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Ethyl Phenylcyanoacetate

    • Product Name Ethyl Phenylcyanoacetate
    • Alias Ethyl 2-cyano-3-phenylpropanoate
    • Einecs 223-470-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    498012

    Cas Number 94-05-3
    Molecular Formula C11H11NO2
    Molar Mass 189.21 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 158-160°C (at 2 mmHg)
    Melting Point -35°C
    Density 1.098 g/cm3 at 20°C
    Refractive Index 1.527 (20°C)
    Flash Point 137°C
    Solubility Insoluble in water; soluble in organic solvents
    Purity Typically ≥98%
    Synonyms Ethyl 2-cyano-3-phenylpropanoate
    Smiles CCOC(=O)C(C#N)C1=CC=CC=C1
    Storage Temperature Store at room temperature
    Hazard Statements May cause skin, eye, and respiratory irritation

    As an accredited Ethyl Phenylcyanoacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of Ethyl Phenylcyanoacetate is packaged in a sealed amber glass bottle with a secure screw cap, labeled clearly for laboratory use.
    Shipping Ethyl Phenylcyanoacetate is shipped in tightly sealed containers to prevent moisture and contamination, typically as a liquid or crystalline solid. It should be stored and transported in a cool, dry place, away from incompatible substances. Appropriate labeling and documentation are required, and handling should follow relevant safety and regulatory guidelines.
    Storage Ethyl Phenylcyanoacetate should be stored in a tightly sealed container, in a cool, dry, well-ventilated area away from sources of ignition, heat, and direct sunlight. Keep it away from incompatible substances such as strong oxidizing agents. Store at ambient temperature, and ensure proper labeling. Use appropriate precautions to avoid inhalation, ingestion, or skin contact with the chemical.
    Application of Ethyl Phenylcyanoacetate

    Applications of Ethyl Phenylcyanoacetate in Industrial Manufacturing

    Ethyl Phenylcyanoacetate supports several specialized sectors as a chemical intermediate. Our manufacturing experience ensures quality and process consistency for demanding downstream formulations. Below are its principal industrial applications, each with relevant technical details and practical usage guidance.

    1. Pharmaceutical Fine Chemical Synthesis

    Pharmaceutical manufacturers use this compound as a building block in the synthesis of active pharmaceutical ingredients (APIs) and intermediates, particularly for compounds with cyano and ester functionalities. Its established reactivity allows for efficient Knoevenagel condensation and Michael addition reactions, forming backbone structures in antihypertensive, anticonvulsant, and certain anticancer molecules. Strict documentation and lot traceability are maintained throughout the manufacturing and supply process.

    Industry compliance standards

    • ICH Q7 GMP Guidelines for Active Pharmaceutical Ingredients
    • EU Guidelines for Good Manufacturing Practice for Medicinal Products
    • 21 CFR Part 210/211 (US FDA CGMP for APIs and Excipients)
    • Relevant monographs in the European and United States Pharmacopoeias (where applicable for downstream API)

    Typical usage ratio

    • 5–40% molar basis as a key intermediate, adjusted according to the targeted final API structure and yield optimization during the reaction sequence

    Downstream process integration

    • Introduced post-initial condensation phase as a reactant for ring-closure or chain-elongation steps. Reacts with aldehydes and amines or other nucleophiles in batch or continuous reactor setups with controlled temperature profiles and solvent-handling protocols.

    Final product types

    • Small molecule antihypertensive APIs
    • CNS-active drug intermediates
    • Intermediates for anticancer agents
    • Complex pharmaceutical reference standards

    2. Agrochemical Active Ingredient Production

    Producers of crop protection agents incorporate this molecule in synthesis chains for herbicide and insecticide actives. The cyano and ester groups offer critical points for molecular modification, facilitating alpha-cyanoester synthesis used in selective herbicide chemistries and insecticidal compounds. Full batch records and specifications comply with global agrochemical supply norms.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products (Active Ingredient and Formulation Quality)
    • OECD Good Laboratory Practice (GLP) for registration studies
    • ISO 9001:2015 Quality Management Systems
    • EU Regulation (EC) No 1107/2009 (Authorization of Plant Protection Products)

    Typical usage ratio

    • 10–30% by mol basis in precursor formation, further adjustable based on the complexity of the target agrochemical synthesis route and required output purity

    Downstream process integration

    • Enters mid-stage in a multi-step process. Commonly reacts with halogenated aromatics or amines to generate key intermediates, followed by hydrolysis, cyclization, or further functional group modifications in closed system reactors.

    Final product types

    • Alpha-cyanoester-based herbicides
    • Systemic insecticide intermediates
    • Pesticide synergy agents
    • Preformulated technical actives for field-ready formulations

    3. Advanced Organic Pigment Manufacturing

    Specialty pigment and dye producers apply this material as a core scaffold in synthesizing high-performance colorants, especially for azo, anthraquinone, or phthalocyanine pigment variants. The presence of both phenyl and cyano groups enables robust chromophore construction and fine-tuned electronic properties essential for automotive, plastic, and textile-grade colorants. Analytical verification ensures batch-to-batch reproducibility critical for color consistency.

    Industry compliance standards

    • EN 71-3 (Safety of Toys – migration of certain elements, for pigment use in toys)
    • REACH Regulation (EC) No 1907/2006 (Registration, Evaluation, Authorization and Restriction of Chemicals)
    • ISO 9001:2015 and ISO 14001:2015 for environmental management during pigment production
    • ASTM D476 for color pigment classification

    Typical usage ratio

    • 3–10% by weight in dye intermediate synthesis, varied according to desired pigment intensity, fastness, and physicochemical properties of the final formulation

    Downstream process integration

    • Utilized as a key nucleophile during coupling reactions or oxidative processes. Incorporated during controlled heating and catalyst addition steps for backbone assembly in pigment molecule synthesis. Ensures consistency of molecular weight distribution and UV stability.

    Final product types

    • Anthraquinone and azo pigments
    • Solvent-soluble dyes for plastics and fibers
    • Specialty automotive colorants
    • Industrial coatings colorants

    4. Specialty Polymer & Resin Modification

    Chemical formulators in the specialty resin sector exploit this ester for introducing polar and aromatic domains into polymer backbones, tailoring mechanical and thermal properties of end-use plastics. Copolymerization or graft-modification with styrenic, acrylate, or vinyl monomers enhances compatibility, glass transition, and UV resistance, vital for high-performance plastics and coatings. Continuous monitoring assures target molecular architecture and low-residual monomer content.

    Industry compliance standards

    • EN ISO 11357 (Differential Scanning Calorimetry for plastics characterization)
    • ASTM D256 (Impact resistance of plastics)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • REACH-compliant raw material disclosure for all additives and modifiers

    Typical usage ratio

    • 0.5–5% by weight in polymer blends, fine-tuned to balance flexibility, chemical compatibility, and the degree of cyano group introduction for desired surface and bulk properties

    Downstream process integration

    • Fed into copolymerization reactors or extruders with base monomers. Reacts during the polymer chain-growth phase and post-polymerization modification steps, monitored by GPC and DSC to meet application-specific requirements.

    Final product types

    • Engineering plastics with enhanced UV stability
    • Acrylic-based coatings for industrial substrates
    • High-gloss varnishes
    • Modified thermosetting resins

    5. Flavor & Fragrance Intermediate Synthesis

    Within the specialty aroma chemical sector, manufacturers deploy this material in constructing complex aromatic intermediates, which later serve as precursors for synthetic fragrances and flavoring agents. The high-purity grade of this intermediate supports downstream transformations such as reduction, hydrolysis, and cyclization to yield key notes used in perfumery and flavor design for B2B clients in F&F houses.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association) for permissible raw materials
    • FCC (Food Chemicals Codex) for flavor additive safety
    • ISO 9235:2013 for definitions of aromatic raw materials
    • Hazard Analysis and Critical Control Point (HACCP) guidelines in food flavoring production

    Typical usage ratio

    • 1–7% of total formulation mass during intermediate synthesis, adapted as needed for desired target load and purity in the fragrance or flavor formulation

    Downstream process integration

    • Enters reaction cycle post-initial synthesis as an aroma precursor. Undergoes reduction, cyclization, or esterification to create unique aromatic aldehydes and esters, with purity verified by GC/MS and HPLC.

    Final product types

    • Synthetic fragrance bases for perfumes
    • Flavor intermediates for beverage and confectionery
    • Aromatic modulators for detergents and personal care products
    • Scent formulation concentrates
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    Certification & Compliance
    More Introduction

    Understanding Ethyl Phenylcyanoacetate from the Manufacturer’s Perspective

    Real Insights on Ethyl Phenylcyanoacetate Production

    As a producer active in the field of specialty chemicals, I have seen genuine demand and innovation emerge around Ethyl Phenylcyanoacetate. This isn’t another one-size-fits-all intermediate. It plays a crucial role in many synthetic schemes because of its unique balance of chemical stability and reactivity. On the shop floor, we witness the expectation for consistent product quality and tight specification standards, addressing the needs chemists encounter daily. The product we deliver, often referenced by model number EPC-109 in our system, maintains a purity typically above 99%, supporting sophisticated applications that can’t tolerate variability.

    Real-World Advantages in Fine Chemical Synthesis

    Chemists appreciate Ethyl Phenylcyanoacetate for its performance in Knoevenagel condensations, not just for its theoretical reactivity but for results seen in practical synthesis. Over repeated campaigns, our teams discovered improvements in color stability during storage, based on the way we control raw phenylacetic acid input and purification steps. Lab teams conducting pilot work noted fewer issues with by-products compared to traditional cyanoacetate esters. Production lines that switch from methylcyanoacetate to phenylcyanoacetate variants point out the clean filtration profiles, reducing downtime for cleaning and waste separation.

    From Raw Inputs to Final Drums: Focusing on What Matters

    The manufacturing process requires care at every turn: temperature profiles during esterification, solvent recovery efficiency, and even drum selection for extended shelf life. Over years, we found that in-process reaction monitoring using inline IR gives the most reliable detection of compound formation. Our team avoids shortcuts with temperature excursions, aware of the impact tiny fluctuations exert on downstream processing and product shelf stability. There’s a focus on minimizing residual starting material and controlling particle size in the final dried product. Other suppliers may skip multiple recrystallizations to cut costs, but in our experience, those steps keep color and odor in check and improve downstream blends.

    Comparing Ethyl Phenylcyanoacetate to Other Esters

    Comparisons come up all the time. Lab chemists with experience using ethyl cyanoacetate or isobutyl methylcyanoacetate often ask what changes with the phenyl group. From our own batch synthesis data, Ethyl Phenylcyanoacetate’s aromatic ring leads to a noticeable difference in reactivity – it opens possibilities for making advanced pharmaceutical intermediates and fine fragrances. Unlike its aliphatic cousins, the aromatic nature provides more rigidity in the carbon backbone, favoring selectivity in condensation and alkylation reactions. This unique profile comes into play during the synthesis of active pharmaceutical ingredients, especially where selectivity can make or break a project’s viability.

    We hear feedback from contract manufacturers who transitioned away from ethyl cyanoacetate, looking to avoid overalkylation or side reactions during scale-up. On their equipment, our product produced more uniform yields at every scale, meaning less rework and fewer lost batches due to unpredictable exotherms. While on paper the melting points of various esters look similar, real-world batches reveal differences in shelf stability and packaging performance, based on crystallinity and sensitivity to atmospheric moisture.

    Quality Assurance Built from Firsthand Production Challenges

    As a manufacturer, assurance of purity isn’t just about hitting lab values. Our own quality team gets real about routine inspection and true sample retention, not just compliance box-ticking. We schedule intermediate sampling and keep reference spectra for every campaign. Downtime during cleaning cycles led us to refine our solvent selection, moving away from legacy choices that complicated waste disposal or increased cleaning frequency. Our operations crew tracks batch genealogy, making it possible to trace surprises in product morphology back to raw input changes, rather than just blaming transport or end-user handling.

    Over time, repeated observations confirm that small changes during filtration – pan mesh size or cake drying parameters – play a big role in the performance of the end product. Suppliers and traders rarely see these details, but they make the difference between a smooth-running manufacturing line and a constant string of customer complaints. End users want repeatable particle sizing and minimal fines, which we achieve with precise filtration and controlled drying, not just “good enough” approaches.

    Adapting Packaging and Shipping to the Real Chemical World

    Bulk packaging solutions for Ethyl Phenylcyanoacetate evolve because of chemistry, not just cost. We moved away from generic high-density bags after observing unexpected moisture pickup during overseas transport, which affected color and reactivity. Our standard now relies on double-lined, moisture-barrier drums, with inner liners tested for compatibility. We regularly field test shipments to regions with high humidity, using sample pulls at arrival to authenticate stability. These changes emerged from production feedback, not marketing jargon.

    We supply this product in several standard drum sizes and can adapt to customer filling specs, because we realize that handling ease and worker safety on client sites matter as much as shelf life. One client who moved to automated feed systems from smaller kegs cut their production time by 8%. The spent drums, if cleaned in line with local rules, can be returned for reprocessing, reducing waste. These practical details stem from everyday shop-floor lessons rather than theoretical sustainability targets.

    Supporting Chemical Innovators Through Real-World Partnerships

    Pharmaceutical and agrochemical innovators bring us questions about batch-to-batch reproducibility, stability during extended storage, and trace impurity risks. They want specifics — not vague guarantees. As a manufacturer, we respond by offering direct batch samples for validation and running parallel stability trials. Teams on our end know how to document any minor shifts in impurity profiles based on supplier lot changes or ambient conditions in storage. The ability to provide decade-long product histories helps our partners validate agency filings and stand up to regulatory review.

    Our chemists engage directly with R&D teams at customer sites, discussing catalytic behavior, solubility differences, and what to expect under unusual process conditions. An example: a partner exploring a novel dye intermediate achieved better yields with our Ethyl Phenylcyanoacetate because our process delivers a narrower distribution of minor isomers. Every year brings new applications — from flavor and fragrance to specialty coatings — and being nimble means listening to end users and making real changes at the reactor, not just at the sales desk.

    Thinking Beyond the Reaction: Handling and User Experience

    Close relationships with downstream users have shaped our understanding of what makes a reliable chemical intermediate. We invest in packaging that holds up on long hauls and train our teams to spot potential handling issues before product leaves the plant. Frequent feedback centers around the product’s flow properties, especially in automated dosing systems, where a uniform, non-caking profile avoids production stoppages. Real production plants value that kind of consistency more than nominal assay numbers.

    We pay close attention to transportation and handling, learning from occasional customer returns involving trace metal contamination or off-color batches. These cases led us to reengineer tank linings and rethink our handler training, ensuring that every part of the process protects the compound’s integrity. Instead of leaning on paperwork or generic specifications, we build procedures into daily work, so the experience in the warehouse matches the reassurance promised by the lab report.

    Focus on Environmental and Worker Safety at Every Step

    No shortcut can replace careful stewardship in chemical production. Worker safety improvements stem from real incidents, not just compliance audits. Over time, we recognized the hazard potential during drum filling and invested in enclosed nitrogen-blanketed systems to reduce operator exposure. We adjusted standard operating procedures after fielding customer questions about residual solvent levels, measuring not just for regulatory compliance but for actual process safety and environmental needs.

    Our approach increased both yield safety and lowered VOC emissions, meeting evolving regulatory targets. We sponsor regular training on spill procedures and PPE use, shaped by near-miss reports, not just external mandates. These improvements helped reduce employee turnover and supported robust third-party audits by pharmaceutical partners. Other manufacturers may take a more reactive approach, but real, on-site experience convinced us to lead advances in worker safety.

    Meeting Global and Local Regulatory Needs Through Practical Experience

    Current demand for specialty intermediates like Ethyl Phenylcyanoacetate overlaps constantly with evolving regulations. Product destined for pharmaceutical clients requires tighter impurity limits and stricter documentation. We learnt early on that a paper trail isn’t enough: demonstrated control through regular audits and transparent batch histories convinces regulatory agencies. Over the years, customer submissions to international authorities benefited from our retention samples and stability data, making agency reviews more straightforward.

    Emerging environmental and chemical safety programs also drive our plant to adapt. Switching to low-emission process solvents helped us lower our environmental reporting burden. We updated product documentation to reflect new classification requirements and conducted regular training so every operator knows how regulatory updates affect daily work. Our customer service team spends almost as much time supporting compliance paperwork as they do handling logistical questions, emphasizing our commitment to clear, practical communication over marketing promises.

    Supporting Innovation Through Technical Partnership

    Many breakthroughs in fine chemical manufacturing start with a need to overcome technical obstacles. Customers designing new pharmaceuticals or agrochemical actives value how consistently our Ethyl Phenylcyanoacetate performs, even in unproven synthetic routes. When process bottlenecks appear, our own technical support staff visits customer facilities, reviewing dose protocols or refining filtration stages to optimize throughput and reduce input waste. These joint development efforts differ from arms-length supply relationships — our investment in customer success increases demand certainty for our own team as well.

    This approach nurtures chemists’ creativity. In one example, a research group looking for improved α-cyano ester intermediates for heterocycle synthesis saved weeks of development time by working with us to create special order particle size grades, adjusted crystallization protocols to fit their specific reactors, and trialed several packaging types before settling on an optimal solution. Our willingness to find real answers, not just recite technical data, gives us full visibility into the real-world benefits and trade-offs with each adaptation.

    Handling Challenges Unique to Phenylcyanoacetate Chemistry

    Producing and handling Ethyl Phenylcyanoacetate differs markedly from less specialized cyanoesters. The aromatic component makes the compound more sensitive to certain redox reagents and requires more careful control during storage. Many synthetic pathways benefit from this reactivity, allowing for more selective transformations and shorter synthetic sequences, but the manufacturer shoulders the burden of safeguarding purity from start to finish.

    Early on, we encountered unexpected challenges with atmospheric oxidation in unlined storage tanks, leading to trace color formation that flagged problems for downstream purity. Addressing this required capital improvements and retraining of the storage and logistics teams. Each setback taught practical lessons we carry forward, minimizing surprises and delivering a better product for future clients. Other producers may cut corners or “problem solve” after incidents arise, but we embed improvements at each scale, from laboratory to full-scale runs.

    Feeding the Engine of Molecular Innovation

    Ethyl Phenylcyanoacetate, as produced here, isn’t just another commodity building block. Its aromatic backbone opens doors for formulating new drugs, dyes, and advanced organics. Over the past decade, we observed its role shifting from basic intermediate to foundational element in more integrated supply chains. Partnerships between chemical manufacturers, researchers, and end users are essential for accelerating discovery: open lines of communication, sample exchanges, and detailed technical recommendations make the difference. Our field staff help troubleshoot at pilot plants, so the product achieves its full performance potential, rather than being stymied by avoidable scale-up challenges or quality bottlenecks.

    This attitude supports genuine breakthroughs, not just routine transactions. Ethyl Phenylcyanoacetate, produced to exacting standards, brings the right blend of reactivity, selectivity, and physical stability for forward-thinking chemists. Its value increases as chemical manufacturers invest in transparency, iterative improvements, and direct support for customer projects. In a crowded marketplace, this practical approach to manufacturing quality and technical honesty earns the trust of innovative companies pushing the boundaries in pharmaceuticals, additives, coatings, and advanced materials.

    Looking Ahead: Sustaining Trust and Quality

    Trust is earned through every step of the manufacturing process, from raw material qualification to final drum load-out. It is supported by real product stability, honest technical assistance, and a willingness to correct mistakes born from experience. Ethyl Phenylcyanoacetate stands as an example of what careful manufacturing, close customer engagement, and responsible stewardship can deliver. Our approach grows out of years on the line and at the bench, not generic claims. Customers return because we demonstrate a commitment to their success project by project.

    The increasingly complex needs for intermediates in global manufacturing require suppliers to be more than distant providers. As chemistry evolves, manufacturers who remain directly involved in technical validation, safety monitoring, and collaborative partnership will continue to deliver solutions that don’t just meet but anticipate market and regulatory challenges. Ethyl Phenylcyanoacetate, when made and supported in this spirit, offers a launchpad for new molecules and fresh possibilities.