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Ethyl 1,3-Dithiolane-2-Carboxylate

    • Product Name Ethyl 1,3-Dithiolane-2-Carboxylate
    • Alias ethyl 1,3-dithiolane-2-carboxylate
    • Einecs 271-684-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    691963

    Chemical Name Ethyl 1,3-Dithiolane-2-Carboxylate
    Molecular Formula C6H10O2S2
    Molecular Weight 178.27 g/mol
    Cas Number 5974-74-7
    Appearance Colorless to pale yellow liquid
    Boiling Point 110-112°C at 13 mmHg
    Density 1.274 g/cm3
    Refractive Index 1.540-1.545
    Solubility Slightly soluble in water, soluble in organic solvents
    Smiles CCOC(=O)C1SCCS1

    As an accredited Ethyl 1,3-Dithiolane-2-Carboxylate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 25g amber glass bottle with a secure screw cap, labeled "Ethyl 1,3-Dithiolane-2-Carboxylate" and hazard information.
    Shipping Ethyl 1,3-Dithiolane-2-Carboxylate is shipped in tightly sealed containers under cool, dry conditions. It should be handled as a chemical substance, avoiding moisture and direct sunlight. Appropriate labeling and documentation are required. Containers must be protected from physical damage and shipped according to local, regional, and international hazardous materials regulations.
    Storage Ethyl 1,3-Dithiolane-2-Carboxylate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances like oxidizers. Protect from moisture, heat, and direct sunlight. Ensure proper chemical labeling and store at room temperature or as specified in manufacturer guidelines. Use secondary containment to prevent environmental contamination.
    Application of Ethyl 1,3-Dithiolane-2-Carboxylate

    Applications of Ethyl 1,3-Dithiolane-2-Carboxylate in Industrial Manufacturing

    Ethyl 1,3-Dithiolane-2-Carboxylate is a specialized building block in organic synthesis with proven utility across several industrial segments, particularly within heterocyclic chemistry and specialty fine chemicals. As a direct manufacturer, we focus on its real-world adoption in downstream sectors, supporting stringent compliance and production standards throughout each stage of formulation and integration.

    1. Pharmaceutical Intermediate Synthesis

    Ethyl 1,3-Dithiolane-2-Carboxylate functions as a pivotal intermediate in synthesizing thiazole- and thiadiazole-based active pharmaceutical ingredients (APIs), especially where dithiolane scaffolds offer selective reactivity for medicinal chemistry programs. Downstream manufacturers leverage this compound for targeted cyclization reactions and side-chain modifications during multi-step drug substance production, benefitting from its compatibility with established GMP systems and chromatographic purification protocols.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF Monographs relevant to related substances
    • EU EudraLex Vol. 4 – GMP Guidelines
    • US FDA 21 CFR Part 211 for finished pharmaceuticals

    Typical usage ratio

    • 3–15 mol% relative to primary amine or carbonyl reactant, adjusted according to each reaction scheme’s conversion efficiency and impurity control

    Downstream process integration

    • Added into advanced stage intermediates, either via direct addition to condensation or cyclization reactors, or introduced during late-stage derivatization steps following chromatographic pre-purification

    Final product types

    • Thiazole-based pharmaceutical ingredients (e.g., anti-infectives, central nervous system APIs)
    • Thiadiazole derivatives for anti-inflammatory or anti-tumor activity
    • Research-grade heterocyclic scaffolds for medicinal chemistry

    2. Agrochemical Active Ingredient Development

    Downstream crop protection manufacturers use Ethyl 1,3-Dithiolane-2-Carboxylate as a core intermediate in designing fungicides and insecticides where sulfur-heterocycles improve biological compatibility and stability against environmental degradation. The compound responds reliably to large-scale synthesis requirements, interfacing directly with established multi-ton batch and continuous processes in regulated agrochemical production environments.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001-certified Quality Management Systems for agrochemical plants
    • EU Regulation (EC) No 1107/2009 for PPP (Plant Protection Products) Approval
    • US EPA Pesticide Registration Requirements

    Typical usage ratio

    • 5–18% w/w in pre-pesticide intermediates, depending on the desired heterocyclic active’s molecular weight and side-chain complexity

    Downstream process integration

    • Employed during synthesis of dithiolane or thiazole precursors via alkylation and cyclization, often introduced before halogenation or esterification steps

    Final product types

    • Sulfur-containing fungicidal actives
    • Dithiolane-based insecticide ingredients
    • Intermediates for further conversion to herbicidal compounds

    3. Flavor and Fragrance Ingredient Manufacturing

    Fine chemical producers utilize Ethyl 1,3-Dithiolane-2-Carboxylate for its reactivity in the synthesis of sulfur-containing aroma precursors, especially where dithiolane rings impart desirable roasted, nutty, or tropical notes. Its purity and traceability support compliance with global food safety regulations for food-contact and edibility assessments, ensuring manufacturers can introduce sulfur motifs safely into GRAS-compliant and EUFSA-registered flavor blends.

    Industry compliance standards

    • US FDA 21 CFR 172.515 (Synthetic flavoring substances)
    • European Union Regulation (EC) No 1334/2008 on flavorings
    • IFRA Code of Practice for fragrance ingredients
    • FEMA GRAS status requirements (Flavor and Extract Manufacturers Association)

    Typical usage ratio

    • 0.01–0.12% w/w in flavor formulations; exact inclusion optimized based on sensory test panels and target aroma profiles

    Downstream process integration

    • Introduced at precursor intermediate synthesis, then carried through controlled hydrolysis or reduction to yield targeted aroma profiles; monitored via GC-MS for quality consistency

    Final product types

    • Roasted or nutty flavor bases for confectionery and snacks
    • Sulfurous aroma ingredients in tropical fruit or savory flavor compounds
    • Specialty fragrance molecules for perfumery blends

    4. Polymerization Additive for Conductive Polymers

    Materials manufacturers specializing in conductive polymers integrate Ethyl 1,3-Dithiolane-2-Carboxylate during syntheses requiring sulfur group introduction for tunable electrical and solubility properties, commonly in applications where low-level crosslinking or electronic modulation is critical. The compound is evaluated for downstream use in processes aligned with RoHS directives and electronics-grade QMS.

    Industry compliance standards

    • IEC 62321 (Determination of certain substances in electronics and polymers)
    • EU RoHS Directive (2011/65/EU) for electronic materials
    • ISO 9001 for advanced material synthesis traceability
    • UL 94 for flame-retardant polymer compounds

    Typical usage ratio

    • 0.5–3% by mass in monomer feedstreams, customized according to target conductivity and mechanical benchmarks validated through downstream QC sampling

    Downstream process integration

    • Fed into solution or bulk polymerization stages prior to crosslinking, sometimes co-reacted with vinyl or aromatic monomers to incorporate sulfur heterocycles and optimize performance

    Final product types

    • Conductive polymer films for electronics
    • Sulfur-modified resin masterbatches
    • Antistatic coating materials for industrial use
    Free Quote

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    Certification & Compliance
    More Introduction

    Ethyl 1,3-Dithiolane-2-Carboxylate: Insights from Our Factory Floor

    The Story Behind Our Ethyl 1,3-Dithiolane-2-Carboxylate

    At our chemical plant, we’ve watched Ethyl 1,3-Dithiolane-2-Carboxylate become an essential part of production lines in agrochemicals, pharmaceuticals, and specialty intermediates. Most people don’t see what goes on behind the steel tanks and precise reactor systems. Every day, our teams wake before dawn, check raw material lots, and fine-tune batch processes. Out here, you notice quickly that not all dithiolane carboxylates behave the same. Our version earned trust because we control every kilogram, from sourcing the thiol derivatives to careful packing for shipment.

    The chemical structure of Ethyl 1,3-dithiolane-2-carboxylate gives it a distinct place among organosulfur intermediates. That five-membered ring loaded with two sulfur atoms—paired with a carboxylate ester—gives it a strong reactivity with nucleophiles under the right conditions. This isn’t just another line item on a spec sheet. Those sulfur groups set off cyclization and condensation reactions that you can’t duplicate using ordinary esters or even standard dithiolane systems.

    Our workforce includes plant operators who’ve spent decades recognizing batch color changes and subtle viscosity shifts. These details tell us much more about the reactions than anything you’ll find in a catalog. Our people know when a batch is heading for trouble. They also know how to coax purity above 98%, cutting out troublesome side products.

    Specifications Only a Manufacturer Knows

    We don’t treat this as a “one-size-fits-all” product. Batch-to-batch consistency matters for research labs, but at scale, reproducibility prevents downstream headaches. For instance, an agrochemical customer once told us our material dissolved faster and left no residue in their reaction setup. That might sound like a minor handling detail, but for 10-ton batches, slightly better solubility saves hours and avoids filter clogging.

    Our technical people watch for water content as a top priority. High moisture, even at low levels, can degrade the sulfur ring in storage or during coupling reactions. Rigorous drying steps and on-site Karl Fischer titration help us keep water consistently low, minimizing hydrolysis risk. That’s not just theory—our own QC team once tracked a failed pilot run back to a drum lid that didn’t hold its seal. That event solidified our current inert gas blanketing practice.

    We label the product with the proper CAS number (not listed here for confidentiality) and supply it most often with a minimum purity above 98%. This aligns with what we’ve seen as the threshold for complex organic synthesis. Analytical chemists from several client labs corroborated these figures, sometimes using NMR, sometimes using GC-MS. Our internal records back up every certificate we ship.

    Choosing Ethyl 1,3-Dithiolane-2-Carboxylate: Real-World Use Cases

    In the pharmaceutical sector, chemists rely on this molecule as a building block for constructing various heterocyclic frameworks. The dithiolane ring offers a way to introduce sulfur into new scaffolds without risking unwanted decomposition. Researchers in lead discovery often tell us that the reactivity profile helps them prepare libraries of analogs with high yields.

    Agronomic formulators reach out because of the distinctive role sulfur plays in evolving crop protection chemistry. Some active ingredients require precise sulfur incorporation and ring closure, and our dithiolane ester handles those steps without introducing off-odors or colored impurities. Producers want a consistent sulfur donor without sacrificing purity, and our Ethyl 1,3-Dithiolane-2-Carboxylate fills that gap.

    For electronic intermediates, the compound supports formation of sulfur-containing thin films and polymer backbones, as it brings controlled electron-donating behavior. Our technicians receive requests to customize particle size or adapt packaging for cleanroom handoffs. These changes stem from practical conversations with users—not abstract marketing campaigns.

    Standing Out from Other Dithiolanes and Esters

    We see the world’s dithiolane market as a jigsaw puzzle. Some producers turn out simple dithiolane rings without the ethyl carboxylate group. Others stick to methyl esters or tinker with backbone substitutions. From experience, those differences mean more than a shift in molecule shape—they affect how material initiates reaction, as well as purity of the final product.

    Ethyl 1,3-Dithiolane-2-Carboxylate sets itself apart with a blend of ring stability and manageable reactivity. Switching from methyl to ethyl esters alters solubility, boiling point, and compatibility with larger solvent systems. Chemists in scale-up pilots find that the ethyl ester resists premature evaporation and offers steadier performance across batch sizes.

    Other dithiolane carboxylate derivatives can degrade at lower temperatures, producing sulfurous byproducts that escape plant scrubbers. We’ve designed ours for shelf-stability with minimal off-gassing, keeping workplace air cleaner and reducing the risk of alarming odor complaints. This includes proper drum lining, tamper-evident seals, and regular in-process inspection.

    Why Purity, Stability, and Support Matter for This Chemical

    As actual producers, we face the reality of environmental limits, process safety, and customer troubleshooting. Trace impurities in this compound have real consequences in downstream synthesis—lead to excessive foaming, colored byproducts, even lower reaction yields. Over years, we invested in a closed reactor system with real-time monitoring. Any slip—be it a slightly contaminated ligand or a small temperature swing—shows up in the final test reports.

    Certifying the material isn’t enough on its own. We follow up with technical support when partners hit roadblocks. An analytical chemist at a crop science company stuck on a difficult coupling step once shipped us a sample for review. Our lab uncovered trace residual acid left from a supplier upstream. Since then, we instituted an extra wash step on select runs for sensitive clients. That sort of partnership comes from shared goals, not a simple transaction.

    Product stability guides every step. Ethyl 1,3-Dithiolane-2-Carboxylate can react with bases and moisture, slowly breaking the dithiolane ring and undermining both storage and long-term use. Temperature swings during shipping threaten the structure, so we rely on insulated shipping containers and anti-static bulk bags during humid months. Lab staff double-seal drums and track batch lifetimes in a digital lot system. We’ve seen that reducing light exposures, especially strong UV, extends shelf life and cuts down on peroxide formation.

    Feedback Loops: Listening to Chemists, Adapting the Process

    Customers tell the real story. One pharmaceutical engineer working on a chiral separation flagged a faint spike in their HPLC trace. Our QC director spent an afternoon tracing the origin—a small contamination in our upstream supply chain. Immediate tracing, batch quarantine, and supplier reevaluation followed. This led us to change our key raw material provider and to bring in an updated inline filtration module on our esterification step. Now, those peaks are gone, and purity numbers consistently run above customer needs.

    Scale-up brings its own challenges. Laboratory recipes rarely transfer cleanly to plant scale. Agitation rates shift, heat transfer slows, and subtle foam formation can trip up even experienced operators. For Ethyl 1,3-Dithiolane-2-Carboxylate, we ran a series of pilot trials, recording reaction exotherms and adjusting distillation timing to minimize thermal decomposition. Engineers installed custom sensors, and operators completed extra training to recognize off-normal readings. These investments grew out of hard lessons, but now shape the way we maintain consistent output run after run.

    Our technical liaison program draws input from both large buyers and independent researchers. Whether the request is for a new solvent system, adjustments in particle size, or alternative packaging for automated dispensing, we try to iterate where possible. Some custom batches include tailored drying, precision milling for consistent flow, or dot-coded labeling for robotic warehouses. Those features originated from user requests, not marketing staff. In truth, many of our process tweaks started from conversations at industry trade shows or unplanned plant visits.

    Environmental Compliance Starts in Production

    Actual production reveals the daily checks required to run a modern chemical plant. Ethyl 1,3-Dithiolane-2-Carboxylate brings unique environmental concerns, thanks to its sulfur atoms and potential degradation path. We work closely with local authorities and third-party auditors to monitor waste streams, off-gas profiles, and employee exposure. Years back, after a review flagged trace sulfur in rainwater collection areas, plant engineers rerouted storage tanks and replaced old valve seals with advanced fluoropolymer units. Routine monitoring keeps us ahead of regulations, and any flagged trends prompt immediate corrective steps.

    Wastewater from our dithiolane lines receives neutralization, pH adjustment, and high-precision testing before reaching bio-treatment. Each shipment of recovered solvent or spent catalyst gets logged, traced, and properly handled. We periodically update processes in response to both evolving regulations and practical learnings from new chemical runs.

    Training operators in chemical hygiene doesn’t just check boxes; it guards everyone on the floor. Sensors monitor for trace leaks, and teams perform weekly emergency drills. Our philosophy keeps our commitment strong—not only to clients using our Ethyl 1,3-Dithiolane-2-Carboxylate, but to the communities who share our environment.

    Problem-Solving: Adapting to Real-World Hurdles

    Every so often, a shipment runs into customs holdups, extreme weather, or new transportation rules. Our logistics team knows each route, and anticipates these obstacles. In winter, we adjust thermal blankets to avoid crystallization. During shipping delays, we communicate with buyers right away and offer practical storage tips to avoid degradation on arrival.

    For research groups tackling new synthetic targets, small deviations in raw material quality can stall entire projects. We set up a fast-response technical support channel for questions about solubility, reactivity, or downstream purity. That might mean reviewing chromatograms, suggesting alternative solvents, or reporting supply chain interruptions transparently.

    No process stays perfect forever. Years of experience tell us to expect hiccups—pressure drops, color changes, erratic yields. Stopping to inspect these events, enabling batch holds, and investing in root-cause analysis prevented major losses and safeguarded our partners’ interests. Operators learn to spot these cues from hands-on experience, not just manuals.

    Why Our Manufacturing Philosophy Benefits Users

    At the end of the day, users rely on what we make because we treat Ethyl 1,3-Dithiolane-2-Carboxylate as a building block for real progress in science, agriculture, and technology. Our people take pride in anticipating problems, measuring every parameter, and staying responsive to both newcomers and industry veterans. We maintain close partnerships with research labs, design engineers, and process chemists who bring new ideas and tough questions.

    Each kilo shipped comes with the trust built across years of shared problem-solving. Whether a batch finds its way into a new drug scaffold or a field-ready crop protection compound, it carries the hallmark of rigorous production and ground-level knowledge. That’s what sets us apart in the vast field of chemical manufacturing—we stay close to the molecules, and closer still to the hands that use them.

    Continuous Investment in Precision and Safety

    We put new resources and upgrades into our dithiolane production every year. This includes state-of-the-art reaction controls, enhanced vent scrubbing, and better digital recordkeeping. Our control room tracks every tank, with staff rotating across stations to keep eyes on every step. Interlocks, alarms, and emergency cutoffs go through monthly verification. This kind of discipline reveals itself in the long-term stability of our final product.

    Many improvements come from staff recommendations. We invite every operator to report process oddities or suggest equipment tweaks. In many cases, their early warning sharpens our entire operation. From re-balancing centrifugal pumps to adjusting reactor insulation, these ground-level changes keep our material true to spec and easy to work into varied applications.

    Because we work directly with shipping lines and on-site contractors, we reduce handoffs and keep documentation clear from start to finish. That’s a major reason downstream users circle back—they trust the transparency and detail that comes from the source.

    Looking Forward: Meeting the Demands of Tomorrow’s Markets

    Shifts in regulatory expectations and the move toward greener chemistry shape every product we design. As new application guidelines land across drug, agrochemical, and electronics sectors, our teams keep knowledge fresh and look for ways to make processes more efficient and sustainable. Whether it means retooling synthesis routes to cut energy use or reformulating for better safety, we begin with what we learn from each run and each customer conversation.

    New markets and molecules bring unexpected questions and challenges. Our focus stays on quality, support, and partnership. While the path forward includes more automation and digital transformation, nothing replaces the human judgment and problem-solving tradition fostered by manufacturing Ethyl 1,3-Dithiolane-2-Carboxylate for real-world innovators. Every drum, every kilogram, reflects the layers of care, adaptation, and experience we build together with the people who depend on us.