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Ethyl L-Tyrosinate Hydrochloride

    • Product Name Ethyl L-Tyrosinate Hydrochloride
    • Alias Ethyl L-Tyrosinate HCl
    • Einecs 634-802-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    803711

    Product Name Ethyl L-Tyrosinate Hydrochloride
    Cas Number 6269-89-4
    Molecular Formula C11H16ClNO3
    Molecular Weight 245.70 g/mol
    Appearance White to off-white crystalline powder
    Solubility Soluble in water
    Purity Typically ≥98%
    Melting Point 120-124°C
    Storage Conditions Store at 2-8°C, protected from light and moisture

    As an accredited Ethyl L-Tyrosinate Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl L-Tyrosinate Hydrochloride, 5g, is packaged in a sealed amber glass bottle with tamper-evident cap and clear labeling.
    Shipping Ethyl L-Tyrosinate Hydrochloride is shipped in tightly sealed containers, protected from moisture, light, and extreme temperatures. Packaging complies with chemical safety regulations, ensuring secure transport. Appropriate labeling, documentation, and handling instructions are included to maintain product integrity and meet legal shipping requirements. Expedite shipping is recommended to prevent degradation.
    Storage Ethyl L-Tyrosinate Hydrochloride should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Recommended storage temperature is 2–8°C (refrigerator). Keep away from incompatible materials such as strong oxidizing agents. Ensure proper labeling and handling, and avoid prolonged exposure to air to maintain chemical stability and integrity.
    Application of Ethyl L-Tyrosinate Hydrochloride

    Applications of Ethyl L-Tyrosinate Hydrochloride in Industrial Manufacturing

    Ethyl L-Tyrosinate Hydrochloride serves as a critical intermediate and functional additive in several specialized manufacturing sectors. As a direct producer, we supply to industries where process consistency, compliance, and technical differentiation are essential for advanced formulations and high-value finished goods.

    1. Pharmaceutical Peptide Synthesis

    Manufacturers of peptide-based therapeutics rely on this intermediate for solid-phase peptide synthesis (SPPS), especially when the introduction of protected tyrosine residues with customized solubility or reactivity is necessary for downstream coupling. Ethyl L-Tyrosinate Hydrochloride provides precise functional group compatibility, supporting process yields and peptide purity during scale-up and GMP-compliant batch production.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • USP-NF specifications for amino acid derivatives
    • European Pharmacopoeia (EP) Monographs where applicable
    • FDA Guidelines for Investigational Medicinal Products (IMPs)

    Typical usage ratio

    • Mol ratios range from 0.9 to 1.1 equivalents per peptide residue; process engineers optimize based on chain length and desired purity

    Downstream process integration

    • Added during automated SPPS protocol after resin deprotection steps; followed by coupling and side chain de-esterification before final cleavage

    Final product types

    • Pharmaceutical-grade peptide APIs
    • Peptidomimetic intermediates for oncology therapeutics
    • Injectable peptide formulations

    2. Biosynthetic Research and Diagnostic Reagent Manufacturing

    Producers of biosynthetic research kits and diagnostic reagents use this raw material as a protected tyrosine source to achieve enhanced stability and reactivity profiles. Its role is crucial in synthesizing bioconjugates, enzyme substrates, and custom labeling agents used in molecular assays and advanced in vitro diagnostics.

    Industry compliance standards

    • ISO 13485:2016 for Medical Device Quality Management
    • Good Laboratory Practice (GLP) principles
    • REACH Annex IV for laboratory reagent exemption
    • OECD Guidelines for Biological Testing Materials

    Typical usage ratio

    • Usually 5–20 mmol per 100 mmol total amino acid loading; researchers optimize based on conjugation efficiency and detection sensitivity

    Downstream process integration

    • Introduced into solution- or solid-phase conjugation after buffer preconditioning; purified using preparative chromatography for kit assembly

    Final product types

    • Protein labeling reagents
    • Antibody modification kits
    • Colorimetric substrate components for ELISA or Western blot solutions

    3. Chiral Intermediate for Agrochemical Active Ingredient Synthesis

    In the agrochemical sector, formulators depend on this chiral intermediate to access tyrosine-derived core structures, primarily for the synthesis of specific non-proteinogenic amino acid herbicides and growth promoters. Its chemical properties support precise control during enantioselective coupling and downstream formulation for crop protection agents.

    Industry compliance standards

    • OECD Good Manufacturing Practice for Crop Protection Intermediates
    • FAO and WHO specifications for agrochemical active substances
    • ISO 9001:2015 Certified Production Facilities
    • Local Environmental Regulations for Process Safety and Waste Management

    Typical usage ratio

    • Used at 0.8–1.2 molar equivalents in coupling steps, with adjustments for yield optimization based on downstream bioactivity screening

    Downstream process integration

    • Incorporated directly in stepwise or one-pot synthesis of targeted amino acid analogues; later processed with hydrolytic deprotection and purification

    Final product types

    • Chiral agrochemical active ingredients
    • Intermediate feedstocks for selective herbicide synthesis
    • Crop plant biostimulant prototypes

    4. Food-Grade Amino Acid Derivative Blends for Nutritional Supplements

    Manufacturers producing specialty nutritional supplements and functional foods employ this material as a protected amino acid building block to achieve high-purity L-tyrosine derivatives, reducing off-taste and supporting controlled-release matrix formulations. This ingredient is selected for its stability during granulation and microencapsulation processes in high-spec nutraceuticals.

    Industry compliance standards

    • Food Chemicals Codex (FCC) for purity and safety
    • FSSC 22000 for Food Safety System Certification
    • Regulation (EC) No 1333/2008 concerning food additives
    • US FDA 21 CFR 172.320 for amino acid derivatives

    Typical usage ratio

    • Applied at levels of 0.2–1.5% by weight relative to the final blend; formulation adjusted per regulatory limits and sensory evaluation data

    Downstream process integration

    • Added during wet blend premix or fluidized bed granulation, followed by deprotection and blending to achieve controlled amino acid release profiles

    Final product types

    • Controlled-release L-tyrosine supplement tablets
    • Functional beverage additive premixes
    • Fortified nutritional bars with amino acid enrichment

    5. Specialty Polymer and Resin Modifiers

    Producers in the specialty polymer and resin industry utilize this intermediate as a functional monomer precursor to introduce amino acid residues that modify mechanical or optical properties. Typically, formulators leverage the ethyl-protected tyrosine to achieve selective cross-linking, UV-responsivity, or improved hydrophilicity in high-performance materials.

    Industry compliance standards

    • ISO 9001 Quality Management for Specialty Chemicals
    • RoHS Directive 2011/65/EU (where required for electronics)
    • REACH Regulation (EC) No 1907/2006 for polymer intermediates
    • ASTM D256 and ASTM D638 for physical property validation

    Typical usage ratio

    • Dosed at 0.5–3 mol% relative to total monomer content; engineers adjust based on target polymer chain length and desired network density

    Downstream process integration

    • Combined with other monomers during bulk or solution polymerization, with subsequent deprotection and curing under controlled temperature profiles

    Final product types

    • UV-crosslinkable resins with amino acid motifs
    • Specialty coatings for electronic substrates
    • Custom hydrogels for biomedical and sensor applications
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    Certification & Compliance
    More Introduction

    Introducing Ethyl L-Tyrosinate Hydrochloride: Direct Insights from the Manufacturer

    Understanding Ethyl L-Tyrosinate Hydrochloride

    Ethyl L-Tyrosinate Hydrochloride opens up a distinct avenue in fine chemical production, reflecting years of steady research and application experience. From a manufacturer’s perspective, our daily work involves transforming high-purity L-Tyrosine into this ethyl ester hydrochloride with care for each step. With a chemical formula of C11H16ClNO3 and a consistent molar mass, this compound has proven reliable for labs engaged in advanced synthesis, peptide building, and pharmaceutical intermediate development.

    Manufacturing brings real, tangible challenges—batch reproducibility, minimizing byproduct, maintaining optical purity. Each day in the plant, shifts run quality checks for stereochemistry and residue solvent levels. In practice, we have to weigh the cost of high-purity solvents against batch integrity. Through years of production, tight in-process controls and tailored purification methods give our Ethyl L-Tyrosinate Hydrochloride some advantages over common alternatives.

    Reliable Production at Scale

    Scaling from a lab flask to hundreds of kilos per lot doesn’t follow a straight line. Process bottlenecks emerge. Stirring speeds, cooling rates, and moisture exclusion all change subtly as quantities rise. Our operators, with hands-on knowledge from countless production runs, often spot issues only visible in larger reactors. Crystal morphology shifts with ambient humidity and solvent lot. We’ve spent years mapping out these behaviors, knowing that weak points in crystallization can cause headaches down the line.

    As we scaled up, continuous feedback loops with our QC analytics helped improve overall system reliability. In the past, we tried different solvent systems for esterification and neutralization, but ended up standardizing based on analytical trends, not just tradition. We monitor chiral purity by HPLC—one of the areas where smaller resellers sometimes slip. Direct factory experience shows the stability and yield relationships between process controls and final purity.

    Technical Features That Matter on the Factory Floor

    Our Ethyl L-Tyrosinate Hydrochloride consistently meets purity levels above 98% by HPLC, with water content closely managed by optimized drying methodologies. This often means taking extra hours for drying, not cutting corners by using aggressive vacuum alone. For customers who have faced regular moisture creep in competing products, our manufacturing record keeps confidence high. Optical rotation tests on each lot confirm retained stereochemical integrity—our customers in peptide manufacturing know firsthand the effects even minor racemization can have downstream.

    Each batch also undergoes thorough checks for heavy metals and residual solvent levels, with real records archived per lot. While rivals sometimes push out batches with broader tolerance windows, our daily benchwork demonstrates why each parameter matters. Any bump in residual acid, for example, plays out later in solid-phase syntheses, a lesson learned from early process missteps years ago.

    Usage in Research and Industry

    Researchers and industrial chemists bring different priorities when ordering our Ethyl L-Tyrosinate Hydrochloride. Biotech clients, especially those developing new peptidomimetics, rely on sharp consistency. A small drift in quality can ripple through weeks of synthetic work and strain downstream purification. Our product enters the pipeline as a protected amino acid source, where the ethyl group shields the core structure through subsequent transformations. The hydrochloride salt improves handling and solubility over non-salt forms, a practical advantage when you see lab staff weighing out doses.

    In peptide synthesis, our product serves as an essential intermediate, offering easier coupling reactions compared to unprotected L-Tyrosine. Formulation development in pharmaceutical lines also gets a boost, since side reactions drop when the hydrochloride salt form is chosen. Feedback from our customers over the years has led us to tweak physical form, choosing crystallization points leading to free-flowing powders that minimize caking in storage—an ongoing concern for both large and small-scale users.

    How Our Ethyl L-Tyrosinate Hydrochloride Stands Apart

    Direct manufacturing experience has taught us the difference between theory and practice. Some distributors offer numerous amino acid esters from dozens of sources, but variability in supply chains can impact product performance. We see these effects sharply at scale. When trying other market offerings, we have come across varying color, particle sizes, and significant inconsistency in physical properties—even among lots from the same supplier. Some contain higher chloride content than claimed, leading to side effects in peptide work. Others introduce excess organic solvent residues, which can mess with sensitive transformations downstream.

    For synthetic chemists, using a material with batch-to-batch drift means wasted labor and troubleshooting. Our on-the-ground production experience leads us to minimize these uncertainties. Familiar competitors may streamline their process to shorten lead time, but we routinely invest in longer crystallization and drying phases, choosing long-term customer trust over shaving a few days from batch time. The approach sometimes adds to manufacturing cost, but we consistently hear from users that reliability and predictable performance more than justify it.

    Comparisons with Related Compounds

    Ethyl L-Tyrosinate Hydrochloride is often compared with methyl and tert-butyl esters of L-Tyrosine, as well as the unprotected acid itself. Based on internal trials and customer feedback, the ethyl ester offers a practical balance. The methyl ester hydrolyzes more rapidly, which can lead some chemists to prefer it for faster reactions, but it sometimes sacrifices yield if storage or handling takes longer than planned. Tert-butyl protection can bring new selectivity but introduces additional synthetic steps and cost.

    Compared with free L-Tyrosine, the ethyl ester hydrochloride handles better in moisture-rich labs, stays free-flowing longer, and simplifies many peptide routines. Its melting point and crystal structure allow smoother weighing, almost eliminating static-related losses common with lower molecular weight analogs. Our facility regularly tests physical form: clumping and dusting do not just waste time, they increase handling risk. Over the years, our equipment investments have paid dividends in producing a manageable, repeatable solid that customers appreciate.

    Quality, Documentation, and Customer Feedback

    Clients working with our Ethyl L-Tyrosinate Hydrochloride expect more than a specification sheet and certificates. Our technical team supports genuine troubleshooting—sometimes reviewing chromatograms together, sometimes advising on storage and re-drying. Seasoned process chemists in our factory know the pathways that generate known impurities, helping us troubleshoot quality claims directly rather than passing them along.

    Years ago, a client reported unexplained high system pressure during peptide coupling. Drawing on our own experience, we traced it back to trace acid residues—a fix in the drying process cleared the issue. Meeting regulatory and quality audit criteria is standard, but constant improvement comes from active user feedback. Our documentation package includes real chromatography, IR spectra, and batch records for transparency. We aim for open dialogue, not just another sale.

    Problems with Market Alternatives

    The market for amino acid derivatives often splits between high-volume, generic-grade material and boutique, ultra-pure lots with narrow target audiences. Some traders stockpile bulk esters, repackage, and rebrand, but this route introduces storage risks and variable shelf life. Reports of yellowing, caking, and odd odors with some resellers’ products are not uncommon. Industry knowledge and direct plant handling keep our batches fresh, as material does not linger unsold. Our scale supports both small pilot orders and ton-level supply, and each leaves the plant with an up-to-date test record.

    Direct feedback from synthetic labs carries weight with our production managers. Through these channels, we hear about failed couplings, residue build-up, or stability drops seen in alternate brands. Unlike third-party traders, immediate local action—from cleaning tanks to re-running batches—keeps problems small. With each cycle, this feedback drives process improvements and better results for the next order.

    Commitment to Sustainable Practice

    Chemical manufacturing faces environmental pressure everywhere. For our Ethyl L-Tyrosinate Hydrochloride, we have worked over years to reduce total solvent usage, improve heat recovery, and treat process waste streams onsite. Sourcing renewable feedstocks remains a tough challenge, especially for specialty syntheses, but we have shifted cleaning protocols to reduce the need for legacy harsh solvents, reducing operator exposure risk. Regular team retraining keeps up with evolving best practices. The push from regulatory and market-side demand for cleaner and safer operations has only deepened our determination to keep improving.

    Our site management team tracks waste volumes, water use, and energy loads in parallel with output; progress depends on data, not just policy. Choosing safer reagents and seeking out less toxic alternatives serve not only compliance, but day-to-day well-being for operators, many with decades of loyalty. Longstanding relationships with nearby recyclers also help recover byproducts or treat hazardous streams that otherwise would land in landfills. The route to consistently safer chemical production never ends, but lessons from years in operation continually shape daily decisions.

    Serving Both Innovation and Routine Production

    Shifting research priorities among our clients find a partner in our team’s flexibility. Some projects call for bulk Ethyl L-Tyrosinate Hydrochloride in large drums. Others need small, customized lots for early-phase research. We keep inventories at several storage points, ready to match expected demand cycles. Direct manufacturer status allows us to respond fast to special requests, like seeking alternative packaging or developing a higher-purity version for a particularly demanding protocol.

    That field-based approach means our chemists and commercial team talk through both obstacles and opportunities daily. Changes in starting material purity, regulatory shifts in importing countries, or even a discovery of new downstream application—all these get considered rapidly thanks to our vertical setup. Over the years, we witnessed how slow-moving distributors lose the window to fix or react, but our direct plant control removes that lag. Customers stay in touch with people who really know the technical roots of the compound.

    Conclusion: Direct Manufacturing Makes a Difference

    Through the years, we’ve learned that reliable Ethyl L-Tyrosinate Hydrochloride supply, controlled manufacturing, and open customer dialogue create lasting industry relationships. Small process adjustments, investment in people and plant, and attention to each customer’s unique context bring real performance improvements—these do not show up on standard spec sheets. Differences from other products become clear not in the catalog but in hands-on usage, where clean, reliable materials support demanding work in pharmaceuticals, biotech, and academic labs.

    Ongoing partnership with research and process chemists sharpens our manufacturing process. New input, whether requests for technical tweaks or lessons from field failures, shape continuous development. Our aim is not just to offer Ethyl L-Tyrosinate Hydrochloride, but to deliver a product whose behind-the-scenes rigour is apparent in every reaction flask and peptide column run. We will keep investing in new process controls, improved environmental footprint, and genuine support, because decades in specialty chemical manufacturing have shown us these earn loyalty and real-world results.