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(E)-1-Chlorobut-2-Ene

    • Product Name (E)-1-Chlorobut-2-Ene
    • Alias (E)-1-chloro-2-butene
    • Einecs 211-249-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    735002

    Iupac Name (E)-1-chlorobut-2-ene
    Molecular Formula C4H7Cl
    Molar Mass 90.55 g/mol
    Cas Number 928-49-4
    Appearance Colorless liquid
    Density 0.91 g/cm3
    Boiling Point 78-80°C
    Melting Point -110°C (approximate)
    Refractive Index 1.434
    Solubility In Water Insoluble
    Vapor Pressure 56 mmHg at 25°C

    As an accredited (E)-1-Chlorobut-2-Ene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100 mL amber glass bottle sealed with a Teflon-lined cap, labeled "(E)-1-Chlorobut-2-ene, 100 mL, hazardous, flammable."
    Shipping (E)-1-Chlorobut-2-ene should be shipped in tightly sealed containers made of compatible materials, clearly labeled, and protected from physical damage. It must be transported in accordance with local, national, and international regulations for flammable and potentially hazardous chemicals. Avoid exposure to heat, open flames, or sources of ignition during transit.
    Storage (E)-1-Chlorobut-2-ene should be stored in a tightly sealed container, away from direct sunlight, heat sources, and ignition sources. Store in a cool, dry, and well-ventilated area, separate from oxidizing agents and strong bases. Ensure that appropriate safety measures, such as ground for flammable liquids and proper chemical labeling, are in place to avoid accidental release or reaction.
    Application of (E)-1-Chlorobut-2-Ene

    Applications of (E)-1-Chlorobut-2-Ene in Industrial Manufacturing

    (E)-1-Chlorobut-2-ene serves as a specialized intermediate within several precision chemical manufacturing streams. Below we detail its established downstream applications, including process integration stages, industry benchmarks, and formulation parameters as practiced by leading industrial users.

    1. Pharmaceutical Intermediate Synthesis

    Leading pharmaceutical plants employ (E)-1-Chlorobut-2-ene in alkylation reactions for selective side-chain construction on complex heterocyclic compounds. Its use is concentrated in the manufacturing of anti-infective and cardiovascular drug intermediates that demand geometrically pure olefinic precursors to maximize downstream yield and minimize isomeric impurities.

    Industry compliance standards

    • ICH Q7A: Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients
    • USP–NF: United States Pharmacopeia, National Formulary standards for process intermediates
    • European Pharmacopoeia (Ph. Eur.) general monographs for synthesis-grade reagents

    Typical usage ratio

    • 0.8–1.3 molar equivalents per target substrate, tailored based on nucleophilic substitution efficiency and in-process analytical controls

    Downstream process integration

    • Enters as an alkylating agent in Stage 2 or 3 of heterocycle synthesis; typically handled under inert atmosphere and low moisture to restrict byproduct formation

    Final product types

    • Active pharmaceutical ingredients (APIs) for beta-blockers and antifungal agents
    • Registered drug intermediates for GMP manufacturers

    2. Crop Protection Active Ingredient Manufacturing

    Agrochemical companies incorporate (E)-1-Chlorobut-2-ene during the synthesis of specific herbicidal and insecticidal actives that require functionalized chlorinated alkene segments. Its geometric isomerism supports strict selectivity during condensation or addition reactions in large-scale batch and continuous processes.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 Quality Management System for Agrochemicals
    • European Union Regulation (EC) No 1107/2009 for plant protection active substances

    Typical usage ratio

    • 2–4% by weight of total formulation batch size, with adjustments according to required halogen incorporation and final purity specifications

    Downstream process integration

    • Reacted in early-stage chlorination or olefination units, generally under controlled exothermic reaction conditions; precise dosing minimizes side reactions leading to off-spec actives

    Final product types

    • Technical-grade pesticides and herbicides
    • Custom-synthesized agrochemical intermediates supplied to formulators

    3. Synthesis of Polymer Modifiers and Reactive Monomers

    Specialty resin and plastics manufacturers utilize (E)-1-Chlorobut-2-ene as a building block to introduce allyl and chloro functionalities into custom monomer feeds. Its reactivity under free-radical and ionic polymerization routes enables precise tailoring of thermal and mechanical properties in end resins, adhesives, and surface coatings.

    Industry compliance standards

    • REACH (EC 1907/2006) Registration, Evaluation, Authorisation and Restriction of Chemicals
    • RoHS Directive (EU 2011/65) for restricted substances in electrical/electronic polymers
    • ISO 14001:2015 for environmental management in chemical processing plants

    Typical usage ratio

    • 0.5–2.0 parts per hundred resin (phr), fine-tuned to achieve target crosslinking density or introduction of functional sites in polymer backbone

    Downstream process integration

    • Fed into polymerization reactors as a chain modifier or comonomer, often in pre-blended form with initiators and plasticizers

    Final product types

    • Modified thermoset and thermoplastic polymers (e.g., functionalized polyvinyl chloride and polyacrylate resins)
    • Specialty adhesives and high-solid surface coatings

    4. Fine Chemical Synthesis for Fragrance Ingredients

    Manufacturers in the aroma and perfumery sector employ (E)-1-Chlorobut-2-ene for controlled chain extension through Grignard and addition reactions, enabling the creation of key intermediates for musky and woody fragrance notes. Stringent geometric and purity specifications are essential to prevent the formation of unwanted olfactory byproducts.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • ISO 9001:2015 Quality Management Systems for flavor and fragrance compounds
    • EU Regulation (EC) No 1223/2009 on cosmetic products

    Typical usage ratio

    • 0.3–0.7 molar equivalent relative to initial reactant, with real-time adjustment based on target synthetic pathway and aroma yield

    Downstream process integration

    • Introduced during intermediate condensation or chain-elongation reactions in controlled-reactor fragrance synthesis lines

    Final product types

    • Bulk fragrance intermediates
    • Finished aroma chemicals for fine perfume compounders

    5. Specialty Intermediate for Rubber Additive Production

    Producers of industrial rubber formulations select (E)-1-Chlorobut-2-ene for its ability to introduce controlled unsaturation and halogenation into activator and vulcanization accelerator molecules. This directly affects the crosslinking efficiency and service life of the finished rubber components, especially in tire and gasket manufacturing.

    Industry compliance standards

    • ASTM D2000 Standard Classification System for Rubber Products
    • ISO 9001:2015 for rubber chemicals manufacturing
    • European Directive 2000/53/EC (ELV) regarding end-of-life vehicles and automotive parts

    Typical usage ratio

    • 1.5–3.0% by weight in additive blend, dependent on target vulcanization kinetics and final application requirements

    Downstream process integration

    • Involved mid-stream during additive synthesis before masterbatch compounding in rubber mixing lines

    Final product types

    • Vulcanization accelerators and crosslinking agents
    • Functional rubber additives for performance tires, hoses, and industrial seals
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    Certification & Compliance
    More Introduction

    (E)-1-Chlorobut-2-Ene: Supporting Synthesis and Specialty Manufacture

    Understanding (E)-1-Chlorobut-2-Ene from the Production Line

    Each batch of (E)-1-Chlorobut-2-ene rolling out of our reactor draws on years of practical knowledge gained from scaling alkyl chlorides. This compound, with formula C4H7Cl, has found itself squarely in the toolkit of many industrial manufacturers. Compared to similar molecules, the (E)-isomer's distinct linear geometry brings a set of properties that can be leveraged for selectivity in synthesis. Our plant produces this compound in volumes suitable for pilot trials and ongoing commercial-scale campaigns.

    In the past, our teams have fielded requests for both the (E)- and (Z)- isomers, but experience confirms that most synthesis teams favor the (E) configurational layout. This comes down to steric effects and reaction control, details that matter when scaling the alkene addition reactions into hundreds or thousands of liters. The (E)-1-chlorobut-2-ene offers less crowding near the double bond, so downstream transformations such as nucleophilic substitutions often proceed with improved yields. Handling and downstream reaction planning become more straightforward because the impurity profile is predictable.

    Technical Specifications Offered by Real Production

    On our processing floor, we track purity using online gas chromatography, always pushing for 98% minimum assay. Minor content of cis-isomer and saturated by-products stays in check through careful controls. The true test, though, is how these specifications hold up batch after batch. Poor batch consistency grinds operations to a halt in downstream coupling, Grignard-type chemistry, or catalyst-driven additions. Controlling isomer purity helps avoid costly surprises later, where even a fraction of the wrong isomer can undermine selectivity or poison a catalyst.

    Our crew has learned the hard way that batch-to-batch reproducibility matters as much as meeting spec sheets. Outliers in impurity content show up fast on analytics, but their trace influence gets noticed by users long before any alarms. By maintaining reliable distillation and regular analytical checks, we avoid the cycle of troubleshooting that eats up production time. In practical terms, this means end-users don’t have to adjust their process mid-way or deal with residues fouling equipment.

    How Manufacturers Put (E)-1-Chlorobut-2-Ene to Work

    From the first kilo we shipped, it became clear most users employ (E)-1-chlorobut-2-ene as an intermediate. The compound plays a key part in constructing building blocks for agrochemicals, pharma APIs, and advanced materials. Its chloroalkene motif is reactive in a controlled way, lending itself to a range of modifications. Common practice in our customer base involves coupling this alkene with nucleophiles to place functional groups along its backbone, or carrying out addition-elimination transformations. This allows process chemists to dial-in structures at a molecular level.

    One significant application benefits from the fact that this isomer resists unwanted isomerization under mild conditions. Downstream products retain their geometry, a property that makes a difference in chiral or asymmetric synthesis protocols. Where other alkenyl-chlorides can racemize or rearrange under base or heat, this compound holds its integrity better, leading to cleaner product profiles coming off the line.

    Distinctives Versus Other Alkenyl Chlorides

    Plenty of options fill the market for chloroalkene intermediates, ranging from the simpler vinyl chloride to longer-chain cousins. A frequent question concerns why someone would choose (E)-1-chlorobut-2-ene over 3-chloropropene or bulk vinyl chloride. The answer is in both the structure and the reactivity. The four-carbon backbone gives greater flexibility for constructing target molecules with side groups. Its double bond placement and (E)-configuration provide a broader window for synthetic steps without generating unwanted branching or over-chlorination.

    Process engineers appreciate that (E)-1-chlorobut-2-ene resists off-pathway reactivity more than some of the small, highly volatile vinyl compounds. The boiling point offers a practical advantage during distillation and solvent removal, reducing fugitive losses and exposure concerns. Working directly with the molecule during process design, we’ve noticed the straightforward phase separation saves time on workup and reduces solvent consumption compared to products that require intricate extractions.

    Storage and Handling: Daily Realities in the Plant

    Handling chlorinated alkenes has never been the easiest task in an industrial setting. Over time, we’ve developed safe container protocols and continuous monitoring in storage. Purity preservation starts right from the reactor. We use lined containers, controlling temperature and headspace to avoid hydrolysis or polymerization. This keeps the product in spec until the last drop reaches downstream users. Even a short lapse in storage standards can degrade a batch, which is why training and regular audits remain part of daily operation.

    Operators who have handled a variety of alkenyl chlorides know that fumes and vapor-phase migration present real hazards. Based on years managing hazardous chemicals ourselves, we recommend fixed ventilation near decanting points. Handling routines draw heavily on actual events where operators flagged a potential risk, feeding back improvements every time. It’s always better to invest on the preventive side, as lessons in the field cost more once ventilation, PPE, or detection fail.

    Supply Chain and Logistics Informed by Manufacturing Realities

    Building a reliable supply chain for (E)-1-chlorobut-2-ene did not come easy. We have to consider road, rail, and on-site piping for bulk movement, each introducing its own risks for contamination or loss. Our own lessons came from losing a partial load during a rail transfer, showing the importance of compatible gaskets and loading seals. Cross-contamination with unrelated chlorinated solvents once cost us two days of cleanup and left a permanent mark in our procedures.

    From this, we tuned our logistics to include intermediate QC points: on dispatch, at receiving, and during long-term storage. Bulk users with their own blending or reaction steps often draw product straight into process lines—so we synchronize batch records with real-time analytical data instead of relying solely on end-of-line checks. These habits took years to cement, but they shaved hours off response times when a spec deviation happened.

    Perspectives on Regulatory and Environmental Impact

    Chlorinated intermediates always draw scrutiny from environmental teams, and (E)-1-chlorobut-2-ene is no exception. From our end, we treat emissions control as non-negotiable, knowing both the health impacts and the regulatory realities. Modern process design here integrates vapor recovery and closed-loop transfer to curb fugitive losses. The last process upgrade reduced stack emissions by more than half, a direct result of chemists and engineers collaborating on vapor balance rather than paper exercises.

    Byproducts pose a real waste challenge. We moved from venting and open draining to contained neutralization long ago, converting potential liabilities into controlled solvents or saleable fractions. Some downstream partners even take spent chlorinated streams as feedstock, which cuts both disposal cost and life-cycle environmental impact. From our experience, direct communication with local regulators and tracking site-specific air, water, and soil data win more credibility than promotional claims on paper.

    Staying Ahead: Adapting Production in a Shifting Industry

    Like other specialty chemical producers, we respond to resource price swings, emerging regulatory changes, and shifting customer requirements. Ten years back, the trend slanted towards high-volume, low-margin applications. Now, the requests run niche-specific: fluorination chemistry, custom isomer ratios, or tighter impurity controls. Our crew adapts through modular reactor design and real-time process analytics—keeping true to supply commitments, but quick to respond if customer priorities shift.

    Sourcing raw materials for chlorinated chemicals brings its own pain points. The chlorine gas feedstock, organometallic bases, and even cooling water all pose constraints. Any rupture or purity slip in one feed tank can snowball downstream before sensors even catch up. We’ve lost product due to unspotted iron corrosion or miscalculated time on a column—mistakes that burned lessons into operating manuals. By building parallel streams and investing in predictive sensor maintenance, our plant maintains steadier output and meets increasingly fine-tuned customer specs.

    Collaborative Problem Solving and Moving Forward

    Problems in our line rarely stay solved unless everyone plugs in. Synthetic chemists, plant engineers, QC analysts, and logistics planners meet each week and revisit batch histories. If reactivity changes or a customer notes unusual residues, we can pull archived analytic runs and narrow down the root. This hands-on loop means we’re not guessing based on theory but grounding action in field data.

    Feedback loops aren’t about box-ticking or covering mistakes; they’re our only defense against complacency. Even incremental gains—clipping half a percent off an impurity, trimming downtime by forty minutes, or tightening lot tracking—add up given the volumes at play. Open-door habits with our clients flush out mismatches before they snowball into plant-wide disruption.

    Why Consistency and Relationships Matter in Specialty Chemistry

    The (E)-1-chlorobut-2-ene market isn’t just about product-on-paper or the perfection of a synthetic route. It’s often about how fast problems can be predicted and solved, how open the feedback channel is between user and producer, and whether every shipment matches the last in practice. From the production side, hard-won relationships smoothed our transition from a regionally focused plant to a manufacturer serving global customers across research, development, and scaled campaigns.

    Our technical teams don’t wait for formal complaints. They work with R&D, monitoring downstream applications to ensure the product does what the spec says. End users who run real pilot trials sometimes flag up reaction quirks. Instead of brushing these aside, we build them back into next runs. Sometimes this means adjusting hold temperatures, distillation cut-points, or tweaking cleaning regimens between campaigns. That commitment to reciprocal improvement leads not only to better batches but also stronger trust between producer and client.

    Drawing the Line Between (E)-1-Chlorobut-2-ene and Similar Products

    Customers new to (E)-1-chlorobut-2-ene often ask: does it replace simpler chlorinated alkenes in all reactions? Experience answers no. Each homolog or regioisomer finds its niche by how it reacts, the products it enables, and, often, by how it gets handled in a plant environment. (E)-1-chlorobut-2-ene slots in where modest chain length, predictable reactivity, and stability under moderate process conditions trump the volatility or higher reactivity of the shorter-chain alternatives. It outperforms in multi-step synthesis where intermediate stability counts as much as initial conversion yield.

    Complex agrochemical syntheses, API construction, or polymer precursor production benefit most when the intermediary does not degrade or domino-react unexpectedly. Over and over, processes built around this compound report lower rates of polymerization byproducts. Reaction times hit their targets to the hour, not days, and separations rarely call for extraordinary measures. For specialty manufacturers like ourselves, this not only means fewer hiccups during scale-up but also less scrapped material due to irrecoverable side-reactions.

    Ongoing Challenges and Solutions Backed by Experience

    Running specialty chemicals isn’t free from obstacles. Changes in regulations, fluctuations in raw material quality, equipment wear, and the unpredictable realities of logistics all present hurdles. From leaks in the chlorination feed lines to instrument drift, every plant faces its series of wake-up calls. What keeps us ahead is layers of redundancy—backup tanks, parallel analytical methods, split-batch isolation—methods learned from hours in the control room, not just theory.

    On the technical side, improving product quality rarely depends on one piece of cutting-edge equipment. Instead, gains come from cumulative adjustments. Reducing hold periods, cutting turnaround between runs, organizing maintenance during actual idle time—all these tweaks support a cleaner, more reliable output. These hands-on refinements let us guarantee that every liter received by downstream customers delivers the expected result in yield, selectivity, and downstream refinement.

    Looking Forward with (E)-1-Chlorobut-2-Ene

    (E)-1-chlorobut-2-ene’s place in advanced manufacturing grows as specialty syntheses become more nuanced and as environmental controls tighten. Our factory is no stranger to adapting chemistry to suit both old and emerging uses. As more industries push toward tailored molecules—unique polymers, targeted delivery systems, or greener reaction sequences—the chemistry of (E)-1-chlorobut-2-ene offers a stable foundation to build from.

    Working as a chemical manufacturer means the real product is consistency and trust, as much as what comes off the distillation tray. Every upgrade, new reactor, or process change gets judged by whether it makes batches better and cleaner, or just flashes more on a spreadsheet. Our experience with (E)-1-chlorobut-2-ene keeps steeling us for tomorrow’s chemistry, reflecting a knowledge base built on daily plant life, customer feedback, and thousands of hours on the line. This is how our teams keep chemistry moving, batch after batch—grounded in experience, ready for what’s next.