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Ethylpyrazine

    • Product Name Ethylpyrazine
    • Alias ETHYL PYRAZINE
    • Einecs 207-988-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    220866

    Cas Number 13925-00-3
    Molecular Formula C6H8N2
    Molecular Weight 108.14 g/mol
    Iupac Name 1-ethylpyrazine
    Appearance Colorless to pale yellow liquid
    Boiling Point 162-164 °C
    Melting Point -35 °C
    Density 1.028 g/cm³
    Refractive Index 1.503
    Flash Point 54 °C
    Odor Nutty, roasted, cocoa-like
    Solubility Slightly soluble in water, soluble in alcohol and ether
    Pubchem Cid 23652
    Synonyms Pyrazine, ethyl-
    Stability Stable under normal conditions

    As an accredited Ethylpyrazine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of Ethylpyrazine is packaged in an amber glass bottle with a tamper-evident cap and clear hazard labeling.
    Shipping Ethylpyrazine is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. During transport, it should be handled according to hazardous material regulations, avoiding exposure, ignition sources, or extreme temperatures. Proper labeling and documentation are required to ensure safe and compliant transit. Use appropriate PPE when handling spills or leakage.
    Storage Ethylpyrazine should be stored in a tightly sealed container, away from light, heat, and sources of ignition, in a cool, dry, and well-ventilated area. Keep it away from incompatible substances such as strong oxidizers. Proper labeling and secondary containment are recommended. Use in a chemical fume hood to avoid inhalation of vapors. Follow all applicable regulations for safe chemical storage.
    Application of Ethylpyrazine

    Applications of Ethylpyrazine in Industrial Manufacturing

    Ethylpyrazine serves as a high-purity intermediate and functional additive in several targeted industrial applications. Direct manufacturer supply ensures stringent quality control, consistent supply, and technical support throughout large-scale downstream processes. The following sections provide applied scenarios, reflecting real regulatory needs and technical guidance for formulation, dosage, production line integration, and end-use transformation.

    1. Food Flavor Formulations in Processed Foods

    Food industry formulators employ ethylpyrazine extensively to design nutty, roasted, and cocoa-like flavor profiles. The compound’s aroma intensity and thermal stability allow manufacturers to enhance baked goods, confectionery coatings, instant beverages, and snack seasonings. Addition occurs post-blending, before terminal heat processing, to ensure uniform distribution and aromatic retention. Regulatory bodies impose strict limits and batch traceability on such flavor additives.

    Industry compliance standards

    • US FDA 21 CFR §172.515 (Flavoring Substances)
    • EU Regulation (EC) No 1334/2008 (Flavourings and Food Ingredients with Flavouring Properties)
    • GB 2760-2023 (China’s National Food Safety Standard for Food Additives)
    • FSSC 22000 or ISO 22000 food safety management participation for downstream users

    Typical usage ratio

    • 0.05–5 ppm in final food, depending on desired flavor intensity and food matrix volatility.
    • The formulator adjusts within legal flavorant limits for each specific application and region.

    Downstream process integration

    • Metered addition into flavor oil premixes, spray-dried blends, or direct dry blending with seasonings before packing or baking.
    • Integration timing optimized to prevent volatilization losses in thermal steps.

    Final product types

    • Breakfast cereals, chocolate-alternative coatings, roasted snack mixes, instant coffee premixes, savory biscuit products.

    2. Fragrance Ingredient for Tobacco Processing

    Ethylpyrazine is used in tobacco manufacturing to impart a sweet, toasted note to cut and reconstituted tobacco blends and cigar filler materials. Its migration and aroma retention properties suit both primary production and flavoring for reconstituted sheet processes. Additive dosing ensures consistent flavor across production lots while staying within regulatory thresholds imposed by different countries' product standards.

    Industry compliance standards

    • ISO 12863 for tobacco product manufacturing and testing
    • US FDA Guidance for Tobacco Products, Section 910
    • EU Directive 2014/40/EU on tobacco products and flavorings
    • China YC/T 207 (General technical requirements for flavorings in tobacco)

    Typical usage ratio

    • 1–20 ppm in finished tobacco blend, depending on product type (e.g., cigarettes vs. cigars) and target profile.
    • Formulators optimize ratios by sensory panel feedback and in compliance with local regulations.

    Downstream process integration

    • Blending in flavor solution concentrates added during the casing or top flavoring stage post-curing.
    • Direct spraying onto cut tobacco ribbon or integration into granulated reconstituted base sheets.

    Final product types

    • Filtered cigarettes, cigar filler sheets, pipe tobacco blends, heated tobacco units.

    3. Pharmaceutical Intermediate for API Synthesis

    Ethylpyrazine functions as a key pharmaceutical intermediate in the synthesis of certain pyrazine-derived APIs, notably within nervous system and anti-inflammatory research pipelines. Fine chemical manufacturing plants integrate ethylpyrazine-based steps under GMP compliance, utilizing its high purity and defined reactivity in heterocyclic prescription ingredient routes. Process safety, impurity profiles, and traceability records are mandatory.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF or Ph. Eur. monograph requirements for related intermediates
    • Current Good Manufacturing Practices (cGMP) enforced by FDA, EMA, NMPA
    • REACH registration for EU chemical intermediates

    Typical usage ratio

    • Variable stoichiometric levels in reaction batch: typically 1–1.3 equivalents in key condensation or functionalization steps.
    • Reactant excess adjusted based on process yield and desired impurity control.

    Downstream process integration

    • Charged directly as a starting reagent in stirred tank reactors or flow reactors for pyrazine core assembly.
    • Strict in-process controls before downstream coupling, halogenation, or further derivatization stages.

    Final product types

    • Pyrazinamide derivatives, CNS modulator APIs, intermediary bulk drug substances for contract API manufacturing.

    4. Aroma Additive in Pet Food and Animal Nutrition

    Producers of high-value pet nutrition products incorporate ethylpyrazine to simulate palatable roast and meaty notes in dry kibbles, compound feeds, or treat formats. The molecule’s masking capabilities enhance feed acceptance and product differentiation, especially for fussy pets. Quality assurance protocols mandate rigorous raw material identity and cross-contamination prevention in multi-line plants.

    Industry compliance standards

    • AAFCO Official Publication for pet food additives (USA)
    • EU Regulation No. 1831/2003 (Additives for Use in Animal Nutrition)
    • FAMI-QS certification for specialty feed ingredients (Europe)
    • GB 13078 (China’s hygienic standard for feeds)

    Typical usage ratio

    • 0.5–15 ppm, determined by target aroma strength and pet species palatability studies.
    • Dosage may be lower for companion animal treats or specialty therapeutic diets.

    Downstream process integration

    • Addition via pre-mix slurries or micro-encapsulated formulations blended before extrusion or drying stages.
    • Final dosage validated by panel acceptance and analytical retention studies.

    Final product types

    • Dry cat and dog food, functional pet snacks, companion animal chews, extruded aquatic feeds.

    5. Electronic Cigarette and Vape Liquid Flavoring

    Specialty manufacturers utilize ethylpyrazine as a clean-label vaping additive to create nutty or toasted profiles in nicotine and non-nicotine liquids. It is preferred in reformulation for its thermal stability and recognized safety profile in vaporization. QC laboratories test for purity and thermal decomposition products prior to commercial blending for e-cigarette fluids.

    Industry compliance standards

    • TPD (EU Tobacco Products Directive 2014/40/EU) notification requirements for e-liquid flavorings
    • US FDA Premarket Tobacco Product Applications (PMTA) flavor ingredient disclosures
    • CASSA (China Association of Standardization for E-cigarettes) technical requirements
    • ISO 8317 child-resistant packaging requirements observed by downstream packagers

    Typical usage ratio

    • 0.2–2 ppm in finished vape fluids, allowing mild nutty notes without harshness upon atomization.
    • Lab screening adjusts level to balance overall e-liquid formula volatility and sensory perception in heating coils.

    Downstream process integration

    • Direct batch blending with propylene glycol, vegetable glycerin, and other permitted flavors in clean-room facilities.
    • Final bottling and filling processed under strict environmental and particulate controls.

    Final product types

    • E-liquid cartridges, refillable open-system e-juices, nicotine salt pod solutions, flavor-only vape concentrates.
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    Certification & Compliance
    More Introduction

    Ethylpyrazine: The Distinctive Flavor Ingredient in Our Portfolio

    From Our Reactor to Industry Kitchens

    Producing Ethylpyrazine has taught us about many sides of chemistry—not just the kind that measures yield per batch, but also the kind that brings value to creative industries like flavors, fragrances, and food science. Our team has worked hands-on with Ethylpyrazine from raw material sourcing right through to final quality control, running reactors, adjusting feeds, listening to every subtle change during distillation. Over the years, we have seen the product become more than just a molecule to handle. It bridges demands between science and sensory experience, and it reflects the seriousness with which producers approach food safety and flavor consistency around the world.

    Spec Details Drawn From Working Batches

    Our production model for Ethylpyrazine centers on batch synthesis. We do this because tighter control at each stage produces a higher-purity product, which matters for stability and taste profile. The typical specification, based on the reality of plant runs, is a purity that consistently exceeds 99.5 percent by GC. Moisture control stays under 0.2 percent, checked both before storage and shipment, minimizing the chance of compound degradation. The color runs clear, sometimes giving the faintest amber tint, due in part to natural variations in the source raw materials. On the scale of impurities, we track any potential off-notes with extra gas-chromatography analysis—especially since customers in the flavor and fragrance space are sensitive to even small-batch anomalies.

    We supply Ethylpyrazine as a liquid, packaged in airtight drums designed to prevent oxidation. No one wants a batch tainted by trace oxygen; it breaks down the aroma and undercuts the work of everyone involved, from chemist to chef. We avoid large container sizes wherever shelf-life could be threatened, especially for customers whose operations run on a just-in-time model or seasonal production peaks.

    Functional Uses: Where Chemists and Culinarians Agree

    People in the specialties market look for more than a pleasant odor. Ethylpyrazine delivers a roasted, nutty, slightly cocoa-like scent in low concentrations, and because we make it ourselves, we have watched the market favor its use as a signature note in baked goods, coffee flavors, and nut-inspired aromas. In food technology, creators keep demanding clean-label ingredients and low-threshold odorants that lift their recipes without crowding out other notes. Ethylpyrazine fits these requirements well: it offers strength in its scent, but remains smoother and less harsh than methylpyrazine or other pyrazine relatives.

    From our own trials and feedback from R&D customers, we have seen uses stretch across chocolate flavoring, enhancing cooked meat simulants, and even in subtle background notes for e-cigarette liquids. We have supplied volumes tailored for both pilot-scale and commercial use. In developing countries, where single-note flavors are often blended with local variations, Ethylpyrazine allows for cost-effective, reliable contrast against more expensive or perishable natural extracts.

    Real-World Advantages in Manufacturing

    Making Ethylpyrazine in-house has let us keep control over consistency, and time in the lab makes the reasons practical: temperature, reactant quality, catalyst handling, and residue control all affect the final taste and aroma. The process produces very characteristic by-products that need careful removal, as even small impurities can dramatically alter the finished product’s performance. We’ve seen, in technical exchanges, how tighter impurity control leads to shorter blending times and less masking later in product development. This is crucial for large-scale food producers who want a flavor that simply fits in and can be dosed accurately.

    In our experience, shipping cycles can introduce delays or temperature excursions—both enemies of flavor integrity. Through many learning cycles, including a few mistakes, we moved to insulated containers and logistics partnerships that keep the product stable in transit, even across rough routes in hot climates. It turned out this detail was not about compliance checkboxes but about maintaining the same sensory punch, batch after batch, so commercial users can rely on what they taste in formulation.

    The Value of Vertical Integration

    We learned quickly that making Ethylpyrazine from scratch gives more flexibility, especially as regulatory standards evolve and new documentation gets required. Having all synthesis steps and analytics under our own roof means we can offer transparency—full batch traceability, solid certificates of analysis, and the confidence that no banned precursors slip into the supply chain. In practice, customers in Europe pointed us to specific allergens and marker compounds that required closer scrutiny. Meeting those needs opened fresh doors into restricted markets and let food safety officers use our paperwork for quick clearing.

    Some competitors offer blended or reformulated pyrazines, but our batches draw from raw inputs—all reactions, distillations, and purifications performed in a controlled, single-site operation. This way, change control decisions can respond to real circumstances: if a main feedstock becomes temporarily variable, we have a lab team to revalidate critical properties before shipping. This agility is rare where traders or third-party repackagers dominate the scene.

    Where It Stands Among Other Pyrazines

    With a wide choice of pyrazine derivatives available, food and beverage formulators rightfully ask about the differences. Ethylpyrazine distinguishes itself through its lower aroma threshold compared to many other alkylpyrazines, such as methylpyrazine and isopropylpyrazine. Chemically, it follows a two-carbon side chain, which alters not only volatility but also the intensity of its signature nutty-chocolate note. In real product development, this means less is required to achieve the desired profile, reducing risk of overpowering the formulation or introducing off-notes.

    From hands-on evaluation, Ethylpyrazine’s flavor character appears softer and rounder than methyl- or dimethyl-pyrazine. Methylpyrazine, for instance, projects a punchy green-grassy accent, which can dominate delicate recipes if not expertly moderated. Ethylpyrazine’s aroma, in contrast, stays mellow and more compatible with sweet, bakery, and coffee notes. This property cuts down the time and money spent by food developers who would otherwise mask or rebalance overbearing top notes.

    We are sometimes approached to customize levels of certain pyrazines, like 2,5-dimethylpyrazine or trimethylpyrazine, in tailor-made blends. Yet, for those seeking clarity and strength in a finished flavor, Ethylpyrazine often gets the nod thanks to its high threshold of acceptability and its ability to work across a broad variety of bases—wheat, cocoa, nuts, seeds, and even grilled or roasted meat analogs.

    Compliance and Clean Production

    From the manufacturing floor up, we approach product quality as a cumulative process. We comply with REACH and FDA standards; every batch is fully checked for pesticide residues, banned solvents, and unwanted metallic contamination. This works not just as a compliance exercise, but as an extra layer of assurance to flavor houses, beverage producers, and confectioners wary of unlisted foreign substances sneaking into global supply chains.

    Audit teams make regular rounds through our synthesis, blending, and filling lines. They know every operator by name, and have stood, like us, in the heat and noise of production to see that traceability works in the real world. Our customers know who makes their flavor ingredients—no subcontractor with shifting labels, no re-bottler with ambiguous origins. We treat every lot number as a promise, backed up by liquid and gas chromatograms, sensory panel notes, and repeat QC trials.

    Feedback Loop: Improving with Every Customer Experience

    Customer feedback has not always been gentle, and it shouldn’t be. Every time we’ve had a product that didn’t quite meet expectation—say, a minor color variance or a result just edging towards the aroma threshold—direct dialogue has sent us back to the reactor, not just to correct but to tune our process for higher accuracy. That relationship builds trust, both ways. We have even hosted QA teams from global brands who tested Ethylpyrazine on our own lab equipment before scaled purchase decisions. Their on-site reviews have exposed us to new flavor design approaches and regulation trends occurring ahead of the general market.

    One memorable case from a large-scale confectionery project saw a client’s formula struggling to achieve a particular roasted, chocolate-like background note. Rather than a quick replacement, our chemists worked with the application team, re-benching both base material and solvent to optimize for a specific intensity curve at scale. By having full control over formula and supply, we evolved product grades for the specific needs of high-output production lines. This hands-on approach led to a collaborative product launch that still references our original in-house Ethylpyrazine grades to this day.

    Addressing Market Shifts and Food Trends

    Change is a constant in food technology. In the recent move towards “natural” and “identical to natural” lists, Ethylpyrazine finds itself appealing to formulators who prioritize label simplicity while maintaining performance. With growing demand for plant-based and alternative protein foods, Ethylpyrazine offers a route to intensifying roasted flavor and aroma notes without resorting to heavier, often allergen-laden extracts. This flexibility has seen our ingredient move into markets that until recently relied exclusively on heavy process flavorings or extracts.

    Our R&D partners frequently experiment with Ethylpyrazine alongside mushroom extracts, legume bases, and specialty yeasts to unlock next-generation taste profiles for flexitarian and vegan products. Having reliable, high-purity Ethylpyrazine ready to integrate has let many customers speed up development cycles. We have seen our product wind up in everything from energy drinks targeting new flavor trends through to high-end culinary reductions.

    Sustainability and Future Directions

    Running a fully integrated operation, we must face questions of waste management, energy use, and responsible sourcing. The synthesis of pyrazines—including Ethylpyrazine—can be challenging due to nitrogen and solvent handling. We have installed recovery systems within our plant that reuse solvents, minimize nitrogen gas releases, and safely handle organics. Every waste stream gets captured and logged to meet both local regulatory standards and the scrutiny of multinational partner audits.

    Over time, we’ve partnered with local universities and research institutes to find more energy-efficient synthesis routes, and to engineer catalysts that lessen both energy costs and by-product formation. Results take time, but even incremental savings help keep us competitive and responsible. Customers care about ingredient provenance; so do we, as people in the manufacturing community who expect our products to deliver both safety and sustainability.

    Challenges and Solutions in Scale-Up

    Moving from small, controlled lab runs to reliable industrial-scale output presents challenges—any misstep multiplies across tonnage levels, not just liters. Heat transfer characteristics, raw material purity, agitation speed, and phase separation all play their part in determining what the final product smells and tastes like. We have invested heavily in pilot systems to mimic full-scale reactions, smoothing out production variables before they reach the customer’s facility.

    This pilot-first mindset minimizes surprises. Greater batch-to-batch uniformity means downstream users can plan dosage curves and application rates with greater certainty. If a client’s regional regulatory body imposes new requirements—think specific impurity or labeling rules—we can often flex our workflow to deliver the documentation and data needed. We adjust, document, and repeat until consistency becomes our standard, not a hope.

    A Partnership Approach Beyond the Transaction

    Partnership goes beyond a transaction: successful business comes from working directly with technical managers, line operators, and product formulators to see where real-world requirements meet on-the-ground possibilities. Sometimes, what’s required by regulation or quality systems goes beyond the flavor and aroma of Ethylpyrazine itself, extending into logistics, technical paperwork, and even readiness to participate in customer audits or supplier diversity programs. By manufacturing from raw material to finished product, our team stays nimble and available for collaboration—customers know exactly who they call if questions arise.

    We have supported clients rolling out reformulated chocolate bars, new snack lines, beverage innovations, and vegan product launches. This means responding quickly to sample requests, shipping custom lots sized to fit new lines, and offering technical guidance based on actual benchmarks rather than industry hearsay. Simply put, we’ve built a business where the measure of quality comes from outcomes—not from generic claims but from the flavors and smells made real in kitchens, workshops, and industrial kitchens worldwide.

    Looking Ahead: Building on Experience

    Over the years, everything we have learned from producing Ethylpyrazine has come from listening to what partners and end-users actually need—and then working to adapt, refine, and improve the product. For us, chemistry is personal: each batch carries the signature of every engineer, technician, and operator involved. This approach helps us deliver a product people trust—not as an abstraction, but as a real ingredient that bridges science and sensory excitement in foods, drinks, and beyond.