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HS Code |
767603 |
| Chemical Name | Ethyl 3-chlorobutanoate |
| Molecular Formula | C6H11ClO2 |
| Molecular Weight | 150.6 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 175-177°C |
| Melting Point | -49°C |
| Density | 1.084 g/cm3 |
| Refractive Index | 1.425-1.427 |
| Flash Point | 62°C |
| Solubility | Slightly soluble in water, soluble in organic solvents |
| Cas Number | 56544-22-2 |
| Purity | Typically >98% |
| Odor | Characteristic ester-like odor |
| Storage Conditions | Store in a cool, dry place, tightly closed |
| Synonyms | Ethyl 3-chlorobutyrate |
As an accredited Ethyl-3-Chloro-N-Butanoate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 100g bottle of Ethyl-3-Chloro-N-Butanoate comes in a sealed, amber glass container with a tamper-evident screw cap. |
| Shipping | **Shipping Description for Ethyl-3-Chloro-N-Butanoate:** Ship in tightly sealed containers under cool, dry conditions. Avoid exposure to heat, moisture, and direct sunlight. Handle with suitable protective equipment. Label as hazardous if applicable, and comply with relevant transport regulations (e.g., DOT, IATA, IMDG). Ensure proper documentation and secondary containment to prevent leaks or spills during transit. |
| Storage | Ethyl-3-Chloro-N-Butanoate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from heat, sparks, and sources of ignition. Protect from moisture and incompatible materials such as strong oxidizing agents. Store at room temperature and avoid prolonged exposure to direct sunlight. Use appropriate chemical storage cabinets for flammable or corrosive substances as advised. |
Applications of Ethyl-3-Chloro-N-Butanoate in Industrial ManufacturingAs an established manufacturer of Ethyl-3-Chloro-N-Butanoate, we serve a select group of industrial sectors that utilize this intermediate in complex synthesis routes. The following sections detail real downstream application scenarios, offering in-depth information about prevailing compliance requirements, precise formulation guidelines, process integration points, and tangible finished goods relevant to each field. 1. Agrochemical Intermediate SynthesisEthyl-3-Chloro-N-Butanoate acts as a key building block in the multi-step synthesis of selective herbicide and fungicide actives. Agrochemical formulators require consistent purity and controlled impurity profiles to support downstream alkylation and acylation processes. The substance enters the process during early-stage ester transformation steps, which influences critical molecular framework assembly. Formulators optimize dosing based on target crop, compound pathway, and regulatory residue limits. End products include field-ready technical-grade actives and various formulated crop protection agents. Industry compliance standards
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2. Pharmaceutical Intermediate ProductionAs a non-listed raw material, Ethyl-3-Chloro-N-Butanoate participates in key acylation and side-chain elongation steps for producing certain small-molecule pharmaceutical intermediates. These intermediates become building blocks for APIs such as anti-infective agents and CNS drugs. Handling demands precision to control residual solvent and analytical thresholds specified by global pharmacopeias. It enters formulations at the point where selective halogenation or ester exchange is required prior to condensation or cyclization, with the load ratio guided by route efficiency and GMP traceability requirements. Final product yields depend on stage-specific conversion rates. Industry compliance standards
Typical usage ratio
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3. Aroma Chemicals ManufacturingThis compound is used by specialty fragrance and aroma chemical producers as a masked acid precursor or as a reagent to introduce controlled chain branching. It takes part in targeted esterification and reduction steps, where its reactive profile allows fine-tuning of top-note and base-note properties for perfumery bases and flavor additives. Regulatory frameworks impose stringent thresholds regarding residual solvents and trace halide contaminants. Usage rates are determined based on batch size, desired note intensity, and downstream blending mechanics. Process engineers introduce it after core feedstock preparation, just before chain extension and aldehyde formation stages. Industry compliance standards
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4. Fine Chemical Custom SynthesisIn the fine chemicals sector, contract manufacturers utilize this chlorinated ester to provide custom intermediates for research, specialty polymer additives, and advanced materials. Chemists incorporate it at electrophilically activated stages to enable custom functionalization, impacting the molecular properties of surfactants, cross-linkers or modified resins. Industry standards require full batch traceability and validation per customer-provided protocols or globally recognized quality management standards. Addition rates and timings depend on mosaic synthesis design and purity specification demands, making accurate dosing pivotal throughout the multi-batch process. Industry compliance standards
Typical usage ratio
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Stepping inside our facility, the production floor hums with a blend of precision and reliability. Among the range of specialty chemicals we synthesize, Ethyl-3-Chloro-N-Butanoate holds a unique position due to its prominent use in pharmaceutical, agrochemical, and fine chemical manufacturing. Unlike commodity esters, this product demands both tight process controls and careful supply management. Over years of work, our team has fine-tuned the manufacturing steps, ensuring controlled chlorination, careful esterification, and detailed purification to hit consistently high-purity targets. Operators and engineers talk through their tooling, not in distant abstractions but grounded in the day-to-day mechanics of using stainless reactors, keeping water out of lines, and monitoring temperature swings that affect quality. Watching a batch run from start to finish, you see what separates this chemical from simpler esters and realize proper expertise benefits every downstream user.
Every time we check a drum or batch sample, Ethyl-3-Chloro-N-Butanoate brings its own set of cues. The liquid shows its distinct color and odor, a direct signal of purity. Too much discoloration signals off-spec starting material or missteps in the synthesis stage. That’s why we equip our QC lab with advanced chromatographic analysis, giving real-time insight into each lot. Our standard product usually measures up with a purity exceeding 99%, and water content kept below 0.1%. These numbers stem not from remote marketing language, but from regular, hands-on adjustment through feedback from our own instrumentation and customer audits.
The density and viscosity bear mentioning, too. At ambient temperature, Ethyl-3-Chloro-N-Butanoate offers manageable flow and low volatility, vital for both bulk storage and precise dosing in further reactions. Compared to similar esters, the presence of the chloro group gives it slightly higher reactivity, with effects easily tracked by anyone who has ever run an alkylation or condensation process involving this intermediate. Temperature management during storage, generally between 2-8 degrees Celsius, keeps degradation or side-reactions at bay, extending shelf life for both us and our customers.
Years of manufacturing reveal tradeoffs in every step. Feedstock selection matters most—there is no shortcut in sourcing pure raw chloroacetic acid and verified butanol, since even trace contamination from these shows up in the final product’s GC profile. Our reactors feature tight-sealing gaskets and reliable agitation; simple upgrades, such as more precise dosing pumps, have raised our quality and cut waste by measurable margins. Quality control goes beyond a quick certificate. Our operators track every parameter, from reaction time to pressure, benchmarking each batch against internal standards set years ago. Failures prompt real conversations among the team, detailed root cause analysis, and process tweaks. In the rare event a lot falls short, it gets separated, analyzed, and reworked if possible—or written off, so our clients only receive what meets contract specs.
We phase out obsolete processing steps when new regulatory requirements surface or analytical technology advances. The move from older batch processes to semi-continuous operations has trimmed solvent use and reaction by-products, reducing both environmental footprint and operating costs. On the ground, that has meant fewer reactors tied up, safer working conditions, and improved consistency in every shipment. Documents kept on hand aren’t license plate numbers and receipts, but lab notebooks and statistical process control logs—proving to ourselves, regulators, and customers that our operation measures up batch after batch.
We supply Ethyl-3-Chloro-N-Butanoate to some of the most demanding sectors. Pharmaceutical intermediates stand as one of the main application areas. Chemists rely on the chemical’s chloro group for nucleophilic substitution steps, where reactivity, purity, and trace metal levels make the difference between a successful scale-up and a failed run. Our experience working with these partners goes deeper than simple sales. When a customer faces stuck reactions or unexpected by-products, we often help pinpoint root causes, sometimes tied to subtle shifts in our own specs or even supply-chain disruptions in unrelated upstream materials.
Outside pharmaceuticals, pesticide synthesis forms another major outlet. Our technical support has guided formulation chemists through both pilot and commercial batch trials, showing which parameters affect end-product yield and stability. Many agrochemical firms point to our material’s low by-product profile as a reason to prefer it over generic imports. They skip time-consuming intermediate purification and get higher yields, which makes production planning more predictable and costs easier to control. From our conversations on the shop floor, such improvements matter more than ever—competition in crop protection keeps margins tight, and small differences in reacted product can trigger costly re-work or cause delays.
Flavors, fragrances, and other custom organic synthesis fields also put this chemical to work. Our R&D chemists and technicians regularly discuss reaction planning with customers. In most cases, feedback has centered on how careful storage, handling, and batch documentation helps speed their own process validation and eliminate surprises. Some companies have advanced needs, requesting custom packaging or special impurity profiles, which we can accommodate through simple plant modifications or extra QC. Our lab and production teams meet every month, checking for patterns in complaints, test data, and customer requirements to keep best practices up-to-date. The direct line between our manufacturing floor and customers’ benches means better communication and faster issue resolution.
In our line of work, we often weigh Ethyl-3-Chloro-N-Butanoate against structurally similar esters and halogenated compounds. For starters, methyl chloro butanoate and other homologs see use in some of the same fields. But years of feedback and in-house testing show our Ethyl-3-Chloro-N-Butanoate delivers higher performance in alkylation steps, thanks in part to the ethyl moiety’s impact on solubility and downstream reactivity. Chemists using methyl-based analogs sometimes run into lower product yields or face process bottlenecks because of solubility mismatches, while our product streamlines their workflow.
Other chloroesters may look similar on paper, but subtle distinctions—boiling point, hydrolytic stability, and even aroma—show up in repeated application testing. We’ve carried out head-to-head lab trials in our own facility, running parallel reactions with several common competitors. In nearly every case, customers who switch to our grade notice easier downstream purification and fewer losses, supported by their own yield data and our long-term supply records. Documentation comes from internal logs rather than theoretical projections. The chemical’s lower tendency toward side reactions means manufacturers can use less excess reagent or reprocess fewer failed batches.
Handling and storage shape some of the biggest day-to-day differences. Our Ethyl-3-Chloro-N-Butanoate ships in high-integrity drums or IBCs, with tamper-proof seals and nitrogen blankets to reduce moisture intrusion. Aging studies, drawn from accelerated storage and real-time shelf life monitoring, reveal far less degradation compared to lower-purity alternatives. This cuts down on maintenance, cleaning, and wasted raw material after products arrive at customer sites. After decades at the manufacturing level, the consensus from both production side and users shows that these subtle differences protect both cost margins and end-product consistency, especially in tough regulatory climates.
Logistical challenges never go away. Packaging for Ethyl-3-Chloro-N-Butanoate demands careful attention—its chemical nature calls for materials with proven chemical resistance, such as HDPE or coated steel. We deal with regulatory requirements for dangerous goods shipping, and invest in on-site training to ensure every drum and IBC leaves in full compliance. The team routinely coordinates with certified carriers who know how to manage risk and prevent incidents. We log signatures, check seals, and trace each shipment to its destination, catching issues before they turn into emergency calls.
On top of that, regulatory documentation plays a large role. We keep extensive records on hazard classification, REACH registration, and local permits. Inspection and audit teams sometimes visit, and we walk them through each step, showing certificates, change logs, and historical data. If a rule changes in the local or international codebook, we review process maps and retrain staff without delay. Customers know they can request SDS, methods of analysis, and impurity profiles updated to the latest standard and get specifics pulled from the actual manufacturing campaign. This transparency builds lasting trust, and allows users to anticipate issues down the line—such as changing labeling laws for exported materials.
Every batch, every shipment carries an environmental impact. Our plant engineers have worked to close material loops, limit solvent use, and improve energy efficiency during synthesis. We operate water treatment units designed for organic halide removal, and recycle as much process water as possible. Emissions capture and filtration systems route residues for safe destruction or recycling, rather than open discharge. Not every project gets press coverage, but incremental changes stacked up year after year—switching to reusable package media or upgrading to mild temperature processes—have brought meaningful reductions in waste and utilities.
Partnerships with local environmental agencies add another level of accountability. Our data on air quality, water discharge, and waste output go beyond minimum regulatory levels; independent auditors review our logs, validate our systems, and offer suggestions for improvement. Production teams use this feedback not only to assure continued operation, but also to test new ideas, like closed-loop chilling and lower-impact catalysts. Downstream, this translates to cleaner products arriving at our customers’ sites, making their own environmental reporting and risk management easier.
Consumer and public expectations around chemical manufacturing keep rising. Rather than resist, we see regulatory and societal pressure as a push toward efficiency and innovation. From the shop floor, workers recognize that safe processes benefit themselves as much as the planet, and training on spills, emergency management, and ventilation become integral to each job description. These hands-on policies foster real engagement, lower turnover, and, ultimately, support our standing as a responsible supplier—not in theory, but by daily practice.
Raw material disruptions, extreme weather, and global trade fluctuations all pose risks in chemical supply. During past raw material shortages, our operations team quickly secured alternative sources, ran pilot studies to confirm suitability, and communicated openly with our partners. Some clients run just-in-time production lines. Knowing which lots come from which source, and tracing performance back to the earliest batch, keeps surprises out of the production schedule. This attention to the details shows up in repeat surveys, where users point to shipment punctuality and absence of “surprise” defects as reasons for their loyalty.
Relationships with buyers and technical teams go beyond volume and pricing. We run collaborative troubleshooting, root-cause analysis, and even joint pilot plant campaigns. Knowledge from our own manufacturing serves as a practical reference during these sessions. One example: a European pharmaceutical customer faced unexpected color changes during a synthesis; by consulting our long-run QC data and test results, both parties tracked the problem not to our product, but to a subtle flaw in a shared upstream solvent. These cases highlight real industry needs—the ability and willingness to dig deep saves everyone time, money, and headaches.
Our own best practices for risk reduction stem from lessons learned: carry some stock, keep strategic raw inventory, maintain a network of logistics providers. Rather than add multiple warehouses, our answer has often been to strengthen ties with dependable carriers and trusted input suppliers who share our standards.
Developing or troubleshooting processes with Ethyl-3-Chloro-N-Butanoate seldom means following a formula. We offer direct technical consultation, combining the know-how of production and R&D specialists. For customers scaling up a new synthesis, we share first-hand data, run small lab validations, or suggest adjustments in reaction conditions based on our manufacturing history. The benefit to our partners is immediate—they move from concept to commercialization faster, backed by both performance data and incident reports from real-world manufacturing.
Joint projects over the last decade demonstrate the power of collaboration. Pharmaceutical developers often request help on impurity profiling, crystallization methods, or solvent compatibilities. Our plant and lab teams generate batch samples, test shelf-life under simulated shipment, and assess reactivity in parallel with the client. Adjustments made at the manufacturing stage—down to heating/cooling curves and anti-oxidant additives—produce measurable gains in reaction yield and clarity for end users. We treat every request as a specific project, and see firsthand how flexibility in production improves customer success rates.
Innovation also thrives in-house. Our research engineers regularly evaluate catalytic efficiencies, reactor design changes, and greener synthetic routes. Collaboration with academic groups brings fresh technique into the factory; improvements get piloted, validated, and then scaled-up. This genuine feedback loop means the product evolves over time, integrating the latest science, practical demands, and real-world testing.
Manufacturing Ethyl-3-Chloro-N-Butanoate never sticks to autopilot. Process bottlenecks, quality drift, and shifting compliance demands keep us vigilant. Batch variability arises from subtle things—a temperature control spike, a supplier’s storage mix-up, or an operator calibration error. Practical fixes come out of strong plant culture and continual process audits. We trace every batch, retrain on error, and swap out equipment as necessary.
Waste minimization remains one of our biggest operational focuses. Solvent recovery, closed-loop process water reuse, and heat integration systems all reduce both cost and environmental load. Recent investments in predictive analytics allow real-time monitoring and early warning if a process slips out of specification. Every year, operating teams review both internal logs and customer feedback for improvement targets, streamlining the process so quality matches or exceeds the specifications expected by users in key markets.
Facing material and energy price fluctuations, the team employs multi-layer supply arrangements and investigates alternative raw sources. That resiliency doesn’t eliminate risk but keeps our lines running and our contracts fulfilled even in unpredictable markets. Operators, shift leaders, and technologists stay involved through regular feedback sessions, pointing out where small changes have delivered outsized results.
Manufacturing this key intermediate involves continuous adjustment and learning. Quality assurance stems from hands-on process insight, years of teamwork, and ongoing investment in better methods and responsible stewardship. Through each run, we draw on measurable results, close customer interaction, and a willingness to adapt. Such focus makes Ethyl-3-Chloro-N-Butanoate more than just another chemical name on a product list. Customer outcomes, plant safety, and a reduced environmental footprint—each reflect the real-world impact of our work from synthesis to shipment.