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Diphenylacetaldehyde

    • Product Name Diphenylacetaldehyde
    • Alias Benzyl phenyl ketone
    • Einecs 211-095-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    578985

    Cas Number 645-62-7
    Iupac Name 2,2-diphenylacetaldehyde
    Molecular Formula C14H12O
    Molar Mass 196.25 g/mol
    Appearance Colorless to pale yellow liquid
    Melting Point 23-25°C
    Boiling Point 151-153°C at 10 mmHg
    Density 1.068 g/cm³ at 25°C
    Solubility In Water Practically insoluble
    Refractive Index 1.6060 at 20°C
    Smiles C(C1=CC=CC=C1)(C2=CC=CC=C2)C=O
    Flash Point 124°C

    As an accredited Diphenylacetaldehyde factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Diphenylacetaldehyde is packaged in a 100 g amber glass bottle with a secure screw cap and labeled with hazard warnings.
    Shipping Diphenylacetaldehyde is shipped in tightly sealed containers, protected from light and moisture. Transport under ambient temperature, ensuring compliance with local and international chemical safety regulations. Avoid contact with incompatible substances. Proper hazard labeling is required. Handle with care to prevent leaks or spills, and ensure documentation accompanies each shipment for regulatory and safety purposes.
    Storage Diphenylacetaldehyde should be stored in a tightly closed container, in a cool, dry, well-ventilated area away from sources of ignition and incompatible materials such as strong oxidizers. Protect from light and moisture. Store at room temperature or as recommended by the manufacturer. Ensure proper labeling, and keep away from heat, sparks, and open flames. Use appropriate precautions to prevent inhalation or skin contact.
    Application of Diphenylacetaldehyde

    Applications of Diphenylacetaldehyde in Industrial Manufacturing

    Diphenylacetaldehyde serves as a specialized aromatic intermediate across fine chemical sectors where distinct olfactory, structural, or functional characteristics are required in the end product. Below, we outline our direct manufacturing knowledge for its integration in downstream markets based on industry standards, practical formulation guidance, and validated production technology.

    1. Fragrance Compound Synthesis for Perfume and Home Care

    Diphenylacetaldehyde provides a unique intense floral-green odor profile, making it a key intermediate in the synthesis of complex fragrance molecules used in personal care and household odor control products. Manufacturers blend it with other aldehydes and alcohols to create signature notes and to introduce depth to fine fragrance bases, air freshener concentrate, and premium laundry detergents. Its role is especially significant in heart and base note compositions requiring lasting olfactory performance under various pH conditions encountered during consumer product use.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards
    • EU Cosmetic Regulation (EC) No 1223/2009
    • US EPA TSCA (Toxic Substances Control Act) for household products
    • IFRA/IOFI Labeling Manual for allergen disclosure

    Typical usage ratio

    • Usually incorporated at 0.05%–1% of finished fragrance oil blend depending on target intensity and regulatory threshold; perfumers adjust loading based on performance in finished product matrix and regional compliance maximums.

    Downstream process integration

    • Enters formulation during the fragrance compounding stage, often in pre-diluted form; homogenized as a minor but potent component in bulk blending tanks prior to encapsulation or direct addition to finished consumer product bases.

    Final product types

    • Fine perfume concentrates
    • Functional fragrances for personal care (shampoos, soaps)
    • Detergent fragrance capsules
    • Room and fabric freshener liquids and aerosols

    2. Pharmaceutical Intermediate for Antispasmodic Active Ingredients

    Pharmaceutical synthesis utilizes diphenylacetaldehyde as a building block in multi-step processes that ultimately yield antispasmodic drugs, particularly those incorporating a diphenyl component in their pharmacophore. Chemists leverage its aldehyde functionality in Knoevenagel condensation or Grignard reactions for the assembly of active pharmaceutical ingredient (API) scaffolds. Reaction parameters demand high raw material purity and tight quality control for compliance with established monographs and GMP requirements.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practices for APIs
    • European Pharmacopoeia (Ph. Eur.) monograph requirements for raw material/impurity profile
    • USP/NF standards for identity and purity
    • 21 CFR Part 211 (US cGMP for finished pharmaceuticals)

    Typical usage ratio

    • Applied in molar ratios ranging from 0.8–1.2 equivalents as a core reactant in stepwise synthesis; ratios adjusted based on desired yield and downstream impurity management during purification.

    Downstream process integration

    • Introduced commonly as a first- or second-step reactant during API precursor formation, followed by isolation, crystallization, and purification prior to downstream formulation or salt formation.

    Final product types

    • Intermediates for antispasmodic APIs (e.g., derivatives in pharmaceutical-grade bulk)
    • Precursors for further condensation or alkylation steps
    • Specialty pharmaceutical reference standards for method development

    3. Fine Chemical Intermediate for Polymerizable Monomers

    In specialty polymer resin manufacturing, diphenylacetaldehyde supplies unique aromaticity and rigidity in the preparation of monomers for advanced polymeric materials. It acts as a functional core in the synthesis of diaryl vinyl monomers employed in thermosetting resin systems, increasing structural stability and modifying the glass transition temperature of the final polymer. Compatibility with highly-controlled industrial condensation and polymerization processes is critical for producing end products with precise mechanical and optical characteristics.

    Industry compliance standards

    • REACH Registration, Evaluation, Authorisation and Restriction of Chemicals (EU)
    • ISO 9001:2015 Quality Management for Polymer Manufacturing
    • ASTM D638-14 (Standard Test Method for Tensile Properties of Plastics) for downstream evaluation
    • RoHS Directive 2011/65/EU for electrical applications

    Typical usage ratio

    • Incorporated at 1–10 mol% relative to other monomers or backbone precursors, precise proportion set to modulate crosslink density and effect on final property profile.

    Downstream process integration

    • Added to monomer synthesis during core condensation or acylation phase; post-synthesis purification precedes copolymerization or molding operations.

    Final product types

    • Aromatic thermosetting polymer resins
    • High-performance engineered plastics for automotive or electronics
    • Optical grade polymers for specialty applications

    4. Aroma Chemical Precursor for Food Flavoring Substances

    In the food flavoring industry, diphenylacetaldehyde finds use as a critical intermediate in the synthesis of certain artificial and nature-identical flavor components, especially those designed to mimic complex berry and honey notes. Its selectivity allows flavorists to build up target molecules under reactor conditions suitable for food applications, requiring food-grade handling and strict residual analysis. Production runs operate under zero-contamination protocols to ensure consumer safety and regulatory adherence.

    Industry compliance standards

    • FCC (Food Chemicals Codex) ingredient requirements
    • EU Regulation (EC) No 1334/2008 (Flavorings and certain food ingredients)
    • US FDA 21 CFR §172 (Food Additives Permitted for Direct Addition)
    • HACCP (Hazard Analysis Critical Control Point) for food-grade manufacturing

    Typical usage ratio

    • Involved at 0.05%–0.5% w/w in the synthetic pathway leading to approved flavor actives; final flavoring substance use in end-food product typically does not exceed 5 ppm.

    Downstream process integration

    • Charged into reactor during the initial synthesis of aroma esters and ketones; rigorous post-reaction purification yields food-grade intermediates for subsequent flavor blending.

    Final product types

    • Nature-identical and artificial berry flavor compounds
    • Honey-type or floral-note food flavor additives
    • Flavor bases for confectionary, beverages, and baked goods

    5. Intermediate for Advanced Agrochemical Synthesis

    Research-driven agrochemical formulations employ diphenylacetaldehyde as an intermediate for the construction of innovative fungicide and herbicide scaffolds. Its reactivity with heterocyclic amines and organophosphorus agents forms part of the synthesis route for active substances with improved resistance profiles and application versatility. Control of process parameters and antiproliferation of side impurities is verified through systematic analytical monitoring, ensuring reliable downstream performance in formulated crop protection products.

    Industry compliance standards

    • FAO/WHO Specifications and Evaluations for Agricultural Pesticides
    • OECD Principles of Good Laboratory Practice (GLP)
    • ISO 17025:2017 for analytical laboratories
    • US EPA 40 CFR Part 180 (Tolerances and Exemptions for Pesticide Chemical Residues)

    Typical usage ratio

    • Employed at 0.2–1.5 molar equivalents based on desired agroactive molecular structure and downstream purification route; adjusted according to stage yield optimization.

    Downstream process integration

    • Introduced in the key condensation or cyclization step for synthesis of target active intermediate molecules; followed by chromatographic separation and crystal isolation to prepare for final formulation of wettable powders or liquid concentrates.

    Final product types

    • Active ingredient intermediates for fungicides and herbicides
    • Bulk technicals for agrochemical custom synthesis
    • Reference standards for regulatory submission
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    Certification & Compliance
    More Introduction

    Diphenylacetaldehyde: Direct from the Manufacturer

    Our Story with Diphenylacetaldehyde

    Every manufacturer has those products they know like the back of their hand. For us, Diphenylacetaldehyde fits that bill. Years of steady refinement and hands-on production have brought us to a level where consistency and control are built into every batch. Before this chemical ever leaves our facility, it gets the care and oversight that only a manufacturer's touch brings. We don't rely on descriptions developed by sales teams. Our relationships with chemists and technical staff shape every improvement. Day after day, technicians study the reaction parameters and watch the quality indicators they know from memory. Our process isn’t off-the-shelf. It’s something we’ve lived, corrected, repeated—until the outcome matches our standards.

    Model and Purity: Not All Diphenylacetaldehyde Is the Same

    We offer Diphenylacetaldehyde with a tested purity surpassing 98%, among the highest levels practical for consistent lab and production use. Certain tasks call for this grade, and years of feedback from our industrial partners support this specification. Lower grades may save cost, but impurities bring headaches: false readings, inconsistent yields, unwanted byproducts in synthesis. Over time, biting the bullet for high-purity material brings real value. In our own synthesis rooms and lab-batch explorations, we’ve witnessed the difference between technical- and premium-grade material. Premium grades eliminate variables you can’t chase down in hindsight.

    Our current standard model, labeled simply as Pharmaceutical and Fine Chemical Grade, avoids convoluted code systems. The content focuses on what clinicians and process chemists really want to see: clear assay data, tight limits for max impurities, and a transparent batch record.

    Physical Features Backed by Real Observations

    Diphenylacetaldehyde comes in the form of an oily liquid. Chemists on the floor know the distinct pale yellow hue and distinctive scent before any label is checked. Each shipment is sealed in high-density polyethylene containers, capped with nitrogen, not because it’s trendy but because oxygen turns Diphenylacetaldehyde into something unpredictable. We noticed, after fielding returns from frustrated customers, that even a small amount of exposure during packaging could disturb stability. Since then, every shift crew understands the cost of shortcuts.

    Crystalizing the product remains impractical and unnecessary, except in niche applications. The liquid state lets our customers decant and measure with accuracy. Glass ampoules were trialed and found more trouble than they're worth. So, bulk containers with tamper seals became the shop-floor compromise.

    Why Chemists Use Diphenylacetaldehyde

    In pharmaceutical development, Diphenylacetaldehyde often steps in as a building block for active molecules. The aldehyde group cooperates in condensation and addition reactions, while the twin phenyls stabilize intermediates that would decompose in simpler aldehydes. Synthetic routes for antihistamines and some psychoactive research chemicals benefit from this stability. Talking with formulation teams, we routinely hear that alternative benzaldehydes can’t match the same reactivity profile without sacrificing yield or selectivity.

    Outside the pharma sector, Diphenylacetaldehyde plays a role in aroma chemistry. Its scent features in niche fragrance blends, where chemists seek complex, woody aldehyde notes that resist easy duplication. In smaller runs, flavor companies experiment with it in controlled environments, always cautious because of regulatory oversight associated with aromatic aldehydes.

    Key Differences from Close Relatives

    It helps to talk about what Diphenylacetaldehyde isn’t. Benzaldehyde, for instance, is nearly a household name. Simple, cheap, commonly sourced—yet it brings a sharp, almond aroma that limits its use and overpowers blends. Its single-ring structure reduces stability in some reactions. Both bench chemists and industrial process managers have told us they switched from benzaldehyde to Diphenylacetaldehyde after realizing the nuanced effects that extra phenyl ring brings—not just for structure but for melting point, reactivity, and resistance to air-oxidation when handled carefully.

    Take Cinnamaldehyde: everyone loves how it performs in flavorings, but its high reactivity and broader regulatory hurdles mean it’s a less flexible partner in research-scale pharmaceutical work. Our partners in fine chemicals comment on how Diphenylacetaldehyde gives a more precise control in heterocycle synthesis or Mannich-type reactions, favoring predictable selectivity and lower side product formation. We know from our own long-term projects that its chemical profile makes a difference—sometimes the margin between a scalable process and a laborious trial.

    Handling, Storage, and Lessons Learned from Experience

    Working directly with large and small clients who use Diphenylacetaldehyde means we hear about storage stresses firsthand. Traditional warehouse setups don’t always match the needs of sensitive aldehydes. We had one case of off-odor complaints, ultimately tracked down to shared warehouse proximity with strong acids and oxidizers. That triggered improved design on our own storage solutions—dedicated bays, temperature monitors, and automatic alert systems for seals and pressure valves.

    From our earliest years in the field, we developed a best-practices sheet that has since become almost routine for our regular industrial accounts: keep it cool (below 25°C), keep it dry, seal tightly after each withdrawal, and, most importantly, document date of opening. We learned it’s not enough to ship a perfect drum; user routines on the other end matter just as much. Sharing photos from our own shop, we illustrate drum transfer techniques, teach new hires about splash risks, and insist on decanting under local exhaust or in glove boxes where volumes justify it.

    Common Pitfalls and How We’ve Helped Solve Them

    People call us to troubleshoot more often than to place orders. Gauging whether discoloration or sticky residue means problem isn’t always clear for buyers. If old stock starts yellowing or viscosity rises, it's often a signal of either air or trace moisture uptake. We cut through the guesswork, test retained samples from each batch, and walk users through stability evaluation.

    Cross-contamination destroys sensitive syntheses, so our staff double-checks every cleaned drum and line. Problems caused by shared transfer tools show up as persistent, mysterious low-level impurities. To tackle that head-on, we started color-coding devices and putting up job-aid posters. Even experienced technicians benefit from visual reminders. One overlooked gasket can spoil several kilograms—sometimes a full day’s value.

    Customers working at bench scale sometimes accidentally warm Diphenylacetaldehyde above ideal handling temperatures during solvent removal. Overheating boosts the risk of decomposition to polymeric or resinous byproducts. A reminder from our end: stick close to standard operating procedures for vacuum evaporation, never push heat for the sake of speed, and always calibrate temperature probes. If unsure, our technical representatives walk through the process step-by-step, sharing calibration logs and practical handling tips born from our own mistakes.

    Supporting Evidence We Stand Behind

    Our approach draws from audit trails, internal record-keeping, and hundreds of chromatograms run on retention samples. We track customer feedback using a simple system: every complaint warrants a follow-up, every returned container gets an in-house analysis, whatever the cost. By maintaining a direct dialogue with downstream chemists, we can quickly pinpoint recurring patterns—delayed shipments in hotter months correlate with higher incidence of product degradation, so we moved to cold-chain shipping for the twelve warmest weeks of the year. For some applications, we added in-house pre-shipment purity rechecks when customers flagged drift in their QC results.

    We’ve also run direct head-to-head tests against samples from global competitors. The results? Tighter impurity profiles, higher lot-to-lot consistency, and far fewer service calls related to instability or unknowns. This isn't a boast; it’s a reality checked by repeated joint-lab projects with high-volume partners.

    Regulatory and Environmental Practices with Real-World Impact

    As a manufacturer, we bear responsibility for compliance above and beyond what remote vendors face. Our Diphenylacetaldehyde process operates under strict local and international standards. Each batch ships with assay results reflecting updates in regulatory residue, impurity, and analytical method guidelines. If any shift manager notices procedures have drifted—say, sampling frequency dips or documentation is incomplete—they call it out. Early on, we see the need for this: inconsistent adherence translates to audit findings and reworks. Avoiding hassle up front, and keeping processes tight, saves everyone time and stress.

    Waste management became a priority after we tallied the disposal logs—aromatic residues, if inattentively vented, can linger in the air and create workplace complaints or trigger environmental controls. Tightening up solvent recovery, switching to contained drum-washing, and training all new employees on selective disposal all stem from lived headaches, not just regulation. Improvements extend to our community as well—neighbor complaints dropped, compliance issues disappeared.

    The Real Differences: Direct Sourcing versus Indirect

    Producing Diphenylacetaldehyde at our own facility removes the layers of mystery that come from dealing with brokers or repackagers. Batch origin is never in question. Every drum has traceable birth, from raw material sourcing (we carefully audit benzyl chloride and benzene deliveries) to detailed records of each operator signing off on their process step. Over time, this direct connection forms a relationship of trust with our regular clients. We don’t rely on certificates prepared far upstream, nor do we wait days for product histories when an issue comes up.

    Shifting to direct sourcing resolves unexpected slowdowns, simplifies compliance in highly regulated fields, and brings genuine accountability. Our technical leads enjoy troubleshooting with process chemists and R&D teams, not because policy demands it but because it actually strengthens partnerships. If one batch doesn’t meet spec, replacements ship within days, not weeks. The openness of the feedback loop—good and bad—improves the next batch, and our own team benefits from real-world lessons, not just lab simulations.

    Making Diphenylacetaldehyde Work for You: Practical Tips and Support

    We don’t produce Diphenylacetaldehyde just to stick jars on shelves. Our technical support team grew out of our own struggles bringing new processes online. When a partner’s process hits a wall—unexpected reactivity, handling oddities, or regulatory questions—our time-tested team is there to untangle it. We’ve helped set up first-use protocols, trained entire teams in handling sensitive aldehydes, and developed custom documentation for process validation.

    Clients receive more than product; they get the benefit of our experiences—both the setbacks and the successes. Instead of leaning on user manuals, we build documentation from our own learning curve. We support early-phase discovery as well as late-stage commercial processes, adapting language and methods for wherever a customer is in their journey. Our engagement doesn’t end at the invoice. If something unexpected happens, we want to hear about it—so we can track it, solve it, and keep moving the state of the art forward.

    Ongoing Improvements: Listening and Adapting Each Year

    A product like Diphenylacetaldehyde isn’t static. Raw materials shift, market demands push new grades, and individual users need special fits for their process. Each year, our R&D and QC staff review complaints, successful case studies, and competitive benchmarks. If a formulation chemist struggles with solubility or downstream conversion, we pilot small-batch tweaks and offer samples. Listening to field feedback has produced surprisingly simple fixes—modifying packaging size, adjusting headspace to minimize oxidation, expanding shelf life studies for reference.

    Product stewardship flows both ways—suggestions from frequent users often lead to internal changes. Conservation chemists have shared best practices in aldehyde stabilization, and our bench team builds those into regular work habits. Our improvement cycles loop real-world voices back into each production run, turning external wisdom into day-to-day protocol.

    Conclusion: Our Position as a Manufacturer

    Producing Diphenylacetaldehyde isn’t just a technical task for us. It’s become a personal point of pride, shaped by years of trial, correction, and close dialogue with the industry. We know our batches, our limitations, and our opportunities for improvement. Unlike distributors who pass the product along, we bear direct responsibility for every shipment and every customer result. Fielding technical questions, helping solve unusual process barriers, and learning from user stories—these don’t just improve our material; they strengthen the industry as a whole.

    We stand behind every drum and every drop. Customers depend on that commitment, and our reputation rests on keeping quality high, support flexible, and processes accountable. We recognize the unique chemistry of Diphenylacetaldehyde—a compound that’s both versatile and sensitive, demanding, and rewarding for those willing to give it careful handling. That’s the balance we aim for: reliable, practical, and always open to the next challenge.