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Dl-Mandelic Acid

    • Product Name Dl-Mandelic Acid
    • Alias alpha-hydroxyphenylacetic acid
    • Einecs 202-007-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    877387

    Chemical Name DL-Mandelic Acid
    Cas Number 611-72-3
    Molecular Formula C8H8O3
    Molecular Weight 152.15 g/mol
    Appearance White crystalline powder
    Solubility Soluble in water, alcohol, and ether
    Melting Point 119-122°C
    Density 1.30 g/cm3
    Ph Value 2.0-3.0 (10g/L solution)
    Odor Odorless
    Optical Activity Racemic mixture (DL-form)
    Storage Conditions Store in a cool, dry place, tightly sealed
    Stability Stable under normal conditions
    Ec Number 210-277-1

    As an accredited Dl-Mandelic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Dl-Mandelic Acid is packaged in a sealed, amber glass bottle containing 100 grams, labeled with product details and safety information.
    Shipping Dl-Mandelic Acid is shipped in tightly sealed containers to protect it from moisture and contamination. Packages comply with chemical safety regulations, featuring clear labeling and hazard information. It is transported by ground or air, following all applicable local and international shipping guidelines for handling and storage of chemical substances.
    Storage Dl-Mandelic Acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and bases. Protect it from moisture, direct sunlight, and sources of ignition. Ensure the storage area is clearly labeled and complies with safety regulations to prevent accidental exposure or contamination.
    Application of Dl-Mandelic Acid

    Applications of Dl-Mandelic Acid in Industrial Manufacturing

    As a direct manufacturer, we supply Dl-Mandelic Acid primarily to four key industrial sectors. Our raw material supports compliance, precise formulation, controlled integration, and diverse product outputs in pharmaceutical synthesis, cosmetic ingredient production, specialty chemical manufacturing, and analytical reagent preparation.

    1. Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis

    Dl-Mandelic Acid plays a critical role as a chiral intermediate in the synthesis of various antibiotics and cardiovascular agents. Our material enables batch consistency and purity demanded during multistep organic synthesis under stringent GMP environments. Downstream API producers incorporate it during critical condensation, esterification, or amidation steps. Production managers adjust the ratio depending on molecular weight and specific yield requirements for each targeted drug substance. The downstream process ensures robust separation, purification, and crystallization stages to meet regulated excipient and impurity limits.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • EU EMA and US FDA Drug Master File requirements
    • USP/NF and Ph. Eur. monographs for starting materials
    • 21 CFR Part 211 Current Good Manufacturing Practice

    Typical usage ratio

    • 10–30% molar equivalent per batch, adjusted for target compound and reaction type
    • Process chemists refine input based on required optical purity and impurity profile

    Downstream process integration

    • Input at initial condensation or amidation step as starting chiral building block
    • Integrated with automated reactor dosing systems for controlled release
    • Candidates for high-purity DPIs require additional recrystallization prior to isolation

    Final product types

    • Semi-synthetic cephalosporins
    • Amoxicillin derivatives
    • Cardiovascular active ingredients (e.g., antiarrhythmics)
    • Approved pharmaceutical intermediates for global regulated markets

    2. Cosmetic Skin Care Ingredient Production

    Downstream cosmetic ingredient formulators use this raw material to produce alpha hydroxy acid additives for premium skincare. Dl-Mandelic Acid acts as an exfoliating and pH-modifying agent at precise concentrations required by regional regulatory frameworks. Technical managers blend it with surfactants or emollients during emulsion formation, ensuring controlled release and minimizing irritation risk. Quality teams monitor crystalline grade, microbial limits, and free acid content to support end-customer product registrations.

    Industry compliance standards

    • Cosmetic Ingredient Review (CIR) Safety Assessment
    • EU Cosmetic Regulation (EC) No. 1223/2009 Annexes III & V
    • China National Medical Products Administration (NMPA) Safety Technical Standard for Cosmetics
    • ISO 22716:2007 Cosmetic-GMP

    Typical usage ratio

    • 1–5% by weight in direct-to-bulk chemical blends
    • Below 10% inclusion in leave-on and rinse-off finished formulations as required by regulatory limits

    Downstream process integration

    • Added to heated aqueous phase during emulsion manufacture
    • Monitored for pH stability and solubility in pre-mix tanks
    • Integrated into microfiltration or ultrafiltration steps for final clarification

    Final product types

    • Facial cleansers and exfoliants
    • Professional-grade chemical peel solutions
    • Skin brightening serums
    • Clinical dermatological preparations for controlled AHA delivery

    3. Specialty Organic Synthesis for Fine Chemicals

    Industrial fine chemical producers employ Dl-Mandelic Acid as a precursor or resolving agent during enantioselective syntheses, such as in the preparation of optically enriched amines and alcohols. Formulators set the input mass based on desired optical yield and efficiency of post-reaction separation. The raw material's acidity and functional group compatibility support multistage synthesis for flavors, fragrance intermediates, and electronic-grade chemicals. Process control ensures minimal racemization and color development.

    Industry compliance standards

    • REACH (EC 1907/2006) substance registration and control
    • ISO 9001:2015 Quality Management System
    • GHS/CLP compliance for labeling and safety data management
    • RoHS Directive (for specialty electronics-related chemicals)

    Typical usage ratio

    • 5–20% by weight based on stoichiometric calculation for racemic mixture resolution
    • Adjusted with respect to target chiral yield and process efficiency

    Downstream process integration

    • Charged at the resolution or derivatization step after crude synthesis
    • Integrated with solvent extraction, precipitation, or chromatography for enantiomer recovery
    • Monitored by in-process chiral purity testing (HPLC, NMR)

    Final product types

    • Optically pure amine intermediates for APIs
    • High-purity flavor and aroma chemical precursors
    • Specialty intermediates for OLED and advanced materials
    • Enantiomerically enriched starting materials for research compounds

    4. Analytical Reagent and Diagnostic Chemical Preparation

    Producers of laboratory reagents and diagnostic kits utilize our material as a chiral derivatization agent for amino acid and peptide analysis. QC and R&D laboratories require filters and specifications consistent with high-performance analytical standards. Integration includes precise solubilization procedures and compatibility checks with organic solvents or buffer systems. Specialists optimize the input ratio for maximum derivatization efficiency, while production enforces batch-level traceability for regulatory audits.

    Industry compliance standards

    • ISO 17025 accredited laboratory requirements
    • USP Analytical Reagent Grades
    • RoHS and REACH for chemical safety
    • GLP (Good Laboratory Practice) guidelines

    Typical usage ratio

    • 2–10 mg/mL in buffer or acetonitrile for HPLC/GC derivatization
    • Exact concentration based on target compound detection threshold

    Downstream process integration

    • Added during reagent kit assembly after dilution and pH adjustment
    • Processed with automated dosing for high-throughput kit filling
    • Tested for stability under accelerated storage conditions

    Final product types

    • HPLC and GC analytical kits for amino acid analysis
    • Prepacked derivatization reagent sets
    • Diagnostic solutions for clinical laboratories
    • Research-use-only chiral reference materials
    Free Quote

    Competitive Dl-Mandelic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Dl-Mandelic Acid: Reliable Performance from the Manufacturer’s Line

    Building Dl-Mandelic Acid From Raw Materials to Bulk Product

    As a chemical producer with decades of hands-on experience, we tackle the production of Dl-Mandelic Acid step by step, controlling every link in the chain. We start by sourcing quality benzaldehyde and hydrogen cyanide because without carefully selected base materials, you simply don’t get consistent alpha hydroxy acid output. Over the years, we’ve adjusted our synthesis route to favor better purification at each phase. This effort drives low impurity profiles batch after batch, which our downstream partners expect, especially in the personal care segment or specialty synthesis.

    We manufacture Dl-Mandelic Acid with a keen eye for practical results, not flashy claims. Each lot gets run through crystallization and vacuum drying. These steps lower water content and help us tighten control around our typical specification—>99% purity by HPLC, with minimal moisture and color. The market offers Dl-Mandelic Acid in a range of grades, but we concentrate on pharmaceutical and cosmetic applicability. Consistency matters most, as formulators often report performance shifts with even slight changes to input material. Our technical team keeps the particle profile regular—passing through an 80-mesh sieve—because we’ve seen clumping or under-sieving set back the smooth operation of blending and filling lines at customer sites.

    What Dl-Mandelic Acid Brings to the Table: Uses Rooted in Real Markets

    Dl-Mandelic Acid shows up on ingredient lists for good reason. The molecule brings gentle but effective keratolytic action; cosmetic chemists turn to it for skin care lines targeting mild exfoliation and brightening. Since its alpha hydroxy acid structure straddles a sweet spot—not as harsh as glycolic acid, less prone to sting than lactic—mandelic acid-based formulas can widen user appeal. The DL-form offers a racemic mixture. Compared with purely L-forms or D-forms, this version supports broader-spectrum applications in both pharmacy and cosmetics. Our batches flow into facial cleansers, exfoliating creams, and even certain oral pharmaceuticals where stability and mild acidity help modulate product performance. Some of our pharma clients have achieved patent-backed synergies by pairing mandelic acid with antimicrobial agents.

    Not all mandelic acid products work the same, and formulators know it. Over time, we adjusted our production parameters to avoid yellowing and caking, problems that can plague less-controlled acid sources. Our customers, especially those exporting to markets like the EU and Japan, highlight the importance of regulatory screening and traceability. We maintain lot-specific documentation, from raw material origin to finished acid properties, for every order. That comes from pressing through real audits, not just ticking boxes for local authorities. Traceability and access to technical support help our clients pass scrutiny on both sides of the regulatory fence.

    Why Dl-Mandelic Acid’s Differences Matter in Practice

    As a manufacturer, we get asked how Dl-Mandelic Acid stacks up against alternatives. There’s a well-known tendency for mandelic acid in racemic (DL-form) configuration to offer a slightly broader range of activity compared with pure L-mandelic acid. In topical applications, this means our Dl-form blends in both hydrophilic and lipophilic environments. Glycolic acid may drive deeper or faster activity, but often at the price of increased irritation. Salicylic and lactic acids each have supporters, but their safety and efficacy profiles diverge. In our experience supplying active ingredient blends, mandelic bridges this gap, lending itself to formulations for sensitive skin.

    Pharma buyers often ask about antimicrobial use. Here, real-world performance depends on trace impurities: any residue from production can lower shelf life or interact with actives in complex ways. Our laboratory tracks not just major byproducts, but also looks for trace aldehydes and cyanides through the full acidification and purification path. That type of vigilance gets recognized by international clients. For instance, companies making urinary tract antiseptic formulations require material that won’t introduce unexpected residues or visual shifts in tablets. Our Dl-Mandelic Acid feeds into their plant with predictable results, few callbacks, and strong repeat purchasing over several regulatory cycles.

    Understanding the Manufacturing Commitment Beyond the Brochure

    We have always preferred explaining our products via shop-floor reality, rather than slick marketing sheets. The practicalities of making racemic mandelic acid start at bench scale, but headaches scale up as you move from 500 g flasks to 500 kg reactors. Reaction temperatures swing within a tight band, and runaway exotherm is a constant threat. Managing pH and solvent profile means our technical teams run monitoring in real time, since lag leads to unwanted side products. Once the reaction hits quench phase, filtration, and then bulk crystallization, every variable matters. We found through experience that long crystallization times at low agitation sharply improve lot reproducibility. This came from months of trial, not from copying other manufacturers.

    Once dried, we verify not just typical moisture, but also powder flow under simulated customer handling. Packaging is always nitrogen-flushed to fight oxidation or color development—a lesson learned the hard way at client sites seeing yellowed acid in uncontrolled storage. Global clients lean on our flexibility; if they need smaller packs for faster turnover or defined mesh sizes, our crew can retool and respond directly.

    Logistics, often an afterthought, becomes central for bulk acids. Our Dl-Mandelic Acid ships in fiber drums with PE liners, but some clients, especially those producing pre-mixed actives or tablets, ask for vacuum-packed or foil barrier options. Over years supplying diverse users–from pharmaceutical to cosmetics to flavors—we found that clear labeling, straightforward COAs, and precise lot details keep supply chains flowing without confusion or loss from incidental moisture ingress.

    Dl-Mandelic Acid Application Trends Observed in the Field

    We’re not removed from how mandelic acid trends play out at the downstream level. Popularity in skincare has surged across Asia, Europe, and North America, with formulators targeting gentle exfoliation for sensitive skin types. We observed steady upticks in requests from brands focused on acid blends for acne-prone and pigmentation-oriented product lines. Our technical support team gets frequent queries on formulating “clean beauty” products—where non-GMO, low-allergen, and cruelty-free sourcing comes under the microscope. Since our production avoids animal derivatives and uses traceable, monitored inputs, we’ve been able to document ingredient origin, something required by several multinationals pressing for responsible sourcing.

    Outside cosmetic use, pharmaceutical preparations—especially urinary antiseptics—rely on Dl-Mandelic Acid for its high stability and reliable microbial action. In this sector, manufacturers face stiffer regulatory review. Reproducible quality, clear documentation, and reliable shipment records remain top priorities. Several clients reported switching to our supply after failing repeated batch records with noncompliant acid from less-controlled sources. Tech transfers run more smoothly, and their compliance headaches shrink, because we stay in close touch about any manufacturing changes or input updates.

    Demand patterns shift over time, but we have seen niche uptake in veterinary and food-research segments. Some animal healthcare companies want reliable bulk acid for experimental oral supplements or cleansing agents. Because we keep our input and process chain locked and only take up customized projects we can support with evidence, we rarely face surprises once goods leave our plant. Those investigating food flavoring uses run up against strict residue rules and purity curves; our team works directly with researchers on short-run, fully documented batches.

    Quality Realities and Everyday Lessons from Manufacturing Dl-Mandelic Acid

    Running a chemical plant for specialty acids teaches respect for batch discipline. Each output reflects input control and attention on the reactor deck. Over-automation has yet to replace sharp human supervision. For all the talk of smart manufacturing, someone with hands-on knowledge still has to assess crystal quality as it comes off centrifuge, decide if fine fractions should be reprocessed, and verify characteristic odor and hue under natural light. Our operators notice subtle color tone changes before they ever show in spectro results. Nearly every complaint ever fielded from a customer has led us to review and, if needed, revise operating steps.

    We’ve mapped the entire production landscape for Dl-Mandelic Acid, from tank farm to railcar load-out. During each shift, process parameters get logged manually and digitally, so that deviation in one batch can get traced within hours. We also keep backup samples from every outgoing lot, in locked storage, for years. That approach has paid off in technical dispute resolution. Any time a downstream client raises a potential issue—be it haze, color, or off notes—we can pull a control sample and survey our production records to re-check all variables involved. This loop has built trust over extended supply relationships.

    A running lesson from years of production: product that falls outside specification, even if just by color, never leaves the plant in client-labeled containers. Operational integrity counts most in repeated supply. Only through sustained self-auditing, surprise plant walkthroughs, and technical exchanges with both local and export clients, can a chemical manufacturer truly deliver what formulators, regulators, and consumers expect.

    Technical Support as an Extension of the Production Line

    Our experience as an original manufacturer goes beyond the shift bell. Clients gain as much from our application feedback as they do from bulk shipments. Downtime from blending or tablet-making holds up entire production runs; our support staff keeps updated on common pitfalls faced by end users. Where Dl-Mandelic Acid interacts with emulsifiers, preservatives, or colorants, our team offers firsthand reports from both in-house trials and shared client case studies. Batch deviation logs remain open for audit if a downstream user requires root cause analysis.

    For new adopters or R&D groups exploring mandelic acid for the first time, we share small quantity samples and best-practice guides built from our actual production records. Instead of blanket recommendations, our team highlights known markers—odor, water content, mesh profile—that frequently make or break an ingredient’s suitability for manufacturing at scale. This pragmatic approach spares customers costly reformulation or regulatory headaches.

    Our goal as a manufacturer isn’t to simply deliver product but to stand behind the results, spotting and fixing issues other vendors may overlook. Across inbound and outbound communications, we document product variables and batch parameters so that project managers, formulators, and regulatory officers can access what they need, when they need it.

    Differentiating Our Dl-Mandelic Acid from Other Market Offerings

    Market practitioners shopping for a source of mandelic acid often compare claims, but manufacturers know that the details come out in actual performance. Competing product might show similar specs on paper—purity, mesh size, and even water content. But close-run trials often highlight “soft” differences: handling consistency, off-note suppression, and resistance to yellowing under warehouse conditions. We have adjusted our drying, packing, and sealing protocol after collating dozens of real-world complaints on clumping or anomalous off-grid lots.

    Many traders and repackagers offer wide-range acid lots with variable quality, sometimes blending in to meet cut-price thresholds. By contrast, our in-house manufacturing keeps every batch on a traceable run, with pre-set production windows and closure on any out-of-spec output. Our technical history has led us to modify solvent management and purification, giving tighter control over trace aldehyde content and residual catalyst loads. For those exporting to pharmaceutical or top-tier cosmetic markets, this difference means lower specification rejection—something that rarely gets flagged at brochure stage, but becomes vital in ongoing supply partnerships.

    Some offerings tout “natural” or “L-form only” mandelic acid, marketing perceived green benefits or higher activity. Dl-Mandelic Acid, as we produce it, suits the widest array of application types, balancing chemical stability, formulation ease, and tangible supply reliability. Over time, experienced buyers and formulators have documented that supply chain quality hinges on physical and procedural discipline at the original plant, not third-party labeling.

    The Manufacturer’s Promise: Quality, Traceability, and Troubleshooting Support

    Supplying Dl-Mandelic Acid at scale means managing risk and expectation. In actual manufacturing, surprises pop up night or day: variation in input purity, upswings in plant humidity, or unexpected changes in demand from global markets. We maintain reserve stocks and flexible scheduling, which gives our partners continuity during unplanned shifts in usage or shipping. Contract clients—especially those supporting OTC or regulated sectors—have learned to appreciate timely notice if any upstream or process adjustment could impact their runs.

    In the real world, no supply runs entirely free of challenge. Batches may get re-blended for slight moisture spikes or inadvertent post-filling exposure. Our own labs conduct random deep-dive cross-checks every quarter, probing for issues not just at typical analysis points, but also after periods in accelerated aging chambers or under transport agitation simulation. By staying open to shared learning, and transparent about process realities, we’ve built lasting bridges with the technical leaders on the client end.

    Choosing a Dl-Mandelic Acid source often comes down to the level of control at the original manufacturing site. Our focus has always been direct, hands-on production, with open technical dialogue and continual improvements based on both on-plant learning and direct client feedback. Each shipment, batch, and support interaction builds on this foundation—a cycle of production, review, and supply that keeps real manufacturer quality moving into end users’ hands around the world.