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Ethyl 2-Mercaptopropionate

    • Product Name Ethyl 2-Mercaptopropionate
    • Alias Ethyl thiolactate
    • Einecs 214-498-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    905613

    Chemicalname Ethyl 2-Mercaptopropionate
    Casnumber 623-03-0
    Molecularformula C5H10O2S
    Molecularweight 134.20
    Appearance Colorless to pale yellow liquid
    Boilingpoint 65-67°C at 8 mmHg
    Density 1.05 g/cm3 at 20°C
    Refractiveindex 1.445-1.449
    Flashpoint 88°C
    Odor Strong, unpleasant (mercaptan-like)
    Solubilityinwater Slightly soluble
    Meltingpoint -70°C
    Purity Typically ≥98%
    Storagetemperature Store at 2-8°C
    Vaporpressure 0.36 mmHg at 25°C

    As an accredited Ethyl 2-Mercaptopropionate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl 2-Mercaptopropionate is supplied in a sealed 500 mL amber glass bottle with a secure cap, labeled with hazard information.
    Shipping Ethyl 2-Mercaptopropionate must be shipped in tightly sealed containers under cool, dry conditions, away from sources of ignition or strong oxidizing agents. The packaging should comply with applicable hazardous materials regulations. Proper labeling and documentation are required to ensure safe handling and transport. Spill-containment and emergency procedures must be accessible.
    Storage Ethyl 2-Mercaptopropionate should be stored in a tightly closed container in a cool, dry, well-ventilated area away from heat, sparks, open flames, and incompatible substances such as oxidizing agents. Protect from moisture and direct sunlight. Use corrosion-resistant containers, and store away from food and drink. Ensure proper labeling and secondary containment to prevent accidental release or contamination.
    Application of Ethyl 2-Mercaptopropionate

    Applications of Ethyl 2-Mercaptopropionate in Industrial Manufacturing

    Ethyl 2-Mercaptopropionate serves as a specialty intermediate in multiple regulated industrial sectors. As an original manufacturer, we supply this raw material to qualified downstream producers who require strict quality traceability and technical transparency for process safety and product performance. Below are core industrial application segments based on actual end-user integration and global compliance mandates.

    1. Polymerization Chain Transfer Agent for Acrylic and Styrene Polymers

    Acrylic and styrenic polymer manufacturers select ethyl 2-mercaptopropionate as an efficient chain transfer agent (CTA) to control molecular weight and branching architecture during radical polymerization. This additive allows polymer chemists to achieve fine-tuned flow characteristics required for advanced coatings, adhesives, and engineering plastics. Reactors operate under closed safety control, dosing the CTA at predetermined stages for performance-critical resin grades.

    Industry compliance standards

    • REACH (EC 1907/2006) certification for all supplied intermediates
    • ISO 9001:2015 and ISO 14001:2015 process compliance at manufacturing sites
    • US EPA TSCA listing for chain transfer agents in industrial polymers
    • SDS and full batch COA traceability in line with GHS labeling

    Typical usage ratio

    • 0.05%–0.25% by weight relative to total monomer content
    • The ratio depends on targeted molecular weight range and polymerization kinetics specific to acrylic or styrene system

    Downstream process integration

    • Added directly to monomer premix before or during initial polymerization phase
    • Dosed under nitrogen blanket to prevent unwanted oxidation or volatilization
    • Controlled with automated feed system for reactor consistency in continuous or batch production lines

    Final product types

    • High solids acrylic coatings (decorative and industrial)
    • Styrenic impact resins for automotive interiors
    • Pressure-sensitive adhesives with tailored viscosity
    • Thermoplastic processing aids and impact modifiers

    2. Pharmaceutical Intermediate for Thioester-Containing APIs

    API synthesis routes requiring thioester coupling rely on ethyl 2-mercaptopropionate as a critical building block due to its controlled reactivity and purity. Process chemists in GMP pharmaceutical plants use it for the manufacture of select API intermediates, especially for cephalosporin and custom thioester-class actives. Our material supports high-yield, low-impurity workflows, integrating fully documented production records.

    Industry compliance standards

    • ICH Q7-compliant GMP manufacturing (where supplied as an API intermediate)
    • USP/Ph. Eur. reference for related intermediate impurity control
    • Full regulatory support for Drug Master File (DMF) Type II
    • FDA 21 CFR Part 211 requirements for traceability and documentation

    Typical usage ratio

    • Stoichiometric ratios dictated by API route—typically 1.0–1.5 molar equivalents per coupling step
    • Adjusted for downstream impurity minimization and reaction time optimization

    Downstream process integration

    • Charged to reactor under validated closed-system protocols for thioester formation
    • Monitored for residual content with HPLC/GC documentation at each reaction stage
    • Integration into multi-step synthetic routes for finished compound without manual handling exposure

    Final product types

    • Advanced cephalosporin intermediates
    • Custom peptide thioesters for small molecule drugs
    • API variants with specific sulfur-side chain modifications
    • Pharma-grade building blocks for further regulated synthesis

    3. Odorant and Precursor for Thiol-Based Gas Leak Detection Compounds

    Producers of utility-grade gas odorants utilize ethyl 2-mercaptopropionate as a precursor for synthesizing substituted mercaptans, intended for natural gas and LPG leak detection. Its controlled conversion to target thiol compounds enables formulation of high-purity odorants with well-defined olfactory thresholds, critical for public safety compliance and consistent detector calibration.

    Industry compliance standards

    • EN ISO 13734: Natural Gas Odorization Safety
    • UNE EN 15322 (odorant storage and handling)
    • Regional transport and storage under EU ADR and US DOT 49 CFR
    • Strict compliance with local environmental emission limits for odorant manufacturing

    Typical usage ratio

    • Blending and conversion at 10%–40% by weight in precursor stream, depending on thiol final use
    • Quantities set according to sensitivity requirements for end-use sector (utility or industrial)

    Downstream process integration

    • Used in controlled chemical transformation to yield target mercaptans or thioethers
    • Integration into closed reactors with emission scrubbers
    • Final blending under nitrogen with proprietary diluents and stabilizers

    Final product types

    • Ethyl mercaptan odorant for LPG and propane distribution
    • Methyl mercaptan-based blends for natural gas pipelines
    • Calibrated odorant test kits for pipeline and plant QA
    • Industrial leak detection compounds for process safety

    4. Modifier in Plasticizer and Lubricant Additive Synthesis

    Plastic additive and lubricant formulators employ ethyl 2-mercaptopropionate to introduce sulfur-containing side chains, which improve lubricity and anti-wear performance. In plasticizer synthesis, integration occurs during esterification or transesterification, impacting flexibility and migration resistance. Blenders run QA-controlled batches, monitoring additive reactivity, and long-term thermal stability.

    Industry compliance standards

    • OECD Guideline 107 for partition coefficient testing
    • ASTM D6078 for lubricity assessment
    • EU REACH registration (plasticizer additive use)
    • In-house QC based on ISO 17025-accredited labs

    Typical usage ratio

    • 0.1%–0.5% by weight in lubricant formulation stages
    • 0.5%–2.0% as a co-monomer or modifier in plasticizer production; dependent on application stress load

    Downstream process integration

    • Integrated during high-temperature esterification for high-migration resistance plasticizers
    • Blend addition at pre-mixing stage for lubricant base stocks
    • Continuous in-line monitoring for additive dispersion and sulfur content uniformity

    Final product types

    • Anti-wear lubricating oils for industrial machinery
    • Flexible PVC and polyolefin plasticizers (non-phthalate types)
    • Process aids for thermoplastic elastomer production
    • Specialty bases for high-pressure grease applications
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    Certification & Compliance
    More Introduction

    Ethyl 2-Mercaptopropionate: Insights from the Production Line

    Ethyl 2-mercaptopropionate belongs to a family of organosulfur compounds that keep showing up across industries for good reasons. Our team has been in the business of synthesizing and refining this clear, faintly odorous liquid for years, and every cycle through the reactors offers reminders about what makes it valuable and where it demands extra care.

    Understanding the Backbone: How We Prepare Ethyl 2-Mercaptopropionate

    Ethyl 2-mercaptopropionate, known in some sectors as a chemical intermediate, takes shape here through a direct, batch-controlled esterification route. We start from carefully sourced 2-mercaptopropionic acid and high-purity ethanol. Refluxed with precise heat and controlled exposure, the product takes form—a liquid with the formula C5H10O2S, molecular weight of 134.2. Quality teams hold every batch to strict GC purity standards, and we measure tightly for water content, residual acid, and color.

    Our facility is set up for high-throughput, so we see tanks moving volumes from small drum lots up to commercial bulk. For each shipment, a batch record follows the product out, documenting all process variables: catalyst load, batch temperature curves, times of addition, vacuum steps, and any filtration adjustments. Closed-loop nitrogen systems protect material from exposure, keeping the product low in sulfur species that can cause discoloration or off-odors.

    Not all mercaptoesters are the same. Each order for ethyl 2-mercaptopropionate runs with its own target specs, and we've learned over years of feedback what matters most for different end uses. Cosmetic and fragrance makers insist on low color and absence of side-odor, so we pull longer vacuum and run extra distillation. Polymer folks who blend it as a chain transfer agent usually demand volume, not ultra-high color, so we optimize for throughput with filtration checks. Our expertise boils down to knowing which tweaks matter: every adjustment echoes back from our users.

    Why Do People Choose Ethyl 2-Mercaptopropionate?

    In the plant, we’re used to handling different mercaptoesters: methyl, ethyl, butyl, and propyl. Ethyl 2-mercaptopropionate occupies a spot that balances volatility, reactivity, and cost. Its sulfur group activates it for Michael addition chemistry, chain transfer reactions, and thioesterification—areas where methyl or butyl substitutes don’t always measure up. The ethyl ester presents a moderate boiling point, workable solubility, and distinct reactivity profile suited for specialty polymer resins and performance additives.

    Our product flows into several key destinations. Noticeable among them: the production of acrylic resins for coatings. Polymer chemists rely on our output to adjust molecular weight during chain transfer polymerizations. They value its ability to moderate viscosity, influence flexibility, and impact final polymer clarity. Every time a new acrylic batch kicks off, they draw on this chemistry—and we draw on years of observing how small composition differences shift final performance.

    Chemical synthesis teams working with flavors and fragrances value ethyl 2-mercaptopropionate’s distinct ester profile. The ethyl group gives a lighter note than butyl, cutting through heavier bases while carrying sulfur brightness into specialty blends. Each perfumer has a story about how a batch’s tiny impurity level can overrun a formulation; we put in long hours refining distillation methods, since just a trace of byproduct shifts a fragrance from acceptably fresh to compromised.

    To us, it’s rarely just “making another batch.” Our shop views each drum as part of a longer chain—one that eventually finds its way into the hands of chemists or factory lines from coatings to specialty flavors. Experience has proven that real advantages often emerge from the small things: monitoring the sulfur balance, keeping hands-on with equipment cleaning, and knowing that shortcuts in maintenance can cost everyone down the road.

    Comparing Ethyl 2-Mercaptopropionate with Other Mercaptoesters

    Market buzz often drifts toward methyl or butyl alternatives for chain transfer reactions or sulfur chemistry, but every day at the plant shows why ethyl 2-mercaptopropionate holds its own. Methyl 2-mercaptopropionate comes in with slightly higher volatility and a lower molecular weight. This methyl analog behaves as a more active transfer agent in acrylate polymerization, boosting reaction rates and yielding somewhat lower molecular weights in the finished product. The flip side pops up when considering odors—methyl brings a sharper, more pungent note. Handling is trickier for facility staff as vapor losses rise and workplace exposure grows. Over the years, many operators end up preferring ethyl for its somewhat milder handling and storage profile, especially in high-volume plant conditions.

    Butyl 2-mercaptopropionate introduces a heavier, less volatile feel with a higher boiling point and slightly increased hydrophobicity. Long butyl chains give more flexibility in certain rubbers or functional polymers, but they also drag in more residue risk and handling complexity. We see fewer requests for butyl esters in fine fragrance and food chemical uses because their heavier notes can overpower lighter compositions. Most plant users looking for universality end up choosing ethyl for its “sweet spot” between handling, effectiveness, and downstream odor management.

    Some chemists dabble with isopropyl or propyl analogs, aiming to tweak polarity and reactivity further. Year after year, feedback from production users spotlights several drawbacks: longer clean-up cycles, greater risk of hydrolysis, and additional overhead for inventory segregation. Those headaches weigh against any minor performance boost. Based on direct input from user audits and our field support team, ethyl’s balance keeps most buyers loyal.

    Points Learned from Plant and Lab

    Spot checks and batch tracking tell a story that doesn’t show up in theoretical comparisons. Pure, high-quality ethyl 2-mercaptopropionate holds color under warehouse shelf conditions. After multiple hot summer months, lighter methyl esters tend to show color pickup and sulfur shifts, while ethyl maintains clear tone and remains within most flavor specifications—good news for users with tight quality controls.

    Every facility has its quirks and process risks, and ours is no exception. By tweaking catalyst load and managing residual acid, we avoid downstream corrosion that can trouble other producers. Simultaneously, intermediate filtration steps reduce the formation of blackened sulfur residues. Safety teams monitor vent emissions since mercaptoesters can trigger sharp odors even at parts-per-million levels. We invest in scrubbers and room air turnover, keeping both the workplace and local environment well within compliance.

    Another routine task involves checking compatibility with a range of shipment containers. Ethyl 2-mercaptopropionate, despite its very slight water solubility, manages not to degrade standard drum and tanker linings, and bulk buyers request requalified container certifications. We respond by cycling drums through frequent testing, and our QA group logs every result. Importantly, we adopt a policy of “full traceability”—every shipment tracks back to specific production runs, catalyst matrices, and equipment lots. No customer works in the dark about what they’re getting.

    Meeting Customer Requirements and Responding to Market Shifts

    Over the years, application requests have shifted. The coatings industry continually tightens specs for color, odor, and polymer compatibility. Fragrance formulators have become more vigilant about subtle byproduct signatures. Some regions press for stricter occupational exposure limits. Staying ahead means committing to continuous investment — not just in reactors or scales, but in analytical gear and line monitoring.

    Spectrometers and gas chromatographs catch minute shifts batch-to-batch; a second or third pass through distillation can make the difference between a sale and a return. We’ve introduced infrared leak detectors in the plant, catching fugitive emissions for workplace safety and neighborhood reassurance. Every step reflects years of listening to formulators, technical teams, and regulators. Years in this business confirm that direct feedback and honest troubleshooting drive progress antennafar more than any glossy marketing.

    From our own experience, nothing surpasses face-to-face collaboration between maker and user. Co-designing test runs, troubleshooting compatibility issues, or brainstorming improved odor thresholds: the most successful partners stick around because we address the real-life snags, not just send a product out the door. That attitude has paid off as regulatory standards worldwide climb higher.

    Product Handling: Insights from Our Production and Warehouse Teams

    Daily handling of ethyl 2-mercaptopropionate at industrial scale forces a level of respect for its hazards. Sulfur-based esters can provoke dermal and respiratory irritation, and plant crew gear up with full face protection as standard. Spills trigger established containment procedures and a prepped clean-up crew with neutralizers. We take extra steps maintaining sealed transfer lines, which control emissions and product loss.

    Feedback from packaging teams has taught us to calibrate fill levels in drums carefully. Mercaptoesters expand in heat, so teams avoid overfilling. Warehouse logs show that even small exposure to sunlight leaks through translucent containers, which prompts routine rotation and dark storage policy. Drum labels plainly show manufacture dates along with color and purity verification. Not every facility provides this much tracking, but after years of dealing with returns from other suppliers, we've found it slashes confusion and builds trust.

    Our QA experts train not just to detect off-spec material but to chase root cause. If a distillation fraction seems a shade darker or the sulfur analysis creeps, we immediately review equipment for fouling or overheating. Small course corrections save time and keep supply lines uninterrupted; downtime from a rejected shipment costs more than any diligent check list.

    Supporting Applications Across Industries

    Ethyl 2-mercaptopropionate makes its presence felt along a broad series of applications, touching everything from high-performance plastics to niche flavors. Professional formulators trust its thioester linkage for precise reaction control, and industrial polymerization routines lean on consistent chain transfer behavior. In the coatings sector, users add it in calculated dose ranges, modifying resin characteristics with every incremental adjustment. A little goes a long way, and the difference between a finished product with appropriate flow or unwanted stickiness often comes down to our batch’s exact makeup.

    On the specialty chemicals front, we’ve worked with groups blending sulfur flavoring notes for food analogs, as well as formulators crafting sulfur-rich fragrance accord molecules. Our track record tells us that material consistency translates directly into creative headroom—the fewer surprises in odor or volatility, the more freedom a compounder feels when extending their formula libraries. Manufacturers who stretch cycles to use up old or off-brand product lose time troubleshooting rather than designing new concepts. Our team field questions about substitution, batch blending, and compatibility nearly every week, and no two answers are alike.

    Some resin and adhesive developers use ethyl 2-mercaptopropionate in closed systems, tweaking the ratio for targeted tack or crosslink density. Their feedback loops drive our own process improvements. If a regular user finds moisture volatility matters more than purity, production adjusts dehydration steps. If a large buyer shifts odor requirements tighter, distillation settings change in kind. Power rests in our direct connection—each request leads to a process tweak, a new certificate, or a packaging rework.

    Regulatory Realities and Staying Ahead

    Compliance drives production as much as chemistry. Sulfur esters operate in a landscape with increasing scrutiny. Our plant maintains up-to-date registrations and batch analysis for international shipment—the product navigates variable rules involving toxicology, workplace exposure, and downstream food safety. Regular outside audits confirm adherence; we make adjustments as standards change.

    Feedback loops with regulatory offices accelerate our adoption of safer practices. When occupational limits for sulfur-containing compounds tighten, we invest in expanded air handling and leak detection. Analytical protocols update in real-time, not just quarterly reviews. Batch records flow straight to customers upon request, building reassurance and evidence for traceability. We’ve learned that transparency never truly interrupts business—it supports longer-term relationships.

    Quality systems extend beyond paperwork. We assign in-plant hazard assessment teams to run mock drills; these groups spot potential compliance gaps before outside authorities do. The payoff lands in both safety records and steady repeat custom—a rare compliment in an industry prone to fluctuation.

    Lessons in Sustainability and Minimizing Waste

    Over the past decade, industry-wide pressures to reduce waste and process impact have reshaped the way our plant approaches ethyl 2-mercaptopropionate manufacture. Waste streams from mercaptoester production require careful neutralization and management. We deploy closed-loop liquid recovery to minimize solvent discharge, turning what used to be process loss into recaptured, saleable byproduct.

    Energy efficiency sits high on the priority list. Heating cycles needed for esterification and distillation draw on heat exchangers and energy reuse schemes. Every watt saved means lower product cost and reduced carbon impact. Our team shares these best practices with customers looking to benchmark environmental performance. Over time, we’ve found that technical improvements in product quality and cutoff of waste align—better batch definition yields fewer rejects and less landfill load.

    Product shelf life forms another angle on sustainability in action. Users who order tailored lot sizes and follow best-practice inventory rotation benefit from longer in-service product windows, less spoilage, and tighter specification compliance. We provide regular check-ins and guidance for storage and re-testing, reducing both overstocking and wasteful disposal.

    Looking Ahead: Trends and Growth in Ethyl 2-Mercaptopropionate Use

    Markets shift and new applications surprise even experienced hands. Demand for specialty polymers grows, especially in coatings that must meet tighter regulatory and performance criteria. Emerging electronics require custom polymerization routes, with ethyl 2-mercaptopropionate finding new footing as a tailored chain transfer agent. We work alongside research teams, helping pilot runs scale up while keeping consistent product available for critical launch windows.

    Flavor and fragrance formulators face more pushback against allergenic impurities and residual solvents. Our plant moves in step, adding analytical lines and adopting new standards. This transformation isn’t just defensive—it creates space for innovation. Free from legacy batch problems or odor uncertainty, our customers push creative boundaries further. From food analogs to next-wave encapsulants, materials that start in our reactors end up in products reshaping their end markets.

    Direct user partnerships chart the path forward. Early trials, rapid feedback, and support with technical hurdles keep both plant and buyer ahead of the curve. The future for ethyl 2-mercaptopropionate stays dynamic, with new uses, tighter controls, and market shakeups arriving each year. Our job is to anticipate, equip, and support those who rely on our materials—not just with words but with quality, traceability, and real attention to the chemical realities at stake.