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Diethyl N-Butanephosphonate

    • Product Name Diethyl N-Butanephosphonate
    • Alias Diethyl butylphosphonate
    • Einecs 237-115-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    215560

    Chemical Name Diethyl N-butanephosphonate
    Molecular Formula C8H19O3P
    Molecular Weight 194.21 g/mol
    Cas Number 1974-49-2
    Appearance Colorless to pale yellow liquid
    Boiling Point 220-222 °C
    Density 1.01 g/cm3 at 20°C
    Solubility Soluble in organic solvents, insoluble in water
    Purity Typically ≥97%
    Storage Conditions Store in a cool, dry, and well-ventilated place

    As an accredited Diethyl N-Butanephosphonate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Diethyl N-Butanephosphonate, 100g, is securely packaged in an amber glass bottle with a tamper-evident screw cap and safety labeling.
    Shipping Diethyl N-Butanephosphonate should be shipped in tightly sealed containers, protected from light, heat, and moisture. Transport in accordance with local, national, and international regulations for chemicals. Ensure proper labeling and use secondary containment to prevent leaks. Handle with appropriate personal protective equipment and avoid exposure during handling and transit.
    Storage Diethyl N-butanephosphonate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizers. Protect from moisture and direct sunlight. Label the container clearly, and store at room temperature or as specified by the supplier. Follow all applicable safety and storage regulations for organophosphonate chemicals.
    Application of Diethyl N-Butanephosphonate

    Applications of Diethyl N-Butanephosphonate in Industrial Manufacturing

    Diethyl N-Butanephosphonate serves as a crucial organophosphorus intermediate in specialized industrial sectors. Our facility supplies this raw material primarily to downstream chemical companies, where it supports precise synthesis pathways for high-value end products. Below we detail practical industrial applications, including industry-specific standards, usage ratios, production integration points, and typical finished goods types.

    1. Agrochemical Active Ingredient Synthesis

    Diethyl N-Butanephosphonate acts as a selective phosphorus source in the synthesis of certain crop protection agents. Technical teams at agrochemical manufacturers use it as a core building block in the phosphorus functionalization of heterocyclic intermediates, enabling high selectivity in the preparation of novel herbicides and insecticides. The acetylation and alkylation reactions integrate the phosphonate group under controlled reaction environments, supporting precise active ingredient manufacture.

    Industry compliance standards

    • FAO/WHO International Code of Conduct on Pesticide Management
    • ISO 9001:2015 Quality Management for Agrochemicals
    • REACH Annex XVII Substance Restrictions
    • China GB 4839-2016 Pesticide Safety Criteria

    Typical usage ratio

    • 5%–14% by mass in the phosphorylation step, variable based on targeted active content and precursor reactivity

    Downstream process integration

    • Feeds directly into the phosphorus alkylation stage after initial heterocycle formation
    • Used before final chlorination and formulation steps

    Final product types

    • Phosphonate-based herbicides (e.g., grass control agents)
    • Systemic insecticides where the phosphonate group increases soil stability
    • Intermediate stock solutions for custom pesticide formulation

    2. Flame Retardant Synthesis for Engineering Plastics

    Manufacturers rely on this phosphonate ester to introduce flame-retardant functionality into high-performance polymers. The molecule is grafted onto polyamides, polyesters, or epoxies through precise transesterification or aminolysis reactions. Such modifications improve limiting oxygen index (LOI) and reduce total heat release in plastic components. Companies working in transportation, electronics, and building infrastructure sectors specify this intermediate for its consistent reactivity profile and phosphorus content.

    Industry compliance standards

    • UL 94 Flammability Ratings for Plastic Materials
    • IEC 60695 Fire Hazard Testing
    • EN 13501-1 Building Product Fire Classification
    • RoHS Directive (2011/65/EU) for restricted hazardous substances

    Typical usage ratio

    • 7%–18% by weight, adjusted according to resin type and targeted V0-V2 classification

    Downstream process integration

    • Incorporated during the compounding phase of polymer pellet manufacturing
    • Sometimes used in reactive extrusion systems for grafting onto polymer backbones

    Final product types

    • Flame-retardant polyamide compounds
    • Electronic device housing plastics
    • Fire-rated construction sheet materials
    • Automotive wire insulation

    3. Pharmaceutical Intermediate for Antiviral and Anticancer APIs

    APIs in select antiviral and anticancer pharmaceuticals utilize this compound as a phosphorus-containing building block. Research-driven formulators perform alkylphosphonate coupling, supporting the construction of nucleoside analogs and related bioactive molecules. The introduction of a phosphonate moiety enhances biological stability and oral bioavailability of certain APIs. Manufacturing under strict regulatory protocols ensures traceability from raw material to final drug substance.

    Industry compliance standards

    • Good Manufacturing Practice (GMP, ICH Q7)
    • Ph. Eur./USP/ChP pharmaceutical monographs (where applicable)
    • FDA 21 CFR Part 211 Drug Manufacturing Controls
    • EMA QWP Quality Guidance

    Typical usage ratio

    • 3%–9% of total API synthesis mass, dependent on specific synthetic step and target molecule

    Downstream process integration

    • Used in the early-stage phosphorus coupling reaction
    • Carried through purification before final crystallization and isolation of the API

    Final product types

    • Phosphonate analogue antivirals (investigational and marketed)
    • Nucleoside-based prodrugs in oncology research
    • Clinical trial material for advanced pharmaceutical candidates

    4. Specialty Surfactant Synthesis in Oilfield Chemicals

    Oilfield chemical producers use this phosphonate as a key raw material in the preparation of scale inhibitors, dispersants, and surfactants tailored for enhanced oil recovery. Its phosphonic acid derivative imparts superior calcium sequestration and scale inhibition in harsh downhole environments. Chemical reactions typically involve hydrolysis, neutralization, and subsequent blending with other surfactant actives, creating high-performance additive packages.

    Industry compliance standards

    • American Petroleum Institute (API) Recommended Practices RP 19C/67
    • ISO 9001:2015 for Oilfield Service Providers
    • REACH Registration and SDS requirements
    • EU CLP Regulation for Classification and Labeling

    Typical usage ratio

    • 4%–11% as a proportion of overall surfactant blend, depending on scaling ion load and environmental persistence requirements

    Downstream process integration

    • Enters the synthesis at the phosphonate neutralization step
    • Subsequently incorporated into field-ready additive formulations

    Final product types

    • Calcium scale inhibitors for injection water systems
    • Enhanced oil recovery surfactant blends
    • Anti-fouling dispersant packages for upstream production

    5. Ligand Precursor in Metal Chelating Agents

    Industrial water treatment and electroless plating manufacturers require metal chelators with robust phosphorus-based coordination groups. This intermediate supports the synthesis of chelating ligands by providing reliable phosphorus-carbon linkages. Typical processes include alkylation and subsequent reaction with nitrogenous base compounds, yielding chelators with enhanced sequestration efficiency for heavy metals in process water or surface treatment baths.

    Industry compliance standards

    • EN 15049:2013 Water Treatment Chemicals Requirements
    • ASTM D512 Standard Test Methods for Metal Ion Content
    • China GB/T 5009.11 Determination of Total Phosphorus
    • ISO 14001:2015 Environmental Management

    Typical usage ratio

    • 5%–13% by mass in chelating agent synthesis reactions, modulated according to target metal ion load and pH operation window

    Downstream process integration

    • Participates in ligand backbone assembly during primary synthesis
    • Followed by salt formation and purification before blending

    Final product types

    • Phosphonate-based water softening agents
    • Heavy metal chelating additives for industrial waste treatment
    • Feedstock for electroless nickel plating baths
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    Certification & Compliance
    More Introduction

    Diethyl N-Butanephosphonate: On the Shop Floor and in the Lab

    Everything starts with curiosity and need—a question about what could work better, more efficiently, or with greater reliability in a real chemical process. That’s the point where innovation walks into the plant. Diethyl N-Butanephosphonate came out of such questioning. Plenty of people know the complex world of organophosphorus chemistry, but seeing these molecules in action is a different thing than reading about them in a technical paper. On our lines, every batch tells its own story and every request from a research chemist points us toward making a better product, not simply a new one.

    What We Make: The Real Substance

    Diethyl N-Butanephosphonate, in all practical discussions, is not simply a bottle with a tag on it. We run production under controlled conditions to guarantee the purity and reactivity scientists, formulators, and process engineers demand. The model produced at our site keeps tight on quality—colorless to pale yellow liquid, free from bothersome byproducts that derail downstream reactions. Phosphonate compounds like this one bring a balance between stability and reactivity. That balance does not happen by accident; it takes equipment, skilled handling, and a deep understanding of what chemists will try to do next with our product. That’s where trust comes in: people return to a manufacturer when every batch delivers as expected, without surprises.

    What’s the Difference? From Raw Material to Useful Tool

    The question often lands at our desk—why not just use a general phosphonate, or grab something a distributor claims as “similar”? We see the difference every day in actual use. Diethyl N-Butanephosphonate’s butyl backbone doesn’t just add length; it shifts solubility, changes volatility, and affects reactivity in organic syntheses. Where shorter chains sometimes bring volatility concerns and potential losses in distillation, the butane chain brings manageable boiling points and compatibility with a wider range of organic solvents. Add to this the diethyl groups, which contribute a familiar, useful reactivity profile for phosphorylation reactions, ligands, and chemical modifications.

    There’s nothing generic about working with phosphorus-containing molecules. Some organophosphonates struggle when exposed to moisture, quickly hydrolyzing and losing utility. Fine-tuning the structure, as with Diethyl N-Butanephosphonate, doesn’t just keep the bottle stable on the shelf; it keeps reactions running consistently. Researchers relying on organophosphonates in catalysis or functional group protection can’t afford shifting performance between batches. Our process engineers check every lot to keep the specs inside narrow margins on both purity and residual moisture, understanding how even trace impurities change product outcomes in high-stakes work.

    Lives Behind the Product: Tight Process, Constant Review

    Chemical manufacturing rarely offers quiet routines. Every week, production teams revisit procedures, look at data, and chase down the root causes behind the tiniest spectral anomaly. Diethyl N-Butanephosphonate production brings hands-on lessons: small temperature swings during alkylation lead to unwanted side reactions; a poorly flushed line brings cross-contamination visible as color or, worse, as a failed reaction for a customer. Every plant operator knows the teeth-grinding tension of waiting for a GC-MS trace during a shift, hoping for that crisp peak, clear of interference. Even with years of automation and continuous monitoring, what really keeps quality high is experience and a refusal to cut corners.

    The transition between pilot to full-scale involves more than drawing up SOPs or punching recipe numbers into a control system. It’s a dance between process stability and market demand, each batch requiring calibration based on feedback from both the plant and the field—actual user results, not theoretical numbers. Sometimes a new customer asks for tighter controls on chloride content, or a research partner circles back requesting a different impurity threshold. We listen because once the product lands on a bench or runs through a reactor, every variable counts.

    Use Cases: Where Diethyl N-Butanephosphonate Goes

    We get the phone calls that start simply: “Can it be used in [some new synthesis]?” or “Have you got data for [a different solvent]?” Most applications land in advanced chemical synthesis—medicinal chemistry, agricultural compounds, custom ligands, and functional materials. Diethyl N-Butanephosphonate slips into use where reliable alkylphosphonate moieties matter, such as building protected amino phosphonates for peptidomimetic research. In synthesis for organophosphorus agrochemicals, the longer chain can increase compatibility with nonpolar active ingredients or provide more manageable formulation properties. Working with this molecule offers a tool with predictable reactivity, clean handling, and a shelf life engineers and chemists can count on for both small-scale screening and multi-kilogram campaigns.

    Many seasoned researchers find the “devil in the details” when scaling up from grams to many kilos. They want assurance that their raw materials will not throw off ratios or introduce new headaches. We developed our product lines around those demands, investing in rigorous in-process analytics and transparency. Researchers feeding data back to us spot trends in batch-to-batch variation that help us fix issues before they ever become visible to the broader market. We treat those insights as gold. Direct conversations—sometimes in video calls, sometimes in late-night emails—keep us responsive to shifts in the landscape, whether that’s a new class of molecules or a regulatory push for defined impurity profiles.

    Supporting Modern Chemistry

    The world has set high demands for cleaner, more efficient chemical synthesis. We’ve watched, over the years, as the needs of chemical manufacturers, CROs, academic labs, and agrochemical producers have changed. Requirements for documentation, analytical data, and targeted performance grow steeper each year. We approach these changes not as checkboxes, but as living demands. Our in-house QA documentation travels with every drum and bottle, but the most important factor remains the ability to adapt. When a project calls for new analytical cutoffs, better traceability, or a new stabilization step, we design it into the line, not after the fact but as part of the solution. That’s how relationships survive new market twists and evolving science.

    In chemical manufacturing, sources matter. Product consistency is built from stable raw materials, predictable supply chains, and trustworthy logistics partners who don’t treat delicate intermediates and performance chemicals like just another commodity. Managing that end-to-end process, from raw material qualification through final batch release, anchors reliability. We rarely have the luxury of simply moving a spec or hope that the next delivery will fix a lingering impurity. Years of practice went into making Diethyl N-Butanephosphonate not just meeting, but anticipating, evolving requirements—better shelf stability, minimal trace acids, and fast response on documentation.

    Why Quality Beats Standardization

    Most of our team have worked on technical desks, sometimes even white-knuckling through late hours trying to solve a reaction mystery caused by an off-spec phosphonate. We built our manufacturing lines from the perspective of users, not only producers. Sample after sample, trial after trial, we saw how subtle differences in purity, water content, or residual solvents could make or break a planned synthetic step. This taught us to invest in fine-tuning every stage of our process. We calibrate instruments not just because our certificates demand it, but because a faulty detector can let through impurities that cost the end user days of lost work or wasted reagents.

    We never stop at “good enough.” Batch records are double-checked by eyes that have seen the cost of failure. Analytical labs operate as an essential partner, not an afterthought, for each production run. Each step—distillation, solvent switches, even filter choices—gets constant scrutiny. Every operator has seen what happens when a shortcut is taken. Keeping impurity profiles clean, water content controlled, and batch records complete is the unglamorous part of real chemical manufacturing, but our best clients came to us because they know we care about their end product as much as they do.

    Solving Real Problems: From Bench to Bulk

    The best chemical products meet actual problems head-on. Our early experience came from hearing stories about competitive products failing purity tests, missing technical support, or arriving with inconsistent labeling. People looking to use Diethyl N-Butanephosphonate for custom synthesis want more than a simple label—they expect clear communication and active engagement with process issues. We regularly fine-tune our technical service to solve real-world headaches, such as tweaking stabilization packages for harsh handling environments or providing dissolved formats for companies moving toward higher throughput and continuous flow.

    No factory survives for decades by making one-size-fits-all solutions. Every research group, R&D team, or plant manager comes with unique priorities. Our production runs change as quickly as the industry demands; sometimes a pharmaceutical CRO requests a different impurity profile, sometimes an agrochemical pilot team wants help with custom packaging. Flexibility in manufacturing arose out of necessity, not just inspiration. We keep our ears open to changes, questions, and demands, adjusting production schedules and raw material sourcing to match what our partners find most urgent.

    Learning From the Industry—and Giving Back

    No product enters the market untouched by community input. We’re not just watching for new papers or regulatory warnings—we keep a dialogue open with collaborators facing challenges in synthesis, scale-up, and commodity pricing. More than one process change came out of a phone call from a field chemist, alerting us to a novel impurity, or an academic running into trouble purifying an intermediate. We listen and build those lessons into our SOPs, plant changes, and training for new staff. Regular exchanges between users and our technical team lead to a deeper, shared pool of knowledge that helps everyone, whether that’s a startup producing a new specialty chemical or a multinational seeking more reliable supply chains.

    We put collaboration at the center of everything. Technicians, engineers, analysts—everybody involved brings their own perspective. Meetings with outside partners show us the places we still have room to improve. Sometimes it’s documentation gaps; sometimes bottlenecking in the filling line; sometimes tweaks in handling protocols. We share what we learn with our customers, not just to promote our successes but to build a more resilient industry—one less reliant on luck and better able to control outcomes. The more feedback we gather, the more closely our products track with actual user needs instead of theoretical “market fit.”

    Adaptation: The Only Constant

    Markets change fast. Chemical supply always faces realities—shipping delays, geopolitical hurdles, sudden regulatory requirements. Our answer is infrastructure that builds in redundancy, product lines that can shift as needed, and supply contracts shaped by honest estimates instead of empty promises. Regular stress tests, paired with contingency planning, keep our supply flow reliable for partners who absolutely depend on delivery timing and consistent quality. We partner with logistics providers who understand what a delayed or damaged shipment means—not just an administrative headache, but real costs to research and production schedules.

    We work with evolving environmental expectations. The trend toward greener chemistry, stricter handling, and more transparent supply demands drives us to adapt our process flows. Where possible, we build reclamation for solvents, optimize reaction steps to curb waste, and regularly audit for energy savings. These changes don’t come from regulation alone. Our technical staff actively seeks practical ways to drive waste down and push yields up, always with an eye on minimizing non-target byproducts in the finished Diethyl N-Butanephosphonate. Updates don’t stop at the compliance office—they travel to every technician, every operator, every analyst.

    Experience Earned, Not Inherited

    Anyone on our team can tell stories about early production runs—chasing a stubborn impurity, learning new purification strategies, and hammering out the protocols that actually work on an industrial scale. We’ve learned what projects stall because of inconsistent raw material, incomplete analytical packages, or inflexible supply. Every misstep, every customer call, every lab-scale anomaly taught us to build stronger systems and closer relationships with our end users. Our communication style mirrors our process: open, transparent, and immediate. By sticking to the facts, owning our mistakes, and building on our wins, we’ve created trust that cannot be claimed by any slogan or flashy marketing.

    Few products enjoy long runs without close management and thoughtful adaptation. Diethyl N-Butanephosphonate, as a backbone for advanced organic synthesis and specialized industrial use, challenged us daily to anticipate what might go wrong and address it before the problem surfaces at a customer’s bench. Quick action, careful listening, and technical rigor created the consistency we are known for—and that our customers expect. No week goes by without a review of what worked, what changed, and what should be adjusted going forward.

    Looking Forward—Making Chemistry Work for the Next Challenge

    The world doesn’t slow down for any chemical manufacturer. More specialized chemistry, increasingly intricate regulatory demands, and global shifts in raw material sourcing keep every plant on its toes. Our focus remains stable: listen to the needs of working chemists, build lines that adapt quickly, and never sacrifice quality in pursuit of volume. Diethyl N-Butanephosphonate production is not driven by routine; it is a series of active choices, grounded in years of experience and a continuous exchange with the end users who push chemistry forward.

    Chemists want answers, not wishful thinking. Every production run, every conversation, every technical challenge has brought our team to a place where we can confidently recommend Diethyl N-Butanephosphonate—not as the only product you could use, but as one crafted by people who understand the value of doing the job right, every time. Our product stands as proof of that commitment, and every bottle leaving our facility carries the experience of teams dedicated to making chemistry work at every scale.