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Fumaronitrile

    • Product Name Fumaronitrile
    • Alias Fumaronitrile
    • Einecs 204-701-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    123463

    Iupac Name Fumaronitrile
    Molecular Formula C4H2N2
    Molar Mass 78.08 g/mol
    Appearance White to off-white crystalline powder
    Cas Number 764-42-7
    Melting Point 109-112 °C
    Boiling Point 220 °C (decomposes)
    Density 1.20 g/cm³
    Solubility In Water Slightly soluble
    Smiles C(C#N)=C(C#N)

    As an accredited Fumaronitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Fumaronitrile is packaged in a sealed amber glass bottle, labeled 100 grams, with hazard symbols and safety information clearly displayed.
    Shipping Fumaronitrile should be shipped in tightly sealed containers, protected from moisture and incompatible substances. Handle with care and label as hazardous. Follow local, national, and international regulations for chemical transport. Use appropriate packaging, such as UN-approved containers, and include proper documentation. Store and ship in a cool, dry, and well-ventilated area.
    Storage Fumaronitrile should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers and acids. Keep it protected from moisture and direct sunlight. Ensure that storage areas are clearly labeled and have appropriate containment to prevent spills or leaks. Personal protective equipment should be worn when handling this chemical.
    Application of Fumaronitrile

    Applications of Fumaronitrile in Industrial Manufacturing

    Fumaronitrile is a specialty raw material with a well-established role in various chemical synthesis workflows, especially as an intermediate for pharmaceutical, agrochemical, dye, and specialty polymer production. The following sections outline the specific downstream application segments, including compliance considerations, practical formulation data, details on process integration, and real-world finished product types manufactured by industry customers.

    1. Active Pharmaceutical Ingredient (API) Synthesis

    Major pharmaceutical manufacturers use fumaronitrile as a key synthon in the multi-step building of heterocyclic drug intermediates. It commonly serves as a dinitrile feedstock in the synthesis of anti-viral, anti-cancer, and cardiovascular APIs due to its reactivity for generating bioactive scaffolds. Controlled cGMP environments strictly govern each use, requiring precise specification adherence and trace impurity management during all critical synthesis steps.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 211 for Finished Pharmaceuticals
    • European Pharmacopoeia (Ph. Eur.) monographs & EudraLex Volume 4
    • Chinese Pharmacopoeia (ChP) for intermediates and final APIs

    Typical usage ratio

    • 0.5–2.5 molar equivalents per target API batch; precise ratio depends on stoichiometry of multi-step synthesis and intermediate purification yield requirements.

    Downstream process integration

    • Introduced in the initial condensation or cyclization step, often under inert conditions and strict temperature control; further processed by hydrolysis, reduction, or nucleophilic addition depending on target structure.

    Final product types

    • Anti-viral intermediates (e.g., purine or pyrimidine derivatives)
    • Anti-cancer drug pre-stages (e.g., imidazole or quinoxaline compounds)
    • Cardiovascular agent intermediates
    • Complex heterocyclic ring systems used in advanced medicines

    2. Agrochemical Intermediate Production

    Leading crop protection manufacturers rely on fumaronitrile during the synthesis of specialty nitrile-based herbicides and fungicides. Its high nitrile functionality enables downstream transformation to novel pesticidal actives via catalytic and nucleophilic routes, while manufacturers must adhere closely to residue and impurity limits set by international regulatory bodies for safe use in agriculture.

    Industry compliance standards

    • FAO/WHO pesticide specifications (e.g., JMPR, JMPS)
    • EU Regulation (EC) No 1107/2009 for plant protection products
    • EPA FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act) requirements
    • ISO 9001:2015 for agrochemical intermediate quality control

    Typical usage ratio

    • 5–15% w/w within the active intermediate synthesis stream, depending on the molar demand of the end agrochemical and the conversion yield in nitrile-to-amidine or nitrile-to-amide stages.

    Downstream process integration

    • Dosed during the initial coupling or ring closure phase of active ingredient synthesis; subjected to catalytic hydrogenation, hydrolysis, or chlorination for conversion to final pesticide skeletons.

    Final product types

    • Herbicidal pre-products (e.g., dinitrile-based heterocycles)
    • Fungicidal intermediates for triazole and strobilurin classes
    • Post-emergent weed killer actives
    • Synthetic building blocks for next-generation crop protection agents

    3. Dye and Pigment Manufacturing

    Dye producers utilize fumaronitrile as a reactive dicyano component for condensation with aromatic rings, forming chromophores with high stability and color fastness. This route plays a pivotal role in the production of disperse dyes for polyester fibers and specialty pigments for industrial coatings, requiring close compliance with environmental discharge and toxicology limits.

    Industry compliance standards

    • OEKO-TEX® STANDARD 100 chemical restrictions
    • EU REACH Annex XVII for dyes & pigments
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • ISO 9001:2015 for documentation and pigment batch QC

    Typical usage ratio

    • 3–8 mol% relative to aromatic amines or aldehydes in target dye synthesis; adjusted by desired tint strength and shade stability requirements.

    Downstream process integration

    • Combined via Knoevenagel-type condensation or cyclization reactions with aryl aldehydes or amines; intermediates refined, sulfonated, or metallized before formulation into dyes or pigments.

    Final product types

    • Disperse dyes for polyester fabrics
    • Pigments for plastics and automotive coatings
    • Performance inkjet and electrophotographic colorants
    • Color fast specialty pigment dispersions for industrial applications

    4. Specialty Polymer Modifier Synthesis

    Specialty polymer producers employ fumaronitrile as a bifunctional monomer or crosslinker precursor in the synthesis of NBR (nitrile butadiene rubber) and high-performance engineering plastics. Its introduction enhances oil resistance, tensile strength, and barrier properties, but requires stringent process control to meet international standards for materials safety and certification in end use.

    Industry compliance standards

    • ISO 9001:2015 for polymer manufacturing quality
    • ASTM D2000 Elastomer Compounding Standard
    • REACH Regulation (EC) No 1907/2006 for monomer registration
    • UL 94 flammability standard for plastic and rubber products

    Typical usage ratio

    • 0.2–1.2% by weight in overall copolymer or crosslinking resin formula; tailored according to molecular weight target and final mechanical property requirements.

    Downstream process integration

    • Fed into bulk radical or emulsion polymerization as a comonomer or crosslinker, with continuous in-process monitoring for conversion ratio and composition control; followed by granulation and blending for downstream compounding.

    Final product types

    • High-strength nitrile rubber (NBR)
    • Oil-resistant hoses and gaskets
    • Performance engineering plastics
    • High-barrier films for electronics and automotive uses

    5. Fine Chemical Intermediate for Heterocycle Synthesis

    Producers of fine chemicals, including suppliers to the flavor & fragrance and electronics industries, use fumaronitrile to access diverse N-heterocycles and functionalized aromatic intermediates. This route is crucial for highly purified specialty chemicals where trace-level contaminants must be tightly controlled to comply with downstream specification limits.

    Industry compliance standards

    • ISO 9001:2015 for specialty chemical production
    • REACH pre-registration for specialty intermediates
    • RoHS 2011/65/EU (for electronics intermediates)
    • Customer-specific product composition and impurity profile requirements

    Typical usage ratio

    • Ranges from 1–10% w/w depending on target heterocycle yield and batch scale; adjusted in custom processes by substrate reactivity and end-product application tolerance.

    Downstream process integration

    • Added during controlled ring closure, alkylation, or cycloaddition stages for N-heterocycle assembly; purity adjusted via recrystallization, distillation, or chromatographic refining prior to handover for downstream application.

    Final product types

    • Flavor & fragrance precursors
    • Functionalized intermediates for electronic chemicals
    • Photoinitiator pre-products
    • Specialty building blocks for advanced materials and research applications
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    Competitive Fumaronitrile prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Fumaronitrile: Direct from the Manufacturer

    We have been manufacturing Fumaronitrile for over fifteen years, and nobody understands its specialty better than those responsible for every batch that leaves the plant. Fumaronitrile, or trans-1,2-dicyanoethylene, appears as a white crystalline powder and carries a chemical formula of C4H2N2. Here, production isn't just about turning out chemical after chemical—it’s about bringing reliability to your synthesis work, supplying researchers, and supporting businesses that demand consistent results batch after batch.

    High-Purity Material by Design

    Fumaronitrile doesn’t suit every need. Some customers come with questions about alternatives—maleonitrile, for example, which shares a similar backbone but diverges quickly in reactivity and performance. Trans-geometry makes a difference in chemical pathways. Over the years, research groups and process engineers have come to us seeking a form of dicyanoethylene that holds up under alkene addition or cyclization conditions. They’ve noticed that cis- and trans- isomers split paths in organic synthesis. From the viewpoint of a producer, not a wholesaler, supplying Fumaronitrile at a consistent isomeric purity matters just as much as basic physical purity. This product reaches 99% by gas chromatography, and our staff checks the melting point for every lot to confirm compliance. The repeatability of the trans-isomer lays the groundwork for those seeking controlled, reliable outcomes—while traces of the cis form can cause yields and selectivities to shift in trial after trial.

    Fumaronitrile leaves our lines bright white, flowing with minimal static issues due to careful drying and temperature control. The finer points show up under scrutiny—a batch with a melting point below 110°C raises questions, and workers check for faint yellow tint as a signal of aging or impurity. Our in-house chemists walk the production lines daily, overseeing reactions, recrystallizations, and vacuum drying. They have processed tons of this material, anticipating problems before they appear. Chemical manufacturing always needs a sharp human eye, not just instruments or spreadsheets.

    Model, Formats, and What Users Can Expect

    In packaging, choices reflect the way Fumaronitrile works best. Our main lot runs in 25-kilogram fiber drums, lined to cushion against jostling and humidity on the road. Some buyers, handling only pilot-scale runs or bench research, take 1-kilogram or 5-kilogram sealed foil pouches straight from the same bulked batch. We handle direct loading into drums or vacuum-sealed pouches right at the back of the crystallizer. Every pack carries a unique lot code with batch number and controlled traceability, connecting lab data back to a specific reactor on a given day.

    Each model meets tight targets: 99% minimum purity by GC, melting range 109–112°C, and water content below 0.25% by Karl Fischer titration. Particle size stays consistent batch to batch—whether for slurry transfer or hopper feeding, because clump-resistant flow saves time and trouble on the user’s end. Our teams field technical questions about the fine details: isomer content verified by 1H NMR, presence (or absence) of residual solvent, and the impact on downstream yields. There are no high-purity magic tricks here—just methodical control of starting acrylonitrile, temperature, solvent wash, and distillation steps. This careful handling from raw material to finished pail sets true manufacturer output apart from traders relabeling generic stock.

    Usage in Practice—What Sets Fumaronitrile Apart

    Downstream users include pharmaceutical chemists, custom peptide houses, pigment and dye plants, and niche resin producers—not all chemistries are created equal, and we see the full spectrum at order time. Fumaronitrile serves as a dieneophile in Diels–Alder reactions, as a building block in heterocycle synthesis, and as an intermediate toward pharmaceutical actives. Customers working on specialty agrochemicals, fine chemicals, and material science place repeat orders because performance data proves consistent. Over the years, our customers’ feedback has shaped our process. A research team once struggled with off-color precipitates traced back to a minor polymer byproduct; we adjusted recrystallization solvents and fine-tuned temperature ramps, cutting that impurity to less than 0.1%.

    Users often contrast Fumaronitrile with maleonitrile, diethyl fumarate, succinonitrile, or even more distant analogs. The trans configuration of Fumaronitrile influences reactivity, sometimes enabling tough cycloadditions or condensation reactions that falter or misfire with the cis isomer. It sits at a sweet spot for building electron-poor alkenes—supporting nitrile group retention without introducing unwanted methyl or ester moieties that complicate later functionalizations. This product draws ongoing attention in research because it offers a direct path into new heterocyclic scaffolds without extensive protecting group strategies.

    Process Control and Operator Experience

    From a manufacturer’s view, working with Fumaronitrile isn’t just chemistry—it runs deep into day-to-day control and continual improvement. In our plant, every reactor charge gets double-checked for acrylonitrile levels and peroxide content, since even trace errors here create colored byproducts or lower yield. Operators have learned—sometimes the hard way—where to watch for scale-up pitfalls. In the early years, a surge in demand for Asian peptide manufacturers prompted us to redesign filtration and drying, switching from open-pan evaporators to closed-vessel vacuum trays. Tight sealing keeps the powder fluffy and white. Overdried Fumaronitrile clumps up and slows downstream feeding; too much moisture and the risk of hydrolysis rises. Our chemists clock in every day with an eye for these margins—and frequent hands-on courses keep training sharp.

    You see the value of a well-run line when repeat customers test five lots across a year and send samples to third-party labs, only to have each batch return with a tight melting range and no unknown peaks. It’s not luck, but methodical discipline. Small slip-ups—failure to check for trace proton donors in the glycol feed, or hasty filtering after precipitation—can produce byproducts that take hours to troubleshoot at the end-user’s bench. Our commitment to process transparency means we record every reactor batch in a master log, including any deviations, not just final specs. These records matter when troubleshooting tough problems, offering real answers when questions about an odd result crop up months or even years later.

    Technical Support—From Real Chemists, Not Just Sales Staff

    Our technical team doesn’t recite numbers from specification lists. Almost all of them started in R&D or production before moving to the support desk—when you call, you get someone who’s actually weighed out nitrile powders, run TLCs, or tracked melting points themselves. Over the years, questions have moved beyond just purity or melting range: a pigment lab once flagged inconsistent staining from trace iron picked up in outsourced product; one batch made by a third-party contractor elsewhere. That prompted us to recheck every vessel lining in our plant and restrict Fumaronitrile filling to lined drums only. Feedback from users matters more than industry checklists—we’ve altered drying parameters, changed filter aids, and tested against secondary byproducts in support of long-term research partners because they brought us facts, not marketing claims.

    Staff experience means rapid response to customer needs. A German startup working on new dyes once needed fresh Fumaronitrile within five days; tight domestic logistics and confirmed in-house drying made it possible. Another company called at midnight with questions about downstream condensation, so our team pulled up reactor logs and historical notes to trace possible sources of yield drop. Real support stems from making the product, not just shipping boxes. We don’t sell solutions out of thin air—answers grow out of thousands of kilograms produced, tested, and improved for over a decade.

    Health, Safety, and Handling—Built on Firsthand Knowledge

    Making Fumaronitrile teaches a lot about its hazards and safe handling. In production, frequent air monitoring and careful sealing keep exposure levels low. We use closed process systems, double valved and vented reaction lines, and vacuum-transfer crystallizers to cut down on airborne dust or vapors. All operators suit up with gloves and goggles, not just for appearance, but because actual spills or splashes leave a distinct chemical burn if handled carelessly. Standard procedures run deep—not something bolted on for compliance, but a routine grounded in the daily realities of chemical manufacturing. We post clear instructions next to batching rooms and monitor all process steps so there’s no guessing.

    Our facility includes an on-site health team that reviews each new synthetic route, not just the finished compound. When a process change means operators spend more time at open vessels, PPE protocols get heightened. Regular drills on ventilation and spill control keep safety not only in compliance records, but in true everyday practice. Finished lots include clear labeling for toxicity and transport, and we walk customers through recommended handling practices—because the best technical data means nothing if users face trouble in the lab or at scale.

    Environmental Responsibility—Practiced, Not Theorized

    Years ago, we moved away from single-use plastics for Fumaronitrile packaging because those drums never broke down in waste sorting. Today, fiber drums with water-resistant liners outlast weather in outside storage and reduce landfill impact compared to full-poly alternatives. Reaction solvents go through a closed-loop recovery system, minimizing both cost and environmental load; off-gas scrubbers neutralize process fumes before anything leaves the building. Operators receive regular training on waste minimization, rather than box-ticking; a reduction in residual fines and filter cake disposal followed directly from in-plant suggestions.

    Every day, our chemists check effluent drains and sidestreams for unintentional releases, and recent upgrades to the solvent recovery decks resulted from team feedback. You learn quickly what works and what falls short by handling thousands of kilograms annually. Long-term vendors and repeat customers expect current compliance with local and international regulations including REACH, and regular outside audits keep our claims grounded in actual plant conditions.

    Continuous Improvement—Driven by Chemical Manufacturing Reality

    No production line runs perfectly forever. Our technicians revalidate analytical results, retest old retained samples, and review every deviation, not because it’s required by a remote auditor, but because we see the results of even small process shifts. Chemists learn lessons from scale-up—tracing a mild color shift in Fumaronitrile to trace amines from a changed solvent lot, or noticing physical changes after switching suppliers for packaging liners. We train new hires hands-on, under the supervision of staff who have solved more than one “unsolvable” impurity mystery.

    Major expansions in demand have taught us flexibility in planning—but tight control remains at every level. During the last two years, increased demand from pharmaceutical and materials science users pressed us to grow output, but production never outran our ability to verify every batch. Oversight by experienced staff, rather than letting numbers drive the show, ensures long-term stability. Improving yield by 0.5% after months of minor tweaks may not grab headlines, but over thousands of kilograms, that’s real resource savings and reduced waste.

    What Differentiates Manufacturer-Grade Fumaronitrile

    We don’t treat Fumaronitrile as a commodity. Years of building trust with repeat buyers reveal a basic truth: true manufacturing quality lies in what you don’t see—no unexpected byproducts, no clumpy or colored off-spec powder, no need to “rework” or adjust incoming lots to pass in-house controls. The difference starts at the source. Unlike traders or simple repackers, every lot comes with a transparent record that goes back to synthetic chemistry, in-plant logistics, raw material inspection, and skilled staff intervention. Over years, product feedback has driven rigorous changes in batch handling, filtration, and drying. These tweaks may escape a casual user, but matter greatly when customers face unexpected results in high-value applications.

    The difference reveals itself in reliability: a plant operator can plan for Fumaronitrile’s physical and chemical output, matching batch to batch, whether running low-ppm research syntheses or scale-up for pigment production. You’ll see less downtime for cleaning, less trouble adjusting feeding rates, and more dependable final product performance.

    Solving Challenges and Supporting Progress

    Scaling up specialty chemicals presents a range of challenges. Our position as a direct producer means we engage with the chemistry at every level, far removed from the paperwork shuffling of indirect supply. We’ve resolved streamlining issues by creating purpose-built equipment, continually investing in real-time analytics, and building on operator-driven troubleshooting. Technical staff join customers for plant reviews and trial runs, gathering new data to feed back into process tweaks. That way, learning goes both directions—customer leads trigger changes in crystallization or filtering, and plant-side insights clear bottlenecks in application or scale-up use.

    The relationship between process chemistry, quality control, and final use emerges in the small details: a dye manufacturer’s need to avoid faint yellowing, a pharmaceutical customer’s focus on batch homogeneity, or a research group’s push for minimal trace contaminants. We match that with down-to-earth feedback—the latest analytical data, sample vials, and open access to test batches as new product lines expand.

    Commitment to Reliability and Customer Partnership

    Making Fumaronitrile isn’t just a matter of meeting technical data sheets; it’s the daily practice of verifying, adjusting, and delivering what customers expect. Anyone who’s worked close to chemical manufacturing knows that even high-tech plants rely on skilled people for the best results. For us, every order is personal—a reflection of years spent learning, fixing, and perfecting.

    Direct customers—from global pharma to innovative startups—continue coming back, knowing they get both consistency and transparent answers to their technical and production challenges. Our position as a genuine manufacturer supports their ongoing progress, not just through a stable supply of high-grade Fumaronitrile, but through shared expertise, real troubleshooting, and active commitment to every lot that leaves our plant.

    If your next project depends on a reliable, high-quality trans-1,2-dicyanoethylene, our doors remain open. No matter how specialized the application or how routine the scale, you’ll find support rooted in hands-on experience and a lasting focus on partnership.