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Ethyl Glycolate

    • Product Name Ethyl Glycolate
    • Alias Glycolic acid ethyl ester
    • Einecs 203-305-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    203635

    Cas Number 623-50-7
    Molecular Formula C4H8O3
    Molecular Weight 104.11 g/mol
    Appearance Colorless liquid
    Boiling Point 166-168°C
    Melting Point -60°C
    Density 1.104 g/cm3 (20°C)
    Solubility In Water Miscible
    Refractive Index 1.418 (20°C)
    Flash Point 67°C (closed cup)
    Odor Mild, sweet
    Vapor Pressure 0.43 mmHg (25°C)

    As an accredited Ethyl Glycolate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl Glycolate is supplied in a 500 mL amber glass bottle with a screw cap, labeled with hazard and chemical information.
    Shipping Ethyl Glycolate should be shipped in tightly sealed, well-labeled containers, protected from moisture, heat, and incompatible substances. Ensure compliance with local, national, and international transport regulations. Use appropriate hazard labels according to its classification and transport guidelines, and avoid conditions that could cause leaks or spills during handling and transit.
    Storage Ethyl Glycolate should be stored in a cool, dry, well-ventilated area away from heat sources, ignition sources, and direct sunlight. Keep the container tightly closed and store it separately from oxidizing agents and strong acids. Use appropriate containers made of compatible materials, and ensure good labeling. Avoid moisture exposure, and store at recommended temperatures to prevent decomposition and maintain chemical stability.
    Application of Ethyl Glycolate

    Applications of Ethyl Glycolate in Industrial Manufacturing

    Ethyl glycolate serves as a specialized raw material in several established industrial domains where its chemical properties drive value-added performance in targeted manufacturing chains. The following sections detail major application fields directly proven in commercial downstream use, with each use case summarized from the perspective of a dedicated producer supplying formulation-grade materials to global industry leaders.

    1. Agrochemical Intermediate Synthesis

    Ethyl glycolate is integral as a glyoxylic acid equivalent and an alkylating agent in agrochemical active ingredient synthesis, specifically herbicide and pesticide manufacturing. Chemical plants utilize it to construct key molecular motifs in various crop protection actives, often employing its reactivity to enhance selectivity and reaction efficiency. Its role appears in multi-step synthesis where moderate ester reactivity is desired, and downstream adoption hinges on strict impurity control and product traceability.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • ISO 17025 (testing and calibration for intermediates)
    • REACH registration requirements (EC No. 1907/2006)
    • Globally Harmonized System (GHS) classification and labeling

    Typical usage ratio

    • 5–15% of total reaction mass, with percentage adjusted based on desired active esterification and reaction pathway optimization

    Downstream process integration

    • Charged during key intermediate formation, following substrate activation in jacketed reactors under controlled temperature and pH

    Final product types

    • Selective herbicide actives (e.g., ester-type weed control agents)
    • Insecticidal intermediates for wide-acre crops
    • Precursor batches for systemic fungicides

    2. Pharmaceutical API Intermediate Manufacturing

    Pharmaceutical companies rely on ethyl glycolate as a building block in fine chemical synthesis for API intermediates, offering selective protection for carboxyl and hydroxyl groups. Manufacturers apply it in multi-stage syntheses, especially in cephalosporin and β-lactam antibiotic segments where specific alkoxy ester intermediates must meet stringent quality attributes. Its controlled reactivity and consistent purity support process validation and regulatory submission requirements.

    Industry compliance standards

    • ICH Q7 GMP Guidelines for Active Pharmaceutical Ingredients
    • USP/NF Monograph referencing starting material specifications
    • EDQM CEP guidance (European Directorate for the Quality of Medicines)
    • 21 CFR Part 211 for process control in US-based plants

    Typical usage ratio

    • 2–8 molar equivalents depending on the stepwise protection/deprotection strategy and overall route yield requirements

    Downstream process integration

    • Introduced during intermediate coupling phases under anhydrous conditions after initial salt-forming or acylation stages, using jacketed glass reactors to minimize cross-contamination risks

    Final product types

    • Beta-lactam antibiotic intermediates (e.g., cephalosporin precursors)
    • Nonsteroidal anti-inflammatory drug (NSAID) intermediates
    • Synthetic amino acid building blocks for peptide APIs

    3. Flavors and Fragrance Ester Synthesis

    In the flavors and fragrance sector, ethyl glycolate functions as a precursor in esterification processes for high-value aroma ingredients. Flavor houses and fragrance blenders incorporate it into scent molecule production, where precise ester functionality imparts fruity and milky undertones found in consumable and personal care goods. Its low impurity profile and high reactivity allow controlled batch production that satisfies international food additive regulations.

    Industry compliance standards

    • FCC (Food Chemicals Codex) for food-grade synthesis
    • IFRA standards (International Fragrance Association)
    • US FDA 21 CFR 182 (Generally Recognized as Safe substances for flavors)
    • ISO 9235 for natural and synthetic aromatic raw materials

    Typical usage ratio

    • 0.1–2% in compounded aroma or as an intermediate, with dosage determined by desired flavor or fragrance profile without exceeding regulatory limits

    Downstream process integration

    • Added during catalytic transesterification at precisely controlled temperatures in stainless steel reactors, prior to final distillation and fractionation

    Final product types

    • Fruit-ester flavoring components
    • Dairy and creamy note fragrance bases
    • Complex aroma compounds for beverage, confection, and fragrance formulations

    4. Polymer and Resin Modifier

    Ethyl glycolate supports specialty polymer synthesis as a chain-modifying co-monomer in certain copolymer and resin technologies. Its inclusion adjusts the physical properties—such as flexibility or adhesion—of the resultant material, useful in adhesives, specialty coatings, and engineered plastics. Downstream producers benefit from its contribution to controlled branching, reduced migration, and superior film-forming ability in advanced applications.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for manufacturing operations
    • RoHS Directive (2011/65/EU) for electronics adhesives and coatings
    • REACH Annex XV dossier requirements for polymer components
    • ASTM D256 for plastics impact resistance testing (post-integration)

    Typical usage ratio

    • 0.5–6% by polymer mass, with optimization based on targeted final performance metrics such as glass transition temperature or adhesion strength

    Downstream process integration

    • Integrated during initial monomer feed in batch or continuous polymerization, with downstream curing or extrusion tailored for end-use requirements

    Final product types

    • Film-forming adhesives and waterborne resins
    • Plasticizer-modified engineering plastics
    • Flexible coating solutions for automotive, electronics, or protective films

    5. Specialty Solvent Systems for Coatings

    Coatings, inks, and surface treatment producers use ethyl glycolate as a tailoring agent in high-performance solvent blends, where its balance of polarity and evaporation rate supports well-controlled drying and dispersion. It features in advanced paint and ink formulations requiring a fine-tuned solvent environment for pigment or binder dispersion, especially in applications demanding low odor and minimal residue on cured surfaces.

    Industry compliance standards

    • ASTM D235 (Standard Specification for Mineral Spirits, Solvents)
    • Directive 2004/42/EC (EU VOC content in paints and varnishes)
    • ISO 16000-6 (indoor air emissions for paints/coatings)
    • GMP for coatings used in food contact or packaging applications (Regulation (EC) No 2023/2006)

    Typical usage ratio

    • 2–10% of total solvent fraction, adjusted to match required viscosity, solvency power, and drying profile for coating or ink system

    Downstream process integration

    • Blended during liquid phase compounding alongside primary binder and pigment addition, with mixing followed by filtration and canning for dispatch

    Final product types

    • Low-VOC decorative and industrial paints
    • Specialty printing inks for packaging and graphic arts
    • High-gloss and clear surface coatings
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    Certification & Compliance
    More Introduction

    Ethyl Glycolate: A Closer Look from the Manufacturer's Floor

    Introduction to Ethyl Glycolate and Our Reason for Making It

    Ethyl Glycolate holds an interesting place among our range of ester products. Its subtle ester aroma drifts through our plant on the occasional leak, making it immediately recognizable to anyone who works in synthesis and blending. Our team has produced countless batches over the years, and each production run always sparks a conversation about its many uses and its steady demand in several industries.

    This compound, also known by the IUPAC name ethyl 2-hydroxyacetate, attracts attention for a straightforward reason. Chemists and formulators from different sectors find its chemical behavior both dependable and adaptable. Every day, on the production floor, we focus on purity and consistency, since even a small variance in water or acid content changes the outcome downstream. Our standard process delivers >99% purity, with water below 0.1%, which has proven essential for groups looking for reaction predictability and stable storage.

    Production Process and Quality Leadership

    Since the late 1990s, we've adjusted our process to reach both efficiency and strict safety. During each batch, temperatures and pH stay under close manual and automated supervision. Seasoned operators can often tell if the distillation is running right just by the faint change in vapors off the condenser. Regular calibration of our glassware and instruments ensures that every flask, reactor, and storage drum meets our company's standards. For us, quality control is not a separate department; it's in the hands of every operator, technician, and engineer who has put in hours learning the quirks of esterification—especially when humidity rises during summer, threatening contamination.

    As a direct producer, we learn firsthand about the difficulty of keeping oxygen, light, and humidity out of storage environments. The insight here is simple: Ethyl Glycolate will not forgive half-measures in handling. Years ago, we transitioned from simple steel drums to internally coated containers after noticing that trace metal contamination altered reaction rates for some customers. These adjustments came from practical challenges, not from reading regulatory guidelines or responding to an audit. The only way to maintain long-term business and trust is to solve the issues before they become talking points in a complaint letter.

    The Main Uses and Why They Matter

    The most common questions we field come from formulators in flavors, drugs, agrochemicals, and fine chemicals. Ethyl Glycolate’s mild, almost fruity aroma, and its moderate polarity, give chemists an intermediate with high flexibility. For flavor and fragrance industries, purity means everything. The essential reality is: one contaminant in a blend can spoil an entire batch that can cost thousands to remake. We run authenticity tests both in-house and sometimes with third-party verification for customers who request extra assurance.

    In pharmaceuticals, Ethyl Glycolate forms an essential building block for advanced syntheses. The hydroxyl group opens up possibilities for downstream esterification, etherification, and coupling reactions. Generic manufacturers trust that our lot-to-lot consistency allows them to pass regulatory scrutiny without added stress of requalification. Our research partners often run pilot reactions here at our site, giving us direct feedback on how small tweaks in purity impact their yields and impurity profiles. Over time, these technical exchanges help push us to optimize not just purity, but the color and odor profile of the material as well.

    Agrochemical teams choose our Ethyl Glycolate for a different reason altogether: reactivity and predictable hydrolysis. The glycolate group serves as a masked form of glycolic acid, enabling controlled release in formulations that fight pests or support plant growth. Resulting products stay stable on the shelf, yet release the active acid when conditions in the field demand it. As manufacturers, we learned long ago that a slight excess of ethyl glycol in production hurts field stability for these formulations; a lesson taught not by textbooks but by farmers and field scientists sharing field failure incidents.

    How Ethyl Glycolate Stands Apart

    In the world of simple esters, confusion between Ethyl Glycolate, Methyl Glycolate, and Ethylene Glycol Monomethyl Ether (EGME) crops up often. Customers sometimes ask, “What makes your Ethyl Glycolate different from other ethers or esters?” From direct involvement in daily synthesis, the main differences come down to both the placement of the functional groups and the resulting chemical reactivity. Our operators can recite offhand how Ethyl Glycolate's ester and hydroxyl separation brings unique solubility and reactivity, making it suitable for specific release profiles in active materials, and compatible with synthetic pathways that other glycol esters cannot match.

    Compared to Methyl Glycolate, Ethyl Glycolate offers both volatility and stability. The extra carbon from the ethyl group makes it safer to handle with less volatility, while its water solubility sits at a comfortable middle ground. Customers from the coatings and resin sector appreciate this balance since they do not want runaway evaporation or lingering residues. It also helps in solvent systems, where too much volatility means more restrictive handling and extra ventilation hardware, which drives up costs. We observed in our own solvent trials that Ethyl Glycolate provided a better drying rate than methyl-based alternatives, without causing white blush or rapid skinning on films.

    Against common glycol ethers such as EGME, Ethyl Glycolate clearly avoids some of the toxicity issues. We focus on this point when discussing with regulatory or safety managers who have grown weary of the increasing restrictions on glycol ethers in European and American markets. From experience, substitution is rarely as simple as changing one ingredient; it involves understanding the entire process and potential side effects. Lessons here include learning about storage limitations, compatibility with standard hardware, and how the material behaves during clean-ups and spills. Over time, the edge comes from correcting these minor inefficiencies, making the operation smoother for our customers.

    Handling, Storage, and Real-World Manufacturing Concerns

    Managing Ethyl Glycolate involves an ongoing dialogue between the needs of the product and the safety of people and property. Every system in our plant, from the automated fill stations to the manual sampling ports, carries the marks of trial, error, and improvement. Ethyl Glycolate likes to absorb moisture and air, so drum closures incorporate precision venting and gasket materials tested for months before we put a solution into full use. Once, a minor leak in a warehouse at another facility wasted several tons. After investigating, both our team and the customer discovered a long-standing crack in a seal—an expensive lesson in why every small detail of storage matters for hygroscopic, reactive liquids.

    Transportation poses other challenges. Temperature variations on long-haul routes can cause pressure buildup or condensation inside containers. To counter this, we worked closely with logistics partners to develop shipping options that keep material stable for weeks, even in summer heat or winter chill. Ethyl Glycolate tends to form peroxides if left exposed, so every shipment includes stabilization solutions based on actual shelf-life data, not guesswork.

    Ongoing Product Development and Research Insights

    From our vantage point on the production line, product improvement never stops. Every change in our facility, from upgrades in reactor design to modifications in the overhead lines, comes after reviewing real-life feedback or direct failures. Over the last decade, we partnered with university labs studying biodegradable solvents, and these collaborations always lead to rewarding discoveries. For example, Ethyl Glycolate's compatibility with bio-based feedstocks sparked new green chemistry programs. From a manufacturing point of view, changing feedstock always means new risks. We spent years validating that biobased glycols resulted in the same high-purity product without introducing problematic by-products or color bodies.

    In coatings applications, research into faster curing while lowering environmental footprints has spurred more interest in bio-friendly glycolates. We have poured considerable resources into scaling up new green pathways. One unexciting fact: every time we change incoming glycol quality, it might take three or four pilot runs and many extra hours in the lab just to restore the old product color and clarity. Our experience tells us this unseen effort at the plant is never visible on a product brochure, but it plays a decisive role in whether customers ever see a supply interruption or a shift in final performance.

    Ethyl Glycolate and Regulatory Trends

    Many customers in recent years demanded tighter controls on trace metals, formaldehyde, or residual solvents. This push comes partly from tightening global regulations around residuals in food ingredients or pharmaceutical products. We saw how the European market began requiring updated certification for every major batch, and how American buyers want to review in-house data with their own compliance teams. Our QC lab doesn't just test near the end of the run; analysts collect samples at multiple points to ensure the profile remains within strict limits at every stage. This effort pays off during random inspections or audits, where full traceability and transparency can mean the difference between approval and lost business.

    Environmental questions touch every step of our operation. Waste glycol streams present special handling problems. In past years, disposal costs have climbed steadily, so we invest in in-house reclamation and recycling. Some reactors recover glycols from vented streams and add them back to the process, helping us cut waste and environmental impact. Those savings translate into less risk and lower costs, both to us as the manufacturer and to customers looking for greener supply chains. Years of troubleshooting effluent challenges led us to install extra distillation columns, which now cut total organic carbon in wastewater by over 90%. Such improvements rarely get headlines, but they matter deeply for the long-term health of both business and environment.

    Customer Relationships Built Over Time

    What sets manufacturing apart is the ongoing relationship with formulators, process engineers, and chemists who use our products every day. Many of our clients have worked with us through shifts in raw material markets, regulatory climates, and technology changes. They come to us not just because of price or supply but for honest troubleshooting and shared learning.

    We remember specific examples, like a paint company whose binder system needed slight modification when a minor change in our glycol supplier led to more rapid hydrolysis in their formulation. Instead of a quick fix, we opened our lab and plant for collaborative trials. The result was not only a sustained business relationship but also a deeper understanding of the material’s role in their system. It proved again that direct dialog between manufacturer and user yields solutions that no distributor or spec sheet could offer.

    Over the past decade, more partners in Asia and Europe joined our customer base. They brought new requirements and, in some cases, harsher regulatory scrutiny or novel technical asks. Committing to batch traceability across all global shipments tested our operations, but it led to smarter process controls and faster issue resolution for all partners, not only those in regulated markets. The core insight here: every location and every industry has unique challenges, and manufacturing excellence lies in adapting rapidly and sharing data transparently.

    What Experience Taught Us About Ethyl Glycolate

    Decades of work with Ethyl Glycolate taught us that making a quality product requires honesty about failure and determination to improve every small step. Operators share practical tips on how to keep lines clear, minimize fouling, or speed up tank turnovers. These real-world practices often get lost in engineering diagrams and manuals, but they matter just as much as any test result. Safety incidents, too, taught us about the limits of automation and the irreplaceable value of hands-on experience. The plant’s success rests as much on vigilance and shared responsibility as on equipment sophistication.

    Long-term stability and product confidence come from putting every batch through a slate of analytical and sensory checks, not because a regulator said so but because our customers ultimately count on these standards. When the product heads out for shipment, our team knows the stakes, as we have seen customers face production stops from one bad batch. This reality brings focus to every morning’s discussion about blend accuracy, contamination risks, and new ways to secure long-term supply.

    Anticipating the Future for Ethyl Glycolate Manufacturing

    In the coming years, pressures from sustainability, changing production economics, and labor skills will continue shaping what it means to be a chemical manufacturer. Many younger engineers and chemists in our plant think about Ethyl Glycolate as both an opportunity and a test of continuous process improvement. On the sustainability front, simple targets like reducing emissions, increasing recycled content, or using renewable energy already influence equipment choices and production schedules.

    We have started programs to capture more utility data, automate more safety checks, and involve the next generation of operators in tackling persistent maintenance headaches. Every production manager knows: complacency breeds risk. The best operations teams carry a sense of pride in their track record, but they also own up to what isn’t working and push for smarter controls that prevent batch failures altogether. For Ethyl Glycolate manufacturing, that means ongoing investments not just in reactors and storage systems, but in people, training, and problem-solving routines.

    Why Ethyl Glycolate Continues to Matter in the Chemical Industry

    The place of Ethyl Glycolate in modern industry doesn’t hinge on hype or vague marketing. Its steady, predictable behavior in the reactor and consistent support for downstream processes deliver real value to chemists and formulators around the world. Whenever we hear of a new application, a shift in regulation, or a fresh technical hurdle, our first thought is not just about a product spec, but about the practical challenges of delivering reliable material at scale.

    Every line worker, shift supervisor, and chemist in our facility understands that “commodity” doesn’t mean “replaceable.” The lessons built up through direct experience—incremental equipment changes, overlooked failure modes, and persistent conversations with customers—form the backbone of our reliability. In this sense, Ethyl Glycolate serves as a proving ground for everything that matters in chemical manufacturing: care in handling, pride in quality, and endurance in partnership.