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Ethyl 4-Methylbenzoate

    • Product Name Ethyl 4-Methylbenzoate
    • Alias p-Toluic acid ethyl ester
    • Einecs 207-429-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    330650

    Chemical Name Ethyl 4-Methylbenzoate
    Synonyms p-Toluic acid ethyl ester; 4-Methylbenzoic acid ethyl ester
    Molecular Formula C10H12O2
    Molecular Weight 164.20 g/mol
    Cas Number 619-64-7
    Appearance Colorless liquid
    Boiling Point 244-246 °C
    Melting Point −25 °C
    Density 1.027 g/cm³ at 25 °C
    Refractive Index 1.507
    Smell Fruity odor
    Solubility In Water Insoluble
    Flash Point 110 °C
    Storage Temperature Store at room temperature

    As an accredited Ethyl 4-Methylbenzoate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl 4-Methylbenzoate is supplied in a 500 mL amber glass bottle with a tamper-evident cap, labeled for laboratory use.
    Shipping Ethyl 4-Methylbenzoate is typically shipped in tightly sealed containers made of glass or compatible plastic to prevent leaks and contamination. It should be stored and transported in a cool, dry place, away from sources of ignition. Proper labeling and adherence to local regulations for flammable organic liquids are required during shipping.
    Storage Ethyl 4-methylbenzoate should be stored in a cool, dry, and well-ventilated area, away from sources of ignition. Keep the container tightly closed and protected from light and moisture. Store away from incompatible substances such as strong oxidizers and acids. Ensure proper labeling and secondary containment to avoid leaks or spills. Dispose of in accordance with local regulations.
    Application of Ethyl 4-Methylbenzoate

    Applications of Ethyl 4-Methylbenzoate in Industrial Manufacturing

    Ethyl 4-Methylbenzoate serves as a key intermediate and functional compound in several specialized industrial sectors. As an experienced chemical manufacturer, we formulate and supply this material to meet the stringent needs of diverse downstream applications, each requiring precise technical integration and compliance with industry benchmarks. Below we detail established industrial use cases, describing critical compliance standards, application dosage, integration into manufacturing processes, and end product categories for each sector.

    1. Pharmaceutical Intermediate for Sartan Synthesis

    This compound functions as an essential intermediate in the multi-step synthesis of several angiotensin II receptor blockers, particularly within the manufacturing lines for sartans such as candesartan cilexetil and valsartan. It is introduced during the condensation and subsequent esterification steps, providing a foundation for further functional group modifications. Strict adherence to global drug synthesis regulations shapes both its upstream handling and downstream impact on final API purity as verified by batch analysis.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • Current Good Manufacturing Practice (cGMP), 21 CFR Part 210/211
    • Pharmacopoeias: USP, EP, JP for related intermediates
    • REACH registration compliance for non-EU transfer

    Typical usage ratio

    • 0.9–1.05 molar equivalents relative to coupling partner, as dictated by process yield optimization and impurity profile targets

    Downstream process integration

    • Introduced after initial benzamide or tetrazole precursor preparation, employed in esterification-reactive steps before final hydrolysis and purification for API isolation

    Final product types

    • Active pharmaceutical ingredients: candesartan cilexetil, valsartan, azilsartan medoxomil
    • Finished oral solid dosage drugs (tablets, capsules)

    2. Fragrance and Aroma Chemical Manufacturing

    In the perfume and fragrance industry, formulators incorporate ethyl 4-methylbenzoate as a high-boiling aromatic ester to impart sweet, mild, and floral notes. It acts as a fixative, stabilizing lighter volatile elements and modulating the evaporation profile in fine fragrance compositions. Manufacturers follow internationally agreed standards to assess olfactory performance and toxicological safety before commercial blending and packaging.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards and Amendments
    • EU Regulation (EC) No 1223/2009 on Cosmetic Products (for personal care applications)
    • IFRA/IOFI Labeling Manual for fragrance ingredients
    • REACH compliance for fragrance raw materials

    Typical usage ratio

    • 0.1–2.5% of total concentrate by weight; perfumers determine dosage through iterative stability and sensory profiling for each fragrance base

    Downstream process integration

    • Direct addition into perfume oil compounding tanks before homogenization; monitored for compatibility during base and top note design in both alcoholic and non-alcoholic systems

    Final product types

    • Fine fragrances (eau de parfum, eau de toilette, cologne sprays)
    • Personal care and cosmetic products with scent components
    • Home and fabric care scented formulations (diffusers, air freshener bases)

    3. Agrochemical Intermediate for Herbicide Synthesis

    Manufacturers in the agrochemical sector use this ester as a building block for synthesizing select benzoic acid derivative herbicides, including methyl-substituted analogs formulated for broadleaf weed control. The compound is integrated during key transformation stages involving aromatic substitution and carbonyl functionalization. Strict stewardship is observed throughout, with process controls supporting compliance with market entry regulations for crop chemistry.

    Industry compliance standards

    • FAO/WHO Specifications for Pesticides
    • OECD Guidelines for the Testing of Chemicals
    • ISO 9001:2015 Quality Management for agrochemical synthesis
    • National regulatory registrations (EPA FIFRA in the US, China ICAMA, EU PPP Regulation EC 1107/2009)

    Typical usage ratio

    • 0.7–1.2 molar equivalents per batch, depending on the downstream product and regional application rate restrictions

    Downstream process integration

    • Employed in intermediate condensation and esterification steps for benzoic acid herbicide analogs prior to technical concentrate formulation and downstream solid/liquid formulation

    Final product types

    • Technical-grade herbicide active ingredients
    • Water-dispersible granules and suspension concentrates for agricultural field applications

    4. Specialty Polymer and Resin Modifier

    Specialty polymer and coatings manufacturers implement ethyl 4-methylbenzoate during the synthesis of tailored polyesters and alkyd resins, optimizing mechanical flexibility, gloss profile, and environmental resistance. The compound provides molecular structural adaptation for polymer chain branching and crosslinking, especially in industrial coatings for automotive and appliance finishes. Each formulation batch follows prescribed industry certifications and performance testing protocols that govern release for commercial and OEM applications.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for polymer synthesis
    • ASTM D3618, D3637 for resin and coating quality assessment
    • Restriction of Hazardous Substances (RoHS) Directive for downstream electrical/automotive applications
    • VOCs and HAPs compliance per EPA 40 CFR Part 59

    Typical usage ratio

    • 0.5–3.0% by weight in the polyol/acid component formulation, adjusted based on targeted polymer molecular weight, ester content, and desired mechanical performance

    Downstream process integration

    • Incorporated during polycondensation reactions as a reactive ester, introduced with glycol and acid feedstocks prior to vacuum stripping or azeotropic distillation in polyester and alkyd resin reactors

    Final product types

    • Industrial coatings (automotive OEM, appliance coatings, protective paints)
    • High-performance polyester and alkyd resins for specialty applications
    • Modified copolymer blends with tailored physical properties

    5. Analytical and Organic Synthesis Reagent

    Certified laboratories and organic synthesis groups employ this ester as a model substrate and derivatization standard, enabling method development and performance validation in chromatographic analysis. Its well-characterized behavior under varied analytical conditions supports GC–MS, LC–MS, and NMR protocol development, while serving as a clean starting point in exploratory organic synthesis of substituted aromatic compounds or esters.

    Industry compliance standards

    • ISO/IEC 17025:2017 Laboratory Quality Management
    • IUPAC Analytical Chemistry Guidelines
    • Relevant ASTM methods for analytical reagents (ASTM E288, E200)
    • Manufacturer’s Certificate of Analysis (CoA) conformance

    Typical usage ratio

    • Typically 0.01–1.0 mg/mL for analytical standards; synthesis-scale use varies by target compound but ranges from 1 to 10 mmol

    Downstream process integration

    • Dissolved in calibration solutions or employed at the initial loading step in preparative and analytical batch reactors, followed by extraction, purification, and characterization procedures

    Final product types

    • Analytical standard mixes for chromatographic detection
    • NMR and MS calibration solutions
    • Substituted benzoate derivatives for ongoing organic synthesis research
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    Certification & Compliance
    More Introduction

    Ethyl 4-Methylbenzoate: A Closer Look from the Production Floor

    Product Introduction: Ethyl 4-Methylbenzoate and Our Direct Experience

    Working in the lab, fused glass lining and all, we measure up batch after batch of ethyl 4-methylbenzoate. Its CAS number gets tossed around the shop, but for us it’s the results—not the digits—that matter. We see not just a colorless liquid or a chemical formula, but a key aromatic ester that underpins consistency batch after batch. Our process refines methyl group chemistry so downstream customers don’t have to second-guess sap content or trace impurities. This is intentional work, forging a clear, high-purity compound that passes muster with the most rigorous industrial checks.

    Our model sits at the intersection of years of bench experience and feedback from real applications. Ethyl 4-methylbenzoate, produced through esterification under controlled heat, remains a go-to solution to introduce mild, floral-sweet notes or serve as an intermediate in larger synthetic schemes. Chemists know the subtle differences in odor, volatility, and reactivity. As producers, we see daily just how much raw material quality can shift odor thresholds, reaction rates, and finished composition.

    Technical Outlook: What Sets This Product Apart

    Aromatic esters make appearances in fragrance houses, flavor labs, and pharmaceutical builds. Early in my career, a mentor stressed to check boiling points and flashpoints after every new distillation change. That instinct never goes away—ethyl 4-methylbenzoate flashes at a higher point compared to its smaller methyl or ethyl benzoate cousins, so it sticks around longer in formulas that matter. Spec sheets list state, purity, molecular weight, and boiling point. Day to day, quality hinges on the subtler points: color under clear light, clarity against reference, absence of water or residual acid from incomplete reactions.

    Our facility targets the ethyl ester for its resilience. The 4-methyl substitution tweaks the ring enough to hold a sweet, lightly balsamic odor profile. Compare this to unsubstituted ethyl benzoate and the change feels obvious in both bouquet and solubility. This difference matters for flavor and fragrance teams striving for nuanced base notes. In pharma syntheses, that methyl group gives a slight change in reactivity, often making certain transformations cleaner or more predictable than using structural isomers.

    Day after day, our QC team pulls product for GC-MS. Even slight shifts in chromatographic purity signal changes upstream—temperature, pressure, and raw alcohol quality all tell their tales. Big production numbers often miss the tension one feels keeping side reactions and colored byproducts in check with every batch, especially when nothing but practical results satisfy end clients.

    Practical Use: What Ethyl 4-Methylbenzoate Means for Different Industries

    Downstream, real-world applications drive our stringent production routines. The perfumer’s studio values ethyl 4-methylbenzoate for its subtlety and staying power. Anyone layering traditional rose, cherry blossom, or muguet notes expects a reliable, non-overpowering fixative. We track complaints on unwanted off-notes in finished fragrance blends. Even trace contamination can spoil a month’s product line-up, so our plant’s vigilance focuses hard on distillation cuts and contamination controls.

    In flavor, strict regulatory controls drive sourcing. Our batch records tie every drum or container back to its original synthesis run, so flavorists don’t stumble over chemical inconsistencies sprouting unexpected side tastes. From ice cream to marzipan, this compound goes unnoticed by most consumers, but not by those tasked with QA. It holds just enough volatility to function well in candy and baked applications, dissipating in the right timelines during cooking to leave behind a mild, clean profile.

    Industrial synthesis introduces another chapter. Ethyl 4-methylbenzoate serves as a building block—almost anonymous within bulk chemical routes, yet essential for putting methyl-substituted benzene rings into more advanced molecules. My production team swaps notes with custom manufacturers making specialty polymers, plasticizers, and pharmaceutical intermediates. They see our meticulous quality control reflected in their fewer purification steps and higher yields down the line.

    Comparing Ethyl 4-Methylbenzoate to Similar Compounds

    Every year brings calls from formulators weighing the differences between ethyl 4-methylbenzoate and other common esters. Ethyl benzoate, for example, stands as a broader workhorse in aroma chemistry, prized for its strong fruity notes and greater volatility. Methyl benzoate, equally well-known, brings sharper wintergreen notes and an even lighter touch. Our offering, ethyl 4-methylbenzoate, wins out in cases where a subtler, rounder profile is needed and where slower evaporation better suits the application. The methyl group at the para position (the “4” in the name) changes not only smell but, in some uses, the speed and completeness of targeted synthetic reactions.

    Our reactors also see ortho- and meta-methylbenzoate variants periodically. These subtle positional changes impact where the chemistry clicks: small modulations in boiling point, solubility, and reaction specificity appear. Our data feedback loops with end-users who share their successes, confirming what we see in our spectral readouts and distillation cuts. Having hands-on practice tracking these variants allows us to advise directly on swap-outs or troubleshooting, rather than falling back on textbook comparisons alone.

    The downstream effects ripple forward. A single point of substitution can nudge the whole product suite’s regulatory standing or environmental profile as well. This came home during a trial run for a cosmetic house, when regulators flagged a structurally similar compound, yet ethyl 4-methylbenzoate cleared both safety reviews and IFRA guidance. In flavor, its use rates remain subject to the softer, rounded notes it imparts, earning it a place in nuanced formulation pipelines. No other product in our ester line delivers this intersection of mildness, persistence, and clean odor.

    Production Reality: Purity, Consistency, and Practical Constraints

    We keep purity in sharp focus. The slightest margin off 99% can flag downstream, causing solubility issues in fragrance alcohol or skewing GC profiles. Our standard process, refined over repeated cycles, strips unwanted acids, catalyst residues, and color bodies. Evaporating off low-boilers, capturing target fraction, and closing with a drying and filtration step create not just a product, but repetition—familiar to both senior plant workers and new recruits. Waste minimization and energy tuning walk alongside batch documentation.

    Seasonal procurement jolts come with aromatic chemical manufacture. Soft global markets can make it tempting to shave corners, but we find backward tracing plant throughput—the batch origins, even the source benzoic acid—brings long-term savings no shortcut can match. Duress tests, even years after implementation, pay dividends when a sudden off-note threatens a major client’s launch window.

    Beyond the process lies scale. A small-scale esterification in a jacketed glass flask reveals impurities hidden on industrial runs. Each upscaling step—new reactor volume, different agitator speed—exposes vulnerabilities. Fouling, foaming, and the rarely discussed clogging of condenser lines demand round-the-clock vigilance. We train crew not just to recognize spectral anomalies but to calibrate by taste and smell, knowing the difference between a trace of acid and the sharpness of oxidized residue. Hands-on know-how, across shifts, cannot be replaced by automation alone. Even the modern PLC weighs in as a tool, not a final answer.

    Challenges and Solutions: Staying Relevant in a Demanding Market

    Strict import inspections, evolving labeling laws, and green chemistry trends keep the entire category on its toes. Not so long ago, a single audit or product recall could trim months off a plant’s momentum. We’ve learned to anticipate regulators with batch-level track and trace, not just for customer peace but to protect our own legacy of clean runs. More than once, we’ve revised synthetic routes to eliminate questionable reagents, not because of immediate pressure, but to keep orders sailing past bottlenecks and delays.

    Downstream clients, particularly in cosmetics and food sectors, call for comprehensive residual solvent tests and allergen-free declarations. We built out regular HPLC and Karl Fischer titrations as standard fare, using in-house chemists trained to interpret findings, not just record them. This isn’t just compliance—truly useful data traces back to the real world, keeping us tied to our clients’ priorities. Pairing this technical rigor with the reality of fluctuating raw material markets presses us to secure deep supplier relationships and redundancy plans—every shipment double-checked and cross-referenced.

    We see steady inquiries from R&D teams asking for customization—special color cuts, low-odor, or higher-boiling variants for harsh processing. In the past, variations meant hours resetting stills and revalidating. Today, we pull from decades of operator insight, making quick turnarounds possible under even heavy schedule loads. Plant operators love to recount the trial-and-error horror stories that led to our current standard: start with raw stock on the cold side, gradual ramp-up under nitrogen, carefully monitored pH, and sparing catalyst—all timed to nail purity first pass.

    Environmental Stewardship and Worker Safety

    Attention to environmental responsibility shapes our procedures as much as product quality. Many may overlook the reality of effluent stream management, but a single miscalculation here crops up as a shutdown—or worse. Benzoate synthesis historically lent itself to persistent waste, and we counter by capturing and treating not only liquid but also vent gas. Our wastewater permits require downstream treatment that tracks back to every shift’s processing summary. Operators get direct, detailed feedback when anomalies spike; we tie real rewards to measurable plant efficiency goals.

    Worker safety deserves mention. Older facilities sometimes let aromatic vapors accumulate, raising health and odor complaints. We tack toward full-hood operation, frequent air changes, and direct exposure monitoring—not only because law demands it, but because our own team’s health depends on vigilance. Secondary containment and early leak detection serve both compliance and peace of mind.

    Outlook: Adapting to Tomorrow’s Needs

    Flavor, fragrance, pharma—each asks different things of ethyl 4-methylbenzoate. Each year shifts priorities: pantry-safe labeling, higher allergen scrutiny, better biodegradability. As manufacturers, we don’t wait for competitors to force changes. Feedback pours in from field reps and contract partners who first see a trace residue pop up or need faster scale-up for a global rollout. Every new challenge prompts another round of formulation tweaks: resampling, extra distillation steps, cross-plant checks before loading another outbound drum.

    We hire operators with practical sense—people who can smell the hint of unreacted acid or hear the difference in an overpressurized reactor. Without that bench-level habit, even the best equipment leaves cracks. In many ways, it’s the shop floor tenacity, not the central office, that keeps new product models (like our color-stabilized ethyl 4-methylbenzoate) on specification through changing regulations and shifting customer expectations.

    Questions about performance compared to other esters never really go away. Fragrance clients cite color stability over time. Pharma asks for purity and documentation. Batch after batch, we hand over samples knowing months of labor lie behind every kilogram sent out the door. We learn from failures, adapt to tighter specs, and train our crew to think like the end-user. It never rests on a single plate, but cycles forward with each new marketplace demand or regulatory tweak.

    Building Forward: Keeping Relationships Central

    Chemistry rarely moves in isolation. Our customers, much like our own crew, expect straight answers when a problem arises. We never talk just purity or compliance, but how changes up or downstream alter timelines, cost, or even long-term viability. The best product emerges from a direct line—the kind of give-and-take that only comes from years working through setbacks and new requirements. Time has taught us that long-term reliability grows not just out of tightened specs, but out of keeping our word and being transparent about what we can and cannot control, especially as environmental and health expectations rise.

    On the shop floor, production lines do not run on data alone. Skills passed down through repeated trial, careful taste and odor checks, and detailed logbooks create more reliable batches than remote oversight. Information from the field—process tweaks, customer complaints, or creative new uses—change the next run’s focus and prompt improvements that filtered theories never do.

    Ethyl 4-methylbenzoate keeps proving its worth in products needing reliable, lasting appeal and in multi-step syntheses that can’t tolerate impurities. We continue refining, responding, and testing, sure that the work cannot stand still. The market sets new challenges, and every success or stumble sets the tone for the years ahead. As a direct manufacturer, we build forward by keeping the focus as much on relationships and practical know-how as on instrumentation or automation. In this, our real value lies not just in what goes out the door, but in the daily grind and shared knowledge that keep us aligned with our partners’ evolving goals.