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Ethylmalonic Acid

    • Product Name Ethylmalonic Acid
    • Alias EMA
    • Einecs 205-508-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    231551

    Chemical Name Ethylmalonic Acid
    Cas Number 697-23-8
    Molecular Formula C5H8O4
    Molecular Weight 132.11 g/mol
    Appearance White crystalline powder
    Melting Point 103-105 °C
    Solubility In Water Soluble
    Boiling Point Decomposes before boiling
    Pka 2.77, 5.44
    Density 1.384 g/cm3
    Iupac Name 2-Ethylpropanedioic acid
    Pubchem Cid 77694

    As an accredited Ethylmalonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethylmalonic Acid, 100g, is packaged in a clear, sealed glass bottle with a screw cap, labeled with safety and chemical details.
    Shipping Ethylmalonic Acid should be shipped in tightly sealed containers, protected from moisture and direct sunlight. It must be packed according to local and international regulations for hazardous chemicals, with correct labeling. Transport should ensure stability during transit, using secondary containment if necessary to prevent spills or leaks. Handle with appropriate personal protective equipment.
    Storage Ethylmalonic acid should be stored in a tightly sealed container, in a cool, dry, well-ventilated area away from sources of heat, sparks, or open flames. It should be kept away from strong oxidizing agents and bases. Avoid moisture and direct sunlight. Use appropriate chemical storage cabinets, label clearly, and restrict access to authorized personnel only. Always follow safety regulations.
    Application of Ethylmalonic Acid

    Applications of Ethylmalonic Acid in Industrial Manufacturing

    Ethylmalonic acid serves as a key intermediate in several downstream industries, where its unique molecular structure and reactivity enable precise chemical transformations. As an original manufacturer, we support production partners in fields demanding strict compliance, consistent batch quality, and robust traceability across stringent global regulatory frameworks. Below, explore major application domains, with detailed insights for each processing environment.

    1. Pharmaceutical Intermediates: Synthesis of Antiparkinsonian Agents

    Ethylmalonic acid acts as a critical building block in synthesizing L-(-)-carbidopa, a clinically significant antiparkinsonian pharmaceutical. Its methylene activation allows for regioselective alkylation, directly impacting yield consistency and impurity control. Depending on the synthesis pathway, the acid integrates at the early carboxyalkylation step, ensuring high stereopurity in the final active pharmaceutical ingredient (API).

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, 21 CFR Parts 210/211, US FDA)
    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) Monograph Compliance for APIs
    • Chinese Pharmacopoeia (ChP) API standards

    Typical usage ratio

    • 0.9–1.2 molar equivalents relative to targeted aldehyde group reagents; adjusted based on impurity threshold and downstream chiral control steps

    Downstream process integration

    • Introduced during the carboxyalkylation phase, after formation of haloalkyl intermediates, just before decarboxylative coupling

    Final product types

    • L-(-)-carbidopa (API)
    • Dopamine biosynthesis inhibitors (preclinical intermediates)

    2. Agrochemical Synthesis: Fine Chemical Intermediate for Herbicides

    In agrochemical manufacturing, ethylmalonic acid functions as a nucleophilic coupling substrate for constructing malonyl-based moieties within selective herbicide frameworks. Its stability permits safe storage and measured reactivity under controlled process conditions, enabling streamlined multi-step synthesis in active ingredient production lines, such as pyridine- or pyrazole-based crop protection agents.

    Industry compliance standards

    • ISO 9001:2015 Certified Quality Management System
    • FAO/WHO Guidelines for the Quality Control of Pesticides
    • REACH Registration (EC Regulation No. 1907/2006) for EU agrochemicals
    • China’s Pesticide Management Regulations (Decree 677 of Ministry of Agriculture)

    Typical usage ratio

    • 5–20% w/w relative to total malonyl component in the herbicide precursor batch; exact proportion may be optimized for yield and impurity profile

    Downstream process integration

    • Charged as a feedstock in the malonylation coupling reactor, integrated following condensation of core heterocyclic units

    Final product types

    • Active herbicidal compounds containing malonyl or dicarboxylate fragments
    • Intermediate agrochemical blocks for further derivatization

    3. Specialty Polymer Manufacturing: Monomer Modifier in Polyesters

    Producers of high-performance specialty polyesters and polyamides incorporate ethylmalonic acid as a co-monomer to adjust crystallinity, chain flexibility, and degradability profiles. By introducing precise dicarboxylic units during melt-polycondensation, manufacturers tailor the thermal and mechanical properties of polymers used in engineering plastics and biomedical devices.

    Industry compliance standards

    • ISO 9001:2015 for polymer product quality systems
    • FDA 21 CFR 177.1590 (if intended for food-contact polymer grades)
    • EU Regulation (EC) 1935/2004 on materials intended for food contact
    • ISO 13485:2016 for medical polymer components

    Typical usage ratio

    • 0.5–3 mol% of total diacid component; dosage tailored based on target polymer flexibility or hydrolytic degradation rate specifications

    Downstream process integration

    • Fed into the esterification or amidation reactor at the co-monomer charging step, ahead of high-vacuum polycondensation

    Final product types

    • Degradable polyesters for medical suture and implantable device applications
    • Engineering resins with controlled flexibility for automotive and electronic parts

    4. Fine Chemical Synthesis: Custom Synthesis of Malonic Derivatives

    Custom molecule manufacturers apply ethylmalonic acid as a versatile substrate for producing complex malonic derivatives used in dye, fragrance, and specialty materials industries. Its dual carboxyl groups and ethyl substitution facilitate straightforward functionalization and minimize side-product risks during controlled esterification or amidation reactions.

    Industry compliance standards

    • ISO 9001:2015 for contract and toll manufacturing quality assurance
    • International Chemical Safety Cards (ICSC) for worker and environmental safety
    • TSCA (Toxic Substances Control Act, US) if supplied to US specialty markets
    • Responsible Care® Management System (Chemicals Manufacturing)

    Typical usage ratio

    • 10–45% as a molar basis in stepwise synthesis of bespoke malonate esters or amides; proportion tuned for desired functional group introduction

    Downstream process integration

    • Added post-activation of precursor alcohols/amines in a reaction sequence designed around minimal by-product formation

    Final product types

    • Functional malonate esters for pigment and dye synthesis
    • Alkyl-substituted malonic amides applied in fragrance intermediates
    • Specialty chemicals for advanced material research
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    Certification & Compliance
    More Introduction

    Ethylmalonic Acid: Reliable Performance, Practical Value

    Our Direct Commitment to Quality and Honest Production

    Every batch of Ethylmalonic Acid produced at our facility results from years of experience and careful attention to every step in the process. Our team manages raw material sourcing, chemistry, and handling in-house, so every shipment comes from the hands that made it. Quality isn’t just a number on a certificate; it’s the outcome of strict procedures, hard lessons learned over decades, and pride in our craft. You won’t find middlemen fluff—just a straightforward product and the story of its making.

    What Sets Ethylmalonic Acid Apart

    Ethylmalonic Acid offers a specific advantage due to its unique structure—a two-carbon ethyl group attached to the malonic acid skeleton. This alters its reactivity compared to simple malonic acid and opens doors in synthesis where standard compounds fall short. Chemists looking for selective diacid functionality with a manageable melting point and good solubility have come to appreciate just how this compound behaves in the lab and in industrial settings. In our experience, subtle adjustments in synthesis and purification yield tighter control over particle size and color, which matters when you’re scaling up for demanding downstream reactions.

    Proven Reliability in Polymer and Pharmaceutical Pathways

    Chemists come to us asking for a diacid that stands up to real process conditions—whether they’re making specialty polymers or designing intermediates for active pharmaceutical ingredients. Ethylmalonic Acid, with its specific model known as EMA100, slots in well where malonic acid or methylmalonic acid fall short. EMA100, our main grade, comes with assay values above 99%, a low water content, and smooth, fine crystals that handle well both in the pilot plant and on production lines. That sounds technical, but what it means for most customers is fewer re-work cycles, easier filtration, and reproducibility in every synth run.

    When we supply EMA100, we aren't shipping something we found on a spreadsheet. Our process eliminates batch-to-batch drift. We perform full trace metal and impurity checks, because catalytic residues from earlier production stages can sneak into poor-quality diacids and poison sensitive processes. Our clients—many focused on pharmaceutical quality—demand data and results, not reassurances, so we give them certificates built from real daily analysis, not templated paperwork. They tell us their downstream chromatography gets smoother, and their crystallization steps stop clogging up, since our product runs clean and doesn't clump or dust.

    Why Practical Experience Matters in Chemical Manufacturing

    There's a tendency in the fine chemical world to focus on abstract benefits or to rely too heavily on marketing language. In practice, the people who actually make things—who handle pumps, pre-weigh solids, and watch titrations swing color—know what matters. Laboratory-scale production of Ethylmalonic Acid involves careful control over ester hydrolysis and acidification. We track every variable: temperature consistency, choice of acidifying agent, aging time, filtration speed, drying pressure. Scale-up uncovers new wrinkles—thermal lags, suspensions that settle too quickly, sampling lines that cake up. You deal with these processes every day, not in theory but on the shop floor in real time.

    We have found, for instance, that a minor adjustment in solvent volume can turn a murky batch into a fine, free-flowing powder. It took us months of frustrating batches to pin down just how to get the smallest possible impurity signature when moving from reaction to crystallization. Customers who’ve worked with commodity-grade ethylmalonic acid from brokers often call us up just to say thanks—their process lines stop fouling and their workers don’t have to spend overtime on filter changes.

    Practical Usage in Industry

    Ethylmalonic Acid finds most of its use as a building block in pharmaceutical, agrochemical, and specialty chemical synthesis. The presence of two carboxyl groups on the same molecule, separated by a single carbon, make it valuable for reactions requiring decarboxylation or carbon chain extension. Many companies buy Ethylmalonic Acid for cyclizations that require predictability and reproducibility; when molecules need precise substitution patterns, there aren’t good shortcuts. Some use it in research settings where alternative diacids might break down too easily, leaving side products that cost time or money to remove.

    The differences between Ethylmalonic Acid and similar compounds, like malonic acid or methylmalonic acid, can be significant. With an ethyl group, the molecule is less volatile and has slightly different solubility. It’s this difference that makes it better suited for some selective alkylations, estifications, and even as a precursor for specific heterocyclic intermediates. Customers sometimes ask about using malonic acid instead, but their reactions often need reoptimization or simply won’t perform at the same yields. In fields like pharmaceutical or specialty polymer development, those percentage points matter.

    Specs That Serve the Workbench, Not Just the Spreadsheet

    Over the years, our preferred model, EMA100, has become the go-to for process chemists who want certainty. The fine, nearly white crystals dissolve quickly in water and common polar solvents. The melting range—often around 103-105°C—gives reliable purification behavior. Purity matters most, but we’ve also learned that consistency in physical form can shave hours off a campaign or reduce scrap rates. You can weigh, mix, and stir EMA100 without worrying about dust explosions or erratic wetting, even in batch vessels running over several shifts.

    Technical managers visiting our facility usually comment on how we keep every batch under strict control. We don’t allow cross-contamination, and we test every output for trace solvents or colored byproducts that ruin some specialty syntheses. A few grams of a contaminated feedstock can turn an expensive batch into waste, so most buyers care less about a few percent off list price and more about clean runs, day after day.

    Addressing Common Issues with Competing Grades

    Not every ethylmalonic acid on the market meets production requirements. We've seen shipped grades with undissolved clumps, odd tints, or sulfated residues. These issues arise not just from poor raw materials, but often from shortcuts in workup, washing, or drying. With direct production, we can show visitors exactly how we avoid these pitfalls. For one, the choice of acidifying agent during hydrolysis is critical—trace metals or inorganic salts from cheaper agents often slip past lax filtration and show up as black or yellow streaks in customer reactors. We use techniques that strip these residues early, even if it means more steps for us. Less rework saves both us and our clients time, energy, and money in the long run.

    Another common problem comes from inconsistent particle sizing. Big clumps won't dissolve evenly, causing lags and cold spots in large reactors. Conversely, a too-fine, dusty product invites dust inhalation and poor pour control—a safety issue in open charging typical of older plants. After years of feedback, we tuned our dryers and crystallizers to deliver a balanced, free-flowing powder that tips nicely but won't go airborne with every scoop.

    Supporting Responsible Chemical Use and Downstream Value

    We produce Ethylmalonic Acid with the broader chemical community in mind. Each process tweak comes from actual user feedback: maintenance engineers call us after line blockages, synthetic chemists share batch notes, and quality teams alert us when trace contaminants creep up. By passing this collective experience into each lot, we build reliability into the product, not just on the paper trail, but in repeated use.

    Customers from regulated or high-stakes industries, especially pharma and agrochemical, rely on us for traceability. We keep real sample archives and transparent records. If a customer reports a downstream hiccup, they reach our technical manager directly—no call center runaround. This accountability encourages us to keep records honest and batches repeatable, so mistakes can be traced and not repeated.

    Many facilities face increasing regulatory scrutiny—good manufacturing practice (GMP) audits, environmental discharge checks, and greater pressure on batch-to-batch variation. Ethylmalonic Acid, as a relatively low-volume but critical intermediate, can be a regulatory bottleneck if not managed properly. By keeping our process under the same roof, we answer regulators with facts and documentation, not guesswork.

    Looking Ahead: Efficiency, Sustainability, and Ongoing Improvement

    The fine chemicals field never stands still. Raw material swings, process innovation, and sustainability demands keep us on our toes. Ethylmalonic Acid might seem like a straightforward molecule, but we treat it as a dynamic product. Recent years have seen us switch to greener hydrolysis agents and introduce recycling on process water, not because it’s trendy, but because waste minimization and energy savings make long-term sense. Our carbon footprint per kilo keeps dropping because we track inputs, test our boilers, and invest in better controls every season.

    Clients also push us on documentation—their end-users need detailed impurity profiles, rationalized change control, and baseline data for registration dossiers. Our analytical team runs not only the routine checks for assay and metals, but also screens for residual solvents and obscure side products that could disrupt a sensitive synthesis. New requests roll in every cycle: can we lower the trace halide? Will a custom particle size distribution help? Does color matter for an application in electronic materials? We're equipped to take these questions back to production because everyone, from shift operators to plant managers, knows the value of a trustworthy product in a finicky synthesis.

    We find satisfaction in seeing our product move from warehouse to workbench and ending up in critical molecules for health, safety, and innovation. As direct manufacturers, we watch the carbon, water, and materials balance over every batch. This attention isn’t driven by outside pressure—it’s been baked into our process since our first kilogram. Our role in the supply chain is clear: deliver genuine consistency, support practical solutions, and place direct experience above sales decks or spec-sheet gloss.

    Direct Understanding of User Needs

    Whenever someone asks what makes our Ethylmalonic Acid different, we point to our experience as makers, not middlemen. Knowing the work that goes into a single kilo means we respect every step—each filtration, each test, each delivery. By controlling the process, we control the outcome, and that lets every customer—from early-stage R&D to full production—trust that what they get in the drum or bag is what they asked for. Our connection to the chemical, from raw material through purification to packaging, gives us a unique perspective on its unspoken value—the hours saved, the batches run on time, and the results made easier.

    We believe that trust in a chemical supply partner comes from showing the full picture and solving problems as they appear, not hiding behind layers of delay. Our clients keep returning not just for purity, but for answers, responsiveness, and relentless fine-tuning of each batch. That’s our real difference—visible in every kilo delivered, every technical call, every customer batch note. Ethylmalonic Acid doesn’t just serve as a molecule in a bottle; it stands for something honest, practical, and proven through hands-on work.