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Fthalide

    • Product Name Fthalide
    • Alias Phthalide
    • Einecs 207-333-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    400541

    Name Fthalide
    Iupac Name 1(3H)-Isobenzofuranone
    Cas Number 87-41-2
    Molecular Formula C8H6O2
    Molar Mass 134.13 g/mol
    Appearance White crystalline solid
    Melting Point 72-74 °C
    Boiling Point 290 °C
    Solubility In Water Slightly soluble
    Density 1.243 g/cm³
    Smiles O=C1OCc2ccccc12
    Inchi InChI=1S/C8H6O2/c9-8-5-6-3-1-2-4-7(6)10-8/h1-4H,5H2
    Synonyms Phthalide; 2-Benzofuran-1(3H)-one
    Storage Conditions Store in a cool, dry, well-ventilated place

    As an accredited Fthalide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Fthalide is packaged in a 100-gram amber glass bottle, sealed tightly, labeled with hazard information and chemical identification details.
    Shipping Fthalide should be shipped in tightly sealed containers, protected from moisture and direct sunlight. Ensure proper labeling and include relevant hazard information according to local regulations. Store and transport in a cool, well-ventilated area, segregated from incompatible substances. Follow all applicable guidelines for chemical transportation to ensure safe handling and delivery.
    Storage Fthalide should be stored in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizing agents. Keep the container tightly closed and protected from light and moisture. Ensure proper labeling and secure storage to prevent spills or contamination. Use secondary containment if necessary, and handle under conditions that minimize exposure.
    Application of Fthalide

    Applications of Fthalide in Industrial Manufacturing

    Fthalide serves as a crucial raw material in several specialized production lines within the chemical, pharmaceutical, and agrochemical industries. Below, we detail authentic downstream application sectors, each with their own operational prerequisites, compliant formulations, integration points, and manufactured end-use products.

    1. Pharmaceutical Intermediate Synthesis

    Pharmaceutical manufacturers use Fthalide as a key intermediate in the synthesis of cardiovascular agents and antihypertensive drugs. Its aromatic lactone structure allows for selective reaction in multi-step organic syntheses, where purity and consistency are critical for regulatory acceptance. This application demands strict control of reaction parameters and residual solvent content to ensure compliance with global pharmacopeial standards and cGMP manufacturing processes.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.) guidelines for active pharmaceutical ingredient manufacturing
    • Current Good Manufacturing Practice (cGMP) as per ICH Q7A
    • US Pharmacopeia (USP) monographs for APIs and intermediates
    • FDA 21 CFR Part 211 for finished pharmaceuticals

    Typical usage ratio

    • Used at 1–5% molar equivalent as a precursor in target molecule synthesis
    • Reaction quantities adjusted depending on required yield and purity targets outlined in process validation

    Downstream process integration

    • Introduced after initial condensation stages during the construction of core pharmacophores
    • Processed with subsequent functional group derivatization, followed by crystallization and purification steps

    Final product types

    • Antihypertensive drugs (e.g., n-butylphthalide derived APIs)
    • Active intermediates for stroke treatment drugs
    • Precursors for vasodilator drug substances
    • Final APIs sent for tablet or capsule formulation

    2. Agrochemical Herbicide Formulation

    Agrochemical producers apply Fthalide as a building block in the synthesis of selective herbicides used for broadleaf weed control. It enables targeted synthesis via controlled condensation and cyclization reactions, necessary for the production of high purity actives. Manufacturers must manage strict limits on chemical residues and product stability, with compliance to international pesticide additive regulations.

    Industry compliance standards

    • FAO specifications for pesticide technical materials
    • ISO 9001 certified quality management systems
    • REACH registration for European Union–bound products
    • National Agrochemical Residue Standards (e.g., GB2763 in China)

    Typical usage ratio

    • Applied at 2–10% of total synthesis batch weight, variable by desired final strength of active ingredient
    • Modified based on intended field application rates and toxicological thresholds

    Downstream process integration

    • Undergoes esterification or amide formation during early-stage actives synthesis
    • Feeds directly into active ingredient manufacturing lines before formulation into concentrates or wettable powders

    Final product types

    • Herbicide technical concentrates
    • Emulsifiable herbicidal active solutions
    • Formulated ready-to-spray weed control agents
    • Pre-mixed tank additives for agrochemical distributors

    3. Dye and Pigment Intermediate Production

    Dye manufacturers use Fthalide to generate chromophoric intermediates essential for developing high-performance pigments in textiles and coatings. The material’s reactivity under Friedel–Crafts reactions provides electrophilic centers required for the formation of colorant frameworks. The process must adhere to both environmental and occupational health limits on aromatic compound handling, as per global textile and pigment standards.

    Industry compliance standards

    • Oeko-Tex Standard 100 for textile safety
    • Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) compliance
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • ISO 9001:2015 for quality management in pigment production

    Typical usage ratio

    • Composes 3–8% by weight in intermediate stage dye formulations
    • Adjusted according to desired chroma and substrate compatibility requirements

    Downstream process integration

    • Introduced into nitration or halogenation reactors before coupling reactions with amines or phenols
    • Further processed by acid-base work-up and filtration before mixing into masterbatch or paste

    Final product types

    • Sulfonated azo dye intermediates for textile coloration
    • High-performance pigment dispersions for plastics and coatings
    • Leuco dye precursors for thermochromic and photochromic inks
    • Color additives for specialty printing and packaging films

    4. Fine Chemical Synthesis for Flavor and Fragrance Applications

    Specialty chemical companies use Fthalide in the development of aromatic aldehydes and lactones involved in synthetic fragrance and flavor ingredients. Its structural features enable the creation of nuanced aroma compounds via controlled acylation, reduction, and cyclization steps. All operations must align with international food additive regulations and IFRA safety guidelines for end-use in consumables.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • EU Commission Regulation (EC) No 1334/2008 for flavorings
    • US FDA 21 CFR Part 172 for food additives
    • ISO 22716 Good Manufacturing Practice for cosmetics

    Typical usage ratio

    • Distributed at 0.1–2% of total synthesis mass depending on aroma intensity and molecular structure requirements
    • Refined based on end-use safety thresholds and allergen data

    Downstream process integration

    • Employed as a building block during ketone or aldehyde precursor assembly
    • Further transformed via catalytic hydrogenation or rearrangement ahead of final distillation/blending

    Final product types

    • Synthetic flavoring agents for beverages and candies
    • Fragrance intermediates for fine perfumery
    • Aromatic compounds for air care products
    • Complex lactones for use in food flavor formulations
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    Certification & Compliance
    More Introduction

    Fthalide: The Manufacturer’s Perspective on Quality, Application, and Innovation

    Introduction to Fthalide Production at Scale

    Experience in chemical manufacturing brings a more hands-on understanding of what makes a product like Fthalide unique. This compound often shows up as a benchmark in the field of fine chemicals because it stands out both for its chemical stability and its reactivity, which offers versatility across multiple industries. Our factory teams encounter its distinct odor right from the first stage of synthesis, and this familiarity with its physical and chemical characteristics has made Fthalide more than just another name in a product catalog—it’s become integral in more applications each year.

    Every kilogram produced brings with it the responsibility to meet stringent quality checks. We monitor each batch to ensure content purity, as this directly impacts downstream applications. There’s a tangible difference in handling an off-spec sample—the final product falls short in crucial reactions or formulations, something end-users notice. Our reputation with Fthalide comes from consistent delivery: a pure white to slightly yellow crystalline material, free-flowing, with a defined melting point, and a minimum purity that satisfies both regulatory and industrial expectations.

    Understanding Specifications Through Hands-On Experience

    Specifications aren’t merely numbers on a sheet for our chemical operators. Minimum purity of 99% isn’t a selling point; it’s a baseline built on years refining synthesis, filtration, and crystallization steps. Each parameter, from moisture content to residual solvents, affects the material’s performance. If residual solvents rise above thresholds, you risk contaminating downstream products—an issue that can force recalls or failures if left unchecked. Many customers ask us about the importance of low-total impurities, and those conversations always lean on real-world results: truer yield rates, smoother reactions, and more reliable QA outcomes.

    Much of our ongoing work involves comparing batches from new raw material suppliers or pilot-scale synthesis routes. Labs analyze every lot, running both classical titrations and chromatographic purity tests. A batch that hits 99.5% and below 0.2% moisture rarely triggers customer complaints in pharmaceuticals, fine chemicals, or dye synthesis. Small differences in melting point and particle size can change API quality or pigment tones in industrial applications. Our manufacturing lines are tuned to keep these parameters as close as possible to optimal values, minimizing rework and maximizing production uptime.

    Fthalide Usage Across Diverse Applications

    Fthalide acts as a cornerstone intermediate for several industries. Pharmaceutical researchers rely on it as a key starting material in synthesis of nerve relaxants and anticonvulsant drugs, particularly in routes requiring controlled oxidation processes. On production runs for such clients, the stakes climb. We’ve seen how a minor inconsistency in Fthalide can disrupt the final synthesis of important drugs. For those ordering in large volumes for pharmaceutical intermediates, tight control over trace impurities reduces the risk of adverse reactions, and supports smoother regulatory filings in global markets.

    Looking beyond the pharmaceutical industry, Fthalide plays an equal role in the dye and pigment sector. Manufacturers of fluorescent brighteners and specialty dyes incorporate it for its ability to introduce certain ring structures that hold up against sunlight, heat, and washing cycles. Every production manager remembers the challenge of matching color fastness from batch to batch; high-purity Fthalide helps meet these benchmarks with fewer formulation adjustments. Even players in the agrochemical space value its role as an intermediate; here, the focus shifts to residue limits and compatibility with other synthesis steps.

    What Sets Fthalide Apart from Similar Compounds

    In the specialty chemicals world, every manufacturer compares offerings. Fthalide stands out against phthalic anhydride or phthalate esters because it carries unique reactivity while shedding some of the regulatory and toxicological baggage associated with other phthalic derivatives. Experience tells us that customers come to us specifically for Fthalide when they hit a bottleneck with oxidation or ring opening-reactions where other phthalates fail.

    From a technical team’s perspective, substituting Fthalide’s core structure is no simple task. Few analogues combine its reactivity, solubility profile, and ease of purification. Trying to use o-phthalic acid or phthalic anhydride usually means adding steps to the synthesis process or ending up with a less clean product profile. By dialing in our process to minimize side products common in other routes, we provide a material that shortens clients’ timelines from concept to finished product.

    Production and Quality Assurance: What Matters on the Line

    Inside our plant, operators track each batch of Fthalide with a mixture of pride and responsibility. These are not just standard operating procedures—they are guardrails protecting both our partners and our reputation. We draw from practical experience to flag any drift in melting behavior, particulate content, or hue, because these can spiral into downstream processing headaches for customers. When an out-of-specification event hits, we remember the pain points it causes: stalled reactors, off-color products, and costly cleaning between runs.

    On the ground, small process tweaks—adjusting reflux timings, fine-tuning solvent ratios, or switching distillation columns—yield measurable improvements in final quality. These insights do not come from a manual, but from years on the production floor and feedback from users whose operations depend on our reliability. Technical teams don’t just solve the problem of the day; they build up institutional knowledge, passing down the best practices that define a manufacturer’s edge.

    Industry Challenges in Sourcing and Safety

    Raw material sourcing for Fthalide has grown more complex as regulations and customer expectations shift. Environmental regulations now shape supplier selection as deeply as price or proximity. We watch upstream for fluctuations in o-xylene or other aromatic precursors, recognizing that disruptions—whether supply chain breaks, geopolitical events, or regulatory actions—immediately affect schedules and costs. Our purchasing colleagues work with vetted suppliers who meet sustainability audits, confirmed by site visits and sample testing.

    Handling and storage at scale forces every plant to focus on real-world safety, not just paperwork compliance. Fthalide itself isn’t classified as hazardous compared to some aromatic compounds, but the solvents, catalysts, and by-products along the process route still present occupational risks. Our safety protocols result from actual incidents and near-misses: we invest in improved ventilation, explosion-proof equipment, and upgraded effluent management. Worker training gets evaluated with every batch—this reduces both human error and costly downtime.

    Traceability and Documentation in Modern Manufacturing

    Auditors and regulatory authorities now require robust traceability from each drum of Fthalide. We maintain complete batch histories—raw material lots, processing conditions, QC reports—because customers in regulated fields audit every step. Missing paperwork can halt shipments or destroy business relationships. Our production team works closely with the compliance group to ensure every shipment leaves our plant with a complete chain of records, audit trails, and tested reports.

    Documentation has evolved beyond hand-written logbooks. Integrated systems track changes in reaction conditions, equipment status, cooling curve deviations, or maintenance issues. Beyond meeting requirements, this practice resolves disputes quickly and makes troubleshooting root causes easier. When a client’s own audit team arrives, everything stands ready for inspection, with test results to support every specification claimed.

    Environmental Impact and Waste Management Related to Fthalide

    Decades ago, large chemical producers paid less attention to waste minimization; environmental fines were smaller, and disposal seemed cheap. Today, pollution controls shape every process parameter for Fthalide production. By tweaking yields and recycling solvents, waste output cuts down, both for cost savings and regulatory peace of mind. Our teams fine-tune purification to minimize not just visible waste, but also difficult-to-treat secondary streams.

    Innovations in water and air emissions management have slashed discharge levels in modern plants. Specialty scrubbers and upgraded water treatment plants now run alongside core production lines; they are not afterthoughts. Most improvements begin with line workers spotting discharge issues early and proposing practical changes that pass both technical and environmental screens. Down the value chain, customers increasingly ask about lifecycle analysis—evidence our approach provides real value beyond what’s written on a spec sheet.

    Continuous Improvement and Technical Support

    The depth of technical service matters just as much as product quality in specialty chemicals. Our technical support blends theoretical expertise with decades of shop-floor troubleshooting. When clients report a filtration issue or an unexpected impurity profile, we don’t send generic responses—we examine every possibility, starting from raw materials down to handling techniques in their own facilities. This exchange, from production line to customer plant, brings mutual improvements. Feedback returns to optimize our synthesis route, resulting in fewer quality deviations and happier long-term partners.

    We believe in transparency and knowledge sharing, not in hiding behind jargon or buried notes in material documents. Real-world feedback from users—whether pharmaceutical plants, dye mills, or academic research labs—feeds directly into our iterative product development and QC enhancement. This hands-on approach allows us to stay ahead of the curve on new regulations, novel synthetic routes, or competitive innovations.

    Real-World Impact: Why Customers Choose Fthalide From a Manufacturer

    For us, reputation builds batch by batch. Over years, customers give feedback not only on price but on everything from ease of dissolution in their reactors to the color and odor impacts in the end products. In industries where small differences translate into significant gains or losses—be it pharmaceutical yields, pigment shade accuracy, or agrochemical potency—small lapses can lose long-term business.

    What keeps customers returning isn’t a sales brochure or spec table; it’s direct experience with product reliability. Missed batch consistency leads to downtime, waste, and regulatory headaches. Consistent Fthalide batches mean smoother scaling from lab to plant, fewer emergencies in production, and superior finished goods. Our factory sees these outcomes as proof of the value created by the manufacturing process. Teams get to know end-users by name, and satisfy their unique profiles—never settling for minimum regulatory approvals, but aiming for operational excellence.

    Looking Forward: Innovation Without Cutting Corners

    Fthalide manufacturing does not stand still. As client requirements evolve and new end uses appear, we invest continually in process optimization, raw material traceability, and worker skills. Our product managers work closely with R&D to develop new derivatives or blends that meet changing needs. The drive for lower residuals, better solubility, or improved processability leads straight back to ongoing pilot projects and testing campaigns.

    Every innovation gets evaluated in commercial-scale context. If a change means lost control in reaction yields, reduced batch-to-batch uniformity, or heightened safety risks, it gets reworked or shelved. This discipline, refined by hard lessons from both failure and success, protects customers from the downsides of unproven shortcuts. All stakeholder voices get heard, from shift supervisors to R&D chemists, delivering improvements that actually work on the ground.

    Collaborative Problem-Solving and Market Responsiveness

    Partnership takes top priority once sales move from sample to routine supply. Our technical, commercial, and regulatory teams stay in close touch with clients’ engineers and project managers, working through challenges that arise in real-world manufacturing. Direct conversations, joint testing, and data sharing lead to sharper solutions. Situations such as reaction stoppages, new impurity profiles, or regulatory changes get resolved collaboratively—sometimes over months or years—building deep, trust-based relationships.

    This close interaction allows us to anticipate market shifts before they reach crisis levels. For example, if a customer’s industry faces tighter limits on trace benzene or other impurities, we prioritize process changes to stay ahead of deadlines. If a sudden regulatory shift in the EU introduces new hazard codes, teams assemble rapidly to update both paperwork and process controls. This responsive approach gives customers confidence to invest in their own product lines, knowing our Fthalide quality has them covered.

    Key Differences From Commoditized or Third-Party-Supplied Fthalide

    Relying on a manufacturer instead of a trading company means getting more than just a shipment; it means direct access to process expertise, decades of production history, and an open channel for technical discussion. Returns and complaints get cut drastically, because every order’s origin and history are traceable. Our plant teams know exactly what went into each batch: if an issue arises, they can troubleshoot it at the source, not just file a ticket with an offshore agent.

    Fthalide sourced from manufacturers with robust process design avoids surprises often encountered with “commodity” versions—whether odor deviations, unexpected melt ranges, or mystery impurities. Many customers arrive at us after frustrating purchases through unrelated resellers, and the sense of relief after switching is universal. Bypassing intermediary steps strips out misinformation and delivery risks, supporting long-term, stable partnerships.

    Quality Recognized By End Users

    Over time, direct users learn to distinguish between Fthalide from a manufacturer-invested operation and no-name background suppliers. Plants handling high-value API synthesis or demanding pigment blends send us direct praise—cycles run more smoothly, offline troubleshooting drops, and unplanned shutdowns become rare events. Purchasers value not only the direct savings in rework costs but also the hidden benefits in project continuity and technical support.

    Many client success stories arise from simple but crucial process stability. Small details like reduced filter clogging, superior shelf-life, or batch traceability stack up into meaningful advantage. Experienced engineers and chemists seek Fthalide that delivers both purity and real-world consistency—attributes only achieved when the manufacturer stands firmly behind every kilogram shipped out the door. Each successful production run cements our place as not just a supplier, but a full-fledged partner in innovation and reliability.