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Dihydrocaffeic Acid

    • Product Name Dihydrocaffeic Acid
    • Alias 3,4-Dihydroxyphenylpropionic acid
    • Einecs 210-064-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    560446

    Chemical Name Dihydrocaffeic Acid
    Iupac Name 3-(3,4-dihydroxyphenyl)propanoic acid
    Molecular Formula C9H10O4
    Molar Mass 182.17 g/mol
    Cas Number 5137-52-0
    Appearance White to light tan powder
    Solubility Soluble in water and ethanol
    Melting Point 133-135°C
    Structural Class Phenolic acid
    Boiling Point Decomposes before boiling
    Pka Approximately 4.4 (carboxyl group)
    Source Metabolite of caffeic acid, found in dietary plants
    Synonyms 3,4-Dihydroxyhydrocinnamic acid

    As an accredited Dihydrocaffeic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Dihydrocaffeic Acid is packaged in a 25-gram amber glass bottle with a secure screw cap, labeled with product details.
    Shipping Dihydrocaffeic Acid is shipped in tightly sealed containers to prevent contamination and moisture absorption. Packages are clearly labeled and include all relevant hazard information. Shipping is conducted in accordance with local and international chemical transport regulations, typically via ground or air, ensuring safe handling and storage during transit.
    Storage Dihydrocaffeic Acid should be stored in a tightly sealed container, protected from light and moisture. It is best kept in a cool, dry place, ideally at 2–8°C (refrigerator). Avoid exposure to heat and air, as these may degrade the compound. Handle under inert atmosphere if possible, and ensure good laboratory practices to prevent contamination or accidental exposure.
    Application of Dihydrocaffeic Acid

    Applications of Dihydrocaffeic Acid in Industrial Manufacturing

    Dihydrocaffeic acid is a specialty phenolic compound processed in-house to high-purity grades for industrial use. We actively support multiple downstream sectors with bulk supply and technical service for various end-use formulations. Below, we detail verified industrial applications where this material enters specific production chains, including compliance, usage ratios, integration steps, and finished product outputs.

    1. Cosmetic Antioxidant for Skin Care Formulations

    Major skin care brands worldwide employ dihydrocaffeic acid as a primary antioxidant for stabilizing emulsions and protecting sensitive actives in facial creams, serums, and lotions. Its polyphenolic structure provides free radical scavenging at trace dosages, ensuring extended shelf-life and performance in high-purity formulations. Integration begins at the emulsion compounding stage, with critical points at homogenization and pre-packaging QC. European and Asian cosmetic regulations govern ingredient use, and formulators test pH-compatibility to optimize antioxidant benefit without destabilizing complex blends.

    Industry compliance standards

    • EU Cosmetic Regulation (EC) No 1223/2009
    • Cosmetics Ingredient Review (CIR) safety assessments
    • China National Medical Products Administration (NMPA) Cosmetics Supervision
    • Good Manufacturing Practice (GMP) ISO 22716 for cosmetics production

    Typical usage ratio

    • 0.05% – 0.2% w/w in finished cosmetic formulations
    • Exact percentage varies by antioxidant system and product viscosity

    Downstream process integration

    • Added during oil or water phase mixing at 35–45°C
    • pH adjustment after incorporation to maintain 4.0–6.5
    • Homogenization with surfactants and actives, followed by QC assays for polyphenolic content

    Final product types

    • Facial creams (anti-aging, brightening, daily hydration)
    • Eye serums and gels
    • Sunscreen emulsions requiring oxidation stability
    • Body lotions and specialty moisturizers

    2. Food Contact Polymer Stabilizer

    Our dihydrocaffeic acid grades are standardized for compounding into food contact plastics such as PET bottles and food wrap. Its radical scavenging action helps delay polymer yellowing and degradation, especially under light or thermal exposure. Integration occurs during masterbatch preparation, and processors employ melt compounding or solution addition depending on the polymer system. All input is batch-traceable for food safety audits.

    Industry compliance standards

    • US FDA 21 CFR 177.1630—Polyethylene Terephthalate Polymers
    • EU Regulation (EU) No 10/2011 on plastic materials for food contact
    • China GB 9685: National Standard for Food Contact Materials Additive Use
    • BRC Global Food Safety Standard for packaging manufacturers

    Typical usage ratio

    • 100–500 ppm (0.01%–0.05% w/w) in PET or PP matrices
    • Adjustment based on end-use light stability and migration testing

    Downstream process integration

    • Blended with polymer resin and other additives during masterbatch production
    • Extrusion compounding at 250–280°C, followed by pelletization
    • Melt flow and migration checked per downstream food packaging specifications

    Final product types

    • PET beverage bottles with extended shelf life
    • Food-safe film and flexible packaging
    • Microwaveable food trays
    • Caps and closures for dairy and juice packaging

    3. Pharmaceutical Intermediate in Cardioprotectant APIs

    Select API manufacturers introduce dihydrocaffeic acid as a key synthetic intermediate for cardioprotective drugs, connecting its scaffold with specific pharmacophores during late-stage synthesis. In this regulated vertical, we provide traceable GMP-compliant lots with tight heavy metal and solvent residue controls. Custom batch documentation supports DMF filings, and finished API quality profiles align with international pharmacopoeias. The material enters at protected coupling or esterification steps, depending on the target molecule’s structure-activity requirements.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for API production
    • European Pharmacopoeia and US Pharmacopeia (USP) monographs for APIs
    • WHO GMP guidelines for pharmaceutical intermediates
    • Drug Master File (DMF) support documentation with full traceability

    Typical usage ratio

    • Variable, typically 1–2 molar equivalents as intermediate
    • Adjusted to achieve complete conversion in condensation or esterification step

    Downstream process integration

    • Fed into key condensation step in late-stage API synthesis
    • Catalysis and protection group strategies applied as required by target molecule design
    • Subsequent purification by crystallization or chromatography inline with API QC

    Final product types

    • Active ingredients with cardioprotective or anti-hypertensive indications
    • Bulk intermediates for finished generic drug manufacturing
    • End-use tablets, capsules, or injectable forms licensed for therapeutic applications

    4. Functional Ingredient in Food Additive Blends

    Certain food supplement and nutraceutical producers utilize dihydrocaffeic acid in formulated antioxidant blends for processed meats, beverage powders, and fortified foods. Food scientists balance the dosage to support oxidation stability of oils or shelf life without exceeding regional maximums. Batch-to-batch analytical controls address flavor impact. Ingredient staging occurs during powder premixing or aqueous blending, followed by micro encapsulation or dry granulation for free-flowing product forms.

    Industry compliance standards

    • Codex Alimentarius General Standard for Food Additives (GSFA)
    • US FDA GRAS (Generally Recognized As Safe) notification where applicable
    • China GB 2760: National Food Additive Standard
    • HACCP and FSSC 22000 certified food production systems

    Typical usage ratio

    • 10–100 mg/kg in food matrices, within local regulatory limits
    • Dosing varies according to product fat content, shelf-life targets, and flavor requirements

    Downstream process integration

    • Premixed with other antioxidants or vitamins in powder blending stage
    • Dissolved directly into beverage or oil base under mild heating as required
    • Encapsulated or spray dried for inclusion in instant powders or bar coatings

    Final product types

    • Protein and health drink powders
    • Processed meats and ready-to-eat snacks
    • Fortified edible oil blends for retail or food service
    • Nutraceutical supplement capsules and tablets

    5. Corrosion Inhibitor for Industrial Cooling Systems

    Engineering firms in chemical and power plant operations apply dihydrocaffeic acid in closed-loop cooling and boiler systems to reduce oxidative metal corrosion. Its phenolic moiety chelates trace metals, mitigating free radical-driven pitting. Operators add it to established biocide or anti-scaling regimes, tuning injection rates based on water chemistry and process temperature. Real-time monitoring ensures compliance with local environmental wastewater guidelines for discharge.

    Industry compliance standards

    • ASTM D1384—Corrosion Test for Engine Coolants
    • ISO 9001:2015 certified water treatment chemical manufacturing
    • REACH regulation (EC) No 1907/2006 for chemical safety
    • Local water authority limits for biocide and corrosion inhibitor discharge

    Typical usage ratio

    • 2–20 mg/L in closed-loop cooling or heating water
    • Adjusted based on system volume, pH, and corrosion monitoring data

    Downstream process integration

    • Injected via dosing pumps into recirculating water
    • Manual or automated chemical feed based on process control
    • Routine sampling for metal ion concentration and inhibitor residuals

    Final product types

    • Blended corrosion inhibitor packages (liquid concentrate or powder)
    • Premixed industrial coolant fluids
    • Water treatment chemicals for HVAC, chemical plants, or power generation
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    Certification & Compliance
    More Introduction

    Dihydrocaffeic Acid: Working with a Versatile Phenolic Compound

    Introduction to Dihydrocaffeic Acid Production

    Dihydrocaffeic acid often catches the attention of research labs, formulators, and specialty product developers alike. As a chemical manufacturer, we have spent years refining the production of this specific phenolic acid, ensuring both purity and consistency. Our expertise centers not only on synthesis but also on how the compound behaves through each processing and storage step. With the push for innovative antioxidant systems, natural preservation methods, and value-added nutraceuticals, we regularly field custom batches, adjusting parameters for our partners’ evolving needs.

    Dihydrocaffeic acid stands apart from many other phenolic acids like gallic acid or ferulic acid, both in molecular structure and in solution stability. This compound offers a unique pathway for businesses aiming to enhance product shelf life, support antioxidative blends, or deepen their research into free radical scavenging. Over the years, scientific communities have found it indispensable in oxidative stress studies, plant extract enhancement, and even in novel polymer modification work.

    Our Manufacturing Journey: From Precursor to Purified Acid

    We start with high-purity feedstock, applying a tightly monitored reduction process to obtain dihydrocaffeic acid from its natural caffeic acid precursor. This defines the product’s chemical fingerprint and physical appearance—fine, off-white crystalline powder that dissolves well in both water and ethanol. By avoiding high-temperature steps that risk decomposition or isomerization, we maintain phenolic hydroxyl activity and limit impurities. This careful approach means downstream applications remain reliable, batch after batch.

    Through ongoing feedback from university labs and food technologists, we have progressively reduced trace contaminants and heavy metals below even strictest guideline targets. Rigorous monitoring is carried out with HPLC and mass spectrometry in our in-house lab. Typical assay confirms dihydrocaffeic acid content exceeds 98 percent, minimizing interference from unknowns in sensitive analytical or medicinal work. Moisture remains below 1 percent, avoiding caking or premature polymerization. This attention to downstream handling often determines which supplier researchers trust for their next experiment or product launch.

    Specifications in Practice—Not Just on Paper

    A piece of paper rarely tells the whole story. Labs and formulators want predictable melting range, pH solubility profile, and resistance to ultraviolet or heat-driven breakdown. We watch for color change or crystalline instability in storage. Our standard offers melting around 131-136°C; the compound holds up in typical ambient conditions if bags remain sealed from humidity. Some clients plan for large-scale extractions, while others prefer pre-dissolved solutions—so batch sizing and packing formats adapt to every project’s scale. Our solid-phase purification step ensures that even high-volume clients receive the same quality as boutique scientists.

    The practical demand for accurate, easy-to-handle phenolic compounds shapes every lot we release. For example, our packaging avoids polypropylene—the acid can discolor some plastics—so we stick with glass or lined fiber drums. We ship powders in food-grade liners when customers intend for ingestion studies or cosmetic applications. Each operational detail roots back to honest communication with real-world users and a willingness to adapt.

    Where Dihydrocaffeic Acid Makes the Difference

    Our scientists have followed dihydrocaffeic acid’s journey from a niche antioxidant in academic circles to a more plugged-in role in commercial blends. Compared to parent caffeic acid, the dihydro derivative does not oxidize as quickly, making it suitable for applications requiring more shelf-stability. While researchers still explore potential biological effects, core uses have gained momentum in food antioxidant systems, cosmetic formulas focused on free-radical defense, and advanced coating chemistries. Its broad-based reactivity means developers can count on anti-browning characteristics for fruit and vegetable preservation—and this outcome gets tested for every new harvest cycle in our pilot labs.

    In natural product enhancement, the molecule’s two catechol hydroxyl groups bring strong scavenging activity without introducing notable color or odor to finished products. Our partners find this essential in clear serums, drinks, or non-tinted gels, where other antioxidants either brown quickly or destabilize the system. Even small adjustments to the molecule’s concentration impact measurable antioxidant performance, so tight quality control directly benefits real-world outcomes. We work directly with formulation teams to calibrate these effects, running bench-scale trials long before a new ingredient hits wider distribution.

    Beyond Antioxidants: Polymer and Biomedical Research

    Dihydrocaffeic acid’s chemistry invites further innovation. Researchers in polymer science continue to graft the molecule onto backbone chains for advanced surface modification. The catechol unit confers adhesive properties seen in certain marine organisms, giving rise to new bio-inspired adhesives and coatings. Compared with ferulic or gallic acid, this acid attaches more readily to a wide range of polymers—especially those slipstreaming toward sustainable or biodegradable profiles. We witnessed teams stretch raw dihydrocaffeic acid into cross-linked gels, hydrogels, and medical device coatings, each requiring different purity or particulate profile, so our staff tailors processing to support ongoing innovation.

    Biomedical labs pursue the acid as a model for inflammation modulation or as a signal molecule in enzymatic cascades. Projects run the gamut from oxidative stress detection to supporting cell-culture systems. Our chemists frequently coordinate with project leads at the protocol-writing stage, adjusting product form or purity cutoffs in anticipation of negative controls, reference standards, or co-formulated models. This collaborative approach prevents costly surprises mid-experiment.

    Food and Supplement Strategies

    Trends in food and beverage preservation move rapidly. Developers know dihydrocaffeic acid delivers complex antioxidant action while supporting non-synthetic labeling. Unlike synthetic preservatives, it consistently shows low toxicity and limited allergenic potential. It will not impart artificial aftertaste or aroma, and it supports product freshness in juices, nutraceutical blends, and even ready-meal sauces. Long before delivery, our teams work through production pilots—testing blend ratios, compatibility with other micronutrients, and resistance to temperature swings found in real-world logistics.

    Our food-grade batches meet strict limits on pesticides, heavy metals, and microbiological content. Producers, especially those marketing organic or minimally processed products, rely on this foundation. Dihydrocaffeic acid’s flexible dosing helps target different oxidative risks—whether in oil-rich snacks or plant-based drinks. Because both the catechol structure and carboxylic acid group are sensitive to blends, we regularly work back and forth with flavor chemists and nutritional scientists, ironing out compatibility before processes scale up. This eliminates batch failures or unexpected reactivity later in production.

    Personal Care and Cosmetic Applications

    Personal care formulators look past label claims and want results validated by data. Dihydrocaffeic acid enters these products for both its antioxidant strength and its low profile in terms of irritancy. Creams, serums, and rinses preserve active botanical components using this acid, not only lengthening shelf life but also supporting claims of oxidative protection under stress (whether that stress comes from pollutants or sunlight exposure). Its pale color and low odor align with current trends favoring neutral, non-tinted bases in beauty routines.

    Unlike ascorbic acid (vitamin C) or related compounds, dihydrocaffeic acid does not degrade quickly in water-based systems. Formulators avoid common pitfalls like precipitation or browning often seen with oxidized additives. Our staff consults on blend ratios or buffer choices, leveraging accumulated know-how on how this compound survives in each new matrix—a depth of real-world experience that keeps our partners loyal beyond a single project launch.

    Comparison with Other Phenolic Compounds

    While many phenolic acids line the shelves of distributors and catalogues, each serves a distinct function. Dihydrocaffeic acid distinguishes itself through both stability and reactivity profile. Its lower oxidation potential compared with caffeic acid means products last longer under typical storage—delaying color shifts or rancidity in finished goods. Ferulic acid, another common option, possesses one less active hydroxyl group, which limits its radical scavenging rate in certain applications. Gallic acid can outpace dihydrocaffeic acid’s antioxidant efficacy but will often introduce color instability at higher concentrations and runs into solubility constraints.

    In the real world, formulators do not rely on one molecule alone. We often witness blended strategies—combining dihydrocaffeic acid with fat-soluble tocopherols, or supporting it with mild chelators to provide broader spectrum antioxidant coverage. Because of its neutrality in taste and translucency, the compound slips into both simple and complex blends without forcing a change in sensory profile or processing equipment. The underlying catechol-carboxylic acid structure clears many regulatory hurdles for food and supplement use, compared to more exotic newly emerging antioxidants. Our production methods center on maximizing this compatibility while protecting the acid’s innate activity.

    Regulatory, Traceability, and Sustainability

    Clients working at scale, especially in the food and cosmetic spheres, expect a complete documentation trail. Each batch delivered comes with certificates covering purity, source materials, and absence of problematic residues. Our traceability does not end at shipping; every production lot is mapped from raw input to finished product, enabling rapid root cause analysis should deviations occur. This hands-on chain of custody reassures partners subject to ever-tightening food safety and supplement labeling rules.

    We watch evolving rules in dominant markets—whether EU, North America, or advanced Asian regulatory norms. Staying ahead of banned substance lists, restricted contaminants, or environmental red-flag compounds shapes even our choice of process solvents. For buyers facing global audits, this transparency forms the backbone of their compliance efforts. In-house, we focus on solvent reclamation and water re-use systems, with a goal to minimize effluents and carbon footprint. Partners in environmental certification programs often visit our facilities, attesting to the visibility and open-door policy we maintain for every manufacturing run.

    Challenges and Solutions in Dihydrocaffeic Acid Handling

    Manufacturing and supplying dihydrocaffeic acid at scale brings its own set of difficulties. The catechol moiety remains susceptible to air oxidation during both large-scale synthesis and final storage. We combat this through nitrogen flushing of containers and by employing low-permeability liners. Temperature control during synthesis and packaging ensures maximum shelf-life. Our R&D teams constantly monitor for new stabilizing excipients and better barrier materials for long-haul ocean shipping.

    Because this compound plays a role in both technical and edible goods, cross-contamination risks receive special attention. Dedicated equipment lines handle the acid for each intended market—food, technical, or cosmetic—so regulatory and safety demands are met every time. Customization occasionally slows throughput but delivers the certainty commercial partners require. We openly invite independent inspections and maintain change-control logs as part of good manufacturing practice.

    Servicing Innovation: Partnerships Beyond Transaction

    We often find ourselves situated as both supplier and technical consultant for partners developing new uses for dihydrocaffeic acid. As companies search for ways to clean up labels, extend product life, and develop smarter preservatives, having direct access to our process chemists and formulation scientists speeds their go-to-market pathways. Issues encountered in scaling, such as ingredient sedimentation, solubility mismatches, or reactivity with colorants, resolve faster through open dialogue and shared pilot runs. Our internal data bank houses thousands of stability, compatibility, and assay data points, which we actively share with development teams facing tight regulatory approval cycles.

    Joint development does more than launch new finished products; it strengthens standards that benefit every downstream buyer. Our operational flexibility grows with every unusual client request, leading to expanded batch sizing options, faster delivery timelines, and tailored impurity specifications. This open feedback loop defines our reputation among ingredient innovators and keeps the manufacturing focus value-driven rather than commodity-oriented.

    The Future of Dihydrocaffeic Acid Supply

    Looking back over twenty years of production, we see the renewed interest in dihydrocaffeic acid as an endorsement of reliable, nature-derived chemistry. Scientific citation rates have climbed steadily, particularly in fields focused on stress response, advanced packaging, and microbiome-friendly food additives. Global pressures to cut artificial preservatives and transition toward sustainable, functional ingredient portfolios match directly with what this molecule delivers. This feeling comes through in negotiation tables and in collaborative test runs, spurring us to further refine both product and service offerings.

    Our plant never stands static. Continuous improvements to clean-up methods, process water cycles, and residue reclamation ensure responsible operations. Customer audits, always encouraged, have driven upgrades to documentation, transparency, and on-site training. The tight integration of customer R&D staff, our in-house expertise, and ongoing updates from regulatory bodies means our output stays fit for both today’s and tomorrow’s marketplace challenges.

    Conclusion: The Value of Direct Manufacturer Partnership

    Dihydrocaffeic acid is not a commodity ingredient for our team; it represents a blend of deep practical chemistry and a commitment to supporting innovation across industries. By maintaining direct responsibility from feedstock to final packaging, we control every parameter impacting real-world performance. Our partners see the influence of this approach in easier formulation, faster compliance, and more predictable outcomes with every new batch. Compounds like dihydrocaffeic acid only reach their full potential when trusted relationships between manufacturer, researcher, and product formulator lead the way. With changing industry needs and stricter requirements emerging every year, our experience in both chemistry and customer collaboration keeps us ready to solve the next challenge.