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Ethyl P-Tolylacetate

    • Product Name Ethyl P-Tolylacetate
    • Alias Ethyl 4-methylphenylacetate
    • Einecs EOS 237-240-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    275265

    Cas Number 6079-70-7
    Molecular Formula C11H14O2
    Molecular Weight 178.23 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 271-273°C
    Density 1.029 g/cm3 at 25°C
    Refractive Index 1.500-1.502
    Flash Point 123°C
    Solubility Insoluble in water, soluble in organic solvents
    Odor Mild, pleasant, floral

    As an accredited Ethyl P-Tolylacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl P-Tolylacetate is packaged in a 500 mL amber glass bottle, sealed with a secure screw cap and labeled for laboratory use.
    Shipping Ethyl P-Tolylacetate is shipped in tightly sealed containers, protected from moisture and direct sunlight. It should be stored in a cool, dry, and well-ventilated area, away from sources of ignition. During transport, ensure compliance with local and international chemical shipping regulations to prevent leaks and exposure. Handle with appropriate protective measures.
    Storage Ethyl P-Tolylacetate should be stored in a cool, dry, well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizing agents. Keep the container tightly closed when not in use. Store in a designated flammable liquids cabinet if possible. Avoid excessive heat and direct sunlight. Proper labeling and secondary containment are recommended to prevent leaks and accidental exposure.
    Application of Ethyl P-Tolylacetate

    Applications of Ethyl P-Tolylacetate in Industrial Manufacturing

    Ethyl P-Tolylacetate serves as a specialty raw material supporting the fine chemicals and advanced materials sector. As a direct manufacturer, we supply this ester for controlled synthesis routes across several downstream industries. Each application requires careful adaptation to process requirements for safe and compliant use.

    1. Fragrance and Flavor Compound Manufacturing

    Leading aroma compound manufacturers select Ethyl P-Tolylacetate as a stable intermediate for fruity and floral notes in sophisticated fragrance and flavor blends. Its solubility and chemical stability under typical flavor and fragrance process conditions enable consistent incorporation with other esters and alcohols. Formula developers value this ester for contributing nuanced olfactory characteristics, especially in high-concentration perfume oils and food-grade flavoring agents. Regulatory compliance demands close tracking of dosage levels, residual impurities, and finished product certification for end applications in personal care and food.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • EU Regulation No 1334/2008 for flavoring substances
    • Food Chemicals Codex for food flavor applications
    • US FDA 21 CFR 172.515 Flavoring Substances and Adjuvants

    Typical usage ratio

    • 0.01–0.3% by weight in finished fragrance formulations
    • Up to 0.05% by weight in food flavorings, adjusted per regional limits and product type

    Downstream process integration

    • Metered addition during compound mixing or pre-blending stage
    • Inline dilution with carrier oils or solvents
    • Quality control via GC-MS to monitor purity and residual solvents
    • Blending under nitrogen for stability in sensitive matrices

    Final product types

    • Fine fragrances (EDT, EDP, parfum oils)
    • Toiletry perfumes and air care products
    • Beverage and confectionery flavorings
    • Non-cosmetic scent bases for detergents and home care

    2. Pharmaceutical Intermediate Synthesis

    Pharmaceutical manufacturers use Ethyl P-Tolylacetate as a building block for specific active pharmaceutical ingredients (APIs) and fine intermediates. Its ester function facilitates nucleophilic addition and subsequent transformations under controlled reaction conditions. Strict in-process controls govern its entry point in multi-step synthesis, especially where impurity profiles must meet stringent threshold levels. Custom synthesis requests often specify this compound for targeted esterification or alkylation steps when molecular structure analogues require tolyl substitution.

    Industry compliance standards

    • EU GMP (Good Manufacturing Practice) for active substance manufacturing
    • United States Pharmacopeia (USP) for starting materials
    • ICH Q7 guidelines for API intermediates
    • REACH registration, safety data dossier for raw input chemicals

    Typical usage ratio

    • 5–20 mol% as reactant in target API intermediate synthesis
    • Adjusted for fragment coupling and specificity of the reaction pathway

    Downstream process integration

    • Direct charge to reactor for base-catalyzed esterification
    • Purification via distillation or crystallization
    • Quality assurance by HPLC and NMR characterization for residual starting material
    • Handling under closed system to prevent cross-contamination

    Final product types

    • Synthetic drug intermediates (example: p-tolyl-based anti-inflammatory agents)
    • Prodrug synthesis for improved pharmacokinetics
    • Specialty reference standards for analytical labs
    • Auxiliary pharmaceutical fine chemicals

    3. Polymer and Resin Modifier Production

    Downstream formulators use Ethyl P-Tolylacetate as a chain modifier or co-monomer in advanced resin systems. Its controlled ester function influences the flexibility and glass transition temperature of end polymers, particularly in specialty coatings and plastics. Processing specialists monitor its addition to optimize polymer properties while maintaining environmental limits on volatile organic compounds. The compound's integration in batch and continuous polymerization requires dedicated feeders and real-time monitoring to ensure batch homogeneity and minimize batch-to-batch variation.

    Industry compliance standards

    • ISO 9001:2015 quality management for resin production
    • RoHS Directive 2011/65/EU for electronics encapsulation resins
    • REACH Annex XVII for restricted chemical inputs
    • UL 94 flammability standards for plastics components

    Typical usage ratio

    • 0.5–5 phr (parts per hundred resin) depending on polymer matrix
    • Dosed proportionally for target modulus and flexibility in final compound

    Downstream process integration

    • Continuous feeder during resin pre-polymerization
    • Inline dispersion for solvent-based coatings
    • Emulsion polymerization for waterborne systems
    • Process monitoring for VOC content and residual monomer reduction

    Final product types

    • High-performance acrylic and polyurethane coatings
    • Specialty plasticizers for copolymers
    • Electronic conformal coatings
    • Advanced adhesives and sealants

    4. Agrochemical Intermediate Manufacturing

    Agrochemical formulators engage Ethyl P-Tolylacetate in the synthesis of selective active ingredient intermediates. Its reactivity supports specific steps in the manufacture of herbicides, fungicides, and insecticides where tolyl moieties improve efficacy or environmental stability. The raw material must conform to traceability and impurity requirements under stringent QC controls across all batch records. Integrators adjust dosing to balance reactivity and yield, ensuring efficient downstream reactions while respecting regulatory residue thresholds in end-use agricultural products.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS) guidelines
    • EU Regulation (EC) No 1107/2009 on plant protection products
    • ISO 17025 laboratory testing for agrochemical ingredients
    • China GB 4839-2014 for pesticide raw material quality

    Typical usage ratio

    • 3–15 mol% as intermediate reactant concentration
    • Reactivity optimized to yield for target A.I. pathway

    Downstream process integration

    • Addition during key condensation or alkylation reactions
    • Post-reaction purification by distillation
    • Residue analysis at each stage by GC-FID/GC-MS
    • Full traceability from raw material entry to final batch release

    Final product types

    • Selective herbicide and insecticide intermediates
    • Fungicide precursors for formulated plant protection agents
    • Stabilizer compounds for agrochemical emulsions
    • Crop-specific additive blends
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    Certification & Compliance
    More Introduction

    Ethyl P-Tolylacetate: A Manufacturer’s Perspective on a Niche Aromatic Ester

    Introduction

    Ethyl P-Tolylacetate stands out in the world of specialty chemicals as an aromatic ester that often gets overlooked by large-scale traders and resellers. Manufacturing this compound requires patience, attention to process controls, and a solid knowledge of the raw materials. Our team of chemists and plant engineers have spent years fine-tuning every parameter that goes into the production—right from sourcing high-quality p-tolylacetic acid and ethyl alcohol, through to the careful distillation that is necessary for the final purification. The chemical formula, C11H14O2, tells only a small part of the story. From initial reaction to final filling, real-world batch experience shapes the consistency and organoleptic profile of the ester.

    Production Know-How and Material Integrity

    Ethyl P-Tolylacetate’s value starts with our approach to feedstock selection. Years of running production lines have taught us that raw material variations impact not just general yields, but also the precise odour quality that fragrance formulators demand. Each batch of p-tolylacetic acid is assayed on site. Our materials team checks for off-notes and manages vendor relationships closely. Consistency is not a marketing term in our plant—it's a matter of eliminating headaches for downstream blenders and perfumers.

    Our proprietary reaction sequence achieves a high-purity product. We have moved beyond the textbook Fischer esterification, incorporating real-world improvements learned from decades of scale-up. Real-life equipment corrosion, pressure deviations and micro-leakages in older reactors shape protocols and maintenance schedules. Each turnaround gives us a chance to inspect gaskets, agitator seals, and thermal fluid piping so that no batch ever picks up extraneous odours or trace contaminants. That hands-on vigilance results in an Ethyl P-Tolylacetate which meets or exceeds GC purity levels set by industry standards, and—importantly—avoids residual solvents that can interfere with delicate perfumery accords or cause issues for food-contact applications.

    Physical Properties and Product Reliability

    This aromatic ester typically presents as a clear, almost colourless liquid, with a molecular weight of 178.23 g/mol. Our teams routinely monitor for specific gravity (about 1.04 at 25°C), refractive index (near 1.497), and acid value. These seemingly routine numbers matter: a deviation as small as .01 in density has, on more than one occasion, signalled a condenser pinhole, allowing oxygen ingress and causing micro-oxidation. Reliability is something we take personally—a poor batch can impact a customer's own blend shelf life, and our plant operators see those results not as anonymous statistics, but as reflections of their own day-to-day diligence.

    Application Experience: Fragrances and Flavours

    Ethyl P-Tolylacetate finds most of its demand in the F&F sector. Its sweet, powdery, mildly fruity scent profile blends well with floral, berry, and even citrus accords. Years in production have taught us that delicate notes—the kind sought for high-end fine fragrances and luxury soaps—depend on how clean the esterification and final distillation processes run. On a practical level, this means controlling residual acid below 0.1%, since even trace acidity or unreacted alcohol shifts the final scent and can introduce instability upon storage.

    Our technical team has watched this compound grow in popularity among niche perfumers and boutique personal care brands. With the rise of artisanal and “natural-inspired” products, we now see requests for traceability and origin details. Larger brands tend to focus on deliverability and repeatability between batches; smaller clients ask about the exact grades of ethanol or acid used. We have always provided lot-specific data and stand behind our compliance documentation, aware that regulatory audit trails and safety sheets form part of a growing ecosystem of trust.

    The usage doesn’t end with perfumery. Some specialty flavour houses have experimented with Ethyl P-Tolylacetate as a minor ingredient where its sweet-berry nuance supports strawberry, raspberry, and other red fruit profiles. In these applications, the compound must meet strict food contact norms. Our adherence to legal and safety requirements extends to detailed batch records, available to audited clients—real paperwork, not theoretical claims.

    Comparison: Ethyl P-Tolylacetate Versus Other Esters

    Chemical end-users who turn to Ethyl P-Tolylacetate often compare it against common esters like ethyl acetate or ethyl phenylacetate. In our facility, many of these compounds run on similar manufacturing lines, but the differences become clear by smell and behavioural profile. Ethyl acetate evaporates quickly, offers little tenacity, and fades fast in top notes, while ethyl phenylacetate carries a heavy, honeyed floral note that can mask subtler blends. Ethyl P-Tolylacetate slots between these: less volatile than simple acetates, with greater warmth and resonance, and less tendency to overpower floral bouquets.

    For detergent and household care perfumers who must balance cost with olfactory performance, this intermediate volatility fits well into mid-note structures. While ethyl hexanoate gives a sharp, juicy-fruit note, and methyl anthranilate pushes toward grape, Ethyl P-Tolylacetate adds a gentle, sweet fullness, avoiding the risk of candy-like or acetone off-notes. Our own sensory panels have reported good synergy with ionones, musks, and aldehyde blends. We’ve supplied global cleaning brands, and in these talks, product development teams appreciate our focus on batch reproducibility, since small odour shifts can alter a signature scent across worldwide rollouts.

    Practical Insights: Handling and Storage

    Every chemical manufacturer eventually faces “real world” setbacks: heating trace impurities, unplanned inventory overhang, ageing that isn’t properly winterized. As a company that handles Ethyl P-Tolylacetate in tankers and drums, we log details about tank linings, oxygen pick-up, and packaging stress. Early in our scale-up, a poorly sealed container caused hydrolysis and a run of off-smelling product. That incident pushed us to develop airtight drum protocols and a rotation system matched to actual customer usage rates, rather than theoretical shelf lives.

    We use mild steel lined with epoxy or food-grade HDPE tanks to avoid catalyst leaching. Nitrogen blanketing reduces oxidation risk. Lab-based “paper” stability doesn’t guarantee field success—only close monitoring and periodic retesting ensure acceptable shelf stability for both bulk shipments and sealed drums. Users who need a perfectly consistent aromatic profile rely on these controls. The best product in the world cannot compensate for carelessness in stock rotation, sunlight protection, and temperature management, so our plant managers push for transparent data sharing and honest warnings about real-world limitations.

    Manufacturing Challenges: Batch Quality and Process Control

    Laboratory-scale processes rarely survive direct scaling. In real continuous flow or semi-batch reactors, side reactions—like minor transesterification or thermal decomposition—become evident only after hundreds or thousands of kilograms have run. We have spent years fine-tuning reflux ratios, catalyst dosing, and scrubber design, as a slight deviation sends more impurity through to the distillation column. Our operators log reaction times carefully, keenly aware that high-throughput does not mean “good throughput.” Small increases in temperature or bad mixing can create yellowing or phase separation that’s easy to spot (and even easier for a discerning customer to reject).

    Some years ago, an extended heatwave forced us to adjust our condenser cooling schedules, as ambient temperature impacts both conversion rates and yield per hour. We keep on retesting and setting internal batch benchmarks, as actual field performance—how a perfume holds together over time in a shelf sample, how it smells after six months exposed to plasticizers—matters far more than theoretical numbers alone.

    End-User Concerns and Industry Standards

    Blenders, perfume mixers, and technical buyers expect consistency but value transparency about limitations. Our regulatory staff and sales chemists work together to ensure that everyone in the supply chain receives precise, batch-specific CoA, allergen, and compositional data. In our own experience, batch-to-batch uniformity comes from a plant culture of accountability—operators rotate across shifts and fill in logs by hand, knowing that a missed parameter can set off downstream complaints. Large customers have come to us after encountering “mystery” notes from commodity suppliers, caused by adulteration or rushed recycling of process solvents. By keeping an open-door policy for customer audits, and sharing real-time testing sheets, we keep trust high—this sort of direct accountability is something only the genuine manufacturer can provide.

    Professional users also care about regulatory standing—REACH, TSCA, and IFRA status. Our in-house legal and compliance team does not take shortcuts or make vague compliance claims. Each improvement in the process is documented, and every formulation change is communicated before it affects customers. For us, these standards serve not only as external benchmarks but also as operational guardrails. Meeting the expectations of the F&F, personal care, and specialty chemical markets is not just about box-ticking—reputation travels fast, and word-of-mouth remains the best driver of long-term demand.

    Sustainability and Sourcing Realities

    Decades ago, few asked about renewable feedstocks or carbon footprint. That has changed. Ethyl P-Tolylacetate touches many steps: aromatic precursor, ethanol, catalysts, energy use for distillation. Some suppliers offer “green” or renewable versions, but for true traceability, our team monitors isotope-labelled signatures and secures documentation from chain-of-custody audits. We have partnered with ethanol suppliers who support sustainable farming methods for sugar feedstock, shortening the path to certifiable bio-based content. While this disrupts established raw material cost structures, the manufacturing line adapts—new distillation parameters, more controls for batch-to-batch color, and extra documentation.

    Being a manufacturer puts us in the driver’s seat. We don’t make airy promises; we trial alternative acids and check how solvent residues and recyclability affect the final product. Most F&F end-users remain pragmatic—they demand cost efficiency and high sensory purity—but more are requesting green documentation. Our business has responded by setting up pilot runs and gathering stability and odour panels for recycled- and bio-based lots. Those results go to customers directly, along with our own limitations and statistics. Sourcing from inside the chemical industry, we stay alert to raw material fluctuations, especially for toluene-derived inputs, adjusting forecasts and shipment schedules as global demand ebbs and flows.

    Customer Success Stories and Practical Solutions

    We have longstanding customers ranging from boutique perfumers to major multinationals. Early on, a perfume house approached us about issues with their strawberry accord—a persistent, “flat” middle note. Working in partnership, our technical team adjusted the ratio of Ethyl P-Tolylacetate in their blend, supplementing, not dominating, the fruity volume. Feedback from their evaluators confirmed the improvement—a fuller, longer-lasting berry effect—which helped launch their new product line. These real interactions, not just laboratory reports, cement lasting partnerships.

    On another project, a personal care company received consumer complaints regarding aroma instability in a facial cream kept in clear packaging. Our after-sales chemists ran accelerated stability trials, and results pointed to trace residual acid as the culprit. By dialing down our acid value threshold and sealing off a small leak in our condenser system, we revised the process and provided drums from the improved batch—all before their next production run. Transparency about root causes, along with fast technical solutions, ensured business continuity and improved the end product.

    Technical Support and Partnership Culture

    Our in-house customer support doesn’t stop at order shipment. The manufacturing teams work directly with technical support and quality control. We run small-lot pilot batches for clients developing new fragrances or consumer product lines. For those pushing boundaries in eco-labelling or allergen declarations, we offer panel test results and pilot blends. Years of customer feedback have taught us that practical partnership means being willing to change the reactor setup, to tweak minor process controls, and to run training sessions for end-user QC labs.

    Sometimes the challenges aren’t technical, but logistical—a last-minute rush order to replace a contaminated batch, or customs hurdles caused by inconsistent MSDS paperwork. As the manufacturer, we own every aspect of these hiccups. Each delay causes our team to debrief and fine-tune standard operating procedures. It’s this “own your result” ethos that earns us repeat customers who value reliability and real-world know-how over theoretical maximum purity.

    Continuous Improvement and Forward-Looking Approaches

    We treat every run of Ethyl P-Tolylacetate as both a test and an opportunity. Seasoned operators train new hires on the job, pointing out pitfalls and fine-tuning their sense of smell for off-profile notes. Our R&D team partners with universities and independent labs to stay abreast of analytical improvements, such as GC-MS detection of trace impurities or new quality indicators. Over the years, we have installed multiple improvement loops—manual and automated checks, customer surveys, and direct raw material feedback sessions. Mistakes get logged, fixes get implemented, and root-cause analyses result in procedural change, not just boxed checklists.

    On the technical side, we continue probing for efficiency: recovery of process ethanol, heat integration between reactor and distillation, and improved scrubber and condenser designs to reduce energy footprint. As demands for greater purity, lower impurities, and more “natural” process signatures increase, we anticipate how to adapt the process. Transparent data access, rigorous quality benchmarking, and hands-on customer support will always remain central to our identity as a ground-up chemical manufacturer, not a third-party broker.

    Conclusion: Real-World Reliability, Backed by Experience

    Ethyl P-Tolylacetate does not make industry headlines, but for those working deep in perfumery, personal care, and specialized household applications, it occupies a crucial position. Our plant teams stake their reputation on every batch, knowing the ripple effects of a misstep can stretch from a designer's palette to mass-market shelves around the world. Everything—from raw material purchasing to technical advice after delivery—reflects our roots as a real manufacturer, a partner grounded in the realities of chemical production and end-user needs.

    We don’t over-promise, and we welcome scrutiny. Customers choose us not just for product, but for real-world practical expertise. As the industry changes, we adapt—incrementally, thoughtfully, and with decades of lessons learned on the factory floor. The results are measured not just in kilograms, but in the trust and success of our partners who transform our Ethyl P-Tolylacetate into fragrances, flavours, and consumer products with a unique, enduring signature.