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Dl-Alanyl-Dl-Methionine

    • Product Name Dl-Alanyl-Dl-Methionine
    • Alias Alamethionine
    • Einecs 266-102-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    465200

    Chemical Name Dl-Alanyl-Dl-Methionine
    Molecular Formula C8H16N2O3S
    Molecular Weight 220.29 g/mol
    Appearance White to off-white powder
    Solubility Soluble in water
    Cas Number 2752-50-7
    Storage Temperature 2-8°C
    Purity Typically ≥98%
    Ph Of 1 Percent Solution 5.0 - 7.0
    Melting Point Approximately 250°C (decomposition)
    Usage Nutritional supplement and research

    As an accredited Dl-Alanyl-Dl-Methionine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging is a sealed, amber glass bottle containing 100 grams of Dl-Alanyl-Dl-Methionine, labeled with product details and safety information.
    Shipping Shipping of Dl-Alanyl-Dl-Methionine should be conducted in tightly sealed containers, protected from moisture and direct sunlight. The compound is stable under normal temperature and pressure but should be handled using appropriate personal protective equipment. Comply with all applicable regulations for the transport of chemicals, ensuring clear labeling and documentation during shipping.
    Storage Dl-Alanyl-Dl-Methionine should be stored in a tightly sealed container, protected from light and moisture. Keep it in a cool, dry place, ideally at 2-8°C (refrigerated). Ensure the storage area is well-ventilated and free from sources of incompatible substances. Handle with care, avoiding direct contact and prolonged exposure to air to maintain product stability and purity.
    Application of Dl-Alanyl-Dl-Methionine

    Applications of Dl-Alanyl-Dl-Methionine in Industrial Manufacturing

    Dl-Alanyl-Dl-Methionine is a specialized dipeptide compound widely utilized by industrial customers in nutraceuticals, animal feed, pharmaceutical intermediates, and biomedical research. As an original manufacturer, we support its incorporation into advanced downstream processes to enhance specific product functionalities and regulatory compliance.

    1. Compound Feed Additives for Intensive Livestock Nutrition

    Feed manufacturers add Dl-Alanyl-Dl-Methionine to high-value premix formulas for monogastric animals—especially poultry and swine—to supply supplemental methionine. Its dipeptide structure enables improved intestinal absorption and reduced antagonism with other essential amino acids compared to conventional methionine. Nutritionists balance inclusion to meet species-specific amino acid requirements while optimizing growth rates and feed conversion efficiency within integrator systems. Consistent quality and traceability are central to compliance with national feed safety plans and export protocols in key markets.

    Industry compliance standards

    • EU Regulation No 1831/2003 on additives for use in animal nutrition
    • FAMI-QS Code (European Feed Additives and Premixtures Quality System)
    • US FDA GRAS notifications for amino acid feed ingredients
    • China Feed Additive Safety Norms (GB/T 18860 and MOA registration)

    Typical usage ratio

    • 0.01%–0.15% of complete feed mass, adjusted by animal species, age, and total sulfur amino acid balance; precise ratios determined by formulation modeling and regional nutritional guidelines.

    Downstream process integration

    • Integration in micro-ingredient dosing or liquid spraying systems during premix blending; inclusion prior to granulation or pelleting steps to ensure even distribution.

    Final product types

    • Prestarter and grower poultry feeds
    • Swine nursery diets
    • Fish and shrimp compound feeds
    • High-density micronutrient premixes for feed millers

    2. Amino Acid Supplements in Clinical Nutrition Formulas

    Medical nutrition producers incorporate Dl-Alanyl-Dl-Methionine into oral and enteral formulas requiring enhanced protein value and specific amino acid management. Its use supports patients with increased methionine demand or impaired absorption, promoting better nitrogen utilization and mitigating sulfur amino acid deficiency risks in hospital or long-term care settings. Compliance with international pharmacopeias, as well as medical device regulations and food for special medical purposes (FSMP) standards, governs process validation and product release.

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.) amino acid monographs
    • US Pharmacopeia (USP) for nutritional ingredients
    • China FSMP regulatory regime (CFDA registration and GB 29922)
    • ISO 13485 for medical nutrition manufacturing

    Typical usage ratio

    • 0.05%–0.5% w/w, aligned to the target methionine level per clinical guideline or prescription; adjusted lower for mild deficiency correction and higher for parenteral formulas.

    Downstream process integration

    • Addition to aqueous solution for sterile mixing during batch preparation; filtered and QC-verified before aseptic filling into unit-dose pouches or bottles.

    Final product types

    • Enteral nutrition drinks (ready-to-feed)
    • Clinical food supplements in powder or liquid form
    • Specialized amino acid blends for metabolic disorders
    • IV nutrition admixtures prepared in hospital pharmacies

    3. Precursors for Peptide Drug and Diagnostic Reagent Synthesis

    Peptide synthesis companies and API manufacturers use Dl-Alanyl-Dl-Methionine as a building block in solid-phase and solution-phase synthesis to obtain complex dipeptide or oligopeptide intermediates. Its incorporation supports stepwise assembly of active pharmaceutical ingredients (APIs), peptide hormones, or diagnostic calibrators—demanding high purity and documented traceability under regulated manufacturing environments. Analytical controls and validated cleaning procedures are mandatory to prevent cross-contamination in multi-product facilities.

    Industry compliance standards

    • ICH Q7 GMP for active pharmaceutical ingredient manufacturing
    • US FDA 21 CFR Part 210/211 for finished pharmaceuticals
    • EDQM Certificate of Suitability (CEP) for peptide APIs
    • REACH compliance for chemical intermediates in Europe

    Typical usage ratio

    • Molar equivalents calculated based on desired peptide chain length and synthesis yield; commonly 1–1.5 molar ratios relative to coupling partners, refined after pilot validation.

    Downstream process integration

    • Dissolved or suspended in protected reactor vessels for Fmoc/t-Boc chemistry; purification by preparative HPLC or crystallization; supplied as intermediate or final pure substance.

    Final product types

    • Peptide-based pharmaceuticals (injection, lyophilized powder)
    • Diagnostic calibrator panels
    • Peptide reference standards
    • Custom peptide libraries for drug discovery

    4. Research-Grade Amino Acid Source in Cell Culture Media

    Cell biology and biotechnology laboratories select Dl-Alanyl-Dl-Methionine for customized cell culture media formulations. Its inclusion allows study of dipeptide uptake and metabolism, supports transient methionine supplementation, and facilitates experiments where sulfur amino acid kinetics play a role in cell growth or protein expression optimization. Stringent lot testing and origin documentation ensure alignment with institutional biosafety rules and reproducibility requirements for publishable research.

    Industry compliance standards

    • ISO 9001-based QC system for reagent-grade materials
    • Institute-specific procurement guidelines for reagents
    • National biosafety and laboratory animal guidelines (where used in vivo)
    • Applicable OECD GLP standards for research traceability

    Typical usage ratio

    • 10–200 mg/L, based on cell line tolerance and experimental protocol; optimized by individual research groups depending on target outcome.

    Downstream process integration

    • Direct supplementation of sterile-filtered media prior to cell seeding; batch control ensures uniformity across replicates and experimental lots.

    Final product types

    • Custom cell culture media for R&D
    • Protein expression production cultures
    • Experimental animal diets for laboratory settings
    • Biochemical assay component mixes
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    Certification & Compliance
    More Introduction

    Dl-Alanyl-Dl-Methionine: Commitment to Consistency and Reliable Nutrition

    What Dl-Alanyl-Dl-Methionine Means to Us as a Manufacturer

    In this industry, experience counts for a lot. We've spent years not only perfecting the chemical synthesis of amino acids but also working closely with nutritionists, animal feed specialists, and integrators who need ingredients they can rely on every single day. Dl-Alanyl-Dl-Methionine grew out of those partnerships—from real feedback, not just technical wish-lists. This dipeptide brings together alanine and methionine, both essential in targeted nutrition, especially animal applications where steady, predictable supply chains matter for both animals and producers.

    Product Overview

    As a manufacturer, we pay special attention to purity and consistency in our lot production. Each batch of Dl-Alanyl-Dl-Methionine meets strict quality standards, and routine analyses run daily. In any granular or powder application, the physical properties of the product reflect years of iterative process improvements—improvements set into action because our own production lines and those of our downstream partners depend on trouble-free handling.

    Dl-Alanyl-Dl-Methionine stands apart from its basic amino acid precursors due to how animals utilize it. The combination grants different absorption dynamics than methionine or alanine alone in the diet. With animal feed, much research focuses on methionine for growth and protein synthesis, particularly in poultry, swine, and aquaculture. With the dipeptide form, our customers report more steady bioavailability compared to single, free amino acids. That leads to less nitrogen waste and more efficient use of dietary protein, according to lab and field trial feedback over the past decade.

    Model and Specifications

    Our Dl-Alanyl-Dl-Methionine, sometimes labeled by model designation in our sales contracts, follows tight grading parameters for purity, moisture, and particle size. Chemical synthesis delivers a final product only after repeated crystallization, each step checked by HPLC. Particle size distribution matters because dust or excessive fines cause handling issues during feed blending, so we have long targeted a narrow window for granule structure. Internal batch testing reports keep moisture well below levels that encourage lumping or bacterial spoilage in storage. Each parameter—down to trace element content and heavy metal thresholds—grew out of end-user audits and repeat order requirements.

    We monitor key specifications:

    Nobody in feed manufacturing wants a batch to go out of spec. It throws off sensitive blends and causes returns or complaints. These requirements come from hard-earned lessons in day-to-day manufacturing, not just from what looks good on paper. Each change in our procedures, such as installating new sieving equipment or updating filtration, started because a partner or internal team flagged minor but persistent problems.

    Usage: Animal Nutrition and More

    In most cases, our Dl-Alanyl-Dl-Methionine ships for use in poultry and swine nutrition, where methionine ranks as a top limiting amino acid. As farms modernize, growth performance and feed conversion rates come under scrutiny—and even small percentage improvements translate into big savings on an industrial scale. Customers use the dipeptide to close gaps when feed ingredients naturally lack balanced amino acid profiles.

    Feed specialists started with trials, and once repeated performance gains showed up, many transitioned from single-component methionine to partial or full replacement with the dipeptide form. This isn't just a trend. The feedback from farms that make daily use of our product shows improved weight gain in broilers, more uniform flocks, and tighter conversion efficiency, with some reporting reduced ammonia emissions. That tracks with published research showing better amino acid utilization when methionine is supplied as a dipeptide, since enterocytes in the gut can absorb small peptides directly.

    For us, scaling up production of Dl-Alanyl-Dl-Methionine took rethinking our own plant design. Amino acid products must perform the same in a massive automated feed mill as they do in small nutrition labs. Over the years, we've invested in modifications based on feedback from mill operators: changing drying curves for better powder stability, retesting packaging that stands up to transport, and accommodating custom bulk container sizes requested by industrial users in colder or wetter regions. Each adjustment reflects actual use cases and partnership, not theoretical ideals.

    Dl-Alanyl-Dl-Methionine vs. Other Amino Acid Products

    Methionine alone, whether as dl-methionine or hydroxyl analog, often sets the baseline in feed formulations. Many customers ask why add a dipeptide when straight methionine is available? From the perspective of both animal health and the process at the mill, the answer comes down to absorption and subsequent utilization.

    All animals require methionine for growth and feather development in poultry or muscle accretion in swine. In the intestine, single amino acids rely on specific transporters, which can saturate under load. Peptide transporters handle small groups like Dl-Alanyl-Dl-Methionine and have both higher capacity and different absorption profiles. This means the body uses more methionine per kilogram of feed, with less waste.

    We’ve run tests alongside academic labs comparing various sources such as dl-methionine, methionine hydroxy analog and our dipeptide. In direct feed trials, the dipeptide shows more consistent blood methionine levels after ingestion. For feed manufacturers, this translates to tighter control over nutrient profiles and less risk of swings due to variable uptake.

    Another point our production team learned from frequent site visits is that some of the classic methionine sources carry dust levels or reactivity that complicate storage, especially in humid regions. The physical stability and granule integrity of our Dl-Alanyl-Dl-Methionine helps avoid these mixing headaches.

    Single amino acids, particularly in the form of fine powders, sometimes bridge in hoppers or cling to mixing vessel sides, leading to underdosing and production interruptions. Our approach since the beginning involved working through practical feed mill scenarios, such as high-volume pre-mix lines, and modifying our granulation and drying stages according to partner input.

    Production Reliability: What it Takes Behind The Scenes

    Every shipment of Dl-Alanyl-Dl-Methionine that succeeds in a customer’s facility reflects hundreds of short, daily decisions. From sourcing high-purity raw inputs free of contaminants to maintaining reactors under strict temperature and pH profiles, each step matters. Even seemingly minor aspects like rinse cycles in filtration vessels or specific dryer parameters get tracked and tied to lot performance. QC teams and plant chemists hold each other to account because real-world performance, not just certificate-of-analysis data, determined how we built this product into our catalog.

    We have learned over years of site visits how even trace contaminants impact animal performance, especially in large-scale operations where a margin of error can multiply across thousands of tons of feed. So we hold to tighter specs than some bypass providers, aiming to give each batch the same profile for those mixing systems that run around the clock.

    Environmental and Economic Realities

    Producers today face pressures on both cost and compliance. Ammonia emissions and run-off drive regulation and public concern. Adopting amino acid blends like Dl-Alanyl-Dl-Methionine has helped several of our partners lower their excretion rates, supporting both efficiency and regulatory compliance. Many of our partners operate in regions where land and water use rules shift with each harvest season, so the prospect of tighter protein utilization translates to both direct financial gain and simplified paperwork. We adjust our production rhythms to align with these cycles, ensuring steady delivery through seasonal demand shifts.

    Feed cost savings are driven by two factors. One, feed formulators gain greater flexibility in ingredient sourcing when they know a reliable methionine supplement covers any nutritional shortfalls. Two, improved amino acid balance translates to less crude protein required in the formulation, saving sources of soybean meal, fish meal, or other traditional protein sources. Customers have shared that Dl-Alanyl-Dl-Methionine provides them a buffer during volatile commodity markets, where price swings in protein ingredients can disrupt balance sheets overnight.

    Serving Partners, Not Just Selling a Product

    No manufacturer works in a vacuum. Since introducing Dl-Alanyl-Dl-Methionine, our team has travelled to customer sites on every continent to help commission new feed lines, adapt product presentation formats, and collect field performance data. In each instance, our experience has changed how we produce and package the product. In humid zones, feedback led us to shift toward more robust bag liners and packaging designed to withstand container condensation. In colder climates, shipping protocols shifted to account for moisture pick-up risks during long rail hauls.

    Farmers and feed mills face tight schedules and can tolerate little downtime. Technical support walks side-by-side with what we put in the bag. That support draws on our actual plant engineers, not distant offices disconnected from hands-on manufacturing. Process improvements usually start with a phone call or feedback after shipment, and our R&D team sets aside time each week to review new reports, whether that means unexpected machine behavior in a feed mill, requests for custom blend ratios, or on-site troubleshooting.

    Each year, users push for increased sustainability, both in ingredient sourcing and post-use environmental burden. Responding to these demands, we've taken steps to reduce the waste and energy usage in our own facilities—streamlining batch sizes, investing in solvent recycling, and reducing overall potable water consumption in both the synthetic and purification stages. Our goal remains to deliver Dl-Alanyl-Dl-Methionine that brings both animal performance gains and reduced input requirements, closing feedback loops between end-users and our manufacturing engineers.

    Regulatory Confidence

    Feed safety rules tighten each year, and our partners often face audits or new paperwork demands on short notice. Our experience navigating ever-changing global regulations means we already have those records ready, complete with batch-level documentation, full traceability, and retained samples for future checks. We register or notify appropriate agencies during formula shifts and keep certificates current with international guidelines.

    As manufacturers, we see the risks that come with any uncertainty in raw material or additive supply. Dl-Alanyl-Dl-Methionine production answers that risk by anchoring batch controls logic around ingredient traceability. New lots get pulled for shelf life and stability retests at set intervals. Customer requests for extended documentation, whether organic certification cross-verification or documentation for non-GMO raw material status, feed back into monthly process reviews and supplier audits.

    We respond to regulatory change by in-house reformulation and rapid adjustment to labeling content, avoiding the pitfalls of delayed compliance. Our position at the source of synthesis gives us direct influence over manufacturing parameters, so shifts in impurity thresholds or labeling can happen without costly intermediate storage or shipment delays. For example, a recent adjustment in certificate wording to match new animal feed additive rules originated directly from our synthetic chemistry team rather than waiting for downstream documentation changes.

    Looking Forward: Future Developments and Customer-Driven Innovation

    We see ongoing research into peptide-based amino acid sources, including improved variants of Dl-Alanyl-Dl-Methionine. Field trials and nutritional research keep showing that combinations outperform single components, especially under high-performance feeding regimes. Our own pilot lines prototype custom molecular blends requested by nutritionists looking to fine-tune protein profiles or work against anti-nutritional factors in novel feed ingredients.

    Sometimes feed ingredients change, pushed by shifting crop yields, disease pressures, or new trade patterns. By manufacturing this dipeptide in-house, we can quickly shift sourcing or adjust synthetic steps without relying on third-party suppliers who might lag behind market developments. On repeated occasions, such responsiveness helped our customers maintain compliance and smooth feed transition for animals during regulatory shifts or supply hiccups.

    Ongoing investment in analytical capability—LC/MS for purity, on-line NIR for moisture, and real-time process analytical technology—lets us adapt to feedback with greater speed and precision. As customers uncover new applications, we trial and validate adjustments at bench and pilot plant scale before recommending changes to commercial partners.

    We remain well aware that progress depends on two-way communication. Lessons from daily feed manufacture—from caking in bulk hoppers to subtle shifts in animal growth performance—return to our process engineers for the next incremental improvement. That commitment underpins our model for producing Dl-Alanyl-Dl-Methionine—a model grounded in practical reality, direct manufacturer expertise, and long-term trust between producer and user.