Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride

    • Product Name D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride
    • Alias Methylone
    • Einecs 214-003-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    460994

    Chemical Name D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride
    Synonyms D-(+)-Methyl-α-(2-thienylethylamino)(2-chlorophenyl)acetate HCl
    Molecular Formula C15H16ClNO2S·HCl
    Molecular Weight 346.28 g/mol
    Appearance White to off-white crystalline powder
    Solubility Soluble in water, methanol and ethanol
    Melting Point 159-163 °C
    Purity ≥98%
    Storage Conditions Store at 2-8°C, protected from light and moisture
    Cas Number 37237-47-5
    Stereochemistry D-(+)-enantiomer
    Odor Odorless
    Application Primarily used for research and analytical purposes

    As an accredited D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A white, sealed bottle containing 10 grams of D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride; labeled with safety and handling instructions.
    Shipping The chemical D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride is shipped in tightly sealed, chemically compatible containers. Packaging complies with all safety and regulatory standards for hazardous materials, ensuring protection from light, moisture, and contamination. The shipment includes proper labeling, documentation, and, if necessary, temperature control during transit for stability and safety.
    Storage Store D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride in a tightly sealed container in a cool, dry, and well-ventilated area away from direct sunlight and moisture. Keep the container tightly closed when not in use, and store away from incompatible substances such as strong oxidizers. Follow all standard laboratory chemical storage protocols and safety guidelines.
    Application of D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride

    Applications of D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride in Industrial Manufacturing

    As a specialized manufacturer, we focus on delivering D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride to strictly defined, regulated industrial customers. The following sectors represent current, extensively documented usage in downstream industries, each with distinct integration methods, regulatory expectations, and end product types.

    1. Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical manufacturers incorporate this molecule as an advanced intermediate in multi-stage organic synthesis for certain central nervous system (CNS)-active pharmaceutical ingredients. The material undergoes strict batch integration within validated GMP production lines to support subsequent synthesis and purification processes. Its unique structural motif makes it a key building block in producing compounds with targeted pharmacodynamic profiles.

    Industry compliance standards

    • International Council for Harmonisation (ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • U.S. Pharmacopeia (USP) quality specifications for intermediates
    • European Medicines Agency (EMA) regulations for controlled substances handling
    • China GMP (2010 Revision), API traceability and documentation requirements

    Typical usage ratio

    • Varies from 0.5%–2.3% (w/w) in reaction charges, depending on the desired molar yield and route optimization; stoichiometry adjusted based on downstream requirements and process yield targets

    Downstream process integration

    • Charge to main reactor during the early to mid-stage condensation or substitution steps; followed by controlled solvent, temperature, and pH management to ensure complete conversion
    • Purification through solvent extraction, recrystallization, or chromatographic separation
    • Dedicated API room usage with environmental monitoring according to GMP

    Final product types

    • CNS-active finished dosage forms (oral tablets, capsules)
    • Bulk APIs for export to secondary formulation plants
    • API reference standards for quality control labs

    2. Chemical Reference Substance Manufacturing

    Certified analytical companies use this material as a traceable reference for method validation, stability testing, and impurity profiling. Production requires precise documentation, high purity isolation, and batch-specific analytical certification, with all stages monitored under established quality systems.

    Industry compliance standards

    • ISO 17034:2016 General requirements for the competence of reference material producers
    • Pharmacopoeia standards for reference material certification (USP, EP, JP)
    • OECD GLP (Good Laboratory Practice) requirements
    • FDA 21 CFR Part 211 for analytical lab controls

    Typical usage ratio

    • 100% (neat), prepared directly from the manufactured batch without dilution; mass fraction and identity strictly controlled during aliquoting

    Downstream process integration

    • Subdivided and aliquoted into ampoules or vials under cleanroom conditions
    • Accompanied by completed Certificate of Analysis (CoA) and full batch documentation
    • Lot-specific storage in temperature-controlled environments to prevent degradation

    Final product types

    • Certified reference standards for pharmaceutical analysis
    • Stability study controls for chemical method development
    • Environmental and forensic analysis toolkits distributed worldwide

    3. Custom Fine Chemical Manufacture

    Specialty chemical companies select this compound for use in custom syntheses tailored to client-directed research projects or pilot-scale production of high-value intermediates. The material’s performance supports highly specialized downstream chemistry, where lot-to-lot traceability and impurity profiling are mandatory.

    Industry compliance standards

    • ISO 9001:2015 for quality management in chemical production
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) compliance for imports into Europe
    • NITE (Japan National Institute of Technology and Evaluation) safety registration
    • Custom synthesis protocols validated on customer’s specification

    Typical usage ratio

    • 1%–10% (w/w, depending on project specification); batch input based on molecular conversion targets and required product volume

    Downstream process integration

    • Dosed as a key reactant in closed-reactor systems under inert atmosphere
    • Stepwise addition based on thermal or kinetic profile mapping
    • Integrated into custom downstream purification sequences, including vacuum distillation and solid-phase extraction when required

    Final product types

    • High-purity chemical intermediates for pharmaceutical innovation
    • Pilot-scale specialty molecules for biotech research
    • Laboratory-scale reaction building blocks for academic and industrial development

    4. Advanced Research and Development (R&D) Applications

    Academic institutions, contract research organizations (CROs), and industrial R&D labs leverage this compound as a structure-specific probe for medicinal chemistry, metabolic pathway elucidation, or receptor binding studies. Small-scale integration requires precise sample management and technical documentation to support investigative work in regulated facilities.

    Industry compliance standards

    • Institutional Research Ethics Board (IRB) or Institutional Animal Care and Use Committee (IACUC) approvals, where applicable
    • OECD GLP requirements for preclinical assay development
    • Material Transfer Agreement (MTA) obligations when shared cross-border
    • Internal laboratory SOPs for hazardous material management

    Typical usage ratio

    • Microgram to low gram scales per run (0.01–0.2% solution in typical assay preparation); concentration varied depending on assay sensitivity and validation protocol

    Downstream process integration

    • Dissolved or suspended in analytical grade solvent prior to biological or chemical testing
    • Applied to cell lines, enzyme assays, or chromatography systems in preclinical investigations
    • Documented sample chain-of-custody according to lab accreditation requirements

    Final product types

    • Preclinical research reports
    • Peer-reviewed publication datasets
    • Proof-of-concept compounds for drug discovery programs
    Free Quote

    Competitive D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Understanding D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride from a Manufacturer’s Perspective

    Our Commitment to Consistency and Traceability

    Producing D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride goes beyond mixing raw ingredients in a controlled plant. Each lot enters our facility with a unique signature, and we pay attention as we guide it through synthesis. This compound, known in research circles under various synonyms, requires vigilance from the first weigh-out through to its precise hydrochloride salt form. Our team relies on precision checks and a documented sequence of reactions using established guidelines that were honed through rounds of laboratory observation and pilot runs. Throughout, traceability forms the backbone of confidence—in procedural logs, analytical reports, and batch trace files that link to every drum, vessel, and reactor.

    From Lab to Kilo Scale: Resolving the Challenges

    Scaling up D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride has given us many insights. While small-batch syntheses produce one set of results, transferring those conditions to a larger reactor brings surprises—a change in yield, a shift in crystal habit, an unexpected impurity profile. Our chemists spend weeks running sequence optimizations: controlling addition rates, tweaking temperatures, and monitoring mixing profiles. Every step reflects a lesson learned or a variable logged during a deviation. Documented deviations act as blueprints for future runs, allowing us to approach each batch with reduced uncertainty.

    It’s tempting to look for shortcuts in this work. We insist on tight control ranges instead—our hands know the subtle differences between batches. We watch each reaction flask for signs of successful conversion, and the difference a few degrees or minutes make reaches into downstream purity and ultimately, user application. Impurities or variations can affect downstream processes in research or custom synthesis, leading to variable results. Clients benefit not from what’s promised on a data sheet but the real performance in their hands—something we verify lot by lot.

    The Importance of Raw Materials and Reagent Integrity

    Every kilogram of D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride in our inventory draws its identity not only from the synthesis protocol but also from the character of its building blocks. Sourcing fine chemicals like 2-thienylethylamine or 2-chlorophenylacetic acid with documented purity and origin lets us avoid downstream surprises. Over the years, raw material batches with subtle differences in isomeric ratios or residual water levels taught us that precursors impact final quality. Our procurement office tracks the history of every supplier, and quality checks at the point of entry have caught more than one outlier lot.

    Change in a single input—be it a switching of the hydrochloric acid source, or fluctuation in the lot of a solvent—alters the kinetics of crystallization and can creep into the final product fingerprint. Subtle shifts in particle size distribution matter to some downstream processes, and even shifts in color or flow property can mean more rework. From our experience, building redundancy in raw material evaluation, and cross-verifying supplier claims, keeps us out of costly repeats and supports customers looking for dependable sourcing.

    Typical Usage: A Partner for Complex Synthesis

    Researchers and manufacturers often request D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride for its versatility in medicinal chemistry and pharmacological exploration. It often acts as an intermediate—building a bridge between readily available aromatics and more complex pharmacophores in experimental or developmental settings. Our experience shows it supports structural investigations, analytical calibration routines, and even preliminary bioactivity screens. Clients with diverse background—academic, industrial, or contract synthesis—draw from the reassurance that consistency translates to repeatable assays or downstream functionalization.

    Some partners bring us projects that hinge on this molecule’s stability or specific reactivity. Questions about salt form selection, solubility in specific polar or nonpolar media, and its melting behavior are common. Our team responds with documented experiences from prior manufacturing campaigns and customizes packaging or advice as needed. We have seen this material serve well both in early-stage scale-up studies and structure-activity investigations that demand rigorous analytical control.

    How Our Product Stands Apart

    A frequent question comes from those who compare our D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride with generic counterparts, or with variants available through non-manufacturing outlets. Differences stem not just from paperwork but from the living process behind every kilogram we release. The rigorous analytical spectrum behind each lot—NMR, IR, HPLC, GC-MS—stands not as a checklist but as a window into the life of the molecule. These methods, run by senior scientists, tell us about trace-level contaminants, hydroscopic behavior, and potential degradation under unexpected storage conditions.

    Some off-the-shelf products skip crucial steps in recrystallization or disregard secondary purifications when cost-pressure runs high. As the actual manufacturer, we maintain internal standards above minimum published guidelines. We take time to validate drying protocols, storage humidity, and packaging that minimize risk of degradation during international transit. Packaging integrity and shelf-life matter to us because rejected drums can slow down research and manufacturing timelines for those relying on our output.

    Continuous Improvement Built into Our Process

    Feedback loops allow us to evolve. Researchers in Europe once notified us about a batch with unusually slow dissolution. We investigated, traced the anomaly back to a microscopic shift in crystal packing arising from a colder-than-usual filtration process. Changes went into the playbook for the next cycle. In another case, a contract synthesis partner requested consistent granule sizing for automated dosing systems. Adjusting our screen mesh and drying profile answered their needs, helping them reduce dosing time and wastage.

    As demands for tighter regulatory documentation and international harmonization grow, we invest in upgrading our methodologies. Our analytical laboratory rolled out updated methods for trace metal analysis and volatiles screening. Each improvement roots itself in customer needs, not abstract trends. These iterative upgrades translate into tangible reliability gains—less product hold-up, smooth customs clearance, and improved user satisfaction at the bench or plant level.

    Safeguarding Worker Safety and Environmental Responsibility

    Onsite, the story of responsible production runs deep. Handling sensitive intermediates and controlling emissions call for a culture of safety—one that grows out of daily routines and thorough training, not just posters or policies. Our workers receive hands-on education in controlling dust, safe charging procedures, and recognizing abnormal chemical reactions. Automated monitoring across our high-shear reactors and drying ovens doesn’t replace human vigilance but augments it. Event logs tie into monthly reviews, sharpening our understanding of pathways to better containment and waste minimization.

    Waste treatment and solvent recovery have received more attention as regulations have evolved. The manufacture of D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride involves decisions about solvent usage, salt formation, and mother liquor handling. We built out a closed-loop system for solvents that both improves yields and reduces environmental impact. Spent mother liquors, long regarded as costly side streams, now enter secondary recovery steps. These real efforts keep compliance high and costs stable even as authorities enact tighter controls.

    Training and Staff Retention: Real Value Added

    While machinery and analytical instrumentation garner attention, the institutional knowledge of long-term employees shapes our process development and troubleshooting ability. Our newer operators learn not from strict manuals but from spending time with those who have run hundreds of batches. Quick identification of color changes, odor cues, and heat profiles in reactors distinguish routine operations from special cases calling for intervention. Such intuition grows in an environment where job rotation, ongoing education, and recognition for near-miss identification are encouraged.

    Over the years, we observed that process improvement suggestions often emerge from the shop floor, not only from office meetings. Operators requested changes to glove selection, shift handover routines, and in-line moisture monitoring. These refinements contribute to safer, smoother, and more consistent production. They also nurture a sense of pride, responsibility, and long-term retention—assets that reflect back to our partners through product reliability and support.

    Real-World Problems and Field Solutions

    Every manufacturing cycle brings its own set of issues—logistics delays, sudden equipment shutdowns, climate fluctuations, or regulatory paperwork. A common challenge arises in securing import and export licenses, particularly for controlled substances or precursors associated with D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride. We map out contingency pathways to minimize downtime. Secondary document preparation, dual logistics routes, and warehousing options form part of our business continuity planning. In some periods, this effort means delivering product on time despite customs interventions or laboratory retesting requirements.

    On the technical front, temperature and humidity swings affect the crystallization behavior. After encountering such seasonal variation, we upgraded local HVAC and invested in insulated transport packaging. Expedited samples sent to users in tropical climates receive double wrapping and in-package desiccants based on real shipment data. Rather than simply promising temperature stability, these actions draw from statistical monitoring of complaints and actual loss ratios tracked over years.

    Transparency and Stakeholder Communication

    Effective communication with clients, regulators, and partners helps prevent misunderstandings and builds a reputation for consistency. We supply detailed certificates of analysis, stability data, and change notifications on request. If a run triggers a notifiable deviation, we disclose root causes and corrective actions supported by in-house corrective and preventive action workflows. Recognizing that end users might not have the same analytical gear or regulatory background, we prepare QA packages with practical reference standards or application guidance.

    Seasoned clients often inquire about subtle shifts in specification or new analytical peaks. Rather than sidestep questions, we offer direct access to the technical team responsible for each lot. Over time, this approach has saved client projects from disruption and deepened technical partnerships. Together, we troubleshoot methods, adapt packaging, or pursue custom salt forms that support specific application needs.

    Comparing Our Output with Market Alternatives

    Outsiders sometimes ask what sets our D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride apart from what’s found in catalogs or from intermediaries. As actual producers, we offer both vertical integration—from raw material selection to finished, packaged compound—and transparency in the way each batch comes together. Rather than simply relabeling drums or bottles, our process involves hands-on expertise and real corrective action if something deviates from expectation. This ensures traceable, reproducible material flow backed by specialized analytical data and a willingness to supply technical dossiers validated by external audits or client-site visits.

    Market alternatives might suit low-volume or commodity applications but often show unpredictable performance at scale. Clients invested in process reliability, clinical translation, or further R&D gain efficiency from the predictability of our product—no need to reformulate, retest, or validate across lots. We have handled cases where clients facing variable yields with generic market samples switched to our product and recouped days in project schedules, attributing it entirely to fewer adjustments and minimal downtime.

    Anticipating the Future: Innovation, Regulation, and New Applications

    Regulatory and technical landscapes never stand still. We anticipate higher demands for trace-level impurity profiling, elemental testing, and real-time lot tracking. Investments in new analytical capabilities and process automation allow us to remain ahead of audit cycles and produce forensic-quality data for demanding sectors.

    Applications continue to grow as medicinal chemistry programs, analytical labs, and specialty manufacturers expand their toolkits. Our technical and R&D team stands ready to adapt salt form, packaging, and supply chain logistics for emerging requirements. We welcome collaborative discussions for method transfer, custom grades, or expanded documentation sets—offering not just a prepared product but shared expertise arising from years of manufacturing leadership.

    Partnering with Confidence: Why Our D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride Delivers Peace of Mind

    Beyond technical bullet points and certificates, our commitment to manufacturing D-(+)-Methyl-Alpha-(2-Thienylethamino)(2-Chlorophenyl)Acetate Hydrochloride reflects a culture shaped by attention to detail, practical wisdom, and readiness to support innovation. We measure success not by volume sold but by the integrity of our batches, the speed and transparency of problem-solving, and the depth of technical relationships built along the way.

    For clients who value predictably high standards and firsthand accountability, we provide not just a product, but a partnership grounded in manufacturing experience, open communication, and ongoing investment in quality. Whether supporting a new synthesis route, enabling a safety-critical research run, or troubleshooting an analytical discrepancy, our team brings decades of combined learning to support your goals and uphold the legacy of a manufacturer who stands behind every lot delivered.