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Ethylurea

    • Product Name Ethylurea
    • Alias N-Ethylurea
    • Einecs 205-354-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    662096

    Chemical Name Ethylurea
    Cas Number 625-52-5
    Molecular Formula C3H8N2O
    Molecular Weight 88.11 g/mol
    Appearance White crystalline solid
    Melting Point 102-104 °C
    Boiling Point N/A (decomposes)
    Density 1.14 g/cm³
    Solubility In Water Soluble
    Synonyms N-Ethylurea
    Odor Odorless
    Ph 1 Solution Approx. 7
    Flash Point Non-flammable
    Storage Conditions Store in a cool, dry, well-ventilated place
    Iupac Name N-ethylurea

    As an accredited Ethylurea factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethylurea is packaged in a 500g white HDPE bottle with a tamper-evident cap, featuring hazard labeling and product details.
    Shipping Ethylurea should be shipped in tightly sealed containers, protected from moisture and incompatible substances. It is typically transported as a solid at room temperature. Ensure labeling complies with local regulations. Store and ship in a cool, dry, well-ventilated area, and follow all safety and handling guidelines outlined in the safety data sheet (SDS).
    Storage Ethylurea should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Keep it away from moisture and direct sunlight. Proper labeling and access control are necessary to minimize risks. Use secondary containment to prevent leaks or spills and ensure safe chemical management.
    Application of Ethylurea

    Applications of Ethylurea in Industrial Manufacturing

    With decades of experience in chemical synthesis and process optimization, we supply high-purity Ethylurea for specialized downstream applications where consistent quality and compliance are critical. Below, we outline primary value-adding uses of Ethylurea supported by strict industry standards and established production protocols.

    1. High-Performance Epoxy Resin Hardeners for Electronics Encapsulation

    Ethylurea serves as a key formulating agent in the production of latent curing agents for epoxy resin systems, especially for casting and encapsulating electronic components. Its specific hydrogen bonding properties and controlled reactivity allow formulators to design encapsulation resins that cure under precise thermal profiles, improve electrical insulation stability, and enhance resistance to moisture and chemicals. The material’s low outgassing supports high insulating reliability in power modules and printed circuit board protection.

    Industry compliance standards

    • IEC 60664-3 for insulation coordination
    • UL 94, Flammability Standard
    • IPC-CC-830B for conformal coatings
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)

    Typical usage ratio

    • Formulators usually add 3–10 wt% Ethylurea as a latent hardener within the total resin mass. The exact dosage depends on epoxy base, required pot life, and final cure temperature.

    Downstream process integration

    • Producers dissolve Ethylurea directly during resin compounding, prior to vacuum degassing. The hardener disperses in the epoxy blend before casting molds or dispensing onto assemblies for subsequent thermal cure cycles.

    Final product types

    • Molded power module encapsulants
    • Potting compounds for sensors and relays
    • Protective conformal coatings for PCBs
    • Transformer insulation materials

    2. Intermediate for Sulfonylurea Herbicide Synthesis

    Ethylurea acts as a primary nitrogen source and building block in the production of various sulfonylurea herbicides widely used in commercial agriculture. Process chemists employ its nucleophilic properties for constructing the urea bridge in target molecules, which determine biological selectivity and environmental breakdown rates. This route supports scalable, cost-effective herbicide manufacture with controlled impurity profiles, critical to farmer and regulatory acceptance.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • European Regulation (EC) No 1107/2009 for pesticides
    • US EPA Registration Requirements (40 CFR Part 158)
    • ISO 9001:2015 for agrochemical manufacturing

    Typical usage ratio

    • Ethylurea typically constitutes 0.8–1.3 molar equivalents per batch in the condensation step for each sulfonylisocyanate reactant, with adjustments based on targeted molecule yields and process purification efficiency.

    Downstream process integration

    • Operators introduce Ethylurea into jacketed reaction kettles under controlled temperature and agitation after initial sulfonyl chloride conversion. The subsequent condensation step yields technical-grade herbicides for downstream formulation.

    Final product types

    • Foramsulfuron wettable powders
    • Chlorsulfuron concentrate granules
    • Metsulfuron-methyl dispersible tablets
    • Commercial post-emergent spray solutions

    3. Blocking Agent in Polyisocyanate-Based Polyurethane Formulations

    In the polyurethane industry, Ethylurea operates as a reactive blocking agent for aromatic and aliphatic isocyanates. This makes it possible to manufacture stable, single-component polyurethane prepolymers with controlled latency. Upon heating, Ethylurea releases the blocked group, reactivating isocyanate chemistry for final cure. The approach benefits assembly-line adhesives, insulation panels, and automotive interior foaming applications where long shelf life and precise reaction timing are essential.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for PU systems
    • REACH Regulation (EC) No 1907/2006
    • ASTM D3574 for flexible cellular materials
    • EN 14315 Polyurethane insulation requirements

    Typical usage ratio

    • Blocker content ranges from 5–18 wt% relative to the NCO content of prepolymers, with adjustments according to isocyanate type, targeted deblocking temperature, and end-use reactivity profile.

    Downstream process integration

    • Blend Ethylurea with the chosen isocyanate fraction in inert solvent under nitrogen, heat to initiate blocking reaction, monitor by FTIR for disappearance of free NCO groups, then add polyols and chain extenders for final formulation.

    Final product types

    • Thermally activated assembly adhesives
    • Automotive headliner and seat foams
    • Spray polyurethane insulation boards
    • One-component PU sealing mastics

    4. Intermediate for Pharmaceuticals: Antitubercular Drug Synthesis

    Ethylurea serves as an essential intermediate in the synthesis chain for compounds such as Ethambutol, an established first-line antitubercular agent. Modern pharmaceutical routes depend on precise Ethylurea reactions to introduce and control the ethylated urea moiety, a pharmacophore critical for biological activity and patient safety. Pharmaceutical developers require traceability and GMP compliance at every batch to support registration dossiers for regulated markets.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF and Ph. Eur. Monographs (as applicable to downstream APIs)
    • WHO TRS 986 Annex 2 for APIs
    • Certificate of Suitability (CEP) for European DMF submissions

    Typical usage ratio

    • Stoichiometric ratios typically range from 1.05 to 1.12 equivalents per Grignard or halide reactant per stage, optimized for complete conversion and minimal impurity carryover.

    Downstream process integration

    • Ethylurea is introduced under controlled addition at the urea formation stage, following initial precursor synthesis. Reaction parameters maintain batch homogeneity and minimize residual solvents before the crystallization and API isolation stages.

    Final product types

    • Ethambutol HCl tablets and oral solutions
    • Bulk Ethambutol API for tableting and capsule filling
    • Other ethylurea-derived anti-infective intermediates

    5. Additive for Formaldehyde-Free Paper Strengthening Agents

    Ethylurea is utilized in the synthesis of formaldehyde-free paper dry-strength resins, providing improved wet and dry tensile strength properties to specialty and packaging paper grades. The compound enables water-soluble polyamide or polyurea resin systems through targeted condensation, giving papermakers an alternative to conventional melamine-formaldehyde resins. This meets evolving regulatory and customer demand for low-VOC, food-contact compliant paper products.

    Industry compliance standards

    • BfR Recommendation XXXVI (Germany): Paper and Board for Food Contact
    • FDA 21 CFR 176.170 for paper additives (USA)
    • ISO 187 for conditioning and testing pulp and paper
    • EU Food Contact Materials Regulation (EC) No 1935/2004

    Typical usage ratio

    • Paper chemical manufacturers incorporate 5–15 wt% Ethylurea as the principal crosslinking monomer in resin precondensate formulations, tailored to required final strength levels and paper furnish composition.

    Downstream process integration

    • Resin synthesis begins with aqueous Ethylurea addition to polyamide or polyacrylamide backbones under alkaline or neutral pH, followed by neutralization and storage in dilute form for papermill wet-end dosing.

    Final product types

    • Food wrapping and baking papers
    • High-strength linerboard for packaging
    • Label base papers
    • Tear-resistant specialty grades
    Free Quote

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    Certification & Compliance
    More Introduction

    Understanding Ethylurea from a Manufacturer’s Viewpoint

    Every day on our production floors we meet the challenge of delivering chemicals that the world trusts. Among them, Ethylurea holds a special place, not only by its unique chemistry but by what it allows other industries to accomplish. From the moment batches leave the reactor, we track composition, stability, and moisture content with an eye for detail. Our approach comes from years of direct experience: this chemistry is not just synthesized, it’s built with intent and a deep sense of responsibility.

    Ethylurea: A Direct Result of Proven Processes

    Ethylurea, with the formula C3H8N2O, flows through our processes guided by careful controls. Chemical consistency matters here. We keep the purity at very high percentages—well beyond 99% in our technical and reagent grades. Each lot reflects repeatable controls on by-products, water content, and particle size. These parameters drive how it behaves later, whether as a pharma intermediate or as a building block in fine chemical synthesis. Small slips in these variables will cascade through our customers’ results, so we follow tight batch release protocols, not just standardized ones, but protocols formed by our personal history with this molecule. Our product does not leave without GC and titration checks. This is not just procedure; it's about accountability to the process and our end users.

    Ethylurea’s Role Across Industries

    Our longest-standing clients in the pharmaceutical industry come back year after year because they know our urea derivatives allow them to scale laboratory breakthroughs to production runs. Ethylurea serves as a core intermediate when they build certain anticonvulsants, cancer therapeutics, or specialty drugs. The amide group and ethyl substitution make it reactive under milder conditions for constructing specific nitrogen-containing heterocycles. This gives medicinal chemists flexibility without unnecessary steps. Over decades of supply, feedback keeps feeding into our improvements—easier filtration, higher yields in downstream syntheses, less variability. Every comment we get from a bench chemist shapes upcoming batches. Our alignment with pharma demands is not born in boardroom strategy sessions, but at the intersection of ironclad process integrity and open dialogue with formulation teams who depend on us.

    Pesticide and agrochemical development also lean on our Ethylurea. Laboratories routinely choose it for synthesizing herbicides and growth regulators, relying on its compatibility and non-chlorinated structure. Some clients value the lack of aromaticity, which sidesteps unwanted reactivity and simplifies registration with regulatory agencies. We have learned to prioritize low metal residue and minimized color—important factors that show up during pilot scale applications, where pigments or trace ions can skew field results.

    In specialty and performance materials, Ethylurea finds its place in curing systems for epoxy resins or as a modifier for polyurethanes. The presence of the ethyl group gives chain flexibility and tunes melting or hardening points. Our materials scientists stay in touch with application engineers who use our batches in insulation foams or specialty coatings. We support their development cycles through direct data sharing, not broad marketing claims. Chemical properties are only meaningful if supported by batch analysis, and that transparency sits at the cornerstone of our partnerships. As a manufacturer, our place in their research and development pipelines comes from reliability, not volume alone.

    The Subtle Differences: Ethylurea Versus Other Ureas

    For us, understanding what sets Ethylurea apart matters more than general platitudes about performance. Comparing it to methylurea, propylurea, or unsubstituted urea, the most obvious distinction lies in the ethyl group itself. This changes water solubility, boiling point, and response to catalysis—factors that scale unevenly between lab and plant settings. Through our own in-house pilot plant work, we’ve learned that Ethylurea dissolves more steadily in organic solvents but retains moderate aqueous solubility. Clients often switch from methylurea to ethylurea to fine-tune crystallization points or lower unwanted formation of by-products. We have seen this drive sharper melting range control, which matters for continuous processing.

    Some research groups will chase higher reactivity through dimethylurea or bulk commercial urea, only to run into stability issues. Our Ethylurea maintains structural integrity longer during storage. It is less hygroscopic than unsubstituted urea, which allows for steadier handling in plant conditions that are less than ideal. Our technical team has chased down unexplained color changes for customers, traced them to trace amine impurities, and responded by double washing, optimizing drying cycles, and offering batch-to-batch impurity tracking. Each improvement grows from specific industry requests, not market trends.

    Differentiation does not end at the factory gate. When a client’s pilot batch fails due to a raw material shift, we stand behind our analytical package, not just with certificates but by cross-testing physical properties on retained samples. This mix of chemical insight and sustained problem solving comes from direct engagement, not from static product brochures. Our knowledge here is lived, documented, and repeated at scale.

    Meeting the Challenges: Delivering Consistency Every Batch

    From raw material sourcing to drying protocols, each stage of Ethylurea production garners focused oversight. The industry has seen what happens when ingredient variability sneaks into the batch: off-spec particle sizes, incomplete reactions, color drift, or loss of yield in key runs. We address this with applied process mapping and lean on chemical engineers who have handled thousands of liters under real plant constraints. Their lived experience shapes how we refine condenser settings or optimize mixing speeds. Our QC lab never releases a drum until it clears not just purity limits, but they also look at kinetic performance in representative test reactions. That’s the difference between a spec sheet promise and a manufacturer’s guarantee grounded in use-case feedback.

    Problems do pop up. Moisture can sneak into drums during high-humidity shipments, and even trace decomposition products, if unchecked, will show up later as ghost peaks in downstream analysis. We maintain lot retention and traceability for years, so that a user reporting a yield drop months later can expect us to help reconstruct what might have gone awry. We don’t just trace our Ethylurea back to a drum number, but right back to reactor logs and original source IDs for every main raw material. This approach resists complacency and guards against recall events—which are costly, but more importantly, erode the trust we build batch by batch.

    Compliance: Responsibility Beyond the Law

    Complying with local, national, and international chemical regulations forms the backbone of every shipment. Our teams don’t treat compliance as a series of boxes to tick. Instead, we keep all analytical reference libraries up to date, stay on top of REACH, TSCA, and other reporting requirements, and invest in third-party audits when novel formulations appear in the customer pipeline. Over the years, this proactive approach has saved us and our clients from delayed launches or interrupted supply. We track regulatory shifts globally because our customers export finished goods worldwide. It’s part of the trust equation, not an afterthought.

    Documentation for Ethylurea always ships with complete analytical records, not just the current batch. We offer stability and hazard data, batch history, and any customer-requested supplementary analysis. Some buyers need extended shelf-life statements; others want to see heavy metal or solvent residue below certain thresholds. Our flexibility in documentation follows real requests, not minimal regulations.

    Sustainability: Today’s Choices, Tomorrow’s Results

    Every ton of Ethylurea starts with choices about raw materials and utilities. We work to select renewable or lower-impact sources whenever they meet our performance targets. This gets complicated when suppliers shift or when crop-year changes alter impurity profiles, so we rely on historical data and supplier relationships built over decades. Our waste reduction priorities lifted yields and shrunk our water usage annually—a feat only possible by thoughtful process redesign, not cost-cutting alone.

    Within the plant, our focus remains on closed-loop systems to limit volatile losses and on improving dryer efficiencies. Energy use per kilogram of Ethylurea has dropped year on year because we treat energy savings as core to our own cost structure, not just as a marketing angle. These improvements stem from real, boots-on-the-ground experience: maintenance technicians tweaking burner settings, operators logging utility spikes, process engineers pushing management for better chiller integration. Pride in this kind of progress motivates new hires and veterans alike. It is about stewardship, not slogans.

    Clients increasingly bring sustainability queries to our attention. They want proof of responsible sourcing, meaningful reductions in scope 1 and 2 emissions, and clarity on product lifecycle impacts. For Ethylurea, we supply this with both data and open process walk-throughs. We believe that confidence grows not from simply stating a recycled content percentage, but from showing buyers exactly how and why our operations produce the numbers we claim. If a customer requests data beyond what’s standard, our chemists and analysts collaborate to deliver. Long after regulations catch up with sustainability, our practices will continue driving these improvements because our team comes from an industrial tradition where waste reduction and resourcefulness carry real value on the factory floor.

    Supporting Innovation with Reliable Raw Material

    Innovation needs reliable starting materials. This is a simple truth that we see play out again and again with clients racing to get a new process from lab to pilot to commercial scale. Minor inconsistencies in Ethylurea’s composition can force chemists to redesign downstream chemistry, with costly project delays the inevitable result. Our role is more than building molecules efficiently; it is in collaborating directly with research professionals, troubleshooting process upsets, and providing scaled material with analytical transparency for every drum that leaves the door.

    Many of our process improvements come from client-driven changes. Conversations with technical teams, plant visits, and shared analysis logs uncover ways we can trim contaminants or improve granulation properties. Several years back, one of our largest pharmaceutical partners worked with us to drive down a persistent trace impurity to parts-per-million levels. The solution required not just new filtration hardware, but also round-the-clock monitoring, customized batch record forms, and periodic shipping of reference samples for external validation. Our staff saw firsthand how small compositional tweaks improved our client's yields and simplified their regulatory submissions. This iterative partnership forms the backbone of our business—not one-off sales or generic product lines.

    Ethylurea in a Changing Marketplace

    The chemical landscape does not stand still. Over the past decade, we’ve watched as more of our Ethylurea clients shifted toward automated process control, digital traceability, and tighter global audits. We didn’t simply digitize old forms; we adopted electronic batch records, integrated sensor output with product release logs, and built fail-safes that let us identify and correct process drifts long before product hits the loading dock. Our information systems exist to support process reliability, not replace human oversight, and our people remain deeply involved at each step.

    Major users in new energy materials are exploring urea derivatives for novel battery or hydrogen carrier solutions. Ethylurea fits these efforts by gifting developers a balance: moderate reactivity, chemical stability, and a known safety profile. Time and experience have made it clear to us which downstream markets are just exploring options and which are scaling up long-term applications. As a manufacturer, we spot shifts quickly and share what we see with our whole customer base, offering pilot-scale support and extension services far beyond the initial delivery. This has made our technical support team as vital to our product as the purity of the bag or drum that ships out.

    In paints and coatings, some partners have pivoted from solvent-based systems to water-dispersible ones. We have tailored Ethylurea grades for these requirements by adjusting drying protocols and packaging, consultations that came from short email threads and long-standing mutual respect between our technical experts and theirs. Even regulatory consultants recognize the difference between a manufacturer willing to change and a supplier who coasts along with the market.

    Open Communication: The Driver of Quality and Trust

    Customer inquiries give us invaluable opportunities to refine our Ethylurea and its delivery. Technical issues sometimes begin with a call about a strange reaction profile or unwanted color in finished product. Our routine is not to deflect but to drill down: we review retained samples, pull historical data, and if necessary, have in-person meetings to identify root causes. We see this as good business and good science, not just after-sales obligation. Mistakes surface from time to time—whether in paperwork, process control, or logistics—but every correction feeds back into training and improved operating procedures. Our team takes pride in being able to point to real examples where these fixes led to measurable betterment in both consistency and speed of delivery.

    The expectation of quality in Ethylurea grows from the mutual understanding between us—the producers—and those incorporating the product into critical applications. Our batch release philosophy grows each year, driven by our purpose and responsibility. We empower our QC and R&D teams with the autonomy and tools to catch occasional drift and make strong recommendations without waiting for management to say so. The insight gained from regular dialogue with end-users helps us anticipate industry shifts, regulatory updates, and opportunities for proactive improvement.

    Looking Forward: The Ongoing Ethylurea Story

    We measure our impact not just by tons shipped but by the outcomes Ethylurea enables in medicines, agriculture, materials science, and so many more fields. With each delivery, we affirm our role not as a hidden link but as a visible, accountable participant in customer success. Challenges keep us flexible. Whether it is a spike in global demand, evolving safety standards, or supply chain bottlenecks, our way forward comes from agility in operations and a willingness to enlist every available resource—human and technological—to keep quality at the center. Real progress grows from routine, not surprise heroics or marketing coalitions. That’s the standard we set for Ethylurea, and that’s the standard we work to meet, every shift, every batch, every day.