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Dl-Methionine Methylsulfonium Chloride

    • Product Name Dl-Methionine Methylsulfonium Chloride
    • Alias Vitamin U
    • Einecs 241-554-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    125366

    Chemical Name Dl-Methionine Methylsulfonium Chloride
    Molecular Formula C6H15ClNO2S2
    Molecular Weight 233.77 g/mol
    Appearance White to off-white crystalline powder
    Solubility Soluble in water
    Melting Point 199-205°C (decomposes)
    Odor Odorless or faint characteristic odor
    Storage Conditions Keep in tightly closed containers, store in a cool, dry, well-ventilated area
    Cas Number 3493-12-7
    Synonyms Methionine methylsulfonium chloride, Vitamin U
    Ph Around 5.0 - 6.0 (1% solution in water)
    Stability Stable under recommended storage conditions
    Usage Often used in feed additives and supplements

    As an accredited Dl-Methionine Methylsulfonium Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed, high-density polyethylene drum containing 25 kg of DL-Methionine Methylsulfonium Chloride; product label includes batch number and safety information.
    Shipping **Shipping Description:** Dl-Methionine Methylsulfonium Chloride should be shipped in sealed, moisture-resistant containers to prevent clumping and degradation. Store and transport under dry, cool conditions, away from incompatible substances. Follow appropriate labeling for chemical transport, ensuring compliance with all applicable local, national, and international shipping regulations for safe handling.
    Storage Store Dl-Methionine Methylsulfonium Chloride in a tightly sealed container, in a cool, dry, and well-ventilated area away from moisture and incompatible substances such as strong oxidizers. Protect from light and direct sunlight. Handle with proper personal protective equipment, and avoid creating dust or inhaling vapors. Ensure proper labeling and restrict access to authorized personnel only.
    Application of Dl-Methionine Methylsulfonium Chloride

    Applications of Dl-Methionine Methylsulfonium Chloride in Industrial Manufacturing

    Dl-Methionine Methylsulfonium Chloride functions as a specialized raw material in multiple industrial sectors. Our manufacturing expertise supports strict process control, aligned with customer formulations across established downstream markets. Main applications range from feed-grade amino acid supplements to pharmaceutical intermediates, veterinary nutrition, and select food additive processes.

    1. Animal Feed and Premixtures

    Commercial livestock producers use Dl-Methionine Methylsulfonium Chloride as a key methyl-donor and methionine source in compound feed formulations. Our clients blend it into poultry, swine, and aquaculture diets for efficient growth and improved feed conversion. The low-dust, water-soluble formulation simplifies micro-ingredient dosing during pelleting or extrusion. Customers maintain consistent animal nutrition profiles while meeting strict regional feed standards.

    Industry compliance standards

    • EU Regulation (EC) No 1831/2003 on feed additives
    • FAMI-QS Code (Feed Additives and Premixtures Quality System)
    • FDA 21 CFR 573.920 (GRAS status for methionine in animal feeds, USA)
    • China GB/T 21910-2008 (Feed Grade DL-Methionine)

    Typical usage ratio

    • Inclusion rates typically 0.1–0.5% of total feed weight for poultry and swine, adjusted based on amino acid balancing and species requirements
    • Aquafeed formulas: 0.2–0.6%, tailored for fish/shrimp species and protein levels
    • Consultation with certified animal nutritionists required for blend adjustments per target performance metrics

    Downstream process integration

    • Incorporated during premix milling or directly during final feed blending (pre-conditioning/compounding stage)
    • Diluted into liquid premixers for micro-dosing in high-speed pellet lines
    • Sampling and lab QC conducted at intake and finished batch release

    Final product types

    • Broiler, laying hen, and turkey compound feeds
    • Starter and grower swine diets
    • Aquafeed for tilapia, carp, catfish, and shrimp
    • Ruminant supplement blocks

    2. Pharmaceutical Intermediate for S-Methylmethionine (Vitamin U) Synthesis

    API manufacturers use Dl-Methionine Methylsulfonium Chloride as a precursor in the semi-synthetic manufacturing route for S-Methylmethionine, also known as vitamin U. The raw material’s purity and trace ion profile allow for direct use in GMP-compliant batch reactors. Synthesis protocols require accurate metering of the methylsulfonium chloride salt to optimize yield and control side reaction levels. Final purification and crystallization steps benefit from the consistent lot-to-lot quality we provide.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients
    • Ph. Eur. (European Pharmacopoeia monographs where applicable)
    • US Pharmacopeia (USP) General Chapter 1078 for raw material quality management
    • China GMP (2020 revision) for synthetic pharmaceutical intermediates

    Typical usage ratio

    • Reactant loading ranges from 1–1.2 molar equivalents relative to substrate methionine in synthetic reactions
    • Fine adjustments to reagent ratios based on targeted API yield and impurity profile per batch
    • Purity specification >99% as determined by HPLC for pharmaceutical production

    Downstream process integration

    • Fed into jacketed stirred reactors with dedicated metering pumps
    • Pivotal in methyl transfer step, followed by phase separation and crystallization
    • In-process controls (IPC) track conversion kinetics and by-product thresholds

    Final product types

    • S-Methylmethionine chloride (Vitamin U API)
    • Gastrointestinal mucosa protection tablets and capsules
    • Combination gastrointestinal drug preparations
    • Clinical nutrition injectable solutions

    3. Veterinary Nutritional Supplements

    Veterinary formula manufacturers integrate our raw material into premix and direct-application nutrition blends for companion animals and livestock. Nutritional supplement brands use it as a source of both methionine and methyl groups for liver health, joint function, and antioxidant support in various animal species. Reliable raw material traceability and residue control allow for use in formulations intended for regulated veterinary markets globally.

    Industry compliance standards

    • EU Regulation (EU) 2019/6 for veterinary medicinal products
    • FDA 21 CFR Part 584 (Feed Additives Permitted in Animal Drugs)
    • Australian Pesticides and Veterinary Medicines Authority (APVMA) guidelines
    • GMP+ FSA Module for feed safety assurance in supply chain

    Typical usage ratio

    • 1–2% in concentrated veterinary supplement premixes
    • 0.2–0.5% in direct use therapeutic nutrition blends for equine or canine applications
    • Dosage determined by animal body weight and clinical protocol

    Downstream process integration

    • Blended in ribbon mixers for premix powders during vet supplement production
    • Injected as solubilized solution for liquid veterinary preparations
    • Subjected to metal detection and micro-contaminant screening prior to packaging

    Final product types

    • Liver support chews for dogs and cats
    • Electrolyte solutions for equine and bovine health
    • Veterinary recovery pastes for livestock
    • Specialty blends for exotic animal nutrition

    4. Food Additive Production (Dietary Supplements)

    Nutraceutical producers utilize our high-purity Dl-Methionine Methylsulfonium Chloride as a controlled ingredient in dietary supplement manufacturing. It provides a natural methyl donor and enhances methionine content in protein fortification blends. Clients blending capsules, tablets, and functional powder drinks rely on our consistent material for batch reproducibility, meeting strict food-grade and additive regulations in established consumer health markets.

    Industry compliance standards

    • Codex Alimentarius General Standard for Food Additives (GSFA)
    • FDA 21 CFR 172.320 (Permitted food additives: amino acids)
    • China GB 2760 National Food Safety Standard for Food Additives
    • ISO 22000:2018 (Food Safety Management Systems)

    Typical usage ratio

    • Per serving inclusion typically 50–500 mg in tablet or capsule formulations
    • 1–2 g per kg in powdered nutritional supplements or meal replacements
    • Formulation specifics depend on health claim targets and labeling laws

    Downstream process integration

    • Dosed during wet or dry blending in cGMP dietary supplement plants
    • Tableting or encapsulation followed by uniformity testing and stability studies
    • Final product qualitative and quantitative amino acid assay prior to release

    Final product types

    • Protein-fortified nutritional powders
    • Multi-amino acid dietary supplement capsules
    • Functional drinks for sports nutrition
    • Protein meal replacement tablets
    Free Quote

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    Certification & Compliance
    More Introduction

    Dl-Methionine Methylsulfonium Chloride: Trusted Amino Acid Chemistry from Our Plant

    Product Insight: What Dl-Methionine Methylsulfonium Chloride Brings to the Table

    Dl-Methionine Methylsulfonium Chloride stands as one of the most reliable methyl donors in the laboratory and industrial landscape. Years on our production floor have shown us it’s not just the molecule that matters—it’s consistency, purity, and how the material reacts during actual use. We have worked hands-on through countless batches, making sure each kilogram lives up to strict quality expectations. Our expertise with amino acid derivatization provides downstream users with predictable results every time they open a bag or drum.

    Our Manufacturing Approach: Reliable Quality in Every Run

    In our own experience, maintaining a stable supply of Dl-Methionine Methylsulfonium Chloride is much more than hitting purity target numbers. Every step, from raw methionine selection to final crystallization, involves hands-on monitoring. We inspect particle size early and ensure chloride incorporation reaches completion. Every month, our staff tracks batch-to-batch color and odor, watching for the faint burning note that signals incomplete methylation. Reactions get shut down early if those warning signs appear.

    Unlike the variations sometimes seen in third-party samples, especially those sourced through undefined processing chains, our material comes with a traceable record straight from our plant. It’s not uncommon for chemists in flavor, pharma, or agricultural R&D to reach out after using lower-grade imports and seeing caking, yellowing, or unexpected byproducts. These create problems in scale-up that run well beyond a simple purity reading on a sheet. Small crystal size clogs hoppers, off-odors leach into premixes, and uneven moisture content affects solubility.

    Specifications That Matter in Real-World Use

    For Dl-Methionine Methylsulfonium Chloride, technical buyers and lab staff focus on true content, solubility, and chloride ion presence. We keep the methionine methylsulfonium content tightly controlled, keeping the typical range above 99 percent by HPLC with low variance. Moisture content often separates good product from mediocre supply. Moisture above 2 percent, for example, can trigger caking and unpredictability in aqueous solutions. We maintain tighter control, supporting longer shelf life and easy handling in real-world plant conditions.

    Solubility is another key trait. Producers relying on this material for methylation steps in synthetic pathways see unpredictable yields if chloride balance veers even slightly. We keep close control over residual inorganic chloride. The white crystalline powder mixes quickly into water at room temperature—which chemists find essential when working to transfer batches between vessels or preparing stock solutions for fermentation media.

    Usage: Where Dl-Methionine Methylsulfonium Chloride Excels

    The best-known application for this compound stands in animal nutrition, where it supports methyl group transfer and helps meet essential amino acid requirements for poultry and swine. Feed millers who work with our batches see improved flow properties in mixing lines—a result of our choice of crystal morphology and low dust tendency. Nutrition researchers depend on purity when designing metabolic studies: off-flavors or chemical residues, even at low levels, can throw off results in animal trials and mask genuine nutrition benefits.

    Another core use lies in biochemistry laboratories, as a source of bioavailable methyl groups. Enzymatic reactions involving methionine analogs need stable, predictable starting material. That’s why biochemists with demanding protocols turn to material with verifiable lot history, minimized side-products, and clear documentation.

    Pharmaceutical developers working on methylation-dependent transformations value well-characterized reagent supply. From our control of impurities to our quick, technical support during new process scale-up, we supply more than just a chemical—they get a supplier partner invested in every metric of their project’s success.

    Comparison with Other Methionine and Methylsulfonium Products

    Many in the industry compare Dl-Methionine Methylsulfonium Chloride with regular Dl-Methionine and methylsulfonium-based alternatives—each serves a distinct market need. Regular Dl-Methionine offers value purely as a sulfur amino acid, lacking the methylsulfonium function essential for certain biochemical or synthetic roles. Feed producers who want an extra methyl donor look for the ‘methylsulfonium chloride’ group—we build production schedules to ensure consistent deliveries for these clients to avoid the disruptions caused by switching materials mid-formulation.

    Other methylsulfonium chloride products can differ in crystal habit, color, or guaranteed purity. We’ve visited production facilities in several regions and observed that process differences—reaction conditions, raw material quality, filtration steps—cascade into product quality. Packages arriving with fine dust, yellow discoloration, or residual solvents hint at rushed processing. Over years, we have overhauled our crystallization and drying systems to remove these error sources, aiming for an odorless, free-flowing product that works the same month after month.

    Customers sometimes ask if it’s worthwhile to accept slight color or crystalline differences as long as minimum methionine content is met. Experience says otherwise: Variances here recur in pellet press machines, compounding extruders, and – most of all – in shelf stability across long logistics chains. Labs and production floors both benefit from the peace of mind that comes with consistent starting materials that don’t shift between batches.

    Product Handling and Practical Advantages

    We’ve received plenty of real-world feedback from operators who load mixers or dosing units every day. Fine differences in crystal structure affect dust generation, which causes product loss and potential health hazards. Over time, we refined our drying method to reduce fines while keeping the powder free-flowing and simple to scoop or pour.

    In bulk storage, materials that tend to absorb moisture quickly can develop hard clumps, slow addition rates, or even cause mechanical blockages in feeding systems. Production teams have told us they appreciate our drier product after experiencing these problems with earlier, higher-moisture blends. Our focus on airtight packaging with moisture barriers further preserves the product through shipping and storage, especially in humid climates or open-warehouse environments.

    Supporting Claims with Our Own Data and Experience

    Our plant’s focus on transparent documentation means every lot ships with manufacturing records, test data, and storage recommendations. Internal audits confirm sample retention protocols, so if a question arises years down the line, our technical team can trace back every production parameter. This commitment builds trust not by claims on a label, but by ongoing, responsive support when issues or questions surface.

    Feedback gathered from our partners—feed integrators, research groups, and pharmaceutical developers—drives incremental improvements each year. We’ve revised our drying parameters, switched to more inert packaging films, and invested in better internal QC analytics, all because end users took the time to share pain points and performance goals. Working at the source of production provides flexibility to troubleshoot, adapt, and test solutions in real time.

    Solving Real Industry Problems, Not Just Selling a Product

    We see ourselves as partners to our customers, not just suppliers. Years of working closely with field nutritionists, R&D chemists, and purchasing staff have taught us that packaging, labeling, and technical support often weigh as heavily as purity data when selecting a material. Missing or ambiguous labels create delays and regulatory headaches. Inconsistent appearance undermines user confidence. Slow answers to technical questions hold up pilot trials or delay production reruns. We have put priority on prompt, detailed responses and clear labeling in every shipment we handle.

    The difference between a product straight from our plant and one handled by multiple intermediaries starts with traceability. Especially in regulated or export-driven segments, knowing the full production background supports regulatory needs, minimizes risk of non-compliance, and helps clients ace their own audits. This attention to the manufacturing chain matters to every stakeholder—from plant operator to quality manager.

    The Value of Manufacturer Experience in Everyday Use

    Much of the so-called “commodity” segment in chemical supply has waned under the weight of opaque sourcing and communications breakdown. We’ve built our business on the premise that direct knowledge of every batch, from feedstock to final packaging, yields better outcomes for everyone. Feedback loops—simple things like a call from a mixer operator about stuck powder, or a report from the QC chemist—lead straight to process improvements. This direct ownership of both successes and problems underpins our production philosophy.

    Longevity in methionine chemistry also gives us the depth to adapt when downstream users face shifting specifications or regulatory trends. New demands for labeling transparency, shifts in import tolerances for trace contaminants, or sudden technology changes (such as shifts in premix blending practices) filter up to us almost immediately. Having our own technical resources on site lets us retool and revalidate materials at speed, which intermediaries just can’t do.

    Meeting Future Needs with Ongoing Investment

    Chemical production does not stand still. The real challenges come from the edge cases—outlier batches, tricky applications, new regulatory rulings. To meet these, we reinvest in staff training, laboratory upgrades, process controls, and open communication up and down the supply chain. Over time, that investment pays off not only in fewer recalls and complaints, but also in customers who treat us as part of their own production team.

    Our plant teams routinely review feedback and performance trends not just for compliance but for practical improvement. As an example, repeated requests from export clients for lower chloride levels prompted a round of process optimization, using ion chromatography to tune our washing steps. These changes came directly from user need—not abstract standards—and made a real difference in product adoption rates. This cycle of listening and responding keeps our Dl-Methionine Methylsulfonium Chloride relevant in a demanding industry.

    Real-World Results Shape Our Perspective

    Experience has shown again and again: chemical manufacturing demands more than technical competence. We earn long-term trust by listening, addressing pain points quickly, and taking ownership from raw material to final package on the customer dock. Transparent, honest communication—especially about limits, challenges, or improvement opportunities—forms the nexus of successful supplier partnerships.

    With Dl-Methionine Methylsulfonium Chloride as with any specialty chemical, the true value lies in process know-how, delivering consistent supply, and being ready to tackle and resolve surprises. This material, built on years of refinement and tight quality focus, reflects our hard-won experience as producers—not just packers or traders. The determination to improve, batch after batch, ensures industry users get more than just a chemical—they benefit from a manufacturer’s full experience, invested in their long-term results.