material use in agrochemical synthesis
    • Environmental impact assessment per national agency (EPA, ECHA)

    Typical usage ratio

    • Employed at 1–3% (w/w) relative to the combined mass of synthetic batch precursors
    • Adjusted based on final active content and synthesis route

    Downstream process integration

    • Added at the coupling or cyclization stage in agrochemical molecule assembly
    • Reaction temperature maintained between 50–80°C for controlled conversion
    • Followed by extraction, distillation, and formulation blending

    Final product types

    • Fungicidal actives in seed treatment and foliar applications
    • Soil treatment pesticide concentrates
    • Formulated wettable powders and soluble granules
    • Custom technical grade biocidal intermediates

    3. Synthesis of Industrial Flavor and Aroma Compounds

    In industrial flavor production, Hexyl Isothiocyanate functions as a precursor in the manufacturing of specialty aroma molecules, including certain naturally occurring flavors used in food and beverage. It delivers the characteristic pungent, mustard- or horseradish-like note that is critical for specific flavor blends. Our material is batch-tested for purity, residual solvents, and compliance with food-grade additive standards, ensuring reliable performance during flavor compound synthesis and blending.

    Industry compliance standards

    • Food Chemicals Codex (FCC) purity requirements
    • FAO JECFA food additive guidelines
    • EU Regulation (EC) No 1334/2008 on flavorings
    • HACCP and ISO 22000 food safety management

    Typical usage ratio

    • Between 0.01% and 0.5% (w/w) in intermediate syntheses; never used as a direct additive
    • Adjusted based on final flavor strength and regulatory maximum levels

    Downstream process integration

    • Used at the alkylation step in flavor molecule assembly
    • Carefully dosed under low-temperature mixing and inert gas conditions
    • Intermediate then undergoes further conversion to food-safe flavor compounds

    Final product types

    • Flavor precursors for savory seasonings
    • Spicy flavoring agents in processed foods
    • Aroma chemicals for the fragrance industry
    • Oleoresin preparations for sauces and dressings

    4. Specialty Polymer and Monomer Additive Formulation

    Producers of specialty copolymers and advanced resins incorporate Hexyl Isothiocyanate as a functional monomer or chain modifier to introduce reactive sulfur or alkyl functionalities. This integration improves adhesion, crosslinking behavior, and chemical resistance in high-performance coatings and elastomers. All shipments meet internal polymer grade specifications for contamination control and consistent reactivity.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System for material traceability
    • EU REACH (EC 1907/2006) registration for monomeric raw materials
    • ASTM D256, D638 for mechanical and safety testing of final product
    • In-house QMS protocols to suit international OEM customers

    Typical usage ratio

    • Loadings of 0.1–2% (w/w) as a functional additive in resin or pre-polymer
    • Modified based on required surface energy or crosslinking density

    Downstream process integration

    • Added during feedstock blending prior to polymerization or melt extrusion
    • Incorporated under controlled conditions to avoid premature curing
    • Monitored to ensure target molecular weight distribution and reactivity

    Final product types

    • Reactive polymers for adhesives and sealants
    • Surface-modified elastomers
    • Advanced coatings for corrosion resistance
    • Specialty thermoset and thermoplastic materials
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    Certification & Compliance
    More Introduction

    Hexyl Isothiocyanate – Reliable Performance from Manufacturer’s Experience

    Consistent Craftsmanship at the Source

    For several years, we have been producing Hexyl Isothiocyanate in our own plant, which lets us control every step of the process, from raw material selection to quality inspections. The consistent quality of each batch isn’t an accident; it’s the result of refined methods in synthesis and purification. Our commitment starts at the chemical reactor itself, where operators who know the subtleties of temperature and pressure adjust parameters to suit the unique behavior of this compound. Regular instrument calibration and strict protocols during fractionation keep the product profile steady. Unlike operations reliant on outside contractors or blended lots, we draw from a single, traceable source of starting material which helps us address lot-to-lot differences over time.

    Product Details: A Technical Perspective Rooted in Practice

    Hexyl Isothiocyanate, with the structural designation C7H13NS and a CAS number recognized by chemists worldwide, gives a sharp, recognizable aroma that stands out even in the earliest fractions during distillation. In practice, our product leaves minimal residue and contains low levels of related impurities. Over years of manufacturing, careful adjustments to column length and temperature ramping have helped us minimize co-elution of unwanted byproducts. Each bottle passes gas chromatography analysis with a target purity above 98 percent, with water content and refractive index checked regularly according to our internal guidelines, not just general literature values.

    Diverse Applications Backed by Real-World Use

    Our Hexyl Isothiocyanate finds wide demand from fragrance developers, research labs, and specialty syntheses. Perfumers draw on its spicy, vegetal note to recreate green and horseradish top-notes, often as a foundation for botanical accords. Flavor chemists have told us that using our Hexyl Isothiocyanate in low doses unlocks pungent nuances in wasabi, mustard, and various root vegetables that standard isothiocyanates miss. The controlled levels of sulfur and nitrogen byproducts in our output mean fewer distractions in delicate food compositions or scent profiles. As a manufacturer handling these concerns every day, we structure our distillation cycles not simply to guarantee purity by certificate, but to solve real issues that come up during formulation.

    For organic chemistry labs, Hexyl Isothiocyanate serves as a reagent in synthesizing sulfur-nitrogen heterocycles and related scaffolds. Research groups often need reliable reactivity from batch to batch, which can’t happen if the isothiocyanate contains unknown side products. We welcome inquiries about small- and medium-batch production, as our experience shows that reaction specificity in medicinal chemistry benefits from the low baseline impurity level we achieve during both extraction and bottling. Samples submitted to long-storage experiments remain stable, as each vessel is filled and sealed in a nitrogen environment to prevent degradation.

    What Sets This Isothiocyanate Apart

    We compare Hexyl Isothiocyanate directly to structurally similar isothiocyanates such as methyl, ethyl, and benzyl types. While methyl or ethyl analogs carry a characteristic sharp burn with less body, the hexyl side chain brings a deeper, more lingering character to both sensory and synthetic applications. If you’ve used shorter-chain variants for root-flavored notes or biological experiments, you know the limitations: those compounds often volatilize too quickly, giving unpredictable results, especially in room-temperature blending or moderate-pressure reactions. The hexyl group, by contrast, provides a slower evaporation rate, which is critical for timed-release formulations and long-duration screening.

    In agricultural chemistry and plant biology, researchers test a variety of isothiocyanates to screen bioactivity. Hexyl Isothiocyanate offers a unique balance: its moderate volatility allows it to remain active on surfaces or in vapor experiments long enough to observe effects, unlike butyl or ethyl isothiocyanates that fade out. We have direct feedback from academic partners involved in plant defense studies, who rely on the steady isothiocyanate release profile to model natural biological interactions. Manufacturing at source means we adjust impurity rejection based on feedback, not just routine certification.

    Practical Challenges We’ve Met Along the Way

    As direct producers, we face challenges unique to this compound. Isothiocyanates are notorious for skin, eye, and respiratory irritation. To reduce the risk of accidental releases, we constructed our plant with active ventilation and run all critical stages in enclosed glass systems. Building experience over several years has let us reduce operator exposure, shorten cleaning turnarounds, and minimize off-odors in neighboring facilities. Waste capture and neutralization protocols, tuned to the particular chemistry of hexyl derivatives, allow us to meet local and international safety requirements.

    On the distribution end, Hexyl Isothiocyanate sometimes faces mishandling in transit due to limited chemical compatibility of packaging materials. Early in our manufacturing, we had issues with soft plastics leaching or bottle caps corroding under vapor load. Now, bottles use flame-dried glass and PTFE-lined caps. Each bottle undergoes leak testing and is overpacked with absorbent materials, cutting down on the risk of vapor exposure during shipping. These practical details prove their value in feedback from research buyers who receive our product without surprise odors or contamination.

    Supporting Innovation: Communication from the Factory Floor

    We understand the day-to-day realities researchers and formulators encounter because we have spent years on the front line of chemical production. It isn’t enough to offer a product that “meets specifications.” Feedback loops matter. In one case, a flavor house requested a batch with even lower sulfur-related impurities, which prompted us to adapt our post-reaction washing sequence. This led to a more robust final fraction with cleaner top-notes, confirming in repeated applications across several brands.

    Another specialty chemicals company found that a higher-wax content contaminant, undetected by ordinary analysis, was interfering with their experiments. They sent us trial samples that allowed us to trace the contaminant back to unfiltered side fractions created when local temperatures fluctuated. We reinforced our cooling loop insulation to stabilize conditions and reduced that contaminant peak in subsequent batches. Field-driven improvements like this aren’t possible without full oversight of the production chain.

    Addressing Regulatory Demands with Practical Know-How

    Direct chemical manufacturing brings regulatory scrutiny. Over the years, our facility inspections have grown from occasional reviews into a routine part of our operation. Inspectors check for not only product safety but also environmental controls and traceability. Our documentation runs from detailed batch synthesis records to standardized chain-of-custody logs. Each batch of Hexyl Isothiocyanate we ship can be traced to its starting chemical lot and production date, which reassures partners in regulated industries.

    Beyond paperwork, we undergo regular wastewater and air quality reviews. Every production shift enters emissions records and conducts leak-point surveys. When process vents detect minor releases, we intercept and neutralize them in real time, maintaining clean air for both our team and the surrounding community. These hands-on strategies matter more than any certificate; we know we’re meeting real-world safety and environmental standards, not just technical minimums.

    Listening and Responding – Building Product Knowledge from Use

    End-users of Hexyl Isothiocyanate bring unique, sometimes unexpected challenges. One research institute discovered a non-volatile impurity that standard tests missed. They sent us their analysis, which showed a small but consistent interference with their biological assays. We worked with them to adjust the phase-separation step in our washing protocol, fine-tuning the partitioning of trace components. By implementing a new rinsing cycle with a lab-proven solvent combination, we helped raise their yield in bioactivity testing.

    For companies scaling up from bench studies to pilot plant syntheses, minimizing production disruption is critical. We offer batch reservations and phased deliveries to match their schedule, reflecting our understanding that research timelines often change without warning. Running smaller custom lots lets partners experiment without unnecessary inventory costs or waste. Sharing data openly and following up with users ensures the product continues to meet their evolving technical targets, not just those set by us.

    Why Direct Manufacturing Matters for Quality and Reliability

    Every container of Hexyl Isothiocyanate that leaves our facility has passed scrutiny at every level of production. That means multi-stage chromatography, detailed impurity trending, and direct smell checks from trained staff. We build in redundancies so that the occasional raw material lot deviation does not cascade into missed shipment deadlines or product recalls.

    Unlike generic chemical distribution, where repackaging or third-party relabeling can introduce unknowns, our bottles go straight from our hands to yours. On those rare occasions when customers flag an off-odor or unexpected analytical spike, we recheck historical control charts and, if needed, rerun the batch under tighter controls. Responsibility runs through all stages of our operation, not just at final release.

    Looking Ahead: Continuous Improvement Drawn from Experience

    Our trajectory as a manufacturer has always depended on adaptation. As new applications for Hexyl Isothiocyanate appear in biotechnology, pest management, or crop protection, user feedback shapes our process changes in real time. Chemists contact us about pilot studies or propose tests for yet-undocumented pathways. We don’t treat these as distractions; instead, they open the door to technical improvements. Improvements in reflux control, reaction temperature uniformity, and packaging innovations are driven by conversations with those who use our product in non-standard ways.

    Sustainability is another incentive. In the past, bulk production processes produced unavoidable solvent waste. By investing in solvent recovery and distillation, we’ve cut down on fresh solvent use and disposal costs for both us and our downstream partners. By listening to end-users who require tightly controlled impurity profiles, we are able to experiment with greener solvents and lower-impact production tweaks without sacrificing performance.

    Summary: Reliable Supply from Direct Origin

    Over time, we have seen that reliability, performance, and regulatory compliance grow strongest at the source. Every gram of Hexyl Isothiocyanate is produced by experienced operators who know the consequences of shortcuts or missed details. Our approach avoids generic statements and gets down to the specific, practical points raised by users—whether they develop flavors, run analytical chemistry, or build research compounds. The difference comes from manufacturing expertise, routine investment in process improvements, and a willingness to respond to practical needs as they arise.

    As manufacturers, we are always looking for feedback from the bench, the production floor, and the field. Direct relationships mean better support for your technical needs, more responsive improvements, and steadier supply, batch after batch. We welcome direct communication to make Hexyl Isothiocyanate work for new and demanding applications.