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Furfuryl Thioacetate

    • Product Name Furfuryl Thioacetate
    • Alias 2-acetylsulfanyl-1-furanyl
    • Einecs 410-060-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    223438

    Cas Number 13678-66-5
    Molecular Formula C7H8OS2
    Molecular Weight 172.27 g/mol
    Iupac Name 2-furylmethyl thioacetate
    Appearance Clear yellow to brown liquid
    Boiling Point 260-262 °C
    Density 1.202 g/cm³
    Refractive Index 1.573-1.577
    Solubility Soluble in organic solvents, insoluble in water

    As an accredited Furfuryl Thioacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Furfuryl Thioacetate is supplied in a 100g amber glass bottle with a secure screw cap, labeled with full hazard and handling information.
    Shipping Furfuryl Thioacetate should be shipped in tightly sealed containers, protected from light, heat, and moisture. Handle as a hazardous chemical—avoid contact with incompatible substances and ignition sources. Follow all local, national, and international transport regulations. Ensure clear labeling and include proper documentation for safe and compliant shipping.
    Storage Furfuryl thioacetate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizing agents. Protect it from moisture, direct sunlight, and heat. Ensure proper labeling and store in a chemical storage cabinet designed for flammable or reactive liquids. Use secondary containment to prevent leaks or spills.
    Application of Furfuryl Thioacetate

    Applications of Furfuryl Thioacetate in Industrial Manufacturing

    Furfuryl thioacetate finds targeted use in advanced chemical synthesis and specialty chemical production. As the direct manufacturer, we provide consistent quality, traceability, and technical data for qualified downstream industrial users. The following application fields present established industrial scenarios based on compliance, manufacturing integration, and actual end products.

    1. Pharmaceutical Intermediate Synthesis

    Furfuryl thioacetate acts as a sulfur-donating building block in the synthesis of sulfur-containing heterocyclic pharmaceutical intermediates. Its structure supports specific thiolation reactions and is favored in critical steps where stability and controlled reactivity are required. Manufacturers use it for scalable, reproducible modification, minimizing byproducts and reducing downstream purification complexity.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • USP/NF monographs for intermediates compliance
    • 21 CFR Part 211 for process and documentation control in pharmaceutical manufacturing
    • REACH Annex XVII for chemical handling and environmental safety

    Typical usage ratio

    • 0.8 – 2.4 molar equivalents relative to precursor substrate, adjusted per reaction yield and byproduct target

    Downstream process integration

    • Introduced during mid- to late-stage synthesis after core structure construction, enabling sulfur atom incorporation via direct alkylthio group transfer
    • Applied in single-pot or staged thiolation under base- or acid-catalyzed conditions depending on molecular context

    Final product types

    • Active pharmaceutical ingredient (API) intermediates for anti-infectives
    • Custom sulfur-containing heterocycles
    • Key fragments for anti-inflammatory agents
    • Patent-protected research compounds

    2. Agrochemical Intermediate Production

    Chemical manufacturers select furfuryl thioacetate as a sulfur donor for the synthesis of thiophene-based and related agrochemical active intermediates. Its application streamlines synthesis routes by enabling high conversion rates, improving step economy in the creation of pesticide and fungicide core structures. Its use also supports rigid documentation for regulated agrochemical production.

    Industry compliance standards

    • FAO/WHO Good Laboratory Practice (GLP) for technical grade synthesis
    • ISO 9001:2015 Quality Management Systems for batch production
    • GHS/CLP Regulation (EC) No 1272/2008 Labeling and Hazard Communication
    • OECD guidelines for testing of chemicals

    Typical usage ratio

    • 2 – 4% by mass relative to total reaction feed, modulated depending on product target and reagent excess required for conversion

    Downstream process integration

    • Added in closed reactor systems under inert atmosphere, typically at moderate temperature during sulfur incorporation phase
    • Primarily functions prior to final ring closure of target active intermediates

    Final product types

    • Precursor molecules for thiophene-based insecticides
    • Sulfur-substituted pesticide synthesis intermediates
    • Industrial grade fungicide actives
    • Herbicide intermediate compounds

    3. Aroma and Flavor Ingredient Manufacturing

    Furfuryl thioacetate is present in the formulation of aroma and flavor ingredients, particularly as a sulfurous note-enhancer for savory or roasted profiles. Supply to this field involves precise documentation and batch traceability. Its molecular structure provides unique olfactory character at low inclusion rates, contributing to food-contact mixture formulations for regulated flavoring production.

    Industry compliance standards

    • FDA 21 CFR Part 172.515 for synthetic flavoring substances and adjuvants
    • IFRA (International Fragrance Association) Standards Amendment compliance for perfumery
    • EU Regulation (EC) No 1334/2008 on flavorings and certain food ingredients
    • Food Chemicals Codex (FCC) standards for trace impurity control

    Typical usage ratio

    • 0.01 – 0.1% mass/volume in finished flavor concentrate; lower end for direct use, up to maximum for complex blends

    Downstream process integration

    • Used during compounding of core flavor bases or topnotes, introduced under controlled mixing at defined stage
    • Incorporated before homogenization and stabilization, included in GC/MS analysis for quality release

    Final product types

    • Maillard-type savory flavor mixtures
    • Roasted nut, coffee, or caramel flavoring agents
    • Specialty food-grade aroma compositions
    • Blended fragrances for use in baked goods or beverages

    4. Polymer Crosslinking & Modification Additives

    Specialty resin formulators utilize furfuryl thioacetate as a functional crosslinker or as a chain transfer agent, especially in thiol-ene and related sulfur-modified polymer chemistries. Its structure enables specific tuning of polymer mechanical and chemical resistance properties. Entry into this sector requires adherence to industrial polymer standards, supply documentation, and real-time QC for batch performance testing.

    Industry compliance standards

    • ISO 9001:2015 for production traceability and QC
    • ASTM D638 for mechanical property evaluation of finished polymer specimens
    • REACH Registration (EC) No 1907/2006 for supply to EU polymer sector
    • ISO 14001:2015 for waste and emission management in chemical processing

    Typical usage ratio

    • 0.5 – 3.0% by mass of resin precursor, adjusted based on crosslink density requirements and product formulation type

    Downstream process integration

    • Added during in-situ modification of prepolymers or as co-monomer during bulk, solution, or emulsion polymerization
    • Enables control of sulfur crosslinks, improves heat resistance and solvent stability in finished materials

    Final product types

    • High-performance furan-based thermoset resins
    • Sulfur-crosslinked rubber compounds
    • Anti-corrosive polymer linings
    • Advanced composite matrix systems
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    Certification & Compliance
    More Introduction

    Furfuryl Thioacetate: Precision Chemistry for Demanding Applications

    Meeting Real-World Demands in Chemical Manufacturing

    Working hands-on in chemical production for years teaches a person that real value comes from understanding not just the structure of a compound, but how it behaves on the manufacturing floor and inside customer processes. Furfuryl Thioacetate, unlike many sulfur-containing organics, brings together a delicate balance of furan chemistry and thioester functionality in a way that opens up tailored applications, especially where both reactivity and stability matter.

    We produce Furfuryl Thioacetate as a colorless to pale yellow liquid, with a molecular structure featuring both a furan ring and a thioester group. The synergy of these functionalities allows for unique chemical transformations that set this product apart from either simple furans or common thioacetates. Over repeated synthesis and in large-scale batches, we have witnessed a consistency in chemical integrity that directly impacts downstream product yields for our clients, whether they are in pharmaceuticals, specialty polymers, or advanced material synthesis.

    Understanding the Heart of Furfuryl Thioacetate’s Performance

    At the bench and in tonne-scale reactors, the choice of Furfuryl Thioacetate often comes down to reactivity—how it opens opportunities for carbon-sulfur coupling, and how the furan ring introduces aromaticity without the steric bulk found in phenyl substitutes. Colleagues developing new ligands for catalysis, or experimenting with sulfur-based curatives for high-performance elastomers, have relayed how the compound delivers both speed and selectivity in reactions. Compared to less functionalized thioesters, Furfuryl Thioacetate consistently produces cleaner conversion pathways and leaves fewer side products interfering with complex reaction mechanisms.

    Our current batches meet stringent quality thresholds. Analysts frequently check for trace contaminants that can throw off sensitive organometallic processes, and every drum leaving our facility carries a certificate reflecting both purity and chromatographic profile. This focus on chemical cleanliness earns trust with research chemists and process engineers.

    Specification That Reflects Real-World Needs

    Each lot of Furfuryl Thioacetate we manufacture is crafted for high purity, usually above 98%, based on rigorous gas or liquid chromatography. Technical teams use both visual and instrumental verification, as color shifts can indicate oxidation that might not always register immediately in automated QC. Our feedback loop with clients often spurs incremental improvements, such as more robust packaging that blocks light and moisture, after seeing how trace hydrolysis impacts shelf stability. These are the hands-on lessons that shape every new run.

    The boiling point usually ranges around 100-102°C at reduced pressure, which allows for gentle distillation during scale-up synthesis, keeping thermal decomposition in check. Unlike some mercaptans or thioesters, Furfuryl Thioacetate avoids the overpowering malodor that sometimes leads to headaches during plant-scale operations. Full solubility in organic solvents like dichloromethane or ethyl acetate gives formulators flexibility, especially when blending with other heterocyclic precursors or sulfur donors.

    Real-World Usage: What Sets Us Apart

    Chemists tackling synthesis problems often look for a building block that brings more than the sum of its parts. Furfuryl Thioacetate consistently stands out in this respect—used both as a sulfur source and an aromatic precursor, it solves bottlenecks in multi-step processes where others give out. Research groups building thioether linkages into polymers have told us they see improved molecular weight control and reproducibility. In flavor and fragrance intermediates, the interplay between furan and sulfur gives nuances that contribute to earthy, roasted notes, integrating smoothly without overpowering.

    During pharmaceutical synthesis, the lower reactivity of the furan ring—the result of electron delocalization—slows down unwanted side reactions, aiding in cleaner isolations. Our in-house scale-up experts learned early on that, compared to simple aliphatic thioacetates, product loss and byproduct formation both drop off when adjusting pH and solvent system for this particular molecule. Feedback from custom synthesis customers often points out that the product’s stability in both acidic and basic environments reduces unplanned shutdowns and helps keep projects on schedule.

    Comparisons That Matter in Real Processing

    Compared with more generic thioesters, Furfuryl Thioacetate picks up fewer impurities in synthesizing organosulfur intermediates. Lab teams under tight timelines see the benefit immediately: thin-layer chromatography and GC-MS analysis show fewer ghost peaks, letting purification teams finish batches faster and with less solvent use. Applications that once depended on acyl chlorides now run smoother and safer with Furfuryl Thioacetate, thanks to its lower volatility and higher flash point.

    Our ongoing dialogue with process chemists highlights new differences as well. For instance, during alkylation or ring-forming reactions, the furan backbone enables regiospecific substitutions; this often means more final product with less input waste. Many ‘traditional’ thioesters decompose or polymerize prematurely during high-shear mixing or mild heating, especially in the presence of acids. In contrast, our Furfuryl Thioacetate tends to withstand processing better, providing measurable increases in overall yield—up to 10-12% higher in some cases, according to customer feedback and joint pilot runs.

    Innovation Rooted in Experience

    Years in the plant have shown us that theoretical reaction yield means little if a chemical cannot withstand the realities of storage, transport, or unexpected shutdowns. Repeated feedback cycles taught us that Furfuryl Thioacetate responds well to changes in container lining materials, and that bulk tanks lined with polyethylene have consistently preserved product grade over several months. Temperature excursions and exposure to outdoor humidity both reduce shelf-life in other thioesters, but not to the same extent here—a result we tie back to the higher intrinsic stability of the furan ring against hydrolysis.

    Mid-scale formulators sometimes worry about scale-up hiccups, especially with sensitive intermediates like these. Recent pilot plant trials showed that recoveries above 96% are achievable with careful column setup—especially when closely managing residence time and flow rates. We’ve worked closely with these teams to adjust stirring speeds and phase-separation protocols, and we share these insights directly with clients, because we have wrestled with the same day-to-day technical sticking points ourselves.

    Supporting Advanced Synthesis Through Reliable Quality

    On the R&D side, Furfuryl Thioacetate’s functionality brings a degree of precision not matched by most alternatives. Researchers working on sulfur bridges for peptide mimetics note that reactivity control allows for late-stage functionalization without capping side groups prematurely. We support custom lot sizing and purity adjustments, because sometimes a formulation tweak reveals needs that only show up after moving from glassware to steel reactors. By collaborating on the ground level, we ensure product specs remain relevant for the shifting realities of advanced manufacturing.

    As demand for clean-label and sustainable processes increases, our technical staff review both supply chain and regulatory frameworks continually. All Furfuryl Thioacetate batches are produced using low-impact starting materials, and renewable furan sources factor into strategic planning so that raw material volatility has less downstream effect. Recent changes in local environmental guidelines led us to redesign certain wash protocols; this reduced aqueous waste by 15% while tightening discharge monitoring, showing again that product consistency grows from a total-process viewpoint.

    Operational Insights Drawn from Practice

    Those of us on the production line have learned over the years that every new synthesis brings unplanned challenges, and Furfuryl Thioacetate offers flexibility. Fine-tuning the cooling profile keeps batch crystallizations repeatable, which matters for clients relying on precise melting behavior. Hands-on technical service benefits from familiarity with detail—how line-pressure fluctuations disturb delivery rates, or how even minor solvent residue can change reactivity. Any manufacturer offering this product should emphasize reliable documentation, but practical know-how sets real producers apart: it moves from written specs into actionable results for our partners.

    Unpacking drums during a plant audit, lab staff flagged container residues. Rather than dismiss it, we traced it back to a shipment exposed to unexpected temperature swings during transit. Our ability to reconcile real-world observations with chemistry ensures that future batches leave the gate better protected. Over time, this culture of feedback supports long-term partnerships and drives incremental improvement, more than any theoretical best practice published in journals.

    Strategic Applications and Outcomes

    Beyond the technical chemistry, Furfuryl Thioacetate fits in specialized manufacture where the end-use defines the standard. In advanced adhesive manufacture, for instance, its blend of reactivity and mild odor profile makes it the backbone of sulfur-cured elastomeric adhesives for sectors like automotive sealing and electronics potting. Electroplating operations report better bath stability and more uniform deposition thanks to controlled release of sulfur-containing fragments at relevant currents and voltages.

    We work closely with partners deploying continuous flow systems, where precise metering of the thioacetate group prevents fouling and supports recycling of mother liquors. In these setups, the difference between consistent performance and downtime comes from deep process insight, reinforced by consistent supply and hands-on troubleshooting from our team. This level of responsiveness does not happen overnight—it develops from walking the plant floor, cross-checking field observations, and working through dozens of trial runs.

    Safety and Practical Concerns

    Operators sometimes lose sight of safety when focused on yield or batch time. Through hard experience, we have learned the actual hazards do not come from raw toxicity, but from long-term exposure to vapors and occasional skin contact due to thioester hydrolysis. We reinforce the importance of tight drum closures and proper venting, and all workers receive up-to-date protective training. This is not about ticking regulatory boxes—it comes from seeing corrosion creep up in unexpected valve seats and it underscores the value of practical experience.

    Maintaining separation from incompatible oxidizers and bases results in fewer surprises. Packaging design, informed by customer feedback, now prioritizes tight vapor barriers and standardizes on leak-proof closures, avoiding both off-gassing and loss of batch integrity. In practice, the low volatility also reduces fugitive losses compared to more aggressive thiols, keeping inventory predictable and workplace air quality intact.

    Continuous Improvement through Direct Engagement

    All feedback feeds directly into our product lifecycle. Sometimes this involves adjusting a solvent flush or swapping drum liners for longer shelf life. At other times, it means collaborating with a client’s own R&D team to co-optimize end-use parameters. Trust builds from these repeated, often small, improvements—they add up, and every successful tweak reinforces product reliability in ways that generic alternatives cannot achieve.

    By investing in pilot projects and open technical exchanges, we see how Furfuryl Thioacetate transforms from a line on a catalog into a real, valuable solution. Internally, staff share lessons learned so that every new process run benefits from hard-won experience. The aim remains not just to provide a product, but to grow alongside our customers as their manufacturing ambitions evolve.

    Summary of Insights Gathered Over Years of Manufacturing

    After many years refining both the chemistry and logistics of Furfuryl Thioacetate, our staff have come to respect its combination of stability, versatility, and performance. The product brings together a reactive sulfur source and a functionalized furan in a way no straightforward thioester or furan can fully replicate. Buyers who come for the molecular attributes often find that reliability, adaptability, and responsive service separate great manufacturers from the rest of the field. Technology shifts, market needs shift, but hands-on experience always enriches both the product and the professional relationships that surround it.

    In summary, Furfuryl Thioacetate remains a go-to solution for teams seeking better yields, cleaner reactions, and dependable supply. Each batch carries the imprint of real-world knowledge, continuous adaptation, and the relentless pursuit of better outcomes. This is not just another chemical on a list—through years of direct production and unfiltered customer honesty, we know how to deliver a level of value that theory alone can never match.