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Ethyl Chlorofluoroacetate

    • Product Name Ethyl Chlorofluoroacetate
    • Alias Ethyl chlorofluoroacetate
    • Einecs 211-367-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    688426

    Product Name Ethyl Chlorofluoroacetate
    Cas Number 383-63-1
    Molecular Formula C4H6ClFO2
    Molecular Weight 140.54 g/mol
    Appearance Colorless liquid
    Boiling Point 130-132 °C
    Density 1.308 g/cm³
    Refractive Index 1.409
    Flash Point 41 °C
    Solubility Hydrolyzes in water
    Purity Typically >98%
    Smiles CCOC(=O)C(F)Cl

    As an accredited Ethyl Chlorofluoroacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl Chlorofluoroacetate is supplied in a 100 mL amber glass bottle, tightly sealed with a PTFE-lined screw cap for safety.
    Shipping Ethyl Chlorofluoroacetate must be shipped in tightly sealed containers, protected from moisture and incompatible substances. It is classified as a hazardous material and must be transported in accordance with regulations for toxic and potentially flammable chemicals. Appropriate hazard labeling, documentation, and handling by trained personnel are required during shipping.
    Storage Ethyl Chlorofluoroacetate should be stored in a tightly sealed container, away from moisture, heat, and direct sunlight. Keep it in a cool, dry, well-ventilated area, and segregate from incompatible substances such as strong bases, acids, and oxidizers. Ensure storage area is equipped for containment in case of leakage and clearly labeled, with access limited to trained personnel.
    Application of Ethyl Chlorofluoroacetate

    Applications of Ethyl Chlorofluoroacetate in Industrial Manufacturing

    Ethyl chlorofluoroacetate serves as a specialized intermediate in several chemical manufacturing sectors. As a direct manufacturer, we strictly supply this compound to end-users in industries with established demand and regulatory frameworks. Below, we highlight key downstream application fields and their integration requirements.

    1. Agrochemical Intermediate Production

    Major global agrochemical producers employ ethyl chlorofluoroacetate as a building block in selective herbicide synthesis, notably for fluorinated pyridine and triazine crop protection compounds. These specialty actives require precise control over halogen substitution patterns, making our material critical in early stage alkylation steps within multi-step batch syntheses. Quality assurance laboratories monitor input purity and moisture strictly to mitigate downstream catalyst poisoning.

    Industry compliance standards

    • REACH (EC) No 1907/2006 compliance for registration and evaluation
    • EPA TSCA Registered Substance Listing (US market)
    • OECD Good Laboratory Practice (GLP) for process analytical controls
    • Chinese GB/T 22103-2008 for pesticide intermediates

    Typical usage ratio

    • Applied at 0.85–1.2 molar equivalents relative to target heterocycle precursor; adjusted based on conversion and waste minimization targets.

    Downstream process integration

    • Added during initial alkylation in jacketed glass-lined reactors before base treatment steps; reacts at 30–50°C under controlled nitrogen blanketing to reduce side-product formation.

    Final product types

    • Fluorinated pyridine-based herbicides (e.g., flupyrsulfuron-methyl)
    • Chlorofluorinated triazine pesticides
    • Fine chemical intermediates for agrochemical active ingredients

    2. Pharmaceutical API Synthesis

    Active pharmaceutical ingredient (API) manufacturers utilize our material for introducing mono-fluorinated motifs into beta-keto ester intermediates, improving metabolic stability and binding selectivity in candidate drugs, particularly for anti-infective and CNS compounds. GMP-compliant production sites incorporate strict material tracking and batch documentation as required for regulatory submissions.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • US FDA 21 CFR Part 211 (Finished Pharmaceuticals)
    • European Pharmacopoeia Ph. Eur. monographs on starting materials
    • Japanese JP Compliance (for Asian API processors)

    Typical usage ratio

    • Introduced at 1.0–1.3 molar equivalents in alkylation or condensation reactions, depending on the synthetic route and API structure; monitored by in-process HPLC analysis.

    Downstream process integration

    • Dosed into reaction vessels equipped with vacuum distillation for solvent exchange; quenching and purification steps immediately follow to isolate fluorinated esters before further transformation.

    Final product types

    • Fluorinated beta-ketoester drug intermediates
    • Building blocks for anti-viral and neuropharmaceutical APIs
    • Small molecule reference standards used in regulated labs

    3. Polymer Modifier Synthesis

    Specialty polymer and engineering plastics producers introduce this chemical as a chain-modifying agent to impart partial fluorination in copolyesters and polyamides for improved chemical resistance, hydrophobicity, and flame retardancy. Material selection focuses on minimum residual acidity and low freezing points for operational safety.

    Industry compliance standards

    • ISO 9001:2015 certified production systems
    • ASTM D4032 (Standard Test Method for Stiffness of Fabrics, polymers with functionalized surfaces)
    • EU RoHS Directive for restricted substances in electronics polymers
    • FDA CFR 177 for indirect food contact in select applications

    Typical usage ratio

    • Blended at 0.3–1.5% by weight of total monomer feed; precise ratio determined by the desired degree of hydrophobicity or fire-resistance profile.

    Downstream process integration

    • Continuously metered into the polycondensation feedstream in stainless steel autoclaves; temperature maintained at 180–220°C to ensure complete integration and avoid by-product volatility.

    Final product types

    • Functionalized polyesters for wire and cable insulation
    • Fluorinated copolyamide fibers used in filtration textiles
    • Specialty coatings for chemical process equipment

    4. Fine Chemical Derivatives - Halogenated Building Blocks

    Fine chemical houses employ ethyl chlorofluoroacetate during targeted halogenation reactions to synthesize uniquely substituted esters and acids needed in advanced organic chemistry and as reference standards. Traceability and impurity profiling are central to meeting customer specifications in analytical service markets.

    Industry compliance standards

    • ISO 17034:2016 for reference material producers
    • GHS (UN GHS Rev. 9) labeling and transport codes
    • Responsible Care chemical safety management systems
    • Pico-trace impurity documentation for analytical standards manufacturing

    Typical usage ratio

    • Reacted at stoichiometric ratios (1:1) with nucleophilic agents or metal catalysts; yield optimization may increase to 1.2 equivalents for driver conversion.

    Downstream process integration

    • Charged into laboratory-scale or plant kettles ahead of sequential halogen exchange or substitution steps; systems equipped with advanced vent scrubbing and real-time GC for vapor phase monitoring.

    Final product types

    • Halogenated reference esters for chromatographic use
    • Analytical standards for environmental laboratories
    • Custom synthon libraries for contract research customers

    5. Custom Synthesis for Fluorinated Flavor and Fragrance Intermediates

    Within the specialized flavor and fragrance industry, manufacturers request this intermediate for producing targeted fluorinated esters and lactones with unique aromatic and volatility profiles. Use remains strictly controlled for trace-enriched compositions as allowed under current safety and food additive regulations.

    Industry compliance standards

    • IFRA Safety Standards for flavor and fragrance ingredients
    • US FDA 21 CFR 172 (Synthetic Flavoring Substances and Adjuvants)
    • European Union Regulation (EC) No 1334/2008 on flavorings
    • Kosher and Halal certification for targeted ethyl esters where applicable

    Typical usage ratio

    • Blended at 0.02–0.08% of total mass in microbatch synthesis; ratio determined by target compound purity and organoleptic screening results.

    Downstream process integration

    • Introduced in a controlled feed during esterification or ring-closure reactions; post-synthesis, extensive vacuum stripping and fractionation isolate product fractions relevant for sensorial testing.

    Final product types

    • Fluorinated lactones and esters for specialty aroma applications
    • Trace-level ingredients in compounded beverage flavors
    • High-value intermediates for fine fragrance formulations
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    Certification & Compliance
    More Introduction

    Introducing Ethyl Chlorofluoroacetate: A Manufacturer’s Perspective

    Reliable Building Block for Fluorochemical Synthesis

    Chemical manufacturing moves at the pace of innovation and safety. Among the specialty chemicals we produce, ethyl chlorofluoroacetate delivers a reliable tool for professionals working with fluorinated compounds. This compound offers a rare combination of reactivity and control that’s essential for those synthesizing active pharmaceutical ingredients, developing crop protection agents, or advancing specialty polymers.

    Product Overview: Model and Purity Profile

    Our ethyl chlorofluoroacetate is manufactured to meet demanding specifications. Purity levels exceed typical industry benchmarks, with GC analysis routinely confirming consistency across batches. Appearance is clear and colorless, reflecting our commitment to tightly managed process conditions that suppress unwanted byproducts. The molecular structure—containing both chlorine and fluorine—sets it apart from basic esters, opening up pathways that standard organochlorine or organofluorine intermediates cannot offer.

    Consistency and Reactivity: The Foundation of Confidence

    From decades of industrial experience, we know customers rely on predictable chemistry. Our process controls guarantee the carbon-fluorine bond remains intact, providing exceptional selectivity in nucleophilic substitution and other reactions. Other ester analogs—without the unique balance of halogens—often fail to match the versatility offered by this molecule. Researchers can confidently use ethyl chlorofluoroacetate, knowing its reactivity profile fits neatly into the synthesis of a range of downstream compounds.

    Pathways Opened by Ethyl Chlorofluoroacetate

    Unlike mono-halogenated esters, the presence of both chlorine and fluorine changes the reaction landscape. It allows for stepwise halogen exchanges, facilitates alkylation strategies, and can introduce selective deprotection steps in complex organic syntheses. Pharmaceutical manufacturers have applied this compound in building blocks aimed at generating fluoroalkyl functional groups with pharmacokinetic benefits. In agrochemical research, developers seek out ethyl chlorofluoroacetate as a short, efficient route toward compounds resisting biodegradation and providing sustained field activity. The stability of the carbonyl and fluorine moieties brings practical advantages, streamlining downstream purification and lowering waste.

    Quality Matters in Every Step

    In the lab, small impurities translate to downstream problems. We’ve been producing halogenated esters for years and recognize how purity affects crystallization, distillation, and eventual product performance. Our meticulous purification techniques—rooted in direct manufacturing oversight rather than sub-contracting—reduce unknown residuals. Each lot is tracked through an integrated QC protocol, with particular attention paid to halide content and residual solvents. Handling practices, container materials, and storage protocols all contribute to a quality standard makers trust.

    Comparison with Competing Esters

    Markets offer a variety of fluoro and chloroacetate esters. Many firms opt for mono-substituted options, believing simplicity brings savings or broader usability. Yet we see repeated cases where standard ethyl fluoroacetate or ethyl chloroacetate introduce limitations. Without both halogens on the molecule, flexibility in subsequent chemistry drops. One halogen offers a single type of reactivity; two introduce opportunities for orthogonal transformations. The combined presence can enable selectivity unattainable by other routes.

    Handling and Storage—Lessons Learned Over Time

    Professional chemists know that some specialty reagents carry challenges in stability and handling. Our direct manufacturing experience has shaped the way we package and store ethyl chlorofluoroacetate. It sits stable under anhydrous conditions and sealed packaging, so businesses can plan inventory with fewer surprises. Container choices—carefully evaluated for chemical compatibility—protect against leaks, contamination, and environmental exposure. Safe, reliable supply chains matter as much as the chemistry itself.

    Supporting Innovation in Pharmaceuticals

    Synthetic chemists in drug discovery constantly push for new pharmacophores and molecular motifs. By supplying ethyl chlorofluoroacetate, we support multiple research teams in generating fluorinated scaffolds—structures now common in registered pharmaceuticals. The difference is tangible; the balance of size, electronegativity, and leaving group capacity inherent in this molecule lets chemists reach novel targets without lengthy protection-deprotection cycles. If a researcher previously used alternatives that force tedious workarounds, adopting a true bifunctional halogenated ester can transform productivity.

    Enabling Greener Chemistry

    Environmental compliance is embedded in our thinking. With every batch, we account for emissions, process safety, and downstream waste profiles. Ethyl chlorofluoroacetate helps formulators target more efficient syntheses with fewer isolation steps, thus reducing energy use and solvent waste. Over time, this adds up, not only in operational cost savings but also in regulatory peace of mind for our customers. Our work doesn't end after the drums leave the plant—customers often consult us for advice on process optimization and safe disposal to ensure full lifecycle stewardship.

    Agricultural Applications: Stability Meets Function

    Field chemists in agrochemical R&D face pressure to deliver compounds that persist and act with precision. The halogenated ester backbone in ethyl chlorofluoroacetate allows for the design of agents that withstand soil microbes and light-driven breakdown. Our manufacturing approach ensures the safety and consistency of supply critical to field trials and regulatory filings. Companies have incorporated the product into scalable routes for fungicides and herbicides, leveraging the chemical’s stability to protect active ingredients through formulation and packaging.

    Manufacturing Expertise: Beyond the Data Sheet

    Lab-scale syntheses often hide scale-up headaches. We’ve invested in developing process routes that allow us to control exotherms, emissions, and impurity profiles through continuous processing and in-line monitoring. In-house engineering teams tune reflux ratios, condensation rates, and reagent feeds to optimize yields not just for output but also for sustainability. Our customers need to trust not only the bottle they open but the unseen systems behind it—the years of trial-and-error, process tweaks, and failure analysis that ultimately build a safe, robust supply.

    Molecular Differences that Matter

    We’ve made, tested, and scaled a wide catalog of esters, but ethyl chlorofluoroacetate occupies a unique slot. The presence of two distinct halogens typifies bifunctional building block chemistry, acting as a springboard for derivatives not easily reached through mono-halogenated alternatives. This opens new doors for complex molecule assembly, especially where synthetic chemists need ready options for late-stage diversification. Our feedback from clients highlights that rare combination: quick downstream reactivity without the uncontrollable side reactions seen with more aggressive halides or less sterically compatible esters.

    Safety in Use and Industry Best Practice

    Knowledge about risk is built through direct engagement with real-world production. Our workers, like our customers, know what it means to handle potentially aggressive halogenated reagents daily. Through decades of production, we identified process tweaks and control points—temperature, moisture exclusion, gentle agitation—that prevent runaway reactions and maximize yield. These insights shape our guidelines for customers scaling up their own handling, helping minimize downtime and incident risks. Regular training cycles and knowledge exchange ensure safer manufacturing environments, not just for us but for those who trust our material for their own production lines.

    Customer-Centric Support Throughout the Supply Chain

    We believe customer questions deserve quick, technical answers. Whether troubleshooting a bottleneck in synthesis or navigating emerging regulatory requirements, our technical team stands ready. Having direct access to expertise on halohydrocarbon chemistry, reaction optimization, and environmental compliance means our clients get practical guidance without the runaround found when purchasing from resellers or third parties. Our end-to-end model lets us offer background insight into each batch, supporting efficient and compliant processing at the client site.

    The Evolving Landscape of Halogenated Intermediates

    Industry demand for specialty esters fluctuates with regulatory shifts, new research findings, and the overall tempo of innovation in pharmaceuticals and agriculture. Through each cycle, ethyl chlorofluoroacetate stays relevant due to its unique chemical versatility and reliability. The molecular features—that blend of electrophilic and nucleophilic sites—translate directly into practical utility for synthetic pathways that once seemed out of reach. Every successful campaign using our product further cements its role in the expanding library of fluorinated and chlorinated intermediates.

    Guiding Choices with Industry Feedback

    Over time, we’ve taken in feedback from researchers, process engineers, and operators who work at every stage of the product’s lifecycle. They come to us not just for supply but for risk assessments, optimal storage options, and alternative application advice. These collaborations drive the evolution of our process and help shape the next generation of chemical manufacturing standards, further raising the bar on quality and reliability.

    Continuous Process Improvements—Learning from Experience

    Markets do not stand still, and neither do we. Every product batch serves as a learning point. Direct experience with distillation, purification, and analytical technology pushes our process closer to the ideal. In working with ethyl chlorofluoroacetate, we’ve refined ways to minimize energy input and solvent consumption, shift toward closed-loop systems, and reduce manual handling. Our operators and engineers spot emerging issues early, adapting equipment and protocols for safer, leaner production. It’s this cumulative, hands-on knowledge—honed over years on the production floor—that sets us apart from repackagers or generalist suppliers.

    Real-World Case: Reducing Downtime at Client Facilities

    One of our long-term customers faced operational delays due to inconsistent quality from previous overseas suppliers. The introduction of our ethyl chlorofluoroacetate—coupled with regular feedback and technical follow-ups—completely changed their process. Reaction reproducibility improved, inventory scrap dropped, and plant shutdowns nearly vanished. This kind of case reinforces for us how details in manufacturing and product stewardship translate directly into outcomes for the entire value chain.

    Technical Support Tailored by Manufacturing Insight

    Over years spent making and dispatching this product, we’ve built expertise far beyond the basics of organofluorine and organochlorine chemistry. Our chemists handle inquiries from technical leads and bench chemists with practical insight: troubleshooting adverse reactions, recommending compatible solvents, and guiding on instrumentation sensitivity. A broad base of customer experiences continuously feeds into our best-practice database, delivering not just a raw material, but a full package of applied knowledge for users navigating complex chemistry challenges.

    Supply Chain Management in a Dynamic Environment

    Customers today want confidence in continuity of supply. We control raw material sourcing, in-house production, and logistical distribution. This has proven crucial during supply chain disruptions—our onsite inventory and local warehousing provide buffer stocks so clients avoid extended interruptions. Regular reviews of tariff impacts, shipping protocols, and port logistics keep our network flexible and accountable. Our clients benefit from transparency in timelines, so mission-critical projects run smoother even as global conditions fluctuate.

    Challenges and Direct Solutions

    New regulations and evolving safety protocols keep challenge at the forefront of chemical production. Early adoption of advanced monitoring, containment, and waste mitigation allows us to meet or exceed most environmental and workplace safety standards globally. In the rare instance where incidents arise—a spill, an unexpected analytical blip—our team investigates root causes, adapts the process, and updates our internal training. As a manufacturer, this hands-on problem-solving translates into value for the client, sparing them the learning curve and regulatory headaches that less established producers sometimes trigger.

    The Value of Direct Manufacturer Relationships

    Manufacturing ethyl chlorofluoroacetate is more than synthesis and shipping. It’s about relentless improvement, close customer interaction, and a direct line from process plant to end-user. We share a belief with our clients: quality at the source means less risk, better results, and greater confidence throughout product development. Our business was built on earning and holding that trust—one batch, one partnership at a time. Years of chemical production have shown us that shortcuts in the supply chain rarely pay off; well-managed manufacturing, based on feedback and data, always wins in the long run.

    Looking Ahead: Continuous Commitment to Customers

    The science behind fluorinated and chlorinated esters continues to evolve, driven by sharper analytical tools and the push for greener synthesis strategies. We remain engaged with clients and research communities, using data and real-world feedback to refine every parameter in production and delivery. Whether your focus is scaling up a new pharmaceutical lead, launching a crop protection pilot, or seeking materials for specialty polymer work, ethyl chlorofluoroacetate from a direct manufacturer brings a practical, reliable edge to the table. Together with our partners, we continue building a foundation for innovation and safer industry practice, one molecule at a time.