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Disodium Succinate Hexahydrate

    • Product Name Disodium Succinate Hexahydrate
    • Alias MSG・NA6H2O
    • Einecs 611-022-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    196255

    Chemical Name Disodium Succinate Hexahydrate
    Cas Number 6106-21-4
    Molecular Formula C4H4Na2O4·6H2O
    Molecular Weight 270.14 g/mol
    Appearance White crystalline powder
    Solubility Freely soluble in water
    Odor Odorless or slight characteristic odor
    Ph 1 Solution Around 7.0 - 9.0
    Storage Condition Store in a cool, dry place
    Melting Point 120-125°C (decomposes)
    Synonyms Disodium butanedioate hexahydrate
    Taste Umami, slightly salty
    Stability Stable under recommended storage conditions
    Usage Food additive, flavor enhancer
    E Number E364

    As an accredited Disodium Succinate Hexahydrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White plastic jar, sealed with blue screw cap, labeled clearly as "Disodium Succinate Hexahydrate, 500 g," with hazard and safety information.
    Shipping Disodium Succinate Hexahydrate is shipped in tightly sealed containers to prevent moisture absorption and contamination. Packages are labeled according to chemical regulations and handled as non-hazardous material under normal conditions. Store and transport in a cool, dry place, away from incompatible substances. Ensure containers remain airtight during shipping for safety and quality.
    Storage Disodium Succinate Hexahydrate should be stored in a tightly sealed container, placed in a cool, dry, and well-ventilated area. Keep it away from sources of moisture, heat, and incompatible substances. Protect the container from physical damage and direct sunlight. Store at room temperature, avoiding extreme temperatures, to maintain product stability and prevent degradation or clumping due to humidity.
    Application of Disodium Succinate Hexahydrate

    Applications of Disodium Succinate Hexahydrate in Industrial Manufacturing

    Manufacturers use Disodium Succinate Hexahydrate for specialized functions across diverse production sectors. Strategic dosing, compliance with strict global standards, and process-specific integration enable its use from food formulation to fine chemical synthesis. Below, we outline genuine downstream industrial applications, detailing compliance frameworks, process dosing, integration stages, and representative end products.

    1. Flavor Enhancer in Processed Foods

    Food technology operations rely on Disodium Succinate Hexahydrate to enhance umami flavor profiles in premium snacks, instant soups, and meat analogues. Our clients adjust dosing based on regional additive regulations, sodium content targets, and product moisture retention. It enters the blending stage with other seasoning compounds and receives quality checks for uniformity and solubility. Its precise integration under controlled conditions assures both taste standardization and food safety compliance.

    Industry compliance standards

    • GB 2760 (National Food Safety Standard for Food Additives, China)
    • FDA 21 CFR § 172.898 (U.S. Food Additive Regulation)
    • EU 231/2012 (E Number: E364, European Food Additives Regulation)
    • FSSC 22000 certified production systems

    Typical usage ratio

    • 0.05 – 0.25% by weight of finished product
    • Lower limits for savory snacks (~0.05–0.10%)
    • Higher end for concentrated broths (up to 0.25%)
    • Adjusted per regional sodium restriction rules and sensory trials

    Downstream process integration

    • Dry blending with other seasoning powders
    • Direct dissolution in liquid stocks or brines
    • Addition prior to homogenization for processed meats or surimi
    • Batch QC for moisture content and clump-free mixing

    Final product types

    • Instant noodle seasonings
    • Processed cheese spreads
    • Ready-to-eat broths and soups
    • Plant-based meat alternatives

    2. Injectable Pharmaceutical Solutions

    Sterile formulation lines deploy Disodium Succinate Hexahydrate as a buffer and pH stabilizer in select parenteral preparations. Stringent regulatory standards govern material release and storage, while actual dosing depends on drug substance compatibility and target osmolality. The compound enters during initial solution preparation and undergoes downstream sterilization via filtration or autoclaving. The finished injectable solutions must meet monograph specifications and stability profiles per the target pharmacopoeia.

    Industry compliance standards

    • USP-NF (United States Pharmacopeia - National Formulary)
    • European Pharmacopoeia (EP, Ph. Eur.)
    • China Pharmacopoeia (ChP)
    • GMP Certified Manufacturing Environment

    Typical usage ratio

    • 0.1 – 1.0% w/v in injectable solutions
    • Exact dose based on required buffer capacity and osmolarity
    • pH typically adjusted between 6.0 and 7.5
    • Documented in part of validated batch records

    Downstream process integration

    • Early-stage buffer addition during bulk solution compounding
    • Shifts to sterile hold tank after dissolution and pH adjustment
    • Feeds into aseptic filling line post-filtration (0.22 micron)
    • Routine in-process QC for pH, clarity, and endotoxin levels

    Final product types

    • Sterile injectable sodium succinate formulations
    • Combined sodium succinate-antibiotic solutions
    • Electrolyte replacement intravenous fluids
    • Adjunct buffers in lyophilized pharmaceuticals

    3. Electroplating and Surface Finishing

    Succinate salts act as auxiliary chelating agents and leveling additives in industrial metal finishing, most notably in nickel and zinc plating baths. Operators select dosage based on metal ion concentration, bath pH, and plating speed targets. The material is introduced during electrolyte preparation and monitored throughout production cycles to maintain precise bath chemistry. Quality control teams regularly check succinate concentrations to avoid unwanted deposit characteristics.

    Industry compliance standards

    • ISO 9587:2007 (Metallic coatings — Electroplated coatings of nickel for engineering purposes)
    • RoHS Directive (EU) 2011/65/EU compliance
    • OEM-specific surface finish protocols
    • Internal QC per ASTM B537 (sliding contact resistance)

    Typical usage ratio

    • 0.5 – 3.0 g/L in plating bath solutions
    • Adjusted for high-speed or precision plating lines
    • Maintained via inline chemical dosing systems
    • Periodic rebalancing per bath analytics

    Downstream process integration

    • Batch or continuous addition to electrolyte makeup
    • Monitored during bath maintenance cycles
    • Proportioned relative to complexing agent systems
    • Analyzed using ion chromatography for feed adjustment

    Final product types

    • Decorative and functional nickel coatings
    • Electro-galvanized fasteners and stampings
    • Precision components for automotive assemblies
    • Consumer electronics with enhanced corrosion resistance

    4. Biochemical Research and Diagnostic Reagent Production

    In life science R&D, Disodium Succinate Hexahydrate serves as a defined carbon source and buffering agent in specialized culture media and enzyme assay buffers. Blending occurs under controlled conditions to maintain batch-to-batch reproducibility required for assay calibration and cell metabolism studies. Dosage precision ensures defined metabolic activity and pH stability throughout research protocols. Downstream reagent kits must meet analytical and performance standards dictated by the market.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for laboratory reagents
    • ISO 13485 for medical device and diagnostics manufacturing
    • Certificate of Analysis (CoA) and Material Traceability
    • Purity confirmation per ACS and analytical grade criteria

    Typical usage ratio

    • 0.5 – 10 mM in buffer or culture medium
    • Adjusted for cell line requirements or enzyme assay parameters
    • Optimization via trial batch runs with downstream QC
    • Documented as a key component in SOPs and kit IFUs

    Downstream process integration

    • Dissolution in high-purity water with inert-gas protection
    • Passed through 0.2 micron sterile filtration for cell work
    • Filled bulk or into ready-to-use diagnostic kit components
    • Final QC for contaminant ions and enzyme inhibition checks

    Final product types

    • Cell line culture media
    • Enzyme activity assay reagents
    • Blood gas analyzer solutions
    • Custom diagnostic buffer kits

    5. Fine Chemical and API Synthesis Intermediate

    Producers of fine chemicals and pharmaceutical intermediates employ disodium succinate for its controlled reactivity and easy downstream workup in multistep syntheses. Its salt form improves solubility and facilitates selective transformations, acting as a key building block for active and excipient classes. Process engineers optimize charge ratios based on route yield projections and final purity targets, integrating the compound early in the synthesis or as a purification agent.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • ISO 9001 for Fine Chemical Production
    • Standard customer-specific analytical acceptance criteria
    • REACH Registration for intermediate use in the EU

    Typical usage ratio

    • Stoichiometric to 2x excess, depending on process chemistry
    • Typical range: 0.2 – 1.0 mol per mol substrate
    • Usage determined during process safety studies and scale-up
    • Adjustments per batch to maximize conversion and minimize waste

    Downstream process integration

    • Charged to reactor as aqueous solution under controlled temperature
    • Feeds into condensation, dehydration, or hydrogenation steps
    • Residual monitoring via HPLC or titration after workup
    • Solvent swap or isolation by crystallization in later stages

    Final product types

    • Synthetic pharmaceutical intermediates
    • Specialty carboxylic acid derivatives
    • Excipient components for oral dosage forms
    • Industrial flavor and fragrance pre-cursors
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    Certification & Compliance
    More Introduction

    Disodium Succinate Hexahydrate: A Closer Look from the Manufacturer’s Perspective

    Introduction to Disodium Succinate Hexahydrate

    As chemical manufacturers with years on the production floor, we've watched the rising demand for functional food ingredients and specialty additives shape how we develop each new batch of Disodium Succinate Hexahydrate. Today, this compound finds itself in the spotlight for its role in both food flavoring and broader industrial use. At our facility, Disodium Succinate Hexahydrate leaves the drying drum as fine, white granules. It carries a clean, slightly savory profile and consistently tests above 99% purity. Over the years, we have measured every variable, from water quality to crystallization rates. The result is a product that remains reliable whether our client is blending for instant noodles, soy sauce, or developing animal feed formulas.

    Product Model and Specifications

    We produce the Disodium Succinate Hexahydrate under a consistent model that supports granular and crystalline forms. The typical lot presents itself as odorless and dissolves easily in water, making it suitable for quick incorporation during industrial mixing or direct food application. On-site, we analyze particle size through sieving tests, keeping most granules between 20 and 80 mesh. Each batch is packed and shipped with a moisture content below 40%—an industry-accepted level that preserves the hexahydrate structure and allows long shelf life without caking or degradation. We confirm the sodium succinate content by titration and HPLC, so fields like food processing, fermentation, and feed mixing all get the grade they need.

    The Subtleties of Production

    There’s a craft to making Disodium Succinate Hexahydrate that doesn’t show up on paper. Every batch starts with fumaric acid or succinic acid—dependable, easily sourced feedstocks. We neutralize it with high-purity sodium carbonate sourced from trusted partners, keeping heavy metals and organic impurities out of the picture. Years of refining the cooling rate during crystallization have taught us that temperature swings cause defects, so large modern reactors paired with gentle agitation ensure proper hydrate formation. After filtration, there’s a single-point check for clarity; just a hint of haze signals a need for reworking. With each new production cycle, we monitor both the water of crystallization and sodium content closely, as both affect solubility and reactivity in end-use scenarios.

    Understanding Usage—From Umami to Additive

    The best part about Disodium Succinate Hexahydrate is how it interacts with flavors. Chefs and food scientists come back to it because it brings out umami richness in ready-to-eat noodles, dehydrated soups, soy sauce, and snack foods. Even in low quantities—often less than a gram per kilogram of finished product—its clean profile rounds out the taste, providing that lingering savory sensation many now expect in premium foods. Our customers in the instant noodle segment work with us directly to adjust delivery form, depending on whether they want fast-acting powder for seasoning packs or larger grains for slower dissolution in high-speed mixing.

    But the interest in this compound extends far beyond food. Feed manufacturers add Disodium Succinate Hexahydrate for flavor enhancement and as a metabolic intermediate to support animal growth. Microbiological labs value it as a buffer and as a carbon source in synthetic growth media, especially since it resists rapid breakdown and delivers predictable results. In biopharmaceutical fermentation, its precise sodium and water content allow for strict pH and osmotic control, which helps researchers avoid variability in cell culture or antibiotic production runs.

    How Disodium Succinate Hexahydrate Differs from Other Sodium Succinate Products

    On the technical side, the “hexahydrate” designation sets this material apart. Pure sodium succinate anhydrous, which we also manufacture in limited runs, tends to absorb water from the air and clump during storage, especially in humid conditions. The hexahydrate is more stable; it handles the rigors of storage, long shipping distances, and variable warehouse climates without drastic changes in physical character. Removing moisture leads to the anhydrous form but disturbs the crystal lattice, which can make mixing unpredictable. Customers tell us they notice fewer caked lumps when pouring out our hexahydrate, simply because the water molecules buffer the sodium ions and discourage bridging.

    Other sodium flavor enhancers, like monosodium glutamate or sodium inosinate, offer their own flavor curves but carry different allergen, labeling, and stability profiles. In comparison, Disodium Succinate Hexahydrate fits neatly within both vegetarian and halal food chains and enjoys a reputation as a less controversial flavor agent. End users working in stringent regulatory environments—where transparency about ingredient origin and processing aids matters—benefit from the traceability that comes with supply directly from the manufacturer.

    Quality Control Built on Experience

    Each production run is inspected from raw material receipt through crystallization, drying, packaging, and lot certification. Early on, we realized that the tightest quality depends not only on instruments but also on the people who operate them. Trained staff measure, document, and check for pH, solubility, trace metals, and organic volatiles. Some older members of the team have been with us since the first bags rolled off the line and can spot a subpar batch just by watching how it pours or how quickly it dissolves. When customer complaints arise—rare, but inevitable in any manufacturing operation—we sample the returned product and trace back through logs, process controls, and supplier lots to find the root cause.

    Application Examples from the Factory Floor

    A story comes to mind from a few summers back, when a client developing freeze-dried broth cubes faced repeated flavor inconsistency. With them on-site, we did hands-on blending trials until we matched their sensory benchmarks every time. The switch from a competitor's anhydrous succinate to our hexahydrate led to noticeably more even flavor release.

    In microbiology, a producer of L-lysine bulked up their fermentation yield after switching to our high-purity succinate. Before switching, their anhydrous source introduced variable water content, which skewed concentrations and raised costs for pH adjustment. Our product’s predictable composition made it easier to standardize their batch media. Livestock feed producers also mention how the fine grain of our product resists bridging and improves dosing uniformity in mechanical blending, even when humidity rises.

    Distinctive Benefits in End Use

    The most knowledgeable users ask detailed questions: Will the product withstand autoclaving? Does downstream processing extract too much water? In our experience, Disodium Succinate Hexahydrate stays chemically stable through many thermal cycles, provided storage remains dry and packaging remains intact. The bound water doesn’t strip flavor during pasteurization or extreme pH shifts. Unlike other forms, this specific hydrate reduces the likelihood that the compound will break down or transform during processing, even if the temperature fluctuates for hours at a time.

    Shelf life depends mainly on moisture exposure, so our double-layer polyethylene and kraft packaging locks out damp air and preserves flowability for over a year in warehouse conditions. Each bag carries a clear lot number that traces directly back to production data, which reassures risk managers and food safety auditors alike.

    Environmental Considerations From Manufacturing Through Use

    We’ve learned that environmental stewardship goes hand in hand with sound production. Over the last decade, process optimization has cut our sodium carbonate waste stream in half—by fine-tuning reaction efficiency and recycling process water, we’ve reduced both raw material costs and final effluent load. Since succinate comes from simple hydrocarbons or bio-based routes, sourcing more sustainable inputs represents a future target for us. In application, the hexahydrate version poses low risk, as it breaks down safely in biological treatment plants and doesn’t bioaccumulate in the environment.

    Transport, too, raises questions about environmental footprint. Denser, anhydrous succinate saves shipping costs but presents challenges in both storage and customer processing. We choose to balance these, offering the hexahydrate for clients who prioritize stability and convenience over marginal cost savings.

    Challenges We Have Overcome in Manufacturing

    From the start, the main obstacle revolved around consistency. In older, smaller reactors, even slight temperature or pH drift produced mixed hydrates or unwanted side products. Operators spent long shifts manually dosing and checking conversion rates, and scraps from subpar batches turned into learning experiences. Now, with automated pH control and better heat transfer in the reactors, batch-to-batch reproducibility climbs every year. Regular cross-training lets our team swap roles and spot issues faster, especially during seasonal shifts in raw material quality.

    Packaging also evolved after clients reported minor caking in coastal regions. We worked through several dozen combinations before settling on a dual-barrier package that resists both airborne water and mechanical abrasion in transit. Fine-tuning this required feedback loops between the delivery truck driver, warehouse staff, and QA managers—each catching different weak points.

    Feedback and Collaborative Innovation

    We often invite larger customers onto the plant floor for joint process reviews or customer audits. The suggestions have led to improvements, from faster loading ramps to new inline sieving for even finer particle grade options. In one case, a beverage company visited to discuss how the saltiness and umami profile of succinate behaved in their low-salt soups. After hands-on testing, they found that our hexahydrate produced a rounder flavor with no metallic aftertaste, especially after storage or reheating—so we now hold that lot specification constant for their regular orders.

    Food Safety and Regulations

    Regulatory compliance isn’t just a paperwork job for us—it’s embedded into how we select raw materials, test product, and record data. As rules evolve in each country, we keep up with changes—especially for maximum limits on trace metals or requirement to declare ingredients as vegan, cruelty-free, or kosher. Global food safety certification audits require not only proof of origin but regular equipment validation and operator retraining. All cleaning agents and process aids are documented and tested for absence in finished goods. Auditors often ask to examine our water quality logs and cross-check with finished batch specs, and we supply detailed answers directly from our digital record system.

    Feed sector clients care most about residue and potential for cross-contamination. We have dedicated lines for each compound and use timed, validated cleanouts between shifts. Shipment papers state not only lot and net weight, but every additive or anti-caking aid used, even if it enters only as a process facilitator and not as a labeled ingredient.

    Traceability and Transparency—From Batch to Shelf

    Since buyers for major food brands require full traceability, we keep each batch carefully logged—from incoming acid through filtration, crystallization, and drying, down to the shift and operator in charge. This chain of custody makes it easy for us to respond to any verification request, whether for organic certification, allergen control, or export paperwork. The close relationship between manufacturer and end user means quicker answers and fewer layers of miscommunication.

    Transparency also means regular updates: we send out bulletins when ingredient standards or process parameters shift. Customers appreciate not being left in the dark about formulation tweaks or lot changes. In the rare event that supply chain disruptions cause delays, our production planners notify partners early and offer alternatives or adjusted schedules.

    Supporting Research and Innovation

    As research into taste, nutrition, and fermentation advances, we notice a trend toward cleaner labels and bio-based ingredients. Disodium Succinate Hexahydrate fits neatly into this movement—derived from basic building blocks and produced by well-understood chemistry. Our technical staff regularly supports customer pilot trials, sometimes running split-batch productions to compare new blend ratios or test stability under harsh conditions. We send detailed sample packets on request, complete with certificates and typical analysis data. Open collaboration with R&D teams on both sides leads to better process knowledge and faster scale-up.

    Several academic and private labs approach us for custom specifications: high-purity, ultra-low metal content, or special particle sizes. We can tune the process for tighter sodium limits or alter drying times to reach a specified water content, opening avenues for customized research applications. The growing trend toward fermentation and biosynthesis processes benefits directly from our consistent composition, since downstream separation and analysis rely on predictability in every supply lot.

    Future Directions and Continuous Improvement

    Looking ahead, supply partners increasingly request greener manufacturing approaches. We are actively seeking to expand renewable energy use at the plant and are in the early consultations with suppliers offering bio-derived succinic acid. Our labs are exploring recycling scrap succinate and investigating zero-waste process loops. For those in need of halogen-free additives, we develop ways to reduce contaminants and exceed emerging safety standards—knowing that more regulators demand these as baseline requirements.

    The food and bioscience industries keep driving up expectations for not just purity, but also for documented sustainability and social responsibility. As pressure mounts to move toward biologically sourced starting materials, we’re working with academic consortia to trial fermentation-based production, and we expect interesting results to follow in the coming years. All these efforts tie back to what customers ultimately expect: a stable, consistently high-quality product that solves flavor, performance, and traceability challenges efficiently and transparently.

    Staying Focused on the Essentials

    Every shift at the plant, whether running a thousand-kilo production or checking one last lot before shipment, reinforces a clear theme: Disodium Succinate Hexahydrate delivers not only reliable performance, but the confidence that comes from dealing directly with the source. Drawing on real production challenges and customer feedback, we continually improve—from raw material selection to packing room audits and delivery reliability—because each end-user’s trust is earned batch by batch, not through abstract promises or third-party spin.