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Ethyl Dichlorophosphate

    • Product Name Ethyl Dichlorophosphate
    • Alias Phosphoryl chloride, ethyl ester
    • Einecs 213-449-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    495764

    Chemical Name Ethyl Dichlorophosphate
    Cas Number 1498-40-4
    Molecular Formula C2H5Cl2O2P
    Molecular Weight 178.94 g/mol
    Appearance Colorless to yellowish liquid
    Boiling Point 75-76°C at 15 mmHg
    Density 1.41 g/cm³ at 20°C
    Refractive Index 1.432
    Melting Point -37°C
    Flash Point 64°C (closed cup)
    Solubility Reacts with water, soluble in organic solvents
    Purity Generally ≥98%
    Smiles CCOP(=O)(Cl)Cl
    Inchi InChI=1S/C2H5Cl2O2P/c1-2-6-7(3,4)5/h2H2,1H3
    Odor Pungent

    As an accredited Ethyl Dichlorophosphate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 500g Ethyl Dichlorophosphate is packaged in a sealed amber glass bottle with a secure screw cap and hazard labeling.
    Shipping **Ethyl Dichlorophosphate** should be shipped in tightly sealed, corrosion-resistant containers under cool, dry conditions. Label as a hazardous material (corrosive, toxic), following applicable regulations such as DOT, IATA, or IMDG. Use secondary containment to prevent leaks, and ensure proper documentation and emergency procedures accompany the shipment.
    Storage Ethyl Dichlorophosphate should be stored in a cool, dry, and well-ventilated area away from sources of moisture, heat, and incompatible materials such as strong bases or oxidizers. Store in tightly closed, corrosion-resistant containers (preferably glass or certain plastics). Protect from physical damage and direct sunlight. Ensure proper labeling and use secondary containment to prevent leaks or spills. Handle with appropriate personal protective equipment.
    Application of Ethyl Dichlorophosphate

    Applications of Ethyl Dichlorophosphate in Industrial Manufacturing

    Ethyl Dichlorophosphate serves as a functional intermediate in various advanced chemical manufacturing sectors. As direct manufacturers, we address specific downstream application requirements through tailored supply, process feedback, and rigorous compliance alignment. The following sections outline principal industrial uses, incorporating technical details relevant to each domain.

    1. Organophosphorus Pesticide Synthesis

    Agricultural chemical producers employ Ethyl Dichlorophosphate as a core phosphorylating agent in the synthesis of active insecticidal compounds, such as dichlorvos and related organophosphates. The material introduces the phosphorus-chloride bonding essential for target molecule reactivity. Controlled reaction rates and impurity profiles are critical, with batch formulations set by target C/O/P ratios and environmental emission requirements. Manufacturers integrate this step early in the multi-stage pesticide synthesis route, using specialized containment to manage exothermic release and chlorinated by-products.

    Industry compliance standards

    • EPA 40 CFR Part 180—Tolerance for pesticide chemical residues
    • REACH Annex XVII—Restricted substances regulation
    • ISO 9001:2015—Quality management for crop protection chemicals
    • FAO/WHO specification for pesticide active ingredients

    Typical usage ratio

    • Usually 1.0–1.2 molar equivalents per phosphoric target moiety; adjustment based on substrate reactivity and required yield (scalable 2–10% of total batch mass basis)

    Downstream process integration

    • Introduced at the phosphorylating stage before neutralization and solvent swap
    • Monitored for residual chloride and conversion efficiency via in-process titration
    • Excess reagent removal by aqueous workup, followed by vacuum distillation

    Final product types

    • Organophosphorus insecticide active ingredients (e.g., dichlorvos)
    • Technical grade crop protection intermediates
    • Pesticide formulation concentrates

    2. Flame Retardant Additive Precursor

    Industrial additive manufacturers utilize Ethyl Dichlorophosphate for the production of phosphoric flame retardant intermediates. The compound reacts with polyol or aliphatic substrates to create chlorinated phosphate esters, which enhance char formation and thermal stability in polymers. Stringent process controls are maintained to manage hydrolysable chlorine levels according to specified downstream application standards, especially in thermosetting resin and rigid polyurethane supply chains.

    Industry compliance standards

    • UL 94—Flammability Standard for Plastics Materials for Parts in Devices and Appliances
    • RoHS Directive 2011/65/EU—Restriction of Hazardous Substances in Electrical and Electronic Equipment
    • ISO 178—Determination of flexural properties of plastics
    • EN 45545-2—Requirements for flame retardancy in rail applications

    Typical usage ratio

    • Commonly 0.4–2.2 eq. per active hydrogen group in the backbone; final loading 6–20% weight of finished flame retardant batch (adjusted for target char yield and UL 94 rating)

    Downstream process integration

    • Reacted at phosphorylation stage into polyol or resin backbone under controlled temperature (20–70°C)
    • Post-reaction neutralization and stripping before downstream blending
    • Quality control for residual chloride, phosphorus content, viscosity

    Final product types

    • Chlorinated phosphate flame retardant masterbatches
    • Flame retarded polyurethane foams
    • Fire-resistant thermosetting resins

    3. Pharmaceutical Intermediate for Synthesis of Nucleotide Analogues

    Pharmaceutical manufacturers rely on Ethyl Dichlorophosphate as a phosphorylation and chlorination reagent in the multi-step synthesis of nucleotide and nucleoside analogue drugs. The material offers high reactivity, allowing for selective modification of deoxyribonucleoside hydroxy groups, while maintaining process yields and minimal formation of side-chain esters. Stringent GMP compliance is observed, with trace impurity control and documentation throughout the in-process controls.

    Industry compliance standards

    • ICH Q7—Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP <1079>—Good Storage and Shipping Practices
    • Ph. Eur. 2.2.46—Nucleosides and nucleotides analysis
    • 21 CFR Part 210/211—FDA GMP requirements

    Typical usage ratio

    • Ranges from 1.0–1.5 equivalents per target hydroxy group in the nucleotide precursor; limited excess to control undesired by-products (0.5–3% batch mass basis)

    Downstream process integration

    • Added during phosphorylation stage under inert gas and low moisture (<0.1% water)
    • Reaction monitored with HPLC for isomeric purity
    • Downstream extraction and purification in line with QC batch release

    Final product types

    • Synthons for antiviral nucleotide analogues
    • Phosphate ester intermediates for nucleoside drugs
    • Research-grade nucleotide triphosphates

    4. Synthesis of Surfactant and Detergent Additives

    Manufacturers of specialized surfactants use Ethyl Dichlorophosphate to introduce phosphate-based hydrophilic groups into nonionic surfactant frameworks. The reactivity supports the creation of new emulsifying agents with improved stability in alkaline or oxidizing environments, which are critical for industrial and institutional cleaning products. Accurate dosing is imperative due to the sensitivity of the balanced hydrophilic-lipophilic ratio, and monitoring ensures compliance with ecological and user safety limits.

    Industry compliance standards

    • OECD Guidelines for the Testing of Chemicals—Surfactant Biodegradability (301B)
    • EU Detergent Regulation (EC) No 648/2004
    • ISO 9001:2015—Batch Quality Assurance for Industrial Detergents
    • GHS/CLP Regulation—Classification, Labelling, and Packaging of Substances

    Typical usage ratio

    • Varies from 5–12% of total surfactant batch mass, based on required phosphate group density and final product application (household vs. industrial)

    Downstream process integration

    • Reacted with terminal hydroxy groups in base oil or alcohol under controlled temperature (25–50°C)
    • Monitored with FTIR and acid-value titration through batch reaction
    • Subsequent blending and neutralization for pH adjustment per specification

    Final product types

    • Phosphate ester surfactants for institutional detergents
    • Heavy-duty industrial cleaning agents
    • Solubilizers and dispersants for agricultural spray adjuvants

    5. Synthesis of Lubricant Additives

    Engine oil and industrial lubricant formulators incorporate Ethyl Dichlorophosphate in the manufacture of anti-wear and extreme pressure additives. The compound phosphorylates selected alcohols or amines, generating phosphate esters and salts, which contribute to improved load-carrying and anti-corrosion characteristics in finished lubricants. Dosing precision is necessary for compliance with OEM standards for phosphorus and chlorine content, and the additive must maintain stability throughout high-temperature blending.

    Industry compliance standards

    • ASTM D4951—Phosphorus, Sulfur, Calcium, and Zinc in Lubricating Oils
    • ACEA European Oil Sequences—Additive requirements for motor oils
    • API SN/CF—North American Engine Oil Quality Standards
    • ISO 14001—Environmental Management for Chemical Formulation

    Typical usage ratio

    • Typically 0.5–3.0% by weight of additive package, adjusted for SAE grade and OEM phosphorus restrictions

    Downstream process integration

    • Phosphorylation step performed at 40–80°C in vacuum-sealed reactors
    • Batch blending with base oil following neutralization
    • Batch release after ICP-OES validation of phosphorus and chloride thresholds

    Final product types

    • Anti-wear hydraulic oils
    • Engine oil additive concentrates
    • Industrial gear lubrication fluids
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    Certification & Compliance
    More Introduction

    Getting to Know Ethyl Dichlorophosphate: A Practical Look from the Plant Floor

    What We Produce and Why It Matters

    In the chemical industry, focus often shifts to complex new molecules, but fundamentals still drive innovation. One of these building blocks—Ethyl Dichlorophosphate—remains a staple for downstream synthesis, particularly when precision and reliability are essential. At our production facility, we have spent years perfecting Ethyl Dichlorophosphate, making sure every lot matches the tightest standards established by the industries that rely on it. Behind every drum of this chemical stands a team that understands its importance far beyond a simple label or formula.

    The Heart of the Compound

    Ethyl Dichlorophosphate, with its structure O=P(OEt)Cl2, belongs to the larger family of dialkyl chlorophosphates, but shows features that set it apart. The two chlorine atoms bonded to phosphorus make this molecule consistently reactive without being unpredictable. The ethoxy group gives enough solubility in non-polar solvents, which expands downstream options. Our model offers high purity, usually in the range of 98% or better, supported by rigorous batch testing for hydrolyzable chlorine and minimal residue on evaporation.

    We prepare this product with careful attention to the needs of organophosphorus chemistry. It supports the creation of phosphorus esters, flame retardants, and agricultural intermediates, and remains a workhorse in specialty synthesis labs. Most of our clients mention that switching to a batch-derived from us cut down their process purification steps—often because the byproducts decreased and the yield stayed consistent, month after month.

    From Synthesis to Shipment: How We Approach Reliability

    Every experienced chemist knows that the repeatability of a key reagent’s quality can make or break an entire season's output. Many of our customers don’t want surprises. That’s why rigorous in-process controls back every kilogram from our reactors. The process we use—chlorination of diethyl phosphate under controlled conditions—may look simple, but the real detail lies in fine-tuning reaction temperatures, gas addition rates, and solvent quality. Our continuous re-investment in purification—fractional distillation and moisture control—lets us offer a product ready for use as soon as it hits the customer’s receiving dock.

    Over the years, we have found the most common issue with Ethyl Dichlorophosphate is moisture sensitivity. Whenever trace water sneaks into a drum during storage or transport, decomposition by hydrolysis accelerates. Some producers cut corners by using old containers or neglecting nitrogen blanketing, which costs buyers in lost material and messy filtrations. At our facility, every batch ships under nitrogen and in tested HDPE drums, reducing exposure to air and humidity. These methods didn’t come out of a book—we learned them through real-world trial, error, and listening to customer feedback.

    Comparing Ethyl Dichlorophosphate to Similar Agents

    Putting Ethyl Dichlorophosphate beside other phosphorylating agents—like Dimethyl Chlorophosphate or Diethyl Phosphite—draws interesting lines. Some buyers ask if they can swap one for the other, but each has a performance signature. The ethyl version delivers a balance between reactivity and volatility. Dimethyl Chlorophosphate works faster but tends toward higher toxicity and greater volatility. Diethyl Phosphite offers less aggressiveness, but reactions often stall or require harsher conditions. Our clients in fine chemicals and agrochemical intermediates tell us Ethyl Dichlorophosphate hits the “sweet spot”—strong phosphorus reactivity, but manageable storage and lower off-gassing.

    Working hands-on, we have watched customers choose between these agents for different reasons. Some manufacturing routes tolerate methyl groups, but in scale-up, shorter carbon chains can increase volatility losses and make temperature control harder. The ethyl chain, by contrast, offers moderate boiling points and less evaporation loss, especially in open reactors or where process temperatures climb. For many, this means lower material costs in the long run—less lost to the atmosphere, less residual odor in handling areas, and fewer surprises in the final specs.

    Because Ethyl Dichlorophosphate has a relatively moderate boiling point, you get easier fractionation from higher and lower boiling impurities in multi-step synthesis. In addition, its reaction with alcohols, phenols, or amines forms esters and amides quickly, with less side-reaction than some alternatives. For example, in the production of certain flame retardants, using the ethyl variant helps chemists control unwanted by-product formation, which translates to cleaner downstream purification—especially important in environmental and toxicological testing.

    Safety and Handling—Lessons Learned the Hard Way

    Years in chemical manufacturing teach a company that safety standards demand more than following codes written on paper. All dichlorophosphates, including our Ethyl Dichlorophosphate, require respect. Chlorine release, vapor control, and spill prevention form daily routines. We emphasize airtight connections and real-time leak detection at pump flanges, especially during tank-to-tank transfers. Early in our production history, we learned that staff with hands-on familiarity ask better questions and spot leaks faster than those who only read manuals. This mindset shapes how we train each new technician.

    One big point: water must never contact this product in the tank farm or the lab. The resulting exothermic hydrolysis not only ruins the batch, it releases hydrochloric acid vapors, setting off detectors, triggering evacuations, and potentially corroding equipment. Because of this, we maintain constant humidity checks in storage. Our packaging lines keep a tight seal, tested under both ambient and extreme climate conditions during shipping trials. For customers, this means the worry of ruined lots from poor packaging drops to nearly zero. As a company that deals with the real costs of waste—treatment fees, lost product, downtime—we know reliable supply saves more than it costs up front.

    Supporting Uses Across Industries

    Ethyl Dichlorophosphate doesn’t only show up in one sector. Its most common destination involves synthesis of organic phosphorus compounds, which become everything from pest control agents to intermediates in pharmaceutical production. Since the molecule brings both activating and leaving group features, chemists use it for simple phosphorylations or as a backbone in more elaborate reactions.

    In flame retardants, its role looks almost invisible but proves essential. The phosphorus-oxygen-chlorine framework supports stable char formation, helping finished plastics pass rigorous fire codes. Agritech companies find it useful in pesticide precursors, where reliable phosphorus addition—and predictable side product removal—makes both manufacturing and regulatory compliance easier. Specialty pharma customers pursue its use in custom syntheses, where the ability to control the reaction profile, especially chiral selectivity, links directly to our quality guarantees.

    Our direct relationships with both small pilots and high-volume plants taught us the small differences turn into big process headaches if ignored. Overly reactive analogs often lead to downstream purification nightmares, while under-reactive agents increase batch reaction times and boost overhead costs. For teams working under audit or timeline pressure, choices rooted in real manufacturing data, rather than supplier guesswork, make the difference.

    Why Quality Standards Differ in Our Production

    Producing Ethyl Dichlorophosphate rarely involves glamorous inventions, but perfection in execution brings its own rewards. Our site uses inline quality checks—routine GC purity analysis, moisture probes at every key step, and real-world stress tests to simulate transport across climates. These measures grew from experience. In one year, a run of drums facing ocean freight developed discoloration and pressure buildup; our team traced the problem not to the reaction but to minor impurities from a supplier’s recycled solvent line. From that point on, we began only approving solvent batches with a full chemical fingerprint check—not just a supplier certificate but our own analysis. Since making this change, customer feedback praised the extended shelf life and improved product color.

    Another important learning: the best QA/QC team pairs lab expertise with plant knowledge. Ours spend weeks with both scientists and shipping managers, which helps us fix issues before a product ever leaves our control. For instance, engineers in our plant modified vent valves to handle rare exothermic runaway risk during chlorination, relying on lessons learned from small-producer failures. These details make it into daily checklists, not as afterthoughts but as procedures embedded into every batch release.

    Shaping the Future—Sustainability and Production Waste

    Phosphorus chemicals carry a responsibility toward environmental footprint. We recognized long ago that high-purity Ethyl Dichlorophosphate production often generates unwanted chlorinated byproducts. Our plant invested in neutralization systems to capture hydrochloric acid streams and minimize off-gassing. Each process stream gets recycled through on-site treatment, cutting down on external waste hauls. This project required long hours and direct collaboration with chemical waste specialists, but we saw a reduction in permit fees and compliance delays almost immediately.

    Some industry peers chase cost savings by stretching cycles or skipping in-process cleaning. From our view, neglecting these steps risks repeated batch failures and the hidden expense of regulatory interventions. Instead, our team adopted in-line reaction monitoring tools—spectrometers tuned to detect side products in real-time—allowing fast adjustment before impurities build. This approach increased usable output by nearly 14% per campaign and meant downstream users saw less batch-to-batch variation.

    For customers pushing into greener chemistries, Ethyl Dichlorophosphate still holds a place when managed responsibly. Our R&D staff work alongside customers to trial substitute solvents or design syntheses with better atom economy. While phosphorus chemistry remains both powerful and tricky, our driving principle stays unchanged: lower environmental impact comes from working within the capabilities of proven process controls and honest communication with end users.

    Lessons from the Field—Listening to Those Who Use the Product

    The best feedback comes from companies that use our chemical in their own plants every day. More than once, customers running 24-hour shifts caught bottlenecks or inefficiencies we had overlooked in-house. One shared how a subtle change in trace impurity content helped reduce filter clogging in their downstream application. Another pointed out that customized drum sizes made unloading easier and reduced partial-drum leftovers, allowing them to streamline waste collection and occupational safety routines.

    By visiting customer sites for on-site troubleshooting, our technical staff learned that improvements as simple as adjusted packaging liners or fine-tuned transportation schedules ripple into higher productivity on the recipient’s end. Real production doesn’t happen in a vacuum—unplanned delays in one plant can cascade into missed deliveries down the supply chain. We believe a manufacturer’s job only finishes when the user’s process succeeds—not just when the product leaves our warehouse.

    On rare occasions, our support team guided customers who faced emergency shutdowns due to supplier faults; seeing firsthand the real costs to production reinforced our practice of in-house backup stock and secondary distribution networks. Our approach remains hands-on and rooted in practical fixes, not generic customer service language.

    Looking Ahead—Innovation and Continuing Experience

    Our perspective on Ethyl Dichlorophosphate production keeps evolving. As requirements shift—new regulatory standards, changing hazardous goods shipping rules, emerging applications—continuous investments in both technology and training become essential. While automation helps, our site leaders never let go of the belief that human vigilance and practical experience hold the final say, both for safe operation and product quality.

    Recently, advanced process analytics revealed subtle changes in reaction efficiency at different seasonal humidity levels. This led us to tweak bulk storage designs and air handling systems, which in turn delivered more consistent results—less batch variability, fewer holdbacks, and a drop in off-spec returns. These upgrades reflect our ongoing focus, not on high-gloss marketing promises, but on problem-solving grounded in operational reality.

    With new applications for Ethyl Dichlorophosphate emerging—selective phosphorylating agents in medicinal chemistry, surface modification for advanced composites, and safer alternatives for persistent environmental chemicals—we stand ready to adapt recipes and support for specialists. We work shoulder-to-shoulder with chemists aiming for innovations in reactivity or selectivity, and we remain open to trialing process adjustments based on practical field requests rather than chasing every novelty.

    Ethyl Dichlorophosphate: A Tool Backed by Real-World Experience

    Every drum that leaves our plant sends a message about our approach to chemical manufacturing. Tools like Ethyl Dichlorophosphate may not always make headlines, but their reliability sets the tempo for thousands of downstream reactions. Over years, we have learned that what matters most—product consistency, safety, environmental responsibility—comes from daily hands-on practice, not from distant policy or sales talk. We treat each order as part of a partnership bound by results on the production floor rather than promises on paper.

    Anyone searching for more than just a commodity supplier—instead seeking a partner with firsthand production insights, a record of problem-solving, and commitment to continual improvement—will see the value reflected in each lot we deliver. Ethyl Dichlorophosphate will remain a solid backbone for organophosphorus chemistry as long as users demand honesty, safety, and reliability from their suppliers. Those values mean as much to us on the manufacturing line as they do in the labs and plants that depend on our work.