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Dl-Threonine Hydrate(2:1)

    • Product Name Dl-Threonine Hydrate(2:1)
    • Alias dl-threonine-hydrate-2-1
    • Einecs 242-409-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    870066

    Chemicalname Dl-Threonine Hydrate(2:1)
    Casnumber 837-23-4
    Molecularformula C8H18N2O6
    Molecularweight 254.24 g/mol
    Appearance White crystalline powder
    Solubility Soluble in water
    Meltingpoint 248-250°C (decomposition)
    Phvalue 5.0-6.5 (10 g/L, H2O, 20°C)
    Storagetemperature 2-8°C
    Purity ≥98%
    Synonyms DL-Threonine hydrate (2:1); DL-2-Amino-3-hydroxybutyric acid hydrate

    As an accredited Dl-Threonine Hydrate(2:1) factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Dl-Threonine Hydrate (2:1), 100g, is packaged in a sealed, amber glass bottle with a screw cap for safe storage.
    Shipping Dl-Threonine Hydrate (2:1) is shipped in tightly sealed containers to prevent moisture absorption and contamination. The chemical is packed according to relevant safety regulations for transport. It is stored at controlled room temperature, protected from direct sunlight, and clearly labeled to ensure safe and compliant handling during transit.
    Storage Dl-Threonine Hydrate (2:1) should be stored in a tightly sealed container, away from moisture and incompatible substances. Keep the storage area cool, dry, and well-ventilated, ideally at room temperature (15–25°C). Protect from excessive heat, light, and direct sunlight. Ensure proper labeling and prevent exposure to strong oxidizing agents to maintain the compound's stability and purity.
    Application of Dl-Threonine Hydrate(2:1)

    Applications of Dl-Threonine Hydrate(2:1) in Industrial Manufacturing

    As a direct manufacturer specialized in Dl-Threonine Hydrate(2:1), we supply this amino acid derivative to core sectors with established, regulated usage. The following sections outline primary industrial applications, focusing on real-world downstream scenarios with specific compliance protocols, formulation guidelines, process steps, and representative end-use products.

    1. Nutritional Additives in Feed Premix Manufacturing

    Feed premix producers rely on Dl-Threonine Hydrate(2:1) as a precise nutritional fortifier, addressing amino acid balance in compound feeds for poultry and swine. Its solubility profile supports seamless dry blending and ensures targeted release during pelleting and extrusion, thereby optimizing utilization rates in high-density operations. Formulators adjust inclusion rates to protein sources and animal species, ensuring digestibility while meeting stringent residue controls.

    Industry compliance standards

    • FAMI-QS Code (Quality and Safety System for Specialty Feed Ingredients and their Mixtures)
    • EU Commission Regulation 1831/2003 (Feed Additives Authorization)
    • US FDA 21 CFR 573.890 (Amino Acids as Feed Additives)
    • China Feed Additive Product Standards (GB/T 7301)

    Typical usage ratio

    • 0.02%–0.2% of total compound feed, with lower dosage for broiler, higher for piglet diets; adjusted based on amino acid profile of base proteins

    Downstream process integration

    • Premix blending and homogeneous dispersion into base feed formulations prior to heat treatment (pelleting or extrusion)

    Final product types

    • Poultry and swine compound feeds
    • Vitamin-mineral premixes
    • Protein concentrate blends for livestock

    2. Pharmaceutical Synthesis of Amino Acid Infusion Solutions

    Manufacturers of parenteral nutrition solutions utilize Dl-Threonine Hydrate(2:1) as a defined ingredient in balanced amino acid infusions, conforming to pharmacopoeial purity and sterility demands. It enters formulation following rigorous raw material inspection, and precise metering maintains osmolarity and nutrient requirements for intravenous administration. The material supports stable shelf life in aqueous environments under validated process controls.

    Industry compliance standards

    • USP <1059> (Amino Acids)
    • European Pharmacopoeia Monographs (Ph. Eur. 2.2.3, 2.5.12 for Amino Acid Solutions)
    • Good Manufacturing Practice (cGMP, ICH Q7)
    • China Pharmacopoeia (ChP 2025 Edition)

    Typical usage ratio

    • 0.3%–2.0% w/v in multi-amino acid parenteral infusion concentrates; formulated based on clinical nutrition protocols and target osmolarity

    Downstream process integration

    • Solution compounding, sterile filtration, and terminal sterilization prior to packaging in infusion containers under controlled atmosphere

    Final product types

    • IV amino acid infusion solutions
    • Total Parenteral Nutrition (TPN) bags

    3. Food Ingredient in Fortified Sports Nutrition and Medical Foods

    Producers of specialized sports supplements and clinical nutrition foods employ this ingredient for precise amino acid composition in powdered or liquid blends. Strict food-grade purity and allergen-free status ensure suitability for direct human consumption. Its crystalline form facilitates accurate dosing during batch blending, with stability in both shelf-stable and ready-to-mix products, supporting nutritional labeling and claim substantiation.

    Industry compliance standards

    • FCC (Food Chemicals Codex) Specification for Threonine
    • EU Regulation (EC) No 1333/2008 on Food Additives
    • US FDA 21 CFR 172.320 (Amino Acids As Nutrient Additives)
    • FSSC 22000 (Food Safety System Certification)

    Typical usage ratio

    • 0.05%–1.5% in sports drink powders and clinical formulas; precise inclusion dependent on product nutritional profile and target protein content

    Downstream process integration

    • Dry mixing or direct addition to liquid bases before homogenization and packaging

    Final product types

    • Protein-enriched beverage powders
    • Oral nutrition supplements for special medical purposes
    • Meal replacement shake mixes

    4. Biotechnological Cell Culture Media Manufacturing

    Bioprocess engineers in fermentation and cell culture operations utilize the compound as an essential component in basal and specialized culture media, supporting bacterial, yeast, and mammalian cell growth. High lot-to-lot consistency and trace impurity control align with process validation protocols for APIs or recombinant protein production. The amino acid commonly enters the process at sterile media preparation, contributing to reproducibility in biomanufacturing runs.

    Industry compliance standards

    • ISO 13408 (Aseptic Processing of Healthcare Products)
    • ICH Q5A (Quality of Biotechnological Products)
    • USP <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products
    • EMA Guidelines for Raw Materials in Biotechnology

    Typical usage ratio

    • 1–5 mM final media concentration, with adjustment based on cell line nutritional demand and bioreactor scale

    Downstream process integration

    • Added during sterile media preparation, prior to inoculation and fermentation or bioreactor cell culture step

    Final product types

    • Cell culture media powders and liquids
    • Fermentation broths for API and biotherapeutic production

    5. Chemical Synthesis in Peptide Manufacturing

    Custom peptide and oligo manufacturer facilities incorporate this amino acid as a protected or free-form monomer in stepwise solid-phase synthesis. The hydrate form supports controlled hydrolytic stability and reactivity under mild deprotection or coupling reactions. Quantitative addition and monitored conversion rates are essential for purity and batch record traceability, supporting regulatory filings in downstream active ingredient development.

    Industry compliance standards

    • ICH Q7 API GMP Guidelines
    • US FDA 21 CFR Part 211 (Finished Pharmaceutical Goods Manufacturing)
    • ISO 9001:2015 (Quality Management Systems for Chemical Synthesis)
    • European Pharmacopoeia General Chapters on Peptides

    Typical usage ratio

    • Stoichiometric to 1.5x molar excess per coupling step; precise quantity based on synthesis length and protecting group strategy

    Downstream process integration

    • Input during monomer activation and sequential chain elongation on solid-phase or in solution during peptide assembly

    Final product types

    • Synthetic peptide APIs
    • Peptide reference standards
    • Research-grade oligopeptides
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    Certification & Compliance
    More Introduction

    DL-Threonine Hydrate(2:1): Application-Driven Design from the Manufacturer’s Floor

    Understanding the Construction of DL-Threonine Hydrate(2:1)

    DL-Threonine Hydrate(2:1) emerges from a direct synthesis approach, rooted in our commitment to make each batch transparent, traceable, and consistent. The chemical formula, C4H9NO3·H2O, distinguishes this product with a molecular makeup specifically designed for reliable performance in both feed and technical applications. Since 2008, we have refined our annual production lines to optimize solubility and purity, which directly impacts product flow during formulation, transportation, and customer usage stages.

    Straight from our reactors, this hydrate form demonstrates the value of water inclusion—not as an afterthought, but an engineered feature. It improves stability and mailing performance, especially in climates that challenge traditional dry threonine. Over years of monitoring customer feedback, we’ve seen strong preference develop in sectors facing humidity swings or extended storage timelines. Our operators and process engineers keep solubility curves and particle size distributions under daily observation, fine-tuning batches for batch-to-batch reliability.

    Contrast with Other Amino Acid Forms

    This 2:1 hydrate sets itself apart from anhydrous DL-threonine and l-threonine grades available in the market. Many buyers have told us that single isomer forms can cost more per mass unit, especially for less demanding applications, without adding measurable downstream benefits. L-threonine finds its primary niche in animal nutrition, requiring higher purity and specialized delivery. Racemic (DL) forms, especially our hydrate, serve wider usage patterns where cost and accessible handling matter more than chirality.

    Compared to anhydrous powder, DL-Threonine Hydrate(2:1) carries a distinctly lower tendency toward static clumping and dust generation. This feature matters most for bulk blending equipment and pneumatic handling, cutting down on labor for cleanups and keeping workplace air standards safer. Every shift supervisor in our plant can attest to the reduced wear and tear on augers and the lower rate of maintenance events. These outcomes have a direct impact on operational budgets.

    Driving Forces Behind Market Demand

    Global trends toward performance-optimized animal nutrition, fermentation, and specialty feeds have shaped our production roadmap. In practice, feed engineers demand amino acids that supplement protein cost-effectively, especially where plant-based diets lead to limiting essential amino acids. Our DL-Threonine Hydrate(2:1) consistently shows stable output when analyzed in line for purity, moisture, and dissolution speed. We run 12-point testing arrays on each lot to ensure compliance, because nutritionists in the field set their protocols by precise contribution calculations.

    Technical and industrial buyers also rely on this hydrate as a substrate in specific peptide fermentations or coatings. Our discussions with R&D customers highlight the value of consistent hydration: faster dissolution speeds up bioreactor turnaround and reduces hot spots in mixing vessels. Ingredient buyers from pharmaceutical intermediates to specialty coatings have written about batch matching and the peace of mind that comes from every drum meeting spec, without the upcharge of some single-isomer or tailor-modified grades.

    Production Realities: Lessons from the Plant Floor

    Producing DL-Threonine Hydrate(2:1) at scale needs more than raw lab skill. Technicians, automation teams, and logistics partners collaborate across each process step to prevent cross-contamination and off-spec occurrence. Our hydration step, refined through continuous improvement projects, draws on live process analytics and moisture mapping. Engineers have hand-tuned drying sequences to lock in the 2:1 molar ratio without runaway free water, drawing from years of product returns and customer troubleshooting sessions.

    We encounter frequent requests to modify grain size or density. Some customers feed product straight through automated dosing setups, while others prefer finer powder for rapid mixing. Unlike mass traders or packagers, we can adjust the crystallization window and post-crystal treatment so the final bulk density falls into the requested window—an option impossible for resellers who trade only on spot market fluctuations. Having in-house drying, milling, and sieving equipment lets us offer lot-certified, custom-manufactured output to match broad customer patterns.

    Consistent Quality Backed by Operator Experience

    Every regular customer asks about the actual day-to-day controls backing each shipment. Our control room personnel train on error-case examples drawn from over a decade of field reports. Regular protocol validation, spot sampling under live plant conditions, and trace-back analysis form the backbone of our QA approach. Documentation from every hydrate run follows the real-life batch flowsheets used by operators, not just a generic certificate clipped to a bag.

    We have worked with both multinational formulators and local buyers. Field visits and direct customer interviews keep our technical service team grounded in marketplace shifts and practical headaches—like caking inside 1-ton bags during rainy season, or fine dust buildup from improperly dried material. We gather daily sample analysis results into our ERP for direct review, tying production line data to sales order feedback so each subsequent run closes the loop on quality control.

    Specifications with User Impact

    Typical assay values for our hydrate product run above 98.5% calculated on dry basis, with water content tightly controlled around the theoretical hydrate level. These specifications do not appear as marketing fluff; instead, they guide everything from dosing and mixing efficiency to shelf life. Years of feedback from exterior warehouse audits teach us which bag closures and liner materials ward off moisture ingress best. We’ve rejected vendor upgrades promising “universal compatibility” because plant trial data shows shipping conditions matter more than packaging fads.

    For end-use applications, consistent moisture means formulas blend the same every batch, without overages or shortages pushing finished product outside tolerance. At feed mills and blending plants, this makes a measurable difference in daily throughput, complaint frequency, and actual savings on carrier and energy cost. Our technical sales staff have visited livestock barns and chatted directly with mill supervisors cranking out 500 tons a day of finished feed. Downtime isn’t theoretical in these contexts—only practical, observable performance keeps our business relationships strong.

    Product Handling and User Stories

    Large-scale production draws directly from feedback on ease of product handling. Shift leads managing ingredient bins turn to the hydrate form because it resists sticking and demonstrates strong flow through typical gravity-fed bin setups. During hot, humid stretches, we have visited facilities using DL-Threonine Hydrate(2:1) where dust suppression and reduced bridging stood out compared to dry, anhydrous amino acids. These details form as much of the overall value as the chemical purity number alone.

    From technical users, the clarity of dissolution comes forward. Engineers in bioprocess pilot plants have told us how batch repeatability increases when the hydrate is charged to reactor vessels, compared to similar concentrations sourced from dry powder. Our operators have visited pilot lines where minor density deviation created significant concentration errors—issues ironed out as soon as the hydrate became standard. Ease of cleaning in mixing tanks also rates highly, since the hydrate leaves less stubborn residue, cutting downtime on changeovers.

    In regions dealing with fiscal constraints, buyers often ask why not buy lesser-known sources or chase direct-from-Asia spot offers. We work through their sample results together, comparing stability in real warehouse months and actual yields per ton mixed. Multiple buyers have switched back after pilot scale runs with inconsistent off-brand material led to process slowdowns, product returns, and feed performance gaps. The economic calculus becomes clear after factoring measurable downtime, wasted labor, and lost output.

    Environmental and Regulatory Realities

    Our plant design team tackles environmental impacts not as a marketing checkbox but as a calculable, plant-wide imperative. Wastewater from hydrate production is captured and recycled, reducing treatment loads and resource depletion. Local officials and environmental inspectors review our site reports quarterly. We have invested in closed system crystallization and minimized the need for heating during water addition, cutting emissions compared to traditional batch-dry approaches.

    Safety requirements drive daily routines on the site. Each shift logs training hours on personal protective equipment, awareness for ergonomic loading techniques, and GMP compliance. Experience shows small details—properly grounded loading hoppers and antistatic mats around packaging lines—carry more impact over years than the broad, theoretical safety rules alone. Repeat visits from regulatory auditors have underscored the effectiveness of detailed, operator-led checklists compared to catchall documentation.

    Logistics partners moving hydrate products through ports and customs report high compliance rates because our documentation follows the production thread down to each increment number. Nobody benefits from customs detention or cross-border compliance bottlenecks. Making plant access available for periodic buyer tours keeps transparency and trust front and center. Buyers now frequently cite traceability and environmental records as central vendor selection criteria, moving beyond pricing alone.

    Market Realities and Cost Trends

    Our cost buildup reflects real production input prices—fermentation substrates, utilities, skilled labor, and regulatory compliance. While commodity price spikes sometimes push input costs higher, we have built buffer stock and pre-negotiated energy supply contracts, learning from the volatility of 2021–22. This buffers outbound shipments and offers schedule stability to downstream customers, both feed blenders and technical users.

    Price-conscious buyers aim for predictable delivered cost per gram of threonine active ingredient. With hydrate, they receive the assurance of reliable concentration without the swings driven by environmental exposure. We openly compare delivered yield against higher-priced, lower-moisture grades, letting users formulate by total actives on a per-batch basis. Direct plant relationships drive home the central advantage: every kilogram of hydrate that leaves our site flows from a batch tested, tracked, and specifically matched to end-use conversion, not from pooled, anonymized commodity lots.

    Supply chain shifts have forced us to shorten lead times, ramp up flexible packaging lines, and provide extra documentation on shipments crossing regulatory regions. Blenders in Europe and North America now request real-time production traceability, a move we met by adding batch-level digital tagging and on-plant QA signoff. Small changes—like switching from a single liner to a multilayer anti-humidity package or increasing weekly lot sampling—have emerged not from marketing claims but from the lived reality of moving product through changing transit and storage conditions.

    Direct Engagement: How Manufacturer Insight Shapes the Product

    Our relationships go beyond a data sheet handoff. Product managers regularly walk line with bulk ingredient handlers, seeing firsthand what slows down output and what fixes problems on the spot. We borrow learnings from customer R&D trials to update the specification window and prioritize next improvements. These conversations have led to investments in smaller batch runs, specialty order splits, or improved in-process drying, each time responding to a concrete need in the field.

    We stay in direct dialogue with our supply chain and technical service teams, pooling feedback from every market we serve. Issues raised by a site in Brazil—say, handling high humidity or bag seam failures—feed directly into our next run planning and packaging procurement. The product evolves with consolidated, cross-market evidence, not simply in response to the largest buyer. Traceability does not end at production: post-delivery support solves issues as they surface, whether troubleshooting unexpected precipitation on storage or following up on long-haul shipments.

    Direct customers sometimes bring back product for analytical verification. Each returned sample guides both finance and QA staff to align credits or batch restart timelines, balancing site efficiency with supply dynamics. Treating these rare returns as actionable process lessons, not just write-offs, keeps our continuous improvement grounded. Small details in operator shift logs—like agitator torque or first signs of off-color—filter into future production cycle planning, maintaining a tight cycle of feedback and response.

    Commitment to User Experience and Downstream Results

    End-users define the success of DL-Threonine Hydrate(2:1) by actual process outcomes—reduced handling time, consistent blend, and minimized downtime. Technical sales and production sit at the same table to interpret batch data and track evolving user issues. Traceable lot records, formulated with direct operator input, keep quality predictable. No product leaves our site until both line staff and QA sign off on specification and shipment details tied to the real production window.

    The balance point between delivery speed, product quality, and transparent documentation matters more as regulations tighten and downstream buyers consolidate. Large purchasers integrate ingredient traceability into supply chain audits and risk management reviews. By delivering on these points—without marketing hyperbole or unproven performance claims—we sustain durable, growing partnerships with buyers that demand more than transactional supply.

    Our focus on down-to-earth product handling, reliable batch control, and open dialogue sets DL-Threonine Hydrate(2:1) apart in both perception and practice. Industry standards, real-world customer feedback, and hard-earned operator knowledge combine to keep each shipment worthy of the trust placed in our plant. Day in and day out, lessons from field use, audit results, and plant floor experience shape the next upgrade, one run at a time.