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Ethyl 4-Methoxybenzoate

    • Product Name Ethyl 4-Methoxybenzoate
    • Alias p-Anisic acid ethyl ester
    • Einecs 202-597-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    698088

    Chemical Name Ethyl 4-Methoxybenzoate
    Cas Number 94-05-3
    Molecular Formula C10H12O3
    Molecular Weight 180.20 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 59-62 °C
    Boiling Point 280-282 °C
    Density 1.16 g/cm3
    Solubility In Water Insoluble
    Smiles CCOC(=O)C1=CC=C(C=C1)OC
    Pubchem Cid 7099
    Flash Point 140 °C
    Synonyms p-Anisic acid ethyl ester

    As an accredited Ethyl 4-Methoxybenzoate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 250g Ethyl 4-Methoxybenzoate is packaged in a tightly sealed amber glass bottle with a hazard-labelled screw cap.
    Shipping Ethyl 4-Methoxybenzoate is shipped in tightly sealed containers to prevent contamination and moisture ingress. It should be kept in a cool, dry, and well-ventilated area, away from heat and direct sunlight. During transport, ensure it is securely packed and labeled according to chemical safety regulations. Handle with appropriate protective equipment.
    Storage Ethyl 4-methoxybenzoate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and direct sunlight. It should be kept separate from strong oxidizing agents. Proper labeling and secondary containment are recommended to prevent accidental release, and access should be limited to trained personnel using appropriate personal protective equipment (PPE).
    Application of Ethyl 4-Methoxybenzoate

    Applications of Ethyl 4-Methoxybenzoate in Industrial Manufacturing

    Ethyl 4-Methoxybenzoate serves as an essential intermediate in several chemical manufacturing sectors, where it supports consistent product performance and meets demanding compliance requirements. As the original manufacturer, we ensure full traceability, adherence to industry standards, and strict quality management across every application outlined below.

    1. Pharmaceutical Intermediate for Active Pharmaceutical Ingredient (API) Synthesis

    Leading pharmaceutical formulators employ Ethyl 4-Methoxybenzoate as a reliable ester intermediate for the preparation of various APIs, especially those based on substituted benzoic acid scaffolds. Its purity and batch consistency support robust process validation in multi-step organic synthesis chains. During the N-alkylation or acylation of protected benzoic acid derivatives, this raw material improves yield and reduces the risk of impurity carry-over, which is critical for finished API compliance under international guidelines.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP <795>/<797> Compounding Standards (relevant intermediates)
    • European Pharmacopoeia (Ph. Eur.) purity requirements for excipient-grade intermediates
    • FDA guidance for process and impurity control in API manufacturing

    Typical usage ratio

    • 5%–20% w/w relative to total reactant mass in pathway-specific synthesis
    • Adjustable ratio based on desired yield and by-product control; process chemists optimize according to route specificity

    Downstream process integration

    • Introduced after initial benzoic acid protection phase during esterification
    • Feeds directly into condensation, reduction, or further derivatization stages
    • Utilized both in batch and continuous reactor settings under cGMP conditions

    Final product types

    • Non-steroidal anti-inflammatory drug (NSAID) intermediates such as flurbiprofen acid derivatives
    • Antibiotic side-chain precursors
    • Specialty analgesic compounds

    2. Fine Fragrance and Aroma Chemical Manufacturing

    Compounders in the fragrance and aroma chemical sector use Ethyl 4-Methoxybenzoate as a key precursor in the synthesis of scent molecules featuring ether and ester structures. In this market, the compound’s high purity minimizes odor contamination, supporting stringent olfactory performance in luxury perfume concentrates. Synthesis chemists value it for enabling high-yield transesterification and methylation steps under reproducible, validated batch protocols with attention to IFRA compliance.

    Industry compliance standards

    • International Fragrance Association (IFRA) Amendment guidelines for restricted substances
    • EU CLP Regulation (EC) No 1272/2008 for classification, labeling & packaging
    • ISO 9235 (Natural aroma chemicals identification)
    • REACH registered substance dossier management

    Typical usage ratio

    • 10%–35% as a reaction intermediate for core ester or ether construction
    • Adjusted for final fragrance formulation complexity and target headspace profile

    Downstream process integration

    • Reaction feedstock in aryl ether or aryl ester synthesis for top-note aroma ingredients
    • Distillation and purification steps follow to ensure olfactory neutrality of the intermediate
    • QC analysis for traces of starting esters before downstream blending

    Final product types

    • Musk and floral ingredient bases (e.g., anisic esters)
    • Fine fragrance concentrates for luxury applications
    • Personal care aroma ingredients for soaps and lotions

    3. UV Absorber Intermediate for Polymer Additives

    Producers of light stabilization additives rely on Ethyl 4-Methoxybenzoate as a building block for UV absorber molecules, especially benzophenone- and benzotriazole-type stabilizers. The compound supports controlled functional group insertion, critical for achieving repeatable UV filtering performance in high-stress plastic and coating environments. Manufacturers integrate the material at early condensation or ester interchange steps, where stability and absence of reactive impurities protect downstream polymer properties against degradation.

    Industry compliance standards

    • ASTM D2565 (Practice for Xenon-Arc Exposure of Plastics)
    • RoHS Directive 2011/65/EU for electrical/electronic equipment safety
    • ISO 4892-2 for exposure to laboratory light sources
    • FDA 21 CFR 177.1520 (specific migration limits for polymer additives where relevant)

    Typical usage ratio

    • 8%–25% w/w of total stabilizer precursor batch
    • Ratio depends on target UV stability and polymer matrix compatibility

    Downstream process integration

    • Introduced in bulk reactor for condensation with UV chromophores
    • Integrated in melt-phase or solvent-based synthesis prior to additive finishing
    • Downstream blending with dispersants to ensure polymer compatibility

    Final product types

    • UV absorber additives for automotive polycarbonate applications
    • Light stabilization compounds in polyethylene mulch films
    • Protective coatings for outdoor architectural plastics

    4. Food-Grade Preservative Intermediate (Food Contact Materials)

    Producers of food packaging and preservation systems use Ethyl 4-Methoxybenzoate as an intermediate for permitted food contact additives, especially for controlled-release paraben esters. As a raw material, it supports compliant production of preservative agents, with rigid control over traceable impurities and migration rates. Quality control measures include batch-specific migration testing and compliance with both FDA and EU food contact legislation.

    Industry compliance standards

    • EU Regulation 10/2011 on plastic materials and articles intended to come into contact with food
    • FDA 21 CFR Sections 175.105 & 175.300: Adhesives and resinous coatings for food packaging
    • Japan Food Sanitation Act, positive list system for food packaging constituents
    • GMP regulation (EC) No 2023/2006 for food contact material manufacture

    Typical usage ratio

    • 12%–18% of total synthesis batch for parabens or related esters
    • Level set according to desired preservative migration limits and material compatibility studies

    Downstream process integration

    • Intermediate step prior to final paraben esterification and purification
    • Subjected to sequential filtration and HPLC purity confirmation
    • Fed into extrusion coating or laminate resin production

    Final product types

    • Antimicrobial additives for plastic and paper food wraps
    • Controlled-release agents in multi-layer food packaging films
    • Preservative components in direct food contact container linings

    5. Intermediate for Specialty Dyes and Optical Brighteners

    Producers specializing in textile and paper colorants use Ethyl 4-Methoxybenzoate to introduce methoxybenzene motifs into specialty dye intermediates and optical brightening agents. It facilitates control over desired chromophore extension, which translates to improved absorption and fluorescence properties in target applications. The compound enters at the coupling or diazotization stage, backed by material safety compliance and process-specific emission controls.

    Industry compliance standards

    • OEKO-TEX Standard 100 for tested chemicals in textiles
    • REACH Annex XVII restricted substances (dye intermediates)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • ISO 9001:2015 quality management for dyestuff manufacturing

    Typical usage ratio

    • 10%–28% as a chromophore precursor relative to batch mass
    • Varies by shade requirement and process type (batch or flow chemistry)

    Downstream process integration

    • Activated in initial coupling reactions during dye synthesis
    • Feeds into polymer-bound or sulfonated intermediates under controlled pH
    • Subjected to intermediate purification before final crystallization

    Final product types

    • Fluorescent whitening agents for detergents and papers
    • Anthraquinone and azo dyes for apparel and nonwovens
    • Optical brightener concentrates in paints and plastics
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    Certification & Compliance
    More Introduction

    Ethyl 4-Methoxybenzoate: A Closer Look at a Versatile Specialty Chemical

    Direct Experience with Precision Manufacturing

    Manufacturing Ethyl 4-Methoxybenzoate stems from careful control at every step, starting with the quality of raw anisic acid and high-purity ethanol. Those of us in the chemical production business know the smallest change in feedstock or process temperature can lead to noticeable shifts in product purity or reaction yield. That’s why real manufacturers pay close attention, measuring, adjusting, and investing time to develop a reliable process—something not every supplier can offer with consistency.

    Through years on the production floor, we have observed that high assay Ethyl 4-Methoxybenzoate (CAS No. 100-97-0) stands apart through its fine, colorless crystalline form and reliable melting profile. If batches show unusual color or traces of byproducts, it points right back to upstream choices: controlled crystallization, careful purification, attention during distillation, and prompt packaging. This hands-on experience means the powder coming off our lines meets not only chemical purity requirements but also fulfills the physical properties expected by users with demanding applications.

    Common Uses and Performance in Formulation

    Ethyl 4-Methoxybenzoate’s popularity in the fragrance and cosmetic sectors isn't by chance. Its faint, pleasant, slightly sweet aroma lends itself well to fixative uses in perfume blends. Over time, direct feedback from perfumers helped us optimize product consistency. Textiles and plastics manufacturers come to this ester because it dissolves smoothly in various organic solvents, making it a perfect intermediate for specialty polymers and colorant dispersions, especially where hydrolysis resistance is important.

    Pharmaceutical firms request Ethyl 4-Methoxybenzoate for building block synthesis, especially for APIs where reliability in trace impurity profiles becomes non-negotiable. We have received plenty of feedback from formulation chemists who note that even a few ppm of a related impurity can throw off downstream performance. Years of direct collaboration and process improvement have taught us that purity expectations in this field are far from theoretical—they are measured against regulatory filings and analytical audit trails.

    How Our Product Differs from Commodity Grades

    Through experience, we know that not every supplier meets the same bar for quality. Large commodity batches from lower-tier producers often arrive with visible yellowing or poorly controlled particle size distribution. In contrast, our manufacturing approach focuses on close monitoring of every stage from raw material sourcing through to final drying. This hands-on approach eliminates unwanted side products and ensures batch-to-batch reproducibility.

    A common concern in the market is contamination with phthalates or unwanted aromatic byproducts that creep into poorly managed production lines. We’ve invested in modern reactor control and in-line monitoring, so we catch off-specification material before it ever gets packaged—this is a claim we can stand behind after seeing firsthand how minor lapses translate to end-user headaches. Many end users remark on the trouble-free integration of our powder in their blends, something achieved by focusing on direct, measurable outcomes over flashy marketing claims.

    Key Specifications and Real-World Quality Measures

    Ethyl 4-Methoxybenzoate from our factory ships with target purity above 98.5%, backed by GC and HPLC certificates for every lot released. What these numbers mean on the floor is freedom from off-odors, colorless finished goods, and no surprises at the next synthetic step. Our own staff monitor not only purity but also key identifiers like melting range, moisture content, and package stability. Issues like caking or clumping waste customer time and create headaches, which is why we invested in humidity-controlled packaging and prompt, climate-conscious logistics.

    We’ve learned over time that tight control helps downstream customers. A product delivered out of spec on color can ruin a fine fragrance formulation, and a single outlier in melting point can shut down a pharmaceutical batch run. These lessons usually come from real hard knocks: screening several suppliers, running side-by-side trials, and troubleshooting avoidable problems. We know about these pitfalls because we’ve lived them, so our process delivers the reliability expected by those using Ethyl 4-Methoxybenzoate under tough commercial conditions.

    Consistency, Batch Tracking, and Process Integrity

    We’ve invested substantial resources in developing a batch tracking system. Manufacturing Ethyl 4-Methoxybenzoate at scale means handling many moving parts—reactor conditions, drying cycles, filtration choices, and stocking for seasonal surges. Our teams at the plant know the headaches that come from lost traceability. End-users in the cosmetic and pharmaceutical space rely on full trace histories, including exact raw material sources, lot numbers, operator logs, and intermediate testing points. Transparent, internally auditable production records are standard operating procedure.

    Being a manufacturer—not a middleman—lets us solve issues directly if ever something comes up. Customers have called us after noticing slight differences in powder flow or color, and we could pull up the exact lot, re-run analysis, and get answers quickly. This closed feedback loop with real users and on-site managers creates accountability rare in simple trade-based supply. If there’s a challenge, it becomes our problem, not just a footnote. Customers keep coming back precisely for this reason.

    Environmental Responsibility in Manufacturing

    A major question in modern specialty chemicals turns on sustainability. Our facility upgraded distillation and effluent controls to cut waste, and we use recycling systems for mother liquor streams wherever possible. Small lifestyle changes in the plant—like solvent recycling, and regular audits for fugitive emissions—add up over thousands of kilograms. Continuous feedback from regulatory and community stakeholders spurs us to find practical improvements, not just talk in the press.

    We have worked hard to comply with the toughest environmental regulations here and abroad, sharing data openly with auditors and international buyers. Our experience shows that responsible operation doesn’t only keep our license to operate, it motivates our workforce and wins trust from our local neighbors. We invite regular review and embrace change as part of doing business properly—because the days of hidden or unmonitored waste are over in modern chemical production.

    Supporting Researchers and Scale-Up Development

    Many researchers come to us for small-batch custom variants or special packaging tailored for pilot projects. Developing a new application or next-generation product demands close contact between the research bench and the factory floor. In these cases, chemists appreciate being able to speak directly with those who understand how tweaks in drying time, recrystallization solvent, or storage temperature matter at gram, kilo, and multi-ton scale.

    Requests for tailored flow properties or higher color standards often first come from universities or tech start-ups testing ideas at the edge of what the market needs. We haven’t forgotten our roots as lab-scale producers. We often share comparative analytical data, process improvement tips, and packaging solutions honed over years of scale-up experience. Many long-term relationships form from these conversations, moving from the academic bench to commercial-scale supply under real business conditions.

    Differences from Other Benzoate Esters

    Operators familiar only with basic benzoate esters often overlook the importance of the methoxy group on the aromatic ring. Ethyl 4-Methoxybenzoate offers improved fragrance characteristics and less volatility under heat than simple ethyl benzoate. Customers report that the methoxy substitution delivers subtle odor nuances appreciated where scent profiles must achieve both strength and subtlety. For industrial uses, the methoxy variant stands up better to light exposure, translating to longer-lasting color stability in finished products.

    In high-grade resins or specialty polymers, using the 4-methoxy derivative often means reduced migration—color or odor won’t leach as much over time compared to less substituted benzoates. Process engineers in plastics plants frequently share their preference for Ethyl 4-Methoxybenzoate because these differences show up in end-user complaints (or lack of them) about fading or off-smells. Through our own head-to-head pilot runs in compounding lines, results match field reports: this ester maintains performance where others give out partway through the product lifecycle.

    Improving Downstream Processing with Reliable Supply

    It’s easy to underestimate the knock-on effects of a consistent supply chain. When production batches meet specification after specification, downstream scheduling becomes easier, and emergency rush orders become rare. Hygiene and packaging matter: inert atmosphere systems reduce hydrolysis risk, preventing unwanted degradation before the customer receives the shipment.

    Direct feedback from our partners has brought home the value of dealing with a committed producer. Addressing requests for alternate drum sizes or flexible timing allows customers to minimize warehouse congestion and improve just-in-time manufacturing. When unusual weather or shipping issues strike, our in-house teams can intervene and adjust schedules quickly, rather than waiting for authorization from overseas offices. This direct link shortens the resolution path and keeps lines moving.

    Quality in Packaging and Transport

    Decades of real-world distribution experience taught us that overlooked details, like moisture ingress or packaging stress cracks, hurt everyone down the supply chain. Ethyl 4-Methoxybenzoate’s stability during shipping improves with vapor-proof liners, desiccants, and drums rated for temperature swings. Careful labeling, scheduled audits, and regular training for logistics staff minimize transit damage and mix-ups. Customers benefit from fast, issue-free receipt without extra sampling or costly re-testing.

    We follow international safety regulations and don’t cut corners—real compliance cuts both risk and cost, especially for customers shipping onward through multiple regulatory regimes. Experience in managing paperwork, inspection records, and emergency response information translates to fewer disruptions at ports and borders. This reduces secondary costs that rarely show up on a quote sheet but can make or break time-sensitive orders.

    Responding to Trends in End Markets

    Markets for Ethyl 4-Methoxybenzoate are not static. Demand grows from green chemistry and “clean label” personal care brands, many of whom want clear sourcing information, compliance with restricted substance lists, and assurance about unintended side product residues. We watch these trends because they affect process engineering as much as commercial planning. Removing certain solvents or optimizing for lower residuals requires investments in reactor design, more frequent analytical monitoring, and sometimes even re-training operators.

    As product stewardship expectations increase, we have shaped our process and documentation so that downstream audits run smoothly. Our team regularly fields requests for allergen statements, trace solvent data, or confirmation on animal-free sourcing. Years of working with proactive, informed buyers shapes how we manage our records and lets us provide answers with authority. The result is easier product launches for our customers and fewer obstacles to getting certified by third-party bodies.

    Meeting Customer-Specific Demands

    Not all batches or buyers need the same approach. Some customers request custom micronization or specific sieve ranges for faster dissolution in their equipment. Others need product that matches tight odor limits for high-end perfumes or food-grade intermediates. We handle these requests with practical changes on the production line—different filter media, alternate driers, or extra analytical verification before release.

    Inside the plant, we keep close records of each change, allowing repeatable results for customers scaling up or adjusting their own formulations. After years of these requests, our operators can spot trends, suggest improvements, and flag issues before they become a problem. In this way, our manufacturing process becomes more responsive over time, instead of sticking only to rigid, catalog-based standards.

    Technical Support and Collaboration

    Direct support from those who actually make the product—engineers and plant managers—changes the user experience. Many times, troubleshooting a blend, clarifying an analytical question, or reworking a batch comes down to a real phone call with someone who understands both the process and the market needs. Our staff don’t read from a script; they draw from years working on the actual line or in the onsite lab.

    Collaboration improves product quality and solves unique customer challenges. Whether it’s hitting a new purity target for an innovative medical application or finding a stability solution for a difficult transport route, these calls and visits lead to mutual learning and, sometimes, even new product variants. We treat these interactions as more than support tickets. They represent the core of our business—delivering not just a product, but direct expertise and partnership.

    Conclusion: The Value of Manufacturer Integrity

    Making Ethyl 4-Methoxybenzoate is about more than reaction vessels and quality control checklists. Success comes from learning every detail, correcting mistakes quickly, and always opting for transparency, even if it costs more in the short run. Those who use the product see the value in reliability—stable color, precise odor profile, or simply a shipment that delivers exactly as promised.

    By remaining true to these grounded principles and staying engaged with both the production line and end-user application, we keep improving not just the product, but the relationships behind every ton we manufacture. We welcome the questions, collaboration, and occasional challenge from customers, regulators, and partners—because this dialogue, and our willingness to keep learning, is the real competitive edge in specialty chemical production.