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Dl-1,2-Hexanediol

    • Product Name Dl-1,2-Hexanediol
    • Alias 1,2-Dihydroxyhexane
    • Einecs 221-565-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    467778

    Cas Number 6920-22-5
    Molecular Formula C6H14O2
    Molecular Weight 118.17 g/mol
    Appearance Colorless liquid
    Purity Typically ≥98%
    Melting Point -47°C
    Boiling Point 224-226°C
    Density 0.955 g/cm³ at 25°C
    Solubility In Water Miscible
    Refractive Index 1.442-1.447 at 20°C
    Flash Point 109°C (closed cup)
    Odor Mild
    Vapor Pressure 0.02 mmHg at 25°C

    As an accredited Dl-1,2-Hexanediol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100g amber glass bottle labeled "Dl-1,2-Hexanediol," features a secure screw cap and displays all safety and chemical information.
    Shipping **Shipping Description for Dl-1,2-Hexanediol:** Dl-1,2-Hexanediol is shipped in tightly sealed containers, protected from moisture and direct sunlight. It should be handled according to standard chemical safety regulations, including labeling and documentation. Packaging must prevent leaks, and transport should comply with all applicable local, national, and international shipping requirements for non-hazardous chemicals.
    Storage Dl-1,2-Hexanediol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents. Keep the storage container protected from direct sunlight, heat sources, and moisture. Ensure the area is equipped for safe spill control and that containers are clearly labeled to prevent accidental misuse or contamination.
    Application of Dl-1,2-Hexanediol

    Applications of Dl-1,2-Hexanediol in Industrial Manufacturing

    As a direct manufacturer of Dl-1,2-Hexanediol, we supply high-purity material for established industrial value chains, supporting specialized use cases where stringent technical and regulatory requirements apply. The following application scenarios summarize real-world integration across core downstream segments, detailing compliance, dosage, production fit, and final product specifications.

    1. Personal Care Formulations: Skin Care and Hair Care Preservatives

    Dl-1,2-Hexanediol serves as a multifunctional ingredient in personal care manufacturing, primarily acting as a preservative booster and humectant for skin creams, serums, and hair treatments. Its antimicrobial activity supports the efficacy of traditional preservative systems, addressing microbial contamination risks in high-water formulations. Manufacturers utilize it to maintain product integrity and extend shelf life, while also benefiting from enhanced sensory profiles.

    Industry compliance standards

    • EU Cosmetics Regulation (EC) No 1223/2009
    • US FDA 21 CFR Part 700
    • China National Medical Products Administration (NMPA) Cosmetic Standards
    • ISO 22716: Cosmetic Good Manufacturing Practices

    Typical usage ratio

    • 0.5–2.0% w/w depending on formula water content, with higher rates in leave-on creams and lower in rinse-off emulsions; adjusted to balance antimicrobial and humectant effects.

    Downstream process integration

    • Dl-1,2-Hexanediol is dissolved into the water phase during the initial compounding step and emulsified with oils and actives before homogenization and filling.

    Final product types

    • Face moisturizers and lotions
    • Facial serums and ampoules
    • Shampoos and hair conditioners
    • Sunscreen formulations

    2. Industrial Water-Based Coatings and Dispersions

    In waterborne paints, coatings, and pigment dispersions, Dl-1,2-Hexanediol functions as a coalescent aid and in-can preservative. Its compatibility with polymers and pigments helps manufacturers prevent microbial spoilage during storage and promote uniform film formation. The material supports processing of low-VOC coatings, meeting regulatory push for safer workplace handling and reduced environmental impact.

    Industry compliance standards

    • European REACH Regulation (EC) No 1907/2006
    • US EPA TSCA inventory listing
    • German Blue Angel Eco-Label compliance (RAL-UZ 102 for paints)
    • China GB 18582-2020 (Limits of Harmful Substances in Interior Wall Coatings)

    Typical usage ratio

    • 0.3–1.0% by total formula weight, adjusted by microbial risk and water activity of the dispersion system.

    Downstream process integration

    • Added to aqueous phase before high-speed dispersion of pigments and binders; dosage may be split between grind and letdown stages for in-can preservation.

    Final product types

    • Architectural wall paints (interior and exterior)
    • Industrial primers and waterborne topcoats
    • Inkjet printing pigment dispersions
    • Paper coating emulsions

    3. Pharmaceutical Excipients: Topical Drug Delivery

    Dl-1,2-Hexanediol features in selected topical and dermal pharmaceutical formulations as a solvent and enhancer for drug penetration, complementing established excipients to optimize pharmaceutical bioavailability. Its dual role as a microbial control agent and wetting aid helps contract manufacturers maintain formulation stability for medicated creams, gels, and ointments, subject to global pharmacopoeial requirements.

    Industry compliance standards

    • United States Pharmacopeia (USP-NF)
    • European Pharmacopoeia (Ph. Eur.)
    • ICH Q7 GMP for Active Pharmaceutical Ingredient Manufacture
    • US FDA cGMP 21 CFR Parts 210 & 211

    Typical usage ratio

    • 0.2–1.0% by weight, with adjustment based on excipient compatibility and target drug load; lower levels favored for regulatory Q3 compliance in sensitive products.

    Downstream process integration

    • Introduced into the aqueous or oil phase during bulk mixing, prior to addition of active pharmaceutical ingredients and rheology modifiers, then homogenized and filled aseptically.

    Final product types

    • Antifungal and corticosteroid creams
    • Topical anti-inflammatory gels
    • Medicated ointments and lotions
    • Transdermal solution bases

    4. High-Performance Lubricant Additives

    Dl-1,2-Hexanediol serves as a performance additive in the formulation of water-based metalworking fluids and synthetic lubricants. Its hygroscopic and anti-microbial properties support the control of microbial growth within process fluids, extending re-circulation intervals and reducing biocidal loads. Technical teams select this diol when they require minimal foaming and compatibility with multi-metal and synthetic base stocks.

    Industry compliance standards

    • ASTM E2275-13: Standard Practice for Handling and Preparation of Metal Removal Fluids
    • OECD Guidelines for Testing of Chemicals (Biodegradability & Toxicity)
    • EU REACH (Annex XVII for Lubricant Restrictions)
    • German TRGS 611: Substances Hazardous to Water in Metalworking Fluids

    Typical usage ratio

    • 0.2–0.7% for soluble oil and synthetic coolant formulations, dosage increased in higher microbial-risk systems or with longer expected sump life.

    Downstream process integration

    • Blended during the concentrate manufacturing phase, prior to water dilution at end user sites; incorporated with corrosion inhibitors, surfactants, and pH buffers.

    Final product types

    • Water-soluble metalworking fluids
    • Micro-emulsion cutting fluids
    • Synthetic lubricant concentrates
    • Grinding and honing fluids

    5. Reactive Polyurethane Systems: Flexible Foam and Adhesive Enhancer

    In the polyurethane industry, Dl-1,2-Hexanediol functions as a specialty co-monomer in the synthesis of high-performance prepolymers and flexible foams. Its difunctional alcohol structure allows integration into the polymer backbone, influencing polymer architecture for targeted flexibility, resilience, and hydrolytic stability. Application chemists prefer this diol for automotive and furniture foam grades requiring low VOC emissions and fine cell structure.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for Chemical Synthesis
    • EU REACH Regulation for chemical registration (EC 1907/2006)
    • DIN EN 13999 for adhesives and sealants in construction
    • California Air Resources Board (CARB) VOC regulations for foam and adhesive products

    Typical usage ratio

    • 1.0–5.0% by total polyol component weight, increasing or decreasing based on required flexibility and interaction with main polyol/diisocyanate blend; formula optimization by custom application.

    Downstream process integration

    • Charged during prepolymer synthesis or direct foam batch blending, before catalyst and blowing agent addition; reacts in-situ with isocyanates during polymerization.

    Final product types

    • Flexible polyurethane foams for automotive interiors
    • Furniture cushions and mattresses
    • Reactive hot-melt polyurethane adhesives
    • Flexible packaging laminating adhesives
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    Certification & Compliance
    More Introduction

    Dl-1,2-Hexanediol: Our Experience at the Source of Production

    Understanding Dl-1,2-Hexanediol from the Manufacturer’s Perspective

    As a chemical manufacturer with decades of hands-on experience, we approach each product as more than a catalog entry. Real insight comes from seeing how a chemical behaves on our plant floor, how it responds to shifts in temperature and pressure, and how it interacts with the demands of various industries. This is the foundation from which we offer Dl-1,2-Hexanediol, a key intermediate that has steadily expanded its reach into cosmetics, industrial formulations, and specialty applications.

    Dl-1,2-Hexanediol holds a unique place within the broader family of glycols. It appears as a colorless, slightly viscous liquid, nearly odorless to the trained hand. Many customers come to us looking for purity that keeps their downstream processes trouble-free. Here on the factory floor, maintaining this standard means monitoring each lot for water content, transparency, and acid value. Every outgoing drum traces back through our records, so deviations can be caught at their source.

    Molecular Details and Practical Manufacturing Experience

    Chemically, Dl-1,2-Hexanediol carries the formula C6H14O2. Its structure features two hydroxyl groups on adjacent carbons, which gives the molecule flexibility in both solubilizing and stabilizing roles. This arrangement distinguishes it from other diols like 1,6-hexanediol or 1,4-butanediol, which display less reactivity toward certain co-solvents or less compatibility with hydrophobic phases.

    Each batch we produce targets purity levels above 98%. Water can creep in during distillation, so we rely on constant Karl Fischer titrations to avoid downstream issues like instability or haze in finished products. Our customers rely on specifications rooted in our raw material selection and reaction conditions. Keys to performance include a low acid value, guaranteeing minimal unwanted side reactions, and a consistent refractive index, which we monitor every shift.

    Performance within Formulations

    Dl-1,2-Hexanediol wins over formulators who require gentle, yet effective, multifunctional ingredients. Many cosmetic labs visit to see firsthand how it boosts preservative performance without irritancy. Its compatibility with a broad range of surfactants and emollients comes not just from test data, but years of partnership with users who bridge laboratory and manufacturing environments.

    Customers report its value as a skin conditioning agent and its presence in products which cover both rinse-off and leave-on applications. In industrial terms, it serves as a coalescing agent and wetting aid. Many clients running paint or ink lines share feedback about improved shelf life and better pigment dispersion, a direct benefit of the diol’s solubilizing power. The hands-on feedback from these sectors shapes our product refinements more than any industry study ever could.

    Comparing Dl-1,2-Hexanediol with Other Glycols and Diols

    Discussions around substitutions are frequent. Manufacturers sometimes ask about replacing 1,2-hexanediol with 1,2-pentanediol or 2-methyl-1,3-propanediol. Practical experience shows that while cost and supply availability enter the conversation, the physical and sensory differences matter most. Dl-1,2-Hexanediol stands apart due to its viscosity profile and its lower odor threshold, key for formulations where scent can make or break product acceptance.

    From a chemical behavior standpoint, the shorter chain glycols tend to evaporate faster or bring more tackiness, while longer chain analogs such as 1,6-hexanediol struggle to dissolve in polar media at ambient conditions. Dl-1,2-Hexanediol bridges the gap, giving a balanced hydrophilic-lipophilic character that broadens application possibilities without sacrificing sensory qualities. We have collaborated on side-by-side formulation trials for years, which has allowed us to witness these differences under a microscope and at full scale.

    Quality Control and Regulatory Assurance

    Quality assurance sits at the core of our operation. Every batch draws from our molecule's high-purity specification, with regular GC-MS analysis to check for byproducts common in the synthesis of diols. While we leave abstract terms to marketing, on the shop floor purity means fewer headaches for our clients and tighter process control. We keep close records by lot and maintain reserve samples for two years; this has helped us resolve more than a few disputes both quickly and amicably.

    As regulatory landscapes toughen, especially in personal care and food-related manufacturing, transparency and traceability matter more than ever. We maintain clear documentation for each lot—raw material chain, reaction parameters, analytical results—and make them available for audits or customer reconciliation. This approach builds trust over time, and the feedback from auditors continues to refine our internal systems.

    Dl-1,2-Hexanediol’s Versatility in Application

    Exploring usage scenarios, the molecule finds its way into leave-on personal care, color cosmetics, industrial coatings, textile auxiliaries, and adhesives. In every sector, the way it behaves is informed by the care we invest upstream. Take emulsions, for instance—our quality control ensures consistent droplet size distribution due to predictable viscosity. Ink and paint makers benefit from a solubilizer that does not impair drying performance. Each of these cases links closely to the consistency we maintain during manufacturing, starting well before the product barrels leave our gates.

    R&D teams often visit our facility with tough queries. They care about long-term stability, unusual contaminants, and traceability past the current year’s purchase orders. Few products showcase as much carryover between sectors as Dl-1,2-Hexanediol, and we work closely with clients to troubleshoot issues that textbooks rarely mention—discoloration during curing, unexpected microbial activity, rare odor development after exposure to specialty fragrances.

    Production Know-How and Operational Challenges

    Those who only work with finished chemicals may not realize the complexity behind consistent Dl-1,2-Hexanediol. Humidity, raw material purity, and reactor maintenance all shape quality. For instance, over-recycled distillation fractions can introduce trace byproducts detectable only on sophisticated equipment. As direct manufacturers, we spot trends in impurity profiles and adapt our purification process to suit, something rarely addressed by resellers.

    Our technical teams evaluate new catalysts, tweak vacuum profiles, and pilot alternative feedstocks as the market shifts. These steps ensure that our clients do not face hiccups in their own lines, especially as feedstocks tighten or international laws shift required purity thresholds. We do not treat these issues as afterthoughts—every batch is a reflection of choices made long before reaching the hands of end users.

    Supporting Safety and Sustainability

    Through the years, sustainability has moved from a buzzword to an operational mandate. We minimize waste and invest in solvent recovery where possible, avoiding unnecessary effluent and keeping hazards low for workers and the surrounding community. Dl-1,2-Hexanediol lends itself to such practices, and we design our synthesis steps to minimize both residual solvents and high-boiling waste.

    Safety informs every protocol. Our operators receive specific training on handling glycols, as even small spills or mismanaged waste can have ripple effects inside and beyond our walls. We have updated our plant over time with closed-loop transfers, automated monitoring, and real-time leak detection to keep occupational and environmental risks in check.

    Continuous Improvement Through Industry Collaboration

    No manufacturing process stands still. Over regular industry meetings and direct facility visits, we trade data sets and application notes with experienced partners—often the source of improvements we couldn’t dream up alone. Whether adapting for a customer changing to a preservative-free formula or raising purity for next-generation electronics, real solutions emerge only through this feedback loop.

    As trends develop and new certifications rise in demand, we upgrade our analytics and tweak our processes, but our focus remains on tangible improvements for those using Dl-1,2-Hexanediol in real-world scenarios. Simple paperwork or reams of certificates cannot replace the shared experience built through close technical partnership.

    Addressing Common Problems Authentic to Manufacturing

    Problems come up in the real world—sometimes quality control flags a haze that escaped basic specs, or a long-term client faces regulatory pressure over a minor impurity. Owning the manufacturing process allows us to mobilize labs and adjust process flow in real time. If an unexpected supply gap arises, we can pivot within days, not months, and communicate openly about timelines instead of giving generic assurances.

    Occasionally, clients working with ecocertified brands present new challenges related to trace elements, residual solvents, or secondary metabolites. Since we control each step, we can deliver custom grades or shift to different precursor routes, without sending projects to third-party tollers or blaming supply partners.

    Practical Insights into Downstream Handling and Logistics

    We have observed that Dl-1,2-Hexanediol prefers dry, well-ventilated storage, as moisture can affect shelf stability especially in bulk containers. On our site, this means strict climate controls, regular checks for drum seals, and a first-in, first-out release policy. We do not rely solely on published shelf-life figures; instead, we track performance through accelerated aging studies and customer returns data, which informs our own improvement cycles.

    For clients who move diols across borders or face extended supply chains, we offer guidance—from proper drum lining to preferred shipment periods during peak humidity. Many logistics headaches can be traced back to the plant, so we bypass these by building storage tests into our manufacturing protocol and rapidly responding to problems flagged by receivers in distant climates.

    The Role of Dl-1,2-Hexanediol in Shifting Industry Expectations

    Dl-1,2-Hexanediol’s role continues to broaden as industry expectations evolve. Cosmetic companies now seek multifunctionality and transparency about ingredient origin, while industrial users demand reliability amid tighter specifications. Thanks to full control of manufacturing, our team responds not only to current market needs but also to forecasts about purity, sustainability, and regulatory compliance.

    Regular investment in analytics—such as advanced chromatographic and spectrometric techniques—lets us pick up early warning signs that may lead to customer trouble down the line. Our record in preempting and correcting such issues strengthens customer loyalty more than any marketing claim. Experience has taught us to view these extra steps as essential investments, not just compliance checkboxes.

    Transitioning to New Technologies and Production Scales

    Shifts in market demand and the growth of specialized downstream uses push us to re-examine reactor size, process intensification, and environmental footprint. Scale-up is not only about increasing output; it’s about keeping quality uniform and addressing the bottlenecks unique to Dl-1,2-Hexanediol. Every expansion brings challenges—temperature distribution, mixing, and cleaning-in-place (CIP) adjustments are just the start.

    Feedback from clients running high-purity lines for medical devices or sensitive personal care applications drives further process validation. By staying involved directly with production, we can roll out updates faster, de-bottleneck lines as needed, and adapt to changing regulatory or market pressures without excess bureaucracy.

    Real-World Case Studies—Learning Beyond the Textbook

    Examples from the field illustrate the value of direct manufacturing control. Formulations demanding utmost clarity and microbial inertness, such as premium facial creams and advanced coating systems, often reveal subtleties that only come to light in real production runs. Over the years, our teams have resolved issues such as slight seasonal color shifts traced to subtle variations in feedstock, or shelf-life dips linked back to residual catalysts. These experiences guide us when developing and producing operations fail-safe, with backup protocols to minimize downtime and waste.

    Engagement with clients does not end once product leaves our facilities. In one case, a paints manufacturer noticed batch-to-batch viscosity inconsistencies. Tracing the issue, our process engineers picked up a deviation in pre-heating procedures. Adjustments were implemented immediately, resulting in significant improvement and fewer client complaints. These headaches cannot be anticipated by generic process specs or copy-paste regulatory documents.

    Conclusion: Direct Insight Shapes Reliable Supply

    By controlling our own production, monitoring key parameters, and directly supporting client troubleshooting, we ensure that each batch of Dl-1,2-Hexanediol stands up to the demands of both established and emerging markets. Our experience informs every aspect, from raw material selection to tailoring product grades for specialized needs, and through this process, we deliver not just a chemical, but a true partnership grounded in transparency, reliability, and real-world results.