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Diisopropylamine Hydrochloride

    • Product Name Diisopropylamine Hydrochloride
    • Alias DIPA HCl
    • Einecs 225-056-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    410160

    Product Name Diisopropylamine Hydrochloride
    Chemical Formula C6H16ClN
    Molecular Weight 137.65 g/mol
    Cas Number 4261-68-1
    Appearance White to off-white crystalline powder
    Solubility Soluble in water and alcohol
    Melting Point 193-197 °C
    Boiling Point Decomposes before boiling
    Density 1.00 g/cm3 (approximate)
    Odor Amine-like
    Ph 1 Solution 4.0-5.0
    Storage Conditions Store in a cool, dry place, tightly closed container
    Stability Stable under recommended storage conditions
    Synonyms N-Isopropylpropan-2-amine hydrochloride

    As an accredited Diisopropylamine Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of Diisopropylamine Hydrochloride is supplied in a sealed, amber glass bottle with a secure screw cap and protective labeling.
    Shipping Diisopropylamine Hydrochloride is shipped in tightly sealed, chemical-resistant containers to prevent moisture absorption and contamination. Packages are clearly labeled with hazard information and handled according to safety regulations. Shipments comply with local and international transport guidelines for chemical substances, ensuring secure, prompt delivery to laboratories or industrial facilities.
    Storage Diisopropylamine hydrochloride should be stored in a cool, dry, and well-ventilated area, away from moisture and incompatible materials such as strong oxidizers. Keep the container tightly closed and protect it from physical damage. Store it in a chemical storage cabinet, following standard laboratory safety protocols. Ensure proper labeling and keep it away from heat and ignition sources at all times.
    Application of Diisopropylamine Hydrochloride

    Applications of Diisopropylamine Hydrochloride in Industrial Manufacturing

    As a specialized manufacturer of Diisopropylamine Hydrochloride, we support key industries with precise raw material solutions designed for critical process integration. The following sections highlight established industrial application scenarios where this compound delivers defined chemical performance under regulated standards.

    1. Pharmaceutical Intermediate Synthesis for Antihistamines

    Pharmaceutical manufacturers use our Diisopropylamine Hydrochloride as an alkylation agent and acid scavenger during multi-step synthesis of several antihistamine ingredients, such as those for first-generation agents and related APIs. The compound’s defined amine source supports the formation of intermediate amide and amine structures under controlled pH conditions. Production sites implement strict GMP protocols when introducing this material during core reaction and neutralization phases, ensuring consistent impurity profiles and traceability. The utility of this compound lies in its strong nucleophilicity, promoting targeted substitution and elimination reactions while acting as a transient hydrochloride source in salt-form production.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Part II (APIs)
    • Pharmacopeia Monographs (USP, EP for relevant intermediates where applicable)
    • FDA 21 CFR Part 211 (Finished Pharmaceuticals)

    Typical usage ratio

    • 0.5–3 molar equivalents relative to target intermediate, adjusted based on reaction pathway optimization and stage yield monitoring

    Downstream process integration

    • Charged into controlled reactor vessels during amide or amine coupling and quenching steps of multi-stage antihistamine synthesis; entered post-activation of base structure and prior to isolation

    Final product types

    • API antihistamine intermediates
    • Bulk pharmaceutical active ingredients (e.g., diphenhydramine, chlorpheniramine production lines)
    • Pharmaceutical salt forms for tableting or encapsulation
    • Contract manufactured fine chemical intermediates for regulated markets

    2. Crop Protection Chemical Manufacturing (Herbicide Synthesis)

    Agrochemical formulators and process engineers apply our Diisopropylamine Hydrochloride for nucleophilic substitution and neutralization steps in synthesis of selective herbicide molecules. It serves both as a reactant for constructing tertiary amine side chains and as a pH-modifying agent that enables precise precipitation of technical-grade actives. Continuous-flow and batch reactor setups both leverage this compound to produce stable crystalline or amorphous forms, supporting downstream granulation and liquid concentrate production under tight impurity control. Its defined reactivity enhances throughput in large-scale synthesis, especially for amine salt herbicides destined for global registration dossiers.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System for Agrochemical Production
    • FAO/WHO Specification for Pesticides
    • EPA 40 CFR Part 180 (US Tolerances for Residues of Chemical Pesticides)
    • REACH Regulation (EC) No 1907/2006

    Typical usage ratio

    • 1.2–1.8 molar equivalents per mole of acid functional group in target herbicide molecules; dosing validated via in-process HPLC and endpoint titration

    Downstream process integration

    • Dosage in post-activation neutralization reactors following core backbone synthesis; included in the salt formation and crystallization stages directly preceding filtration and drying

    Final product types

    • Technical-concentration herbicide amine salts
    • Soluble liquid concentrates (SL) and granular herbicide formulations
    • Bulk actives for pesticide premix production
    • Intermediates for custom synthesis of proprietary crop protection agents

    3. Fine Chemical Manufacture for Photographic Chemical Derivatives

    Producers of photographic and imaging chemicals adopt Diisopropylamine Hydrochloride in multi-step production of specialized dye couplers and stabilizers used in high-sensitivity films and digital print developer baths. The compound acts as a critical organic base in nucleophilic aromatic substitution reactions that incorporate multiple functional groups into dye precursor structures. Downstream batch and semi-continuous processes require stable amine hydrochloride input to achieve controlled colorant reactivity and purity. Our material meets the stringent quality parameters necessary for sensitive reactions, supporting trace specification management and stable performance across long operational campaigns.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management for Fine Chemicals)
    • ISO 14001:2015 (Environmental Management)
    • Relevant ANSI safety standards for chemical processing
    • Customer-specific analytical acceptance criteria for colorant precursors

    Typical usage ratio

    • 0.7–1.5 equivalents per mole of core substrate, ratio determined by desired colorant yield and control of by-product formation

    Downstream process integration

    • Enter into heating and reflux stages of aromatic substitution or alkylation; addition timed to maximize conversion efficiency and limit degradant accumulation

    Final product types

    • Photographic coupler intermediates
    • Color developer agents for photo print chemistry
    • Stabilizers for imaging emulsions
    • Raw materials for specialty dyes used in medical and forensic imaging

    4. Polymerization Catalyst for Polyurethane Additive Manufacturing

    Industrial polyurethane producers integrate Diisopropylamine Hydrochloride as a catalyst modifier during prepolymer and foam synthesis, targeting applications that demand well-defined cell structure and enhanced closed-cell content. The compound stabilizes isocyanate and polyol mixing phases, acting as an acid scavenger and chain controller within catalytic systems. Its use facilitates in-tank viscosity adjustment and moderates reaction completion profiles on commercial-scale RIM (Reaction Injection Molding) and slabstock production lines. Regular QC release and process monitoring ensure consistent catalytic activity with minimized side reaction by-products, satisfying stringent customer and regulatory foam performance demands.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management for Polymer Manufacturing)
    • REACH Regulation (EC) No 1907/2006 for Industrial Chemicals
    • ASTM D3574 (Flexible Cellular Materials—Slab, Bonded, and Molded Urethane Foams)
    • OEKO-TEX® Standard 100 for restricted substance sections (foam applications for textiles)

    Typical usage ratio

    • 0.05–0.25% weight of total formulation, range established by pilot-scale runs to balance foam rise time, density, and final physical properties

    Downstream process integration

    • Dispensed into polyol blend tanks prior to isocyanate addition; staged metering systems provide lab-validated dosing adjustments as per daily viscosity and reactivity testing

    Final product types

    • Custom polyurethane foam blocks, sheets, and molded automotive parts
    • Technical polymer additives for insulation board
    • Flexible foam components for furniture and bedding
    • Prepolymer catalyst packages for R&D or specialty process adaptation

    5. Chemical Process Aid in Surfactant and Emulsifier Synthesis

    Specialty surfactant and emulsifier manufacturers utilize Diisopropylamine Hydrochloride to catalyze amination reactions, convert acid functional groups, and adjust pH during downstream fractionation and neutralization sequences. The amine hydrochloride enters continuous and batch operations, facilitating targeted molecular modifications, especially for the production of tertiary amine- and ammonium-based surfactants. Its consistent assay and controlled solubility properties support accurate formulation balance and post-synthesis purification across process scales, contributing to diverse application-specific surfactant blends.

    Industry compliance standards

    • ISO 22716:2007 (Cosmetic Good Manufacturing Practices, for surfactants used in personal care)
    • ISO 9001:2015 (Quality Management—Surfactant Manufacturing)
    • REACH Regulation (EC) No 1907/2006 (Registration, Evaluation, Authorization, and Restriction of Chemicals)
    • IFRA Standards (for surfactant ingredients applicable in fragrance and cosmetic products)

    Typical usage ratio

    • 0.2–1.0 equivalents per acidic group in base substrate; actual proportion optimized for specific surfactant class and product grade

    Downstream process integration

    • Added during post-condensation neutralization and amidation stages; pH monitored inline for final product clearance and fractionation quality

    Final product types

    • Tertiary amine surfactants for emulsification systems
    • Cationic surfactants for home and industrial cleaning
    • Specialty ammonium emulsifiers for agrochemical and cosmetic use
    • Intermediate bases for polymeric surfactant modification
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    Certification & Compliance
    More Introduction

    Reliable Diisopropylamine Hydrochloride—Direct from the Manufacturer’s Floor

    What Sets Our Diisopropylamine Hydrochloride Apart

    Manufacturing Diisopropylamine Hydrochloride for decades has given us a clear view of what industries really need—consistency, reliable supply, and honest, accurate product information. We have built our reputation on the back of that direct experience, producing this specialty chemical in-house, batch after batch, always sticking close to quality, traceability, and real-world handling knowledge.

    Every charge of Diisopropylamine Hydrochloride we synthesize starts with high-purity raw isopropylamine, reacted and controlled in a closed environment. This translates to a material free from nuisance contaminants, one that satisfies rigorous demands from pharmaceutical labs to production-scale chemical plants. Over time, the feedback we hear most often centers on trust in sample-to-sample reproducibility—the way our product works the same, every time, whether twelve drums or a single kilogram leaves our facility.

    Model, Form, and Core Specifications

    We mainly produce Diisopropylamine Hydrochloride as a crystalline solid. It comes in moisture-tight 25 kg fiber drums, smaller HDPE containers for specialty needs, and bulk packaging for high-volume projects. Typical purity exceeds 99.0% by HPLC, and our team pays obsessive attention to chloride and amine content. Water content rarely exceeds 0.3%, which remains below what most formulations can tolerate—even in sensitive API or crop protection synthesis.

    Particle size matters to end-users, particularly those running automated charging systems or tight formulation protocols. Over the past few years, we invested in improved milling and drying lines—so material clumps less, stays free-flowing, and dispenses cleanly even in high-humidity environments. We see this reduce downtime in user facilities and lower their waste, often in unexpected ways.

    User Experience in Key Application Fields

    We learn the most about our chemical’s strengths by supporting users from bench research to full-scale production. The story with Diisopropylamine Hydrochloride is similar, and our real test comes from how it holds up in applications where minor differences make huge impacts downstream.

    Pharma synthesis teams reach out to verify batch-to-batch analysis and impurity profiles. For them, a trace impurity can force revalidation or delay an entire campaign. We recognized long ago that their priorities differ from those of users in agricultural chemical processing, so we became more transparent about our internal quality checkpoints. Certificates come direct from our QC lab, stamped and signed on the day of shipment, with source chromatograms available upon request.

    Custom projects also shape the consistency targets we hit. Certain fine chemical users work with tight timelines and demand predictable solubility with polar solvents. By working directly with these partners, we adjusted granulation methods and polisher steps for a product with faster dissolution times—a small laboratory savings that becomes significant at industrial scale. These conversations push us to refine our approach, again proving that hands-on feedback always trumps generic claims.

    Safety and Handling—From Real-World Experience

    We have worked alongside plant operators who manage Diisopropylamine Hydrochloride day in, day out. These teams face enough stress dealing with complex syntheses—they shouldn’t have to wrestle with a product that cakes up in humid storage, or a grade that throws off analytical balances with invisible static.

    On our floor, improved sealing practices, robust liners, and proper pallet wrapping keep the powder stable during shipping and storage. Labels include handling tips we know from our own experience, not just copy-pasted lines from a data sheet. Long-term bulk users noticed fewer headaches from slow-dispensing bags and found less need to break up material on transfer, which cuts down on potential exposure and material waste. Many of our key clients now order by the pallet, and their warehouses see less spoilage at the bottom of each drum—worth mentioning, since small improvements compound quickly.

    The Role of Diisopropylamine Hydrochloride in Synthetic Chemistry

    Chemists see this salt as a valuable amine source—an intermediate for finding simple, efficient paths to complex molecules. Its role as an acid scavenger and nucleophilic base cannot be understated. We have talked to teams who run multi-step syntheses for pharmaceutical intermediates and appreciate the clean reactivity—no unexpected side reactions, no clumsy pH swings. They trust it particularly for quaternization steps, acylations, and amidations, where results depend on precise molar equivalents actually present in solution, not just a stated bulk percentage.

    A standout difference emerges when comparing our Diisopropylamine Hydrochloride to products from traders or anonymous third-party sources. We go through carbon, nitrogen, and sulfate tests on every lot, so there are fewer last-minute surprises for users conducting elemental analyses. This is not just luck—a consistent upstream process allows for reliable downstream outcomes. When users report fewer failed assays, they become repeat customers.

    Supply Assurance and Scalability

    We aren’t immune to supply disruptions, but in-house manufacturing lets us head off downstream shortages before they reach our customers. After the last few years of logistic turbulence, this in-house certainty means more than ever. Our model delivers flexible lead times, rapid scale-up when users need more product without fear of changing suppliers, and stable pricing that reflects real manufacturing costs.

    Contract partners who scale from 10 kg pilot runs to multi-ton production see the benefit most clearly: they work with one source of Diisopropylamine Hydrochloride from start to finish. This shortens technical validation, avoids tedious requalification, and keeps projects on track even as volumes shift with market demand.

    Customization Rooted in Real Demands

    Custom requests land on our desk every month—different mesh sizes, precise water content, or tailored lot sizes for campaign-based manufacturing. Our technical group sits steps away from the production floor; changes can be implemented with fast turnaround and minimal error. As a manufacturer, this flexibility remains one of our best advantages over distributors, who may only relabel material without touching the actual product.

    Once, a pharmaceutical partner struggled with a competitor’s Diisopropylamine Hydrochloride that clumped under warehouse lights. We worked up a drier process, swapped in a tighter liner, and restored their filling line to normal operation. This kind of iterative tweaking makes “customization” mean something specific—not just a box checked on a marketing slide.

    Regulatory Familiarity and Reliable Documentation

    Downstream users, especially those in regulated sectors, need more than just purity—they need a partner who knows how documentation keeps audits clean and projects green-lit. Our certificates do not come from faceless agents. Each CoA or TDS is cross-checked and matched to the exact batch, with archive copies traceable to source. If a regulatory inquiry pops up, we respond out of direct process knowledge, usually with immediate access to archived records and equipment logs.

    International buyers request additional details for various compliance regimes, from REACH to local environmental registrations, so our team stays current with what each region asks for. Our files go further than simple paperwork; records contain supplier information for each precursor, environmental emission data, and disposal support notes—all built on how we actually run our process, not paperwork fiction.

    Differences Beyond the Spec Sheet

    Many industrial buyers develop “spreadsheet blindness” in selecting chemical sources, finding products that meet headline specs but cause endless frustration in day-to-day use. Small differences in solubility rates, consistency of solute particles, or drift in moisture can disrupt entire operations. Having produced, tested, and shipped this product from one location for the long haul, we know how even tiny improvements ripple out as operational savings for users.

    We do not dilute, blend, or source from anonymous subcontractors. Each drum that leaves our warehouse comes from a process line built for amine chemistry, not a “general-purpose” filler provided by a third party. End-users who try competitor batches often return after one or two procurement missteps, citing performance, traceability, and process smoothness that only comes from original manufacture.

    Honest Challenges—And Our Ongoing Fixes

    No chemical production process stands still. Over the years, we noticed seasonal shifts in powder flow, interference in highly sensitive chromatographic tests, and the need for better packaging to keep the salt moisture-free under monsoon conditions. Instead of hiding behind disclaimers, we focus on incremental, real-world adjustments: more robust drying times in summer, better particle sieving, tighter raw material supplier lists. These institutional habits explain why repeat customers notice that small improvements appear regularly rather than waiting for formal “product upgrades.”

    We do not claim perfection. Our own team tests every lot using the same methods advocated for end-users, and, when we spot an issue, we retrace the error back to the root process. This discipline produces a better product, but also a culture of continuous improvement—real people, real mistakes, and real learning, not vague promises or complicated jargon.

    Environmental Impact—From Process Reality, Not Greenwashing

    More customers demand to know the environmental burn rate for their raw materials. We share actual process mass balances, not just buzzwords. Our production lines recover as much isopropylamine as possible, cut water use with improved scrubbing technology, and limit chloride emissions. Waste is tracked as part of our daily workflow, not tacked on as an afterthought. Both international and local auditors have walked our site, and their feedback has shaped investments in closed-loop waste minimization.

    By owning the full manufacturing loop, we can answer tough questions: How much waste chloride exits per ton of product? How much solvent is genuinely recycled on-site? These details matter more than “eco-friendly” logos, and our alignment with downstream users’ sustainability goals grows stronger every year.

    Diisopropylamine Hydrochloride in Context—Not an Isolated Ingredient

    This specialty salt shows up as an intermediate in hundreds of global chemical syntheses. Its behavior impacts steps far beyond the point of use. Clean, reproducible reactions start with clean, reproducible inputs. We have shared technical notes with partners troubleshooting unstable pH in crystallizations, inconsistent yields in active substance synthesis, or deposit buildup in equipment—findings that track back to material purity, not end-stage troubleshooting.

    Sharing this reality lets clients budget better, plan maintenance, and find new efficiencies. The feedback loop of trusted supply, real process experience, and transparent documentation helps the industry do better work, not just buy a product and forget the source.

    Comparison with Similar Amine Salts—From Practical Use Cases

    We get regular requests to clarify where Diisopropylamine Hydrochloride differs from comparable amine salts like mono- or triisopropylamine derivatives or other hydrochloride forms. These differences seem subtle, but in the plant, they have dramatic implications. Our salt balances volatility, ease of dissolution in organic and mixed aqueous systems, and predictable reactivity. Colleagues working with monoisopropylamine hydrochloride often report increased volatility and odor issues, while triisopropylamine analogs present solubility and residue concerns.

    Our product’s crystalline character means losses to vapor are low and dosing stays reliable—important for long mixing lines and large-scale tanks. In each field where substitution has been attempted, users end up returning to Diisopropylamine Hydrochloride for critical steps, appreciating its middle ground between reactivity and handling safety.

    Integrated Support Without the Middleman

    End-users characteristically dislike the impersonal, slow linkages that come with distributor-driven supply. Technical questions bounce around, answers grow vague, and custom lot needs get lost in slow approval processes. By keeping all points of contact and decision-making in-house, we bring direct answers: exactly how a batch was produced, which operators oversaw which step, and what adjustments addressed specific user feedback.

    If you need a precise analytical standard or small-scale sample, the same line chemist—who knows the batch’s quirks—is involved in prepping and sending the material. This hands-on approach saves time, reduces error, and builds a relationship of mutual trust rare in large-scale commodity chemicals.

    Looking Forward—Continuous Improvement, Not Just Maintenance

    After years of producing Diisopropylamine Hydrochloride, the biggest lesson is that each new application creates feedback that feeds back into our process. New pharmaceutical syntheses, tighter catalyst protocols, or safety-driven packaging all lead to changes on our side. We keep upgrading equipment, question our own documentation, and validate new protocols with real-world user input. Instead of sitting still, we keep improving with every batch, letting hard-earned operator experience shape the future of this vital amine salt.

    This open-loop improvement has real value. Each kilo produced stands for not only chemical purity, but manufacturing knowledge gained from each challenge, complaint, and technical request. With this salt, as with all of our core products, hands-on manufacturing experience remains the foundation of lasting reliability.