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Deuterated Bromoethane

    • Product Name Deuterated Bromoethane
    • Alias Bromoethane-d5
    • Einecs 212-681-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
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    Specifications

    HS Code

    115290

    Product Name Deuterated Bromoethane
    Chemical Formula C2D5Br
    Molecular Weight 127.01 g/mol
    Cas Number 5576-20-1
    Appearance Colorless liquid
    Boiling Point 38-39 °C
    Melting Point -119 °C
    Density 1.535 g/mL at 25 °C
    Refractive Index 1.442 at 20 °C
    Purity Typically ≥98%
    Solubility Insoluble in water, soluble in organic solvents
    Synonyms Ethyl bromide-d5
    Storage Conditions Store at 2-8 °C, tightly closed

    As an accredited Deuterated Bromoethane factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

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    Application of Deuterated Bromoethane

    Applications of Deuterated Bromoethane in Industrial Manufacturing

    Deuterated Bromoethane serves as a key specialty intermediate for multiple high-value sectors requiring precise isotopic labeling or atom-specific transformation. Our direct synthesis and rigorous isotope enrichment underpin consistent supply and performance for regulated downstream integration.

    1. Pharmaceutical Isotope Labeling and Drug Metabolism Studies

    Pharmaceutical innovators require deuterated bromoethane to introduce deuterium atoms into small molecule APIs and intermediates for metabolic pathway tracking, bioavailability studies, and prolongation of half-life in deuterium-enriched drug compounds. We manufacture this material with batch traceability to align with the controlled requirements of isotope-focused R&D and preclinical development, ensuring documentation from raw material to end use. Precise addition to the N-alkylation or O-alkylation step achieves stable deuterium incorporation into target scaffolds, conforming to stringent impurity control and characterization demands in advanced pharmaceutical research.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • Ph. Eur., JP, USP monographs for isotope-labeled reagents
    • FDA guidance on IND-enabling studies using labeled compounds
    • ISO 17034 for reference materials as applicable

    Typical usage ratio

    • Stoichiometry ranges from 1.0–1.2 equivalents relative to nucleophilic substrate, adjusted according to substrate reactivity and extent of deuterium incorporation required by project protocol

    Downstream process integration

    • Added during late-stage alkylation (N-, O-, or S-alkylation) reactions in multi-step synthesis, typically under inert atmosphere with monitored batch-wise addition

    Final product types

    • Deuterium-labeled APIs for clinical metabolism studies
    • Deuterated reference standards for bioanalytical methods
    • Stable isotope-labeled intermediates

    2. NMR Spectroscopy Calibration and Reference Standard Preparation

    NMR facilities within contract labs and pharmaceutical QC departments use deuterated bromoethane as a calibration and spiking reagent during quantitative nuclear magnetic resonance experiments. The defined isotopic label enables precise chemical shift referencing, resolution of co-eluting analytes, and mixture identification. We support such applications with high chemical and isotopic purity, ensuring minimal background and interference. Strict moisture and non-deuterated content specifications meet the needs of analytical workflows requiring highly reproducible spectral outcomes and quantitative traceability.

    Industry compliance standards

    • ISO/IEC 17025 for laboratory competence
    • ASTM E1641 for organic reference materials
    • USP General Chapter <1225> Validations
    • GLP/GMP guidelines for laboratory chemicals

    Typical usage ratio

    • 0.5–3 mol% relative to sample, based on signal/noise requirement and quantitation method design

    Downstream process integration

    • Spiked directly into organic solvent or sample matrix as an external or internal standard before spectral acquisition

    Final product types

    • NMR calibration solutions
    • Isotopically defined internal standard sets
    • Authentic spectral libraries for GMP QC

    3. Deuterated Building Blocks for Specialty Polymer Synthesis

    Advanced materials manufacturers incorporate deuterated bromoethane as an alkylating or chain-terminating agent for the synthesis of bespoke deuterated monomers and oligomers, particularly in applications such as neutron scattering or advanced optical diagnostics. We deliver consistent isotopic labeling and documentation for integration into block copolymers or functionalized specialty polymers. The isotopic modification changes neutron contrast or influences vibrational modes, supporting downstream R&D and bespoke customer formulations for materials science and nanotechnology sectors.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • ASTM D1776 for sample preparation and precision
    • CFR 21 Part 211 for polymer use in regulated environments

    Typical usage ratio

    • Variable: 1–10 mol% as initiator, crotylating, or end-capping agent; level tailored to desired deuterium incorporation and polymer chain length specification

    Downstream process integration

    • Introduced early in anionic or cationic polymerization reactions, or used as a post-polymerization functionalization agent in solvent or melt systems

    Final product types

    • Deuterium-labeled block copolymers
    • Neutron scattering calibration standards
    • Advanced optical polymer materials

    4. Synthesis of Deuterium-Labeled Agrochemical Analytical Standards

    Reference laboratories and agrochemical producers require deuterated bromoethane as a starting material for the synthesis of deuterium-labeled analogs of pesticides and herbicides. These labeled standards ensure reliable mass spectrometry quantitation in residue and environmental monitoring studies. Our material is formulated to meet low non-deuterated contamination, with tight isotopic composition control matching the documentation requirements for reference chemical production. Traceability supports full audit trails from synthesis to delivery according to client and regulatory agency requirements.

    Industry compliance standards

    • OECD Principles of GLP
    • ISO/IEC 17025 for test laboratories
    • FAO/WHO specifications for pesticide reference materials

    Typical usage ratio

    • 0.8–1.1 equivalents per labeled position in target molecule, determined by synthetic protocol for side chain alkylation

    Downstream process integration

    • Employed as an alkylating intermediate during multi-step organic synthesis to introduce deuterated ethyl groups in the structure of agrochemical standards

    Final product types

    • Deuterium-labeled pesticide and herbicide reference standards
    • Internal standards for LC-MS/MS assay calibration
    • Certified analytical solutions for food and environmental testing
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    More Introduction

    Introducing Deuterated Bromoethane: Transforming Precision in Chemical Research

    In the world of chemical research, reliability and accuracy hang on the tiniest details. For scientists and professionals digging deep into the structure and behavior of molecules, the tools and reagents on hand make all the difference. Deuterated bromoethane brings a special twist to the table that goes beyond the basics of regular bromoethane. With a molecular twist—by swapping out a hydrogen atom for its heavier sibling, deuterium—this compound takes on a new role in lab work that standard bromoethane can’t always fill.

    Digging Into the Details: Model and Specifications

    At its core, deuterated bromoethane (C2H4BrD) offers a clean, simple structure, but it’s that subtle replacement of deuterium that matters most for researchers. High purity isn’t just some nice-to-have wish; it’s something most chemists swear by for reliable experimental results. Contamination from water, non-deuterated analogs, or trace byproducts leads to costly errors further down the line. Most labs working with deuterated organics ask for purities above 98%, and anything less prompts skepticism. That attention to cleanliness means researchers don’t spin their wheels explaining odd blips in their data.

    Because it acts not only as a solvent but as a reactant in synthesis, researchers pay close attention to its isotopic purity. Deuterated bromoethane with high deuterium enrichment—frequently above 98 atom % D—helps generate more trustworthy spectra and clearer reaction pathways, especially in NMR experiments where hydrogen's signal often muddies the water. For those who spend hours reading NMR graphs, there’s a sigh of relief that comes from clean, sharp peaks that tell a real story, not one filled with interference from non-deuterated impurities.

    Why Deuterated Compounds Matter in Modern Science

    Most people probably don’t give much thought to plain old bromoethane, let alone its deuterated cousin. In research, though, a switch from hydrogen to deuterium sheds light on the structure and interactions of molecules in a way nothing else does. I’ve spent countless hours puzzling over complex NMR spectra, where overlapping peaks and hidden couplings force even seasoned chemists to second-guess themselves. Switching to deuterated bromoethane means clearer spectra—because the heavier atom changes the magnetic environment, making analysis easier and cleaner.

    This isn’t just about producing sharper data. Deuterated compounds let chemists trace reaction mechanisms or monitor specific pathways. In pharmaceutical research, labs track where molecules go in the body, how fast they break down, and which byproducts appear. Deuterated bromoethane helps in labeling, offering a unique signature that stands out in a jumble of background signals. Changing one atom paves the way for tracing drug metabolism or chasing after intermediates that simply vanish with regular, non-deuterated reagents.

    Comparing Standard and Deuterated Bromoethane

    Switching from standard bromoethane to the deuterated version doesn’t mean trading one-for-one without consequences. The key difference—that heavier deuterium atom—shows up in more places than textbooks admit. Deuterium brings a kinetic isotope effect: reactions involving C-D bonds slow down compared to those with C-H bonds. Sometimes this slowdown becomes an advantage; chemists design experiments to exploit stable intermediates they never spot with faster-reacting regular bromoethane. Other times, this slower reaction rate heads off unwanted side reactions, lending a steadier hand when precision matters.

    The price tag on deuterated bromoethane isn’t low. Anyone hunting for it on a university purchase order sees that extra cost jump right out. The higher price reflects both the cost of deuterium itself—a rare isotope involving specialized production techniques—and the careful handling during synthesis to keep out unwanted hydrogen. But in return, researchers stop wasting time troubleshooting or chasing errors. The return on investment comes in hours saved and the quality of the published data.

    Building Better Experiments: Real Results from Real Labs

    Deuterated bromoethane steps up in a whole range of lab jobs, but it shines brightest in nuclear magnetic resonance (NMR) spectroscopy. Anyone who has spent afternoons slicing through old NMR printouts recognizes how much time goes into assigning crowded peaks and suppressing baseline artifacts. With high-purity deuterated solvents and targets, the background noise drops, non-specific couplings vanish, and what’s left is a spectrum that tells the truth with less interpretive acrobatics. Many times, my fellow researchers and I have pulled out a deuterated product to troubleshoot a tough synthesis. The improved resolution and precision in data cut down on the head-scratching and reduce guesswork.

    Beyond spectroscopy, deuterated bromoethane has become a cornerstone in medicinal chemistry. When drug developers need to test metabolism or metabolic stabilities, deuterium-labeled molecules act as trackers inside biological systems. The contrast between deuterium and hydrogen isn’t detectable by most living systems, so the labeled compound follows the same journey as the regular drug. By using deuterated bromoethane to build up labeled intermediates, researchers get a much clearer sense of biological fate and possible breakdown products. I’ve seen teams avoid dead ends by creating deuterium-labeled versions of promising leads first, learning important lessons about their stability, risks, and behavior.

    Production: Meeting the Need for Quality and Safety

    Sourcing deuterated bromoethane demands more than a few extra purification steps. The journey starts with access to deuterated starting materials, mainly deuterium oxide, which involves investment and mindful production lines. The best labs don’t cut corners; they run quality checks at every step to catch sneaky impurities, measure isotopic ratios, and confirm the absence of residual solvents. I’ve learned never to trust a product until you’ve run your own batch analysis, especially with specialty chemicals like this one. The higher standards required for deuterated bromoethane have always separated reputable suppliers from those who just want to make a quick buck.

    Working with bromoethane, deuterated or not, brings safety questions front and center. It’s a volatile, potentially hazardous compound. I remember the first time a colleague mishandled a reactive alkyl halide and we ended up evacuating the lab. Protocol matters, and labs need to maintain proper fume hood airflow, use protective gloves, and avoid inhalation at all times. Responsible suppliers not only ensure a pure product but pack and label it with real-world risks in mind, using robust containers and clear hazard warnings. Cutting costs on packaging or shipping doesn’t deserve a place where professional standards should rule.

    Redefining Research Efficiency and Precision

    For today’s researchers, precision isn’t just a luxury. It’s a requirement built into grant expectations and peer review. Deuterated bromoethane makes it possible to design experiments where every piece lines up just so. In my graduate school days, even one impure or poorly-labeled compound could set a whole semester’s work off-course. Those lessons stick, so now I keep a mental checklist for every shipment that comes in, double-checking COAs and chromatic purity sheets before anything goes into a reaction flask.

    This compound empowers researchers in fields stretching far beyond core organic chemistry. Analytical chemists, drug developers, environmental scientists—all find themselves tackling unknowns that demand the extra clarity a deuterated reagent brings. When running environmental fate studies, analysts may use deuterium to tag bromoethane’s movements through soil or water. The insights gained support cleaner air and water, giving regulators hard data instead of educated guesses.

    Limitations: Not a Silver Bullet

    There’s no magic in a chemical bottle. Deuterated bromoethane solves serious research problems, but it brings its own constraints. The extra cost isn’t justified for routine procedures that never brush up against analytical challenges. Its volatility, paired with the need for careful storage and transport, means not every lab can or should keep it on hand. More than once, I’ve seen labs order premium deuterated solvents only to let them evaporate on open benches—not a mistake I’d recommend repeating.

    Long-term storage must contend with slow hydrogen-deuterium exchange over time, especially around moisture or basic surfaces. Even the best-purified compound loses its edge if left in less-than-ideal bottles or stored alongside sources of contamination. That reality forces labs to work with trusted suppliers, track stock levels closely, and use up stocks quickly after opening. Proper handling becomes part of the skillset alongside synthesis or analysis.

    The Bigger Picture: Supporting Breakthroughs in Science

    Taking a step back, deuterium-labeled chemicals like deuterated bromoethane represent a commitment to digging deeper into the unknown. The broader scientific community relies on precise and replicable tools to push back boundaries. At a time when reproducibility crises dot the news, using higher-quality reagents keeps the results above suspicion and supports robust, peer-reviewed research.

    Trusted brands make their reputation by being consistent. They don’t throw out a dozen purity grades in the hopes that one will stick; they focus on small-batch, high-purity production with reliable delivery and batch testing that chemistry professionals can read and trust. Building relationships with suppliers who offer sample testing, support specific project needs, and share best practices gives every project a better shot at smooth progress. In my own research circles, I value recommendations from colleagues and collaborations that hinge on trust in core reagents.

    Looking Forward: Opportunities for Improvement

    Deuterated bromoethane, like every specialized product, challenges producers and researchers to raise their standards. Some emerging technologies, including more efficient isotope separation and automated purity checking, are making higher-purity and more affordable products possible. Broader access means young researchers, startup companies, and underfunded academic centers aren’t left behind. Partnerships between universities, industry leaders, and suppliers could smooth out bottlenecks and open the field to fresh ideas.

    Digitizing quality assurance, improving container technology to reduce evaporation, and expanding cold-chain or specialty shipping options go a long way in keeping the product at peak quality. The next wave of research will demand not just precision but accountability—traceable production logs backed by independent lab verification make it easier to retrace steps if something goes wrong. As demand grows in pharmaceutical R&D and analytical chemistry, the whole supply chain stands ready for improvement.

    A Human Perspective: Why We Keep Pushing Forward

    Chemistry draws people who want answers that stick—no matter how tricky the path gets. Deuterated bromoethane reminds us that sometimes the smallest changes in structure unlock the biggest answers in experiments. The times I’ve spent running controls, double-checking spectra, and picking apart results were all built on a foundation of reliable tools. In a world where deadlines loom and grant reviewers want nothing less than perfection, cutting corners simply isn’t an option.

    Choosing the right tool—whether that’s deuterated bromoethane for a crucial experiment or another specialized reagent—gives every researcher an edge. It’s about making the smartest possible use of precious time, budgets, and brainpower to drive real discovery. Every carefully prepared bottle on a shelf tells a quieter story about the attention, diligence, and drive that fuel research every day. As the demands of modern science push higher, the products we reach for have to keep up. Deuterated bromoethane, for its part, has become a sign that we’re aiming for the kind of clarity and accuracy that today’s complex challenges demand.