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Glyoxylic Acid Monohydrate

    • Product Name Glyoxylic Acid Monohydrate
    • Alias Oxalaldehydic acid
    • Einecs 224-641-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    278358

    Chemical Name Glyoxylic Acid Monohydrate
    Cas Number 563-96-2
    Molecular Formula C2H2O3·H2O
    Molecular Weight 106.05 g/mol
    Appearance White crystalline solid
    Melting Point 50-54°C
    Boiling Point Decomposes before boiling
    Solubility In Water Freely soluble
    Odor Slight, pungent
    Density 1.46 g/cm³
    Ph 1.0 (50 g/L, 20°C)
    Storage Condition Store in a cool, dry, well-ventilated area

    As an accredited Glyoxylic Acid Monohydrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White plastic bottle, tightly sealed, with hazard labeling, containing 500g Glyoxylic Acid Monohydrate; features clear product, batch, and safety information.
    Shipping **Shipping Description for Glyoxylic Acid Monohydrate:** Glyoxylic Acid Monohydrate should be shipped in tightly sealed containers, stored in a cool, dry, and well-ventilated area. Handle with care, avoid exposure to heat or direct sunlight. Label packages clearly, noting it is corrosive and may cause irritation. Comply with local and international transportation regulations.
    Storage **Glyoxylic Acid Monohydrate** should be stored in a cool, dry, well-ventilated area away from direct sunlight and incompatible substances such as strong oxidizing agents and bases. The container should be tightly closed and clearly labeled. Store at room temperature and avoid moisture exposure to prevent clumping or degradation. Ensure suitable spill containment and access to safety equipment.
    Application of Glyoxylic Acid Monohydrate

    Applications of Glyoxylic Acid Monohydrate in Industrial Manufacturing

    Glyoxylic Acid Monohydrate serves as a key intermediate and building block for multiple industrial sectors, supporting the synthesis of specialty chemicals, personal care actives, and high-value pharmaceutical intermediates. As a direct manufacturer, we deliver consistent grade and supply chain control to meet the stringent requirements in these diverse downstream fields.

    1. Pharmaceutical Intermediate Synthesis

    This material acts as a core feedstock in the fine chemical synthesis steps for several APIs and advanced pharmaceutical intermediates. It participates in condensation and oxidation reactions critical for assembling active structures such as amoxicillin side chains and other β-lactam antibiotics. Manufacturers operating under strict regulatory scrutiny value its reliable purity and controlled trace profile, which minimize batch rejection risk in regulated drug facilities.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP/NF and Ph. Eur. Monographs (for finished APIs)
    • EU EMA Guidelines for Starting Materials
    • FDA 21 CFR Part 211 and Part 210

    Typical usage ratio

    • 0.7–1.8 molar equivalents per target intermediate, adjusted according to target molecule and reaction pathway optimization; often determined by substrate and conversion yield studies.

    Downstream process integration

    • Incorporated during heterocyclic ring synthesis, direct amidation, and carboxylation steps for β-lactam and cephalosporin derivatives.

    Final product types

    • Amoxicillin intermediates
    • Clavulanic acid side chains
    • Quinolone core intermediates
    • Piperazine and phenylglycine derivatives

    2. Personal Care and Hair Treatment Manufacturing

    In the personal care industry, manufacturers use glyoxylic acid monohydrate in controlled formulations for keratin hair treatment and straightening products due to its aldehyde functionality, which reacts with hair proteins to rebalance cross-link arrangements. Stability and minimal residual contamination are critical for producers targeting global regulatory acceptance and consumer safety certifications.

    Industry compliance standards

    • EU Cosmetic Regulation (EC) No 1223/2009
    • U.S. FDA Title 21 CFR 700.3 and 700.11
    • China National Standard GB 7916 (Cosmetic Safety Technical Specification)
    • ISO 22716: Cosmetics — GMP Guidelines

    Typical usage ratio

    • 3–6% by weight in finished hair formulation, depending on hair type and target straightening/softening effect; adjustments based on efficacy and irritation patch testing.

    Downstream process integration

    • Directly blended into pre-neutralized aqueous phases before emulsification; pH is precisely monitored and brought to 1.0–2.0 for effective crosslinking.

    Final product types

    • Professional hair straightening creams
    • Anti-frizz smoothing fluids
    • Multi-week keratin treatment emulsions
    • Thermal hair restructuring sprays

    3. Aroma and Flavor Ingredient Production

    Producers of synthetic aroma and flavor compounds apply glyoxylic acid monohydrate in the formylation and controlled oxidation of aromatic aldehydes. This step supports the high-yield production of key flavor molecules such as vanillin and ethylvanillin. Tight odor profile control and low impurity backgrounds are essential to gain acceptance in FSSC 22000 and other food-grade certifications.

    Industry compliance standards

    • FAO/WHO JECFA Food Additive Specifications
    • FSSC 22000 Food Safety System Certification
    • U.S. FDA 21 CFR 172 (Food Additives Permitted for Direct Addition to Food for Human Consumption)
    • EU Regulation (EC) No 1334/2008 on Flavorings

    Typical usage ratio

    • 1.1–1.3 moles per mole of target aldehyde, fine-tuned based on desired yield and downstream purification efficiency.

    Downstream process integration

    • Added during intermediate oxidation steps after precursor alkylation; controlled reaction temperature and pH are critical for product consistency and minimal by-product generation.

    Final product types

    • Vanillin crystals and powders
    • Ethylvanillin granules
    • Aromatic aldehyde-based flavor concentrates
    • Complex blended food flavors

    4. Agrochemical Intermediate Manufacturing

    Producers of select herbicides and plant growth regulators employ glyoxylic acid monohydrate to introduce reactive formyl and carboxyl moieties into target scaffolds. High batch purity and conformity to global hazard communication protocols are critical, as downstream agrochemical products require traceability and regulatory acceptance for use in food cropping and land management sectors.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • FAO/WHO International Code of Conduct on Pesticide Management
    • China GB/T 1600-2001 (General Requirements for Pesticide Technical Material)
    • ISO 9001:2015 for quality management in chemical synthesis

    Typical usage ratio

    • 0.5–1.2 mol or weight equivalent per synthesis batch, adjusted for the targeted active molecule’s conversion pathway and recovery yield.

    Downstream process integration

    • Introduced post-alkylation for aldol condensation or carboxylation reactions to construct phenoxyalkanoic acids and related actives.

    Final product types

    • Mecoprop (MCPP) intermediates
    • Chlorophenoxy herbicide precursors
    • Plant growth regulator synthetics
    • Selective weed control actives

    5. Crosslinking Agent for Waterborne Resin and Coating Manufacturing

    Manufacturers of high-performance resins and specialty coatings utilize glyoxylic acid monohydrate as a mild crosslinker and functionalizing agent for acrylic, alkyd, and polyurethane resin systems, especially in aqueous formulations. Batch-to-batch consistency, metal impurity thresholds, and compatibility with downstream waterborne emulsion polymerization stand as central requirements to achieve product qualification in demanding architectural and industrial projects.

    Industry compliance standards

    • ASTM D7066/EN ISO 12944 for industrial coatings
    • EU Regulation (EC) No 1907/2006 (REACH) – Registration and safe handling
    • US EPA VOC regulations for coatings
    • ISO 9001:2015 for quality management during resin synthesis

    Typical usage ratio

    • 0.3–1.0% w/w of resin solids per acrylic or alkyd batch; customized based on desired crosslink density and final mechanical properties.

    Downstream process integration

    • Dosed in post-polymerization blending; in multi-step processes, added during final pre-neutralization before anti-settling agents to ensure resin matrix uniformity.

    Final product types

    • Waterborne acrylic architectural coatings
    • Corrosion-resistant industrial resin finishes
    • Low VOC gloss paints
    • Functionalized emulsion binders for specialty applications
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    Certification & Compliance
    More Introduction

    Glyoxylic Acid Monohydrate: A Closer Look at a Trusted Chemical Building Block

    Direct Insights from Our Manufacturing Experience

    Every batch of Glyoxylic Acid Monohydrate leaving our production plant reflects years of technical refinement. Our team continuously tracks shifts in market applications and feedback from industrial partners who rely on this compound for demanding chemical synthesis or specialty formulations. By tailoring our approach based on real production challenges, we see Glyoxylic Acid Monohydrate as far more than a formula on paper — it’s a versatile asset shaped by real-world use.

    Product Model and Consistent Specifications

    Our standard Glyoxylic Acid Monohydrate comes in a formulation that maintains tight purity controls. Acid content typically falls in the 50% range, a level that ensures both stability during shipping and strong reactivity in application. Crystallinity and moisture content remain consistent batch to batch because we monitor physical parameters at every step — not just before packaging. This focus matters when our partners formulate products for fine chemicals or pharmaceutical intermediates, where errors in concentration can disrupt entire production lines.

    While Glyoxylic Acid Monohydrate appears similar to glyoxylic acid solutions on paper, those who work with both see clear differences. Our monohydrate, which incorporates a single water molecule per molecule of glyoxylic acid, handles with less risk of evaporation loss than pure aqueous solutions. This structure balances reactivity and managed water content, avoiding the handling problems that come with purely anhydrous forms, which can destabilize in normal storage conditions. Our technical team has run side-by-side trials, confirming that relying on monohydrate grades lowers rework in sensitive downstream applications — particularly where concentrations must remain linear for catalytic reactions or finescale polymer creation.

    Usage Backed by Daily Industry Practice

    Chemical production facilities often ask why Glyoxylic Acid Monohydrate sees such broad use across tanning, cosmetics, agrochemicals, and pharmaceutical manufacturing. Through practical experience, we’ve learned its true value comes from its duality: strong as an aldehyde and stable as a carboxylic acid. Whether modifying amino acids, acting as a reagent in the synthesis of vanillin, or shaping ingredients for hair care, it functions both as an oxidizing agent and a carbon source. On our lines, technical operators rely on its predictable reaction path — once the material reaches the reactor, side reactions stay manageable, and separation steps run on schedule. Many years of shipment tracking show that customers using our monohydrate report fewer batch inconsistencies and longer shelf life than when they substitute lower-purity alternatives.

    Some clients ask about direct comparison with glyoxylic acid solution (40% aqueous) or anhydrous glyoxylic acid powder. Based on repeated production tests, our monohydrate delivers better weighing precision for large-scale synthesis than solutions, which can fluctuate through water loss or over-concentration. The monohydrate’s crystalline form pours easily and dissolves quickly in most solvents, cutting prep time in chemical process lines. Chemists in resin formulation and aroma chemical synthesis have shown that monohydrate’s particular water content actually benefits certain condensation reactions, where a small, predictable moisture level helps drive desired yields while preventing localized overheating or foaming.

    Understanding Product Differences Through Hands-On Use

    Distinguishing Glyoxylic Acid Monohydrate from similar products means looking beyond paper specifications. In our day-to-day manufacturing environment, each batch demonstrates how subtle differences in structure or water content affect future reactions. Glyoxylic acid solutions, often used for easier pumping, require vigilance against concentration drift. Solvent evaporation over time, combined with handling losses, raise costs and can derail timed processes; end users in fine chemical synthesis have reported yield drops due to incidental water loss or acid degradation in the storage tank. Powdered glyoxylic acid, while easy to measure, can introduce dust or unpredictable static charge, impacting batching safety and slowing down automated weigh-in units.

    Glyoxylic Acid Monohydrate, by contrast, strikes a balance. Our workers appreciate its manageable texture — neither too dry nor overly moist — which flows easily without caking. Production engineers have told us that, compared to solution grades, the monohydrate resists deliquescence in humid environments and keeps working surfaces cleaner, reducing cross-contamination risk in multi-chemical plants. This real-world feedback led us to refine our drying cycles and storage packaging, ensuring each drum holds its consistency for months, even in less-than-perfect warehouse conditions.

    Reliable Handling and Safer Storage: A Factory Perspective

    Handling experience counts for a great deal in bulk chemical manufacturing. Glyoxylic Acid Monohydrate supports seamless scale-up: pallets move straight from cold storage to the blending line without clumping, jamming, or absorbing atmospheric moisture. Operators find that personal protective equipment holds up longer, and surrounding hardware needs less frequent wash-down than after working with the liquid solutions, which tend to drip or splash. Any time process teams can drop a measured scoop into a reaction vessel with confidence means less downtime overall, a difference that builds trust between production shifts and technical staff.

    On logistics runs, especially for exports, our own test shipments show the monohydrate endures much wider temperature swings than either fully hydrated solution or anhydrous powder. We document each lot’s integrity from plant gate to customer warehouse to prove it. Safety managers also highlight that off-gassing potential remains lower, reducing storage hazards and simplifying long-term warehousing protocols.

    Production Consistency: Meeting Functional Demands

    From a producer’s perspective, no spec sheet captures the way impurities can undercut efficiency. Our teams draw sample after sample throughout the drying, crystallization, and packaging stages, checking for trace formaldehyde, oxalic acid, and insoluble residues. Analytical labs give us hard numbers, but it’s the reduction in after-complaints from industrial accounts that signals our process is working as intended. Clients formulating in the electronics and agricultural sectors demand that trace contamination remain low — not just for regulatory compliance, but to prevent corrosive side reactions on their lines or negative product outcomes. We fine-tune reaction endpoints and washing protocols, sometimes adjusting in real time based on observed plant conditions, not just historical lab data.

    By minimizing batch-to-batch drift in both active acid content and water of crystallization, our Glyoxylic Acid Monohydrate delivers the same effect through every drum. Companies needing to scale outputs swiftly — or switch between product lines with minimal scrap — have confirmed that this consistency builds workflow reliability and boosts overall plant productivity.

    Sustainability in Chemical Manufacturing

    The chemical industry faces mounting expectations around environmental stewardship, from both local communities and international regulators. In the case of Glyoxylic Acid Monohydrate, our plant operations audit and reuse effluents at several points, maximizing the use of starting raw materials. Reaction pathways produce fewer greenhouse outflows compared to solution-grade glyoxylic acid, which often involves higher-energy distillation and more packaging for the same useful output. Our plant design collects process heat for other onsite utilities, reducing the total carbon footprint per ton shipped. We disclose solvent and water consumption figures to major clients on request and welcome third-party audits to verify our claims. These practical advances matter to clients seeking not just cost control, but a verified reduction in environmental impact.

    Chemicals like Glyoxylic Acid Monohydrate also support wider industry shifts to green chemistry. In many cases, downstream production relies on this reagent to create biodegradable or low-hazard intermediates — a key reason our sustainability audits focus on full product traceability and the elimination of persistent organic pollutants from our streams. Each improvement in yield or waste management at our end yields positive ripple effects throughout the global supply chain, as we see from our partners’ year-on-year sustainability targets and end-of-year audits.

    Market Shifts and End User Preferences

    Over the last decade, our order book for Glyoxylic Acid Monohydrate has tracked changing priorities across sectors. Early on, the bulk went to traditional applications like tanning agents and specialty aroma synthesis. In recent years, a growing share supports demand from cosmetic ingredient makers, who value the monohydrate for its fine granulation and stability, as well as from pharmaceutical plants seeking high-purity inputs for API synthesis. Many of these clients transitioned from solution forms in favor of better process control and less transportation cost per unit of active acid.

    Feedback from long-standing production partners shaped much of our modernization program. For example, vinyl resin and water treatment chemical producers pushed for larger drum sizes and new antistatic liners after reporting transport losses with powdered grades. We redesigned packaging workflows accordingly, and now see order cycles that run more smoothly, with few material loss claims at the receiving dock. As market standards evolve — especially around product stewardship and transparency — our customers demand both technical reliability and documentable chain-of-custody records, which we support by embedding traceable lot information and compliance certs into every outgoing shipment.

    Supporting Advanced Applications

    The reach of Glyoxylic Acid Monohydrate continues to expand with new chemical technologies. In recent innovation projects, peptide and chelating agent manufacturers have explored its utility for coupling reactions, where the monohydrate supports faster throughput while maintaining high selectivity. Its clean crystallization pattern makes post-reaction separation less laborious. Analytical chemists at our partner facilities highlight that our refined product line maintains consistently low background color and metal content, critical for electronics and fine chemistry work, where such impurities can skew sensitive analytical results.

    In agriculture, product developers rely on our monohydrate for stable herbicide, fungicide, and plant growth regulator synthesis. Since reactivity depends not just on acid content but on trace element balance, we tailor our raw material sourcing to anticipated downstream needs, shifting input streams where necessary so that finished products align with current agronomic standards.

    Training and Technical Support for Safe Usage

    Reliability isn’t just about what’s in the drum. Over the years, we’ve refined onboarding guides and technical support lines based on genuine field feedback. New plant installations can access our team directly for usage advice, storage practice recommendations, and even live troubleshooting. As production staff rotate in and out, especially at high-turnover sites, our updated handling standards — drawn from direct learning within our plant — help customers maintain safety records and process stability.

    For process engineers tackling unique blending or batch scale-up challenges, our collaboration continues long after the first drum lands. We’ve supported retrofits of injection systems and helped recalibrate automated dosing modules that stumbled with solution-based grades but run smoothly on the monohydrate. This ongoing exchange of real data between supplier and user forms the backbone of practical chemical stewardship throughout the supply chain.

    Long-Term Value and Trust Through Direct Manufacturing

    By running our own dedicated production lines for Glyoxylic Acid Monohydrate, we keep direct oversight of quality, safety, and efficiency. Whenever we update processes — from solvent capture to packaging ergonomics — results show up in fewer customer complaints or product scoping issues. Facility tours for site partners highlight both the large-scale reactors and the skilled hands guiding the process, reflecting a balance between automation and practical plant experience.

    Being the manufacturer means we have an inside track on lot tracing, adjustment of production parameters, and rapid refinement of quality specs in response to end-user demand. In this way, we view our role not as a distant source of material, but as an active participant in our clients’ technical and commercial growth. Each successful application, every higher-yield batch reported from our partners, feeds back lessons that shape our ongoing operational roadmap — making Glyoxylic Acid Monohydrate not just a chemical, but a shared foundation for high-performance industrial chemistry.

    Industry-Wide Challenges and Our Ongoing Solutions

    Despite its reliability, manufacturing Glyoxylic Acid Monohydrate brings new hurdles each year. Fluctuations in raw material supply, rising scrutiny from environmental regulators, and changing downstream production demands all shape our operations. Rather than responding reactively, we invest upstream: securing alternate sourcing, negotiating long-term supply contracts, and building in redundancy to avoid production bottlenecks. On the environmental front, we model our waste minimization programs on global best practices and publish emissions data for stakeholder review, continuing to keep our operating license above reproach.

    Industrial innovation never stands still. We run pilot trials with advanced drying and crystallization units, aiming for lower energy use and even tighter spec controls, so production partners enjoy lower costs and higher quality. Each investment arises not from theoretical gains, but from proven production line learning. These advancements let us keep pace with the ever-shifting needs of industries that trust our Glyoxylic Acid Monohydrate — whether they’re formulating trusted legacy products or experimenting with the next generation of specialty chemicals.

    Final Thoughts on Shared Progress

    For us, Glyoxylic Acid Monohydrate stands as a demonstration of the ongoing partnership between manufacturer and end user. Every production shift, technical support call, and collaborative problem-solving session speaks to the evolving needs of chemical producers. As we listen to market feedback and see firsthand how real chemistry unfolds on the plant floor, we reinforce our commitment to consistency, safety, and meaningful progress for every shipment delivered.