Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)Propionate

    • Product Name Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)Propionate
    • Alias Ethyl Ferulate
    • Einecs 237-770-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    947403

    Cas Number 5366-79-0
    Molecular Formula C12H16O4
    Molecular Weight 224.25 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 61-64°C
    Solubility Soluble in organic solvents like ethanol and methanol
    Purity Typically ≥98%
    Storage Conditions Store in a cool, dry place with tightly closed container
    Iupac Name Ethyl 3-(4-hydroxy-3-methoxyphenyl)propanoate
    Synonyms Ethyl ferulate
    Smiles CCOC(=O)CCC1=CC(=C(C=C1)O)OC

    As an accredited Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)Propionate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)Propionate, 25g: Supplied in a sealed amber glass bottle with tamper-evident cap, labeled with CAS and safety details.
    Shipping Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)propionate is typically shipped in sealed, airtight containers to prevent moisture and contamination. The chemical should be kept in a cool, dry place and handled with care. All packaging must comply with local regulations and include appropriate hazard labeling and documentation for safe transport.
    Storage Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)propionate should be stored in a tightly sealed container, protected from light and moisture. Keep it at room temperature (15–25°C), away from heat sources and incompatible substances such as strong oxidizers. Ensure storage in a well-ventilated, dry place, and label containers clearly. Avoid excessive humidity and direct sunlight to maintain chemical stability and purity.
    Application of Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)Propionate

    Applications of Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)Propionate in Industrial Manufacturing

    Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)propionate, as produced by us at industrial scale, serves specific downstream industries due to its unique aromatic properties and functional compatibility in synthesis-driven sectors. The following structured scenarios detail its established B2B industrial applications, outlining industry compliance, formulation usage, process stage, and typical final products for each downstream application.

    1. Flavors and Fragrance Compounding for Fine Fragrance Bases

    This compound enters high-end fragrance base manufacturing as a specialty aromatic intermediate, prized for its subtle floral and lightly spicy tonalities with enhanced fixative performance. Primary users are flavor and fragrance houses producing compounded bases that require regulatory-compliant aromatic building blocks, where compositional transparency and odor persistence matter. Our ingredient integrates during the aromatic blending phase, supporting creative perfumery solutions subjected to strict global quality audit systems, and aligns with widely used industrial perfumery guidelines.

    Industry compliance standards

    • International Fragrance Association (IFRA) Code of Practice
    • EU Cosmetics Regulation (EC) No 1223/2009 for fragrance ingredients
    • IFRA/IOFI Labelling Manual, safety certification for aromatic raw materials
    • REACH Registration for aromatic compounds

    Typical usage ratio

    • 0.1–2% of total perfume concentrate by mass, adjusted according to base profile and IFRA-restricted maximum levels

    Downstream process integration

    • Direct addition into fragrance concentrate tanks following pre-dilution in carrier solvents, incorporated during the concentrate blending step prior to compounding with solvents and fixatives

    Final product types

    • Fine fragrance concentrates supplied to branded perfumeries
    • Premium eau de toilette and eau de parfum formulations
    • High-end personal care scent accords
    • Fragranced cosmetic body sprays

    2. Pharmaceutical Intermediate for Anti-Inflammatory and Analgesic APIs

    Our product functions as a synthetic precursor and side-chain building block in the assembly of active pharmaceutical ingredients (APIs) that leverage its phenolic and ester groups for targeted pharmacological profiles. Pharmaceutical manufacturers require traceability and batch-level reproducibility, using this compound in small-molecule drug synthesis directed toward anti-inflammatory and mild analgesic actives. Integration occurs mid-synthesis in esterification and hydrolysis reaction stages, with finished products destined for regulated end-markets under strict pharmacopeial norms.

    Industry compliance standards

    • Good Manufacturing Practice (GMP) for pharmaceuticals (ICH Q7, US 21 CFR Part 210/211)
    • European Pharmacopoeia (Ph. Eur.), United States Pharmacopeia (USP)
    • ICH Q3A/B Guidelines for impurities and residual solvents
    • Drug Master File (DMF) and Certificate of Suitability (CEP) systems

    Typical usage ratio

    • 0.5–8% relative to total batch mass in the intermediate reaction step, varying with target API structure and yield optimization during route scouting

    Downstream process integration

    • Reactive incorporation during side-chain elongation or as phenolic esterification precursor, followed by hydrolysis or coupling with core drug moieties in multi-step organic synthesis reactors

    Final product types

    • Bulk active pharmaceutical ingredients for NSAIDs (non-steroidal anti-inflammatory drugs)
    • Analgesic intermediates in solid oral dosage form development
    • Small-molecule pain relief actives in generic formulations
    • API intermediate cargos for international formulation plants

    3. Functional Ingredient in Natural Food Flavors (EU and US Markets)

    We supply this compound to food additive processors specializing in natural vanilla-type flavors, where it reproduces subtle vanillin-adjacent sensory notes for premium confectionery fillings and bakery applications. Food ingredients integrators require verified purity and conformance with international food additive frameworks, and typically blend the material during natural flavor compounding and heat processing steps. All food-grade batches comply with stringent trace allergen and contaminant monitoring protocols for sensitive end-user safety.

    Industry compliance standards

    • FDA 21 CFR 172 Food Additives Permitted for Direct Addition to Food
    • European Food Safety Authority (EFSA) Flavouring Group Evaluation
    • FSSC 22000 Food Safety Certification
    • ISO 22000 Food Safety Management system

    Typical usage ratio

    • 0.05–0.3% by total mass of finished flavoring blend, according to flavor strength required and sensory panel adjustment

    Downstream process integration

    • Mixed into concentrated flavor bases during the heated blending or emulsification step before dilution into carrier matrices or spray-drying for powdered flavors

    Final product types

    • Liquid vanilla-type flavors used in ice cream and chocolate production
    • Powdered bakery flavorings for biscuits and cakes
    • Ready-to-use syrup flavor concentrates for desserts
    • Industrial confectionery filling flavor bases

    4. Fine Chemicals Intermediate for Specialty Ester Synthesis

    This material serves as a substrate or building block in the production of functionalized esters, widely used by specialty chemical companies targeting high-performance resin, plasticizer, or modifier markets. Manufacturing requires accurate molar control in batch and continuous process lines, and integrates the compound as a core reactant during transesterification or condensation routes. Compliance focuses on chemical quality management and environmental control relevant to worker safety and emission limits in chemical plants.

    Industry compliance standards

    • ISO 9001 Quality Management Systems for chemical production
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals)
    • GHS (Globally Harmonized System of Classification and Labelling of Chemicals)
    • Local Chemical Environmental, Health, and Safety (EHS) regulations (e.g., US EPA, EU CLP)

    Typical usage ratio

    • 1–10% by weight of total reactant mass, optimized by target ester specification and process conversion rates

    Downstream process integration

    • Charged directly to reaction vessels for transesterification with selected alcohols or acids, used either as a limiting or excess reagent depending on desired end-group functionality

    Final product types

    • High-performance polymer modifiers
    • Resin intermediates for technical coatings
    • Industrial plasticizers and functionalized esters
    • Specialty surface treatment agents

    5. Cosmetic Raw Material for Skin Conditioning and Sensory Agents

    In advanced cosmetic formulations, this ingredient is incorporated by personal care manufacturers developing conditioning actives and sensory agents for skin-contact products. It is valued for imparting emollient-like feel and controlled aromatic nuance in formulations that undergo extensive regulatory safety review. Quality and traceability are maintained to support claims of non-sensitizing performance and ingredient purity, especially for use in regulated skin-contact applications and finished products distributed internationally.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009
    • US FDA Cosmetics Quality Guidelines
    • Cosmetic Ingredient Review (CIR) Expert Panel Safety Assessments
    • ISO 22716:2007 Cosmetics GMP

    Typical usage ratio

    • 0.1–0.5% w/w of the finished formulation, with adjustment based on panel testing for skin tolerance and sensory performance

    Downstream process integration

    • Introduced during the emulsion blending or aromatic phase addition, typically in the oil or actives pre-mix, before homogenization and packaging

    Final product types

    • Premium skin conditioning lotions
    • Cosmetic creams with natural aroma claims
    • Formulated body oils and emulsions
    • Scented facial serums
    Free Quote

    Competitive Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)Propionate prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)Propionate: A Manufacturer’s Perspective

    Introducing the Compound

    Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)propionate has carved out a dependable spot in our everyday operations. The industry recognizes this compound, sometimes called Ethyl Ferulate, for its stable molecular structure and versatility. Over years in chemical synthesis, we’ve watched needs change, questions evolve, and expectations rise. Our approach stays close to what matters—clear, consistent quality, real-world application support, and full process understanding. We want customers to see the difference that comes from working with a facility where every batch receives hands-on attention and methodical refinement.

    Model and Specifications: Practical Experience Matters

    Production starts from raw feedstocks rigorously sourced for composition and traceability. The chemical formula, C12H16O4, guides process variables during esterification and purification. Each stage brings a checkpoint. Finishing means final GC spectrum review with special focus on purity—aiming for levels above 99%, bench-tested against published spectra. We monitor moisture and trace solvents to keep below 0.2%. Color can reveal oxidation or thermal history; we correct deviations by adjusting environmental control and filtration cycles, never taking shortcuts. These details grow from the feedback cycle—years of hearing about lab upsets, scale-up headaches, and the real difference that reliable batches make.

    Customers often push for clarity about specification differences. In side-by-side trials, we’ve confirmed minimal odor and a distinctly clean crystalline appearance, which end users note as crucial for their downstream processes. Bulk density parameters, particle size, and flow behavior all reflect the consistent operating conditions inside our plant, not just broad guarantees. By the time you hold a sample, it represents at least a dozen separate quality checks, each linked back to a run log and technician. Our labeling includes this audit trail, not because anyone asked, but because it lowers the risk of downstream problems.

    Role and Usage in Industry

    We see Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)propionate making a difference in multiple fields, especially where stability and selectivity matter. In fragrance and personal care, its moderate molecular weight and subtle aromatic backbone lend complex notes—customers value predictability of odor, and we fine-tune drying and handling to avoid cross-contamination. Analogues with close structures often come with background off-odors, or lose desired properties under heat or light. We trace each deviation to process details, not luck.

    In pharmaceutical synthesis, the phenolic and ester groups open many options for further modification. Reliable reagents save time later at the stepwise transformation stage, especially with chiral or regioselective processes. We’ve had process engineers come to us with steep demands: higher reaction yields, less waste, fewer clean-up steps. Listening to these frustrations helps us tune filtration, solvent purge, and storage standards at the source—gains that show up in purity over multiple shipments.

    Some labs care about trace metal content because even blunt levels of contamination disrupt sensitive catalysts. Others flag crystallinity since amorphous inclusions throw off dosing. Our lean structure means we adapt to requests for custom particle cutting, or more sensitive screening for minute metal residues. None of these changes come from a manual alone—they stem from requests fielded by operators with years growing their skills at the bench and line.

    Distinct advantages from the Manufacturer’s View

    Many times, clients ask about the gaps between this compound and alternatives like methyl ferulate or simple phenolic ethyl esters. We spend time walking through the differences that show up in use. For instance, methyl analogues evaporate faster and break down under acidic processing, so the ethyl variation runs cooler and steadier inside storage tanks. Our colleagues in the flavor industry have flagged shelf-life as a problem when a rushed fermentation or careless drying produces unstable isomers. One result: we log storage temperature rigorously and seal product lots with nitrogen to keep phenolic integrity, arriving fresher at users’ plants than generic imports.

    Another distinctive feature comes in tolerance to light and oxygen. The substituted methoxy and hydroxy groups give just enough resonance stability for routine handling, reducing the risk of batch-to-batch color drift. From our viewpoint, holding back on unnecessary stabilizers improves end purity, letting formulators make their blends without untracked side inputs. No need to chase unknown yellowing after mixing.

    In research and discovery settings, clients value certainty over guesswork. Our technical support group remains one call away to dissect spectral quirks or field requests for custom recrystallization runs. We don’t just hand over standard tables; we talk through impurities, answer with batch logs, and help resolve unexplained shifts between pilot and production scales.

    Learning from the Field: Ongoing Process Tuning

    Real progress begins in feedback from our partners. QC engineers spot small spectral changes and raise questions, which trigger plant audits rather than blanket explanations. Maybe a flange weld heated up and set off a trace impurity, maybe it’s a summer humidity shift. Fielding these details helps us strengthen process control instead of patching things on the back-end.

    We keep our reactor loading moderate to preserve consistent agitation and temperature gradients, even under pressure to maximize batch size. Scale-up trials run alongside mainline production rather than as side projects. This approach caught unexpected ester cleavage pathways early in our scale-up phase, limiting unwanted phenolic carryover.

    Over time, our tech staff has worked out pre-purification protocols—benchmarked against customer lab results—to give early warning when a shipment could drift off spec, rather than field complaints days later. Investing in UV-Vis tracking of each stage cuts the lag between problem emergence and response, saving both us and our clients wasted cycles. These upgrades emerged from pressure on tight timelines and learning directly from missed deadlines.

    Comparisons with Other Compounds: No Substitute for Experience

    On paper, closely related phenolic esters sometimes seem interchangeable, but repeated in-plant trials reveal subtle behavior differences. The ethyl chain keeps volatility in check during standard operating conditions, while methyl or propyl substitutions drift faster at elevated temperatures. Starters who try cutting costs with close analogues end up with yield headaches, often from overlooked reversible esterification or side hydrolysis. Over a decade fielding these cases, we have honed our advice and production approach, suggesting the right molecular fit for each scenario—sometimes not the one you expect from the literature.

    Admixtures or generic-grade material might promise cost savings, but our partners in pharma and fragrance repeatedly return, noticing higher consistency and fewer out-of-spec events. Some generic sources use broader cut points in their distillation, and the resulting product carries a choppy profile—peak shifting in GC, color haze, or trace bitter notes. These small markers metastasize into bigger problems over months of storage or after integration with reactive intermediates. Our routine includes a final hands-on visual inspection beside analytic reports, a habit shaped by years of practical lessons.

    User-Focused Solutions: Customization and Support

    R&D groups and large-scale manufacturing teams run on reliability. Getting the right material at the right moment helps keep projects and production on track. We believe technical support makes or breaks a supplier partnership. Instead of offloading questions to automated systems, our in-house staff stays up to date with ongoing process changes and regulatory shifts. When a researcher finds a spectral oddity or scaling issue, we walk through each step, compare logs, and troubleshoot potential process kinks. If non-standard purity cuts or new packaging requirements emerge, we feed those insights back into small pilot batches for confirmation before updating mainline production.

    Customization arose, not from marketing, but repeated urgent requests from formulation teams. Whether it’s tighter particle size for specific blending equipment, or controlled moisture levels for tablet manufacture, our small-batch lab scales up requests with accountability at every step. Batch notes follow each order and provide traceable clarity—a commitment made after seeing how lost context costs a week’s lead time or forces a run to scrap.

    Our flexibility extends into logistics and storage. Every climate brings new preservation needs, from dry winters to humid summers. Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)propionate holds up under most conditions, but we never skip seal checks or run the risk of ambient contamination. Warehousing staff follow explicit turnover cycles and date coding, shaped by seeing firsthand the consequences of delayed rotations.

    Safety, Trust, and Continuous Improvement

    Nothing matters more than safety and integrity at every step, from raw input to packed output. We monitor hazardous handling and cross-train all plant staff on spill prevention and emergency measures. The phenolic ester group calls for cautious handling, especially at scale, since even minor exposure can trigger unpredictable reactions when mixed unintentionally. Staff rotate on call for incident response, and every quality event is logged with direct operator input, not just supervisor sign-off.

    Trust grows from transparency. We open our plant floor for audits and review sessions, welcoming real-time monitoring from key partners, especially in pharma. Scrutiny means scrutiny, right down to impurity logs and calibration runs. This openness keeps us honest, but also improves our products: suggestions from clients prompt meaningful experiments in new purification or packing methods, not quick fixes. Working with buyers who value safety and quality prompts us to address gaps immediately, either via staff training or process improvements.

    Our technical documents stay current, drawing from real observations and evolving standards. If a process change improves purity or storage life at production scale, the details appear in our user-facing paperwork and batch guides. Listening to old hands and new arrivals keeps us learning and ready to adapt—something the lab cannot always simulate.

    Enduring Relationships: Why Source Directly from a Producer?

    Cutting out intermediaries lowers chances for delays or supply errors, but the biggest gain comes from access to the team making the product day after day. Our operators spot trends that never show up in specs, such as subtle shifts in odor or faint changes in melting point, and share these real-life insights so customers can react instead of firefight. When issues appear, resolution means more than issuing a new certificate; it means reviewing historical logs, adjusting the process, and updating the workflow. These relationships take longer to build but deliver tangible risk reduction and smoother operations.

    Some clients start with small test samples and ramp up volume only after seeing proof over months of real product usage in their equipment and processes. This pattern repeats every season with new partners, and the feedback loop strengthens both our methods and their trust. Documentation trails aren’t marketing—they’re real insurance against knowledge loss and costly repeat mistakes. With open data exchange, both sides gain confidence in consistency and avoid surges in field failures.

    Many clients in cosmetic, flavor, and pharmaceutical lines struggle with regulatory surprises and sudden shifts in compliance requirements. Our internal documentation and traceability answer questions faster because we know the product’s entire history, every input, and every test result. This thoroughness removes time spent chasing missing details or patching up rushed compliance paperwork, keeping everyone ahead of disruptions.

    Commitment to Real-World Impact

    Manufacturing Ethyl 3-(4-Hydroxy-3-Methoxyphenyl)propionate is about understanding not just what the product is, but what users actually face. From batch consistency in fragrance bases to reactivity in complex pharmaceutical synthesis, our product brings more than meets the eye. Continuous process upgrades and hands-on support address pain points we hear from the field—not just theoretical needs but daily operational realities.

    The industry challenges us to chase better reproducibility, longer shelf life, tighter impurity controls, and smarter safety practices with every run. Years of direct customer feedback shaped every routine, from sealing caps to batch analytics. As demand evolves, we fine-tune parameters, packaging, and documentation with direct input from the people using our chemical day in and day out.

    This compound, in every lot, reflects not just raw utility but a culture of attention to detail, transparency, and ongoing learning that only a dedicated manufacturer can provide. Sourcing directly from us means access to the expertise, commitment, and practical solutions that matter when unforeseen needs or challenges arise in the field. That’s the difference genuine production experience brings to every shipment.