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Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate

    • Product Name Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate
    • Alias ethyl 4-tert-butylbenzoylacetate
    • Einecs 416-110-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    549025

    Chemical Name Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate
    Molecular Formula C15H20O3
    Molecular Weight 248.32 g/mol
    Cas Number 137293-43-1
    Appearance White to off-white solid
    Solubility Soluble in organic solvents such as ethanol, methanol, and DMSO
    Purity Typically ≥98%
    Iupac Name Ethyl 3-(4-tert-butylphenyl)-3-oxopropanoate
    Smiles CCOC(=O)CC(=O)C1=CC=C(C=C1)C(C)(C)C
    Storage Temperature Store at 2-8°C
    Synonyms Ethyl 4-(tert-butyl)benzoylacetate
    Use Intermediate in organic synthesis

    As an accredited Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The chemical is supplied in a 25g amber glass bottle, clearly labeled with product name, structure, CAS number, and safety information.
    Shipping Ethyl 3-(4-Tert-Butylphenyl)-3-oxopropanoate is typically shipped in chemical-resistant containers, securely sealed to prevent leakage. It is transported at ambient temperature, complying with local and international regulations. Packaging includes clear labeling for contents and hazard information, ensuring safe handling during transit. All shipments adhere to standard chemical safety protocols.
    Storage Ethyl 3-(4-Tert-Butylphenyl)-3-oxopropanoate should be stored in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong oxidizers. Keep the container tightly closed and protect from direct sunlight. Store at room temperature and avoid excessive heat or moisture to ensure chemical stability and longevity. Use appropriate chemical storage cabinets if available.
    Application of Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate

    Applications of Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate in Industrial Manufacturing

    Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate serves as a specialty intermediate in several advanced chemical sectors, contributing unique structural features and reactivity to downstream product formulations. Our manufacturing capabilities support industries that require high purity, strict consistency, and established compliance for effective integration into diverse production processes. The following sections detail key application scenarios, differentiation in industry use, and technical integration points for active B2B customers.

    1. Synthesis of UV Absorbers for Polymer Additives

    Formulators select this raw material as a building block in the synthesis of benzophenone and benzotriazole-based UV absorbers, targeting enhanced photo-stability for engineering plastics and automotive coatings. Its molecular configuration enables efficient downstream conversion to chromophores that protect polymers against light-induced degradation during service life, especially in high-value outdoor and automotive components.

    Industry compliance standards

    • REACH (EC No 1907/2006) – European Union
    • Automotive OEM Specification GMW15581 (General Motors) for UV stabilizers
    • ISO 9001:2015 Quality Management Systems for supply chain traceability
    • UL 94 HB/5VB (Flammability standards include chemical additive compliance)

    Typical usage ratio

    • 0.2–1.0% (w/w) in UV absorber intermediates synthesis; final formulation adjusted based on required light fastness level and polymer matrix compatibility

    Downstream process integration

    • Introduced at the ketone condensation step when manufacturing intermediates, then condensed with amines or hydrazines
    • Integration into melt compounding or masterbatch production for direct addition to plastics

    Final product types

    • UV-stabilized polypropylene, ABS, and polycarbonate automotive plastics
    • Outdoor architectural coatings
    • Transparent food packaging films
    • Masterbatch concentrates for extrusion and injection molding

    2. Fragrance Intermediate for Fine Chemicals

    Perfumery and aroma chemical manufacturers use this ester as an intermediate in multi-step syntheses for specialty aromatic compounds. Its tert-butyl substituted phenyl ring offers steric protection in Friedel–Crafts and acylation transformations, yielding stable intermediates which are subsequently functionalized in high-stability fragrance ingredients demanded in luxury personal care formulations.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association)
    • ISO 9235:2013 (Aromatic raw materials for perfumery)
    • Good Manufacturing Practice for Cosmetics (ISO 22716)
    • European Regulation (EC) No 1223/2009 on cosmetic products

    Typical usage ratio

    • Batch-level: 0.5–2% for key intermediate preparation, scaled according to the desired volume of downstream fragrance molecules

    Downstream process integration

    • Used in acylation or alkylation reactions in batch reactors under controlled temperature/pH
    • Integrated with aldehyde or alcohol functionalities for subsequent esterification or cyclization

    Final product types

    • High-purity fragrance bases for fine perfumes
    • Stabilized aroma chemicals for soaps and detergents
    • Aromatic intermediates for flavor compositions
    • Cosmetic actives for leave-on and rinse-off products

    3. Active Intermediate in Agrochemical Ingredient Synthesis

    Chemical crop protection and plant growth regulator manufacturers employ this ester as a masked enone in crafting advanced agrochemical molecules. Its reactivity supports site-selective functionalization, critical in producing bioactive compounds with optimized environmental safety profiles and extended field performance for regulated agrochemical markets.

    Industry compliance standards

    • FAO/WHO Food and Agriculture Organization Technical Guidelines
    • Regulation (EC) No 1107/2009 for Plant Protection Products—European Union
    • US EPA 40 CFR Part 158 (Data requirements for pesticides including intermediates)
    • ISO 17025:2017 Laboratory Accreditation for QC of active ingredients

    Typical usage ratio

    • 0.1–0.6 molar equivalents in active ingredient synthesis routes, based on crop specificity and regulatory residue limits

    Downstream process integration

    • Charged at the Michael addition or Claisen condensation steps in the synthesis of target pesticide skeletons
    • Purified after conversion using phase separation or crystallization before formulation

    Final product types

    • Selective herbicide active substances
    • Systemic fungicide molecules
    • Plant growth regulator intermediate blocks
    • Inert component integration in controlled-release pesticide formulations

    4. Pharmaceutical Intermediate in Custom Synthesis

    CDMOs and API manufacturers employ this compound as a protected β-ketoester in the custom synthesis of pharmaceutical intermediates, supporting chiral building block preparation and scaffold construction for lead drug candidates. Its sterically hindered aromatic group assists in achieving regioselectivity and stability in multi-step pharmaceutical syntheses subject to regulatory documentation and purity demands.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 – US FDA cGMP for Finished Pharmaceuticals
    • EU GMP Part II for excipient and API intermediates
    • Ph. Eur. and USP Monograph guidelines for related substances

    Typical usage ratio

    • 0.3–1.1 molar equivalents per synthetic step, adjusted to accommodate downstream purification yield and process scale

    Downstream process integration

    • Introduced as a protected intermediate in alkylation, cyclization, or asymmetric reduction reactions
    • Deprotected in late-stage synthesis prior to final active ingredient crystallization

    Final product types

    • Precursor fragments for antineoplastic and anti-inflammatory APIs
    • Chiral scaffolds for CNS-active drugs
    • Building blocks for custom library synthesis in early-phase discovery
    • Regulatory-grade intermediates for New Drug Application (NDA) dossiers
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    Certification & Compliance
    More Introduction

    Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate: Our Thoughts from the Factory Floor

    Every Batch Begins with Consistency

    Years in this industry teach you that subtle details in chemical structure bring sharp changes in performance. Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate stands out in many production cycles inside our facility. The moment this compound flows from our reactors, its faintly sweet aroma hints at the effort behind its creation. Our model for this product, manufactured in our facility for years, shows a crystalline purity that holds up whether you're working with pharmaceuticals or specialty materials. We test each lot right after synthesis and before packaging, catching any deviations. Lab staff tell us the molecule’s stability beats out similar aryl-oxopropanoate esters, with resistance to thermal and oxidative stress setting it apart.

    Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate includes an aromatic backbone that soaks up energy and allows downstream modifications. In our production pipeline, this keeps intermediates from breaking down when other esters might start to fail. This kind of reliability forms the core of why formulators and process engineers trust this chemical. Peering through our spectrometers, signals always match up batch to batch—we learned over time that minor contaminants disrupt reactions down the road, so we clean up every bit before any drums or drums get filled.

    The Specs That Matter Most

    Specs on paper look simple: a high assay percentage, low moisture, minimal impurities, some standard color limits. Experienced hands in the lab understand every downstream application reacts differently to borderline material. We use direct feedback from our customers’ workbenches—an active pharma process or a specialty coating run—to tweak crystallization and drying settings. We hear about failed lots from other suppliers and how minor traces of tert-butyl crosstalk or trace ketone byproducts throw off their yields. There, the difference is technical, but it shows up as hard costs for everyone involved. After multiple process refinements, our typical batches run with purity above 99 percent by HPLC, so users skip repeated recrystallization steps. Water content sits below 0.2 percent, with residual solvents tightly controlled by our recovery process. These specs don’t come from a checklist—they save time during pilot runs, cut down on lumpy material, and reduce downstream surprises.

    Delivering Reproducible Results

    Synthetic chemistry doesn’t forgive slack. Batch-to-batch differences, undetected by cursory checks, derail process scale-ups. In our plant, production logs for Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate reach back over a decade. Data from thousands of liters refined the current process. Our heat-transfer steps start with straightforward kettle reactors, then move into large-scale filtration and drying. Operators monitor inline UV readings, gas chromatography results, and manual refractive checks. Every deviation triggers an immediate root cause hunt. Over the years, staff shared dozens of tales where poorly controlled distillation led to ghost peaks on a QC chromatogram—sometimes imperceptible shifts in pressure or an ill-timed solvent flush sneak minor impurities into what looks like finished product. We step in after each failure, tune the process, tighten up tank cleaning, or swap out old filter media. The consistency isn’t marketing copy—it’s a lived process, one people in production and quality insurance argue about daily so the supply matches the written specs.

    Downstream Impact in Every Kilogram

    Talking to polymer chemists, we learn that reactivity and side-product profiles dictate each result. With Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate, the tert-butyl group on the aryl ring gives steric hindrance that resists overreaction in certain condensation or alkylation routes. Medicinal teams in our network need this for selectivity, keeping byproduct pathways to a minimum. We tested side-by-side with similar ethyl oxopropanoate esters missing the tert-butyl feature: yields in follow-up reactions drop or throw off unwanted folie byproducts. Continuous feedback lets us fine-tune, whether that means lengthening a crystallization hold to catch faint yellow tints or boosting vacuum on final drying stages before packing. In the end, users notice yield bumps, consistent impurity profiles, and fewer troubleshooting headaches.

    Why We Stand by Our Grade

    Every few months, our staff field requests for custom lots—from customized particle sizes to DRY-packs for sensitive runs. We’ve learned from failed experiments that not all modifications work, but tight communication with those on the bench guides our adjustments. Some projects requiring extremely low water or narrow particle ranges often bring challenges: at times, we see slight loss of flowability or caking if the drying pushes too far. Our technicians balance these physical properties against final analytical numbers, knowing that the “grade” label means little if users still need to work up material before the actual synthesis.

    Other suppliers market close analogs with higher levels of unknown side products, or inconsistent color and odor markers. Customers ran into setbacks in critical processes such as Friedel-Crafts acylations or targeted arylations where wrong impurities halt the whole sequence. Our own plant trials proved how even small tweaks in the process—dropping distillation pressure by 0.05 bar, or switching out a carrier gas in the last filtration phase—show up in HPLC peaks, with telltale impacts on end-use performance. Our daily production notes offer reminders: there are no shortcuts to purity, only relentless process discipline.

    The Subtle Advantages of Our Route

    We chose our current synthetic route to cut down environmental risk, odor, and batch variability. For this product, direct alkylation of a para-tert-butylphenyl intermediate with a safe esterifying agent avoids hazardous chlorinated solvents and noxious gases that others sometimes use. This change keeps line workers safer and slashes effluent loads at the treatment plant. With energy recovery steps, we lower steam consumption, and with solvent recycle protocols, we minimize waste. Years of optimization mean that even as orders grew, our scale-up runs didn’t suffer the productivity losses that past product lines saw.

    We skip stabilizers and coloring agents—every bit of the ethyl ester is made as cleanly as the base chemistry allows. Bulk purchasers told us that warehouse stability beats competitors’, even across seasonal temperature swings. Technicians in downstream coating plants saw this: drums cracked open after six months passed quality screens, without sticky hands or yellowing—something less-refined batches just can’t promise.

    How This Product Powers Forward Materials

    Chemists in new material development need starting blocks that won’t decompose before the next step. The oxopropanoate group offers reactivity targeted by those needing clean ring-forming, Knoevenagel condensations, or Michael reactions. A strong tert-butyl group guards against unwanted para reactivity, ensuring that core transformation happens where intended. In our own pilot plant, we’ve run hundreds of side-by-side reactions with and without the tert-butyl group—results speak for themselves: the presence ensures less overreaction and a narrower range of end products.

    Other applications demand attributes such as odor neutrality, low residue, and fast solubility in select organic phases. This ethyl ester melts quickly, dissolves in standard carriers, and shows a mild, characteristically sweet scent, without the harsh acetic vapors of similar molecules. Synthesis teams avoid blocked tubing and gum formation in batch reactors, cutting routine maintenance cycles. These aren’t on a spec sheet—they’re lived wins from years in full-scale production, and they mean smoother operations for our partners.

    Lessons from Quality Failures

    Mistakes educate far better than successful batches. Early in the product’s life, our internal batches sometimes failed color specs due to trace iron pickup in legacy reactor tankage. Color drifted into straw yellow; customer complaints followed. Engineers worked through the system, tracked sources down to gasket degradation, and switched over fittings plant-wide. These small changes—which rarely show up on a product page—made a lasting difference in both appearance and the downstream impurity load. A deep color or faint haze nearly always signals more than an aesthetic issue; functional properties and reaction trouble soon follow.

    Solvent carryover once emerged as another learning moment. Even sub-percent traces hid in a poorly timed fraction cut. Analytical teams flagged this; scaling up solvent recovery and retooling vacuum controls fixed the process. Regular meetings between process groups and analytical chemists became routine, anticipating problems long before finished drums leave the plant. Now, each batch passes a full battery of solvent residue, iron, and heavy metal checks—direct results of years refining our process.

    Supporting Flexible Research and Production

    The world’s demand for new functional materials keeps evolving, and so do project needs. Some research groups want multi-kilo lots for screening, others scale up to drum quantities. We package material from ten grams up to hundreds of kilos, with custom inert-gas padded drums for ultra-sensitive projects. Flexibility only works if the material meets purity and consistency standards every time.

    Our pilots revealed that subtle shifts—longer storage, transfer line carryover, or reshuffling of scheduled runs—affect final outcomes. Operations teams schedule line cleaning and batch sequencing to head off accidental cross-contamination. Every kilogram shipped, whether small bottles for lab use or containers for plant calls, carries the same promise. The experience on the floor matches what end-users see during synthesis: you get the same outcome every time.

    Differentiation with a Purpose

    On the raw numbers, some competitors offer a similar chemical under different trade names, each making claims of purity and performance. Years on the production side—watching drum after drum filled, analyzing each batch in-house—demonstrate that it’s not marketing flare but cumulative knowhow that separates one supplier from another. For Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate, the strength lies in the unbroken supply of high-purity lots, stout enough to handle scale-ups and downstream derivatizations without issues sprouting up. We never blend off-grade material to “meet” a number; each lot gets tracked, and if it misses, it never ships.

    Some users switch to us after multiple failed runs elsewhere: clogged lines, unexpected color changes, ghost peaks in GC traces, “burnt” reaction odors, or outright lost process time. Our input from the factory floor to the R&D bench enables process feedback loops, constantly shrinking the gap between theory and reliable plant output. Direct conversations with chemists and plant managers clarify what needs to change. Our job continues until their results match what we see in-house.

    Solutions Rooted in Experience

    Every answered request—from rush orders during supply chain crunches to tailored packaging for long-haul shipments—builds trust and toughness into our process. The struggles supply chains faced during global disruptions pushed us to strengthen raw material sourcing, run risk audits, and double-up on QA verification. Even with global shifts, our plant kept material flowing, learning new ways to buffer inventory and secure shipping. This means users looking for Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate for the next big synthesis or specialty production find their work uninterrupted.

    Technological upgrades, like inline HPLC and gas sensors, empowered operators to intervene before small signals grew into bigger losses. Instead of relying on spot checks, staff now see every data trend in real time, with the experience and freedom to halt a batch before finished goods get compromised. The pride in clean, front-line problem solving beats top-down management any day—our teams own the results, and that shows in the material quality.

    The Future We’re Building into Each Batch

    With demand surging for more complex chemicals, we invest in flexible production suites and greener, lower-impact synthesis. Shifts to solvent-less or reduced-waste processes cut our footprint and create a safer workplace for every person involved. For customers, it’s more than a spec result—it’s the promise that each new kilo of Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate comes from a plant determined to stay two steps ahead of the risks that plagued old-school chemical manufacturing.

    Our teams continuously learn from suppliers upstream and customers downstream, channeling that collective effort back into refined batches. Each step, from raw material booking to packaged drum, tells a story of trial, error, and hard-won lessons. Ethyl 3-(4-Tert-Butylphenyl)-3-Oxopropanoate reflects decades of effort, constant improvement, and a drive to give researchers and producers what they need without the setbacks that less-diligent manufacturing can cause.

    No flash, no shortcuts—just seasoned hands, technical grit, and a track record of adapting so others don’t have to worry about what’s inside the drum.