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D-Arabinitol

    • Product Name D-Arabinitol
    • Alias Arabitol
    • Einecs 222-720-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    648015

    Name D-Arabinitol
    Cas Number 488-82-4
    Molecular Formula C5H12O5
    Molecular Weight 152.15 g/mol
    Appearance White crystalline powder
    Melting Point 102-104°C
    Solubility In Water Freely soluble
    Boiling Point 229°C (decomposes)
    Optical Rotation [α]20/D +11° (H2O)
    Synonyms D-Arabitol, Arabinitol, D-lyxitol
    Purity Typically ≥ 98%
    Storage Temperature Room temperature
    Ec Number 207-691-1

    As an accredited D-Arabinitol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging for D-Arabinitol (25 grams) consists of a sealed, amber glass bottle with a secure screw cap and clear labeling.
    Shipping Shipping for D-Arabinitol is typically conducted under standard chemical handling procedures. The product is securely packaged in appropriate containers to prevent contamination and moisture ingress. It is shipped at ambient temperature and labeled according to safety and regulatory requirements. Shipping documentation includes the chemical’s safety data sheet (SDS) and proper identification.
    Storage D-Arabinitol should be stored in a tightly closed container, protected from moisture and light, at room temperature (15–25°C). It should be kept in a dry, well-ventilated area away from incompatible substances such as strong oxidizers. Ensure the storage area is clearly labeled and complies with standard laboratory chemical storage protocols to maintain its stability and prevent contamination.
    Application of D-Arabinitol

    Applications of D-Arabinitol in Industrial Manufacturing

    D-Arabinitol serves as a specialized raw material in several advanced manufacturing sectors, contributing unique characteristics that support the production of high-value goods. Our factory integrates strict quality controls and direct support for processing specifications across industries utilizing this material. Below, we highlight principal application fields where D-Arabinitol is established in commercial use, accompanied by processing guidance and compliance frameworks tailored to real-world customer scenarios.

    1. Pharmaceutical Fermentation Substrate for Polyol-Based APIs

    D-Arabinitol is employed as a fermentation substrate or intermediate in polyol-based active pharmaceutical ingredient (API) synthesis. Its chiral structure supports stereospecific pathways for producing rare sugar-based APIs, including certain antiviral and antifungal agents. Manufacturers choose this material for its ability to support strain performance and product yield in microbial or enzymatic processes. Incorporation occurs at critical points requiring reduced sugar interference, maximizing target product purity and process stability.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs relevant to polyol-based excipients
    • US FDA CFR Title 21, Part 211 (Finished Pharmaceuticals)
    • Chinese Pharmacopoeia ChP 2020 (API raw materials standards)

    Typical usage ratio

    • 2-8% w/w in fermentation media, with dosing optimized based on organism strain and desired product concentration, typically kept below 10% due to osmotic pressure considerations

    Downstream process integration

    • Added to sterile fermentation vessels after initial sterilization and media cooling; monitored during feed-batch and continuous processes for sugar uptake and polyol formation stage control

    Final product types

    • Rare sugar-based API intermediates
    • Antifungal polyol derivatives
    • Antiviral nucleoside analogues (precursor substances)
    • Pharmaceutical excipient grades for polyol applications

    2. Food and Beverage Formulation—Low-Calorie Bulk Sweetener Manufacturing

    Within low-calorie and specialty sweetener production, D-Arabinitol contributes to the formulation of novel bulk sweeteners and sugar alcohol blends for the food processing sector. Its role focuses on enabling tooth-friendly, reduced-energy sweeteners with tailored crystallization and dissolution characteristics. This specialty polyol addresses markets driven by sugar reduction regulations and clean label demand, providing manufacturers with an ingredient allowing precise taste modulation in finished products.

    Industry compliance standards

    • Codex Alimentarius General Standard for Food Additives (GSFA, CODEX STAN 192-1995)
    • EU Regulation (EC) No. 1333/2008 on Food Additives
    • US FDA GRAS status (21 CFR Part 172.841 for polyols)
    • China GB 2760 National Food Safety Standard for Food Additives

    Typical usage ratio

    • 0.5–4% w/w in confectionery and bakery ware; 2–8% in sugar-free chewing gums; precise addition based on total polyol matrix, product moisture, and sweetness equivalence thresholds

    Downstream process integration

    • Blended with maltitol, lactitol, or xylitol during wet mixing and syrup preparation; introduced in vacuum cooking or tabletting phases for homogeneous distribution and controlled crystallization

    Final product types

    • Sugar-free chewing gum base
    • Low-calorie confectionery and chocolate
    • Table-top bulk sweetener blends
    • Sugar-free bakery fillings and toppings

    3. Diagnostic Reagent Synthesis—Biochemical and Clinical Testing

    D-Arabinitol plays a functional role in diagnostics manufacturing, particularly as a calibrator or chemical marker in analytical kits for clinical laboratories. The material is valued for its stability, biological activity, and use as a quantitative standard in enzymatic or chromatographic analysis. Clinical test manufacturers include D-Arabinitol in kits for detecting invasive fungal infections and monitoring specific metabolic disorders, requiring traceable purity and consistent batch performance.

    Industry compliance standards

    • ISO 13485:2016 Medical Devices Quality Management Systems
    • CLSI (Clinical & Laboratory Standards Institute) guideline standards
    • FDA 21 CFR 820 (Quality System Regulation, medical devices)
    • CE-IVD Directive 98/79/EC (in vitro diagnostic use in Europe)

    Typical usage ratio

    • 0.01–0.5% w/v as calibrator or test reagent component; dosage customized to meet detection limit and sensitivity range for the specific diagnostic panel

    Downstream process integration

    • Dissolved in buffered solution during kit assembly; filtered and aliquoted into vials under aseptic conditions for integration into reagent set packaging

    Final product types

    • Quantitative fungal infection diagnostic kits (e.g., D-arabinitol/creatinine ratio)
    • Metabolic function test reagent sets
    • Analytical quality control standards for in vitro diagnostics
    • Clinical chemistry calibrators

    4. Specialty Chemical Synthesis—Chiral Building Block in Fine Chemicals

    Chemical synthesis industries utilize D-Arabinitol as a chiral template and precursor for producing high-precision intermediates and specialty fine chemicals, including stereoselective ligands, organometallic complexes, and rare cyclic ethers. Its polyhydroxy structure lends to targeted derivatization, supporting custom reactions where enantiopurity directly influences end-product application such as catalysts or specialty plastics. Consistent performance and traceability requirements demand rigorous manufacturing controls and documentation.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • REACH Regulation (EC) No. 1907/2006 (Europe, for specialty chemical manufacture)
    • Japanese Chemical Substances Control Law (CSCL)
    • US EPA Toxic Substances Control Act (TSCA, Section 8(b))

    Typical usage ratio

    • Ranges from 1–10 mol% in multi-step synthesis, scaled depending on end-product complexity and functional group conversion rate; ratio determined by desired chiral induction or ligand loading

    Downstream process integration

    • Introduced at the chiral resolution or protective-group manipulation stage, or as starting material in enantioselective reactions; monitored via HPLC/GC at critical quality checkpoints

    Final product types

    • Chiral ligands and catalysts
    • Stereoselective synthesis intermediates
    • Pharma-grade building blocks
    • Fine chemical additives for specialty polymers and resins

    5. Microbial Biomass Production for Probiotic Manufacturing

    D-Arabinitol serves as an alternative carbon source in controlled microbial biomass production, fostering selective growth of targeted probiotic strains in industrial fermentation facilities. Its utilization enables process engineers to modulate carbohydrate metabolism, adjust output yield, and refine purity of the final microbial mass. Demand for high-purity, low-byproduct biomass places importance on purity grade selection and GMP-guided process settings during formulation.

    Industry compliance standards

    • FSSC 22000 Food Safety System Certification (for food-related microorganisms)
    • GMP+ International Feed Safety Assurance for feed-grade biomass
    • ISO 22000:2018 Food Safety Management
    • EU Regulation (EC) No 183/2005 on feed hygiene (for animal feed probiotics)

    Typical usage ratio

    • 0.5–5% w/w in fermentation medium, with final concentration depending on strain carbohydrate metabolism profile, biomass yield objectives, and anti-metabolite buildup thresholds

    Downstream process integration

    • Injected into nutrient media before inoculation; sugar utilization tracked throughout batch fermentation with periodic sampling for biomass density, followed by downstream harvesting and stabilization

    Final product types

    • Direct-fed microbial biomass pellets
    • Lyophilized probiotic ingredient powders
    • Starter cultures for dairy or plant fermentations
    • Microbiome modulation input for functional food and feed
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    Certification & Compliance
    More Introduction

    D-Arabinitol: Practical Applications, Quality Insights, and Manufacturer Perspectives

    Working with D-Arabinitol Day In, Day Out

    At our manufacturing facility, D-Arabinitol features strongly among the polyols we produce and refine, becoming more prominent in a range of life science and technical industries. Each batch that leaves our plant reflects careful attention to both its properties and the needs of customers who have come to trust our quality.

    Often, people ask: what sets our D-Arabinitol apart? In daily production, we focus on purity, consistency, and transparency in every step. Over years of engineering improvements, our crystallization, filtration, and drying processes have matured—we review and analyze output to ensure each lot offers reliable performance. Decades of routine testing have shaped our internal standards. We have learned that laboratories and formulators expect D-Arabinitol to behave predictably, so our quality control lab reports not only optical rotation and moisture but also residue, clarity, and absence of color. You can detect a difference during mixing and in final applications. Clear, colorless crystals consistently deliver in sensitive manufacturing and biological workflows.

    Specifications That Come From Experience

    For those searching specs, our D-Arabinitol generally arrives in white crystalline powder or granular form, with an assay that meets high-purity requirements in pharmaceutical development or chemical synthesis. Over time, we've tailored particle size to improve solubility and ease of handling. Moisture content stays tightly controlled, since trace water can affect stability. Impurity profiling is routine; we test for residual sugars, organic acids, and common contaminants, so you know what you're adding to a process line or experiment.

    After years fielding feedback, we recognize that product details matter less than end-results: how does it behave in solution, how clean are the reactions it participates in, what kind of background does it offer for microbial fermentation or analytical applications? In the real world, D-Arabinitol is more than a number or a grade. Keeping batches homogeneous over the seasons, despite raw material fluctuations, is where production experience becomes visible.

    Comparisons With Other Polyols: What We Have Learned

    D-Arabinitol stands alongside other sugar alcohols in our plant—xylitol, sorbitol, mannitol, ribitol—but each has habits that experienced chemists notice. Through hundreds of manufacturing runs and collaborations with end-users, we see D-Arabinitol’s solubility in water, moderate sweetness, and chirality emerge as distinguishing factors. For microbiological use, D-Arabinitol often serves as a carbon source in selective media, taking precedence over more conventional polyols when labs need a distinct metabolic footprint. Our bacterial identification customers report cleaner growth responses compared to mannitol or sorbitol media.

    In pharmaceuticals, D-Arabinitol’s stereochemistry supports certain chiral syntheses that other polyols can’t match. While mannitol features widely in direct compaction or tablet manufacture, D-Arabinitol’s lesser hygroscopicity offers a stability advantage in formulations where water reactivity matters. From our daily production logs, you see weather’s effect on other polyols more than you do with D-Arabinitol. That stability is not trivial for customers shipping to variable climates or planning for long-term storage.

    Sorbitol and mannitol are produced at much larger scales throughout the industry, often designed for sweetness or bulking in foods. D-Arabinitol rarely finds its way into those jobs—it’s never been about taste. For technical applications, including those in chiral research or fermentation, its presence can prevent background interference, making it a reliable ingredient for chemists who want to avoid unexpected signal noise or growth overlap.

    Real Human Use: From Production to Laboratory and Beyond

    Our shift staff, analytical chemists, and shipping crew notice the difference as much as our customers do. Handling D-Arabinitol by bulk or sub-kilo lots requires an eye for crystal flow and odor. True, it takes more finesse to handle hygienically than some compactable polyols—it’s less forgiving, and warehouses need tight air control. Everyone on the line has stories about the adjustments that come with weather swings or long loading days. Talking through production challenges helped us refine our lot acceptance process to catch clumping or off-spec batches long before they become an issue down the line.

    Talking to clients, patterns emerge about how D-Arabinitol support productivity. In fermentation, tighter control over feedstock purity has improved yields. Analytical labs working in clinical microbiology value the absence of background contaminants; a past batch flagged for off-odor resulted in a week’s worth of calls and tests—not something we forget, and a lesson that changed our filtration and rinse protocols. Some of the research groups we supply need subtle assurance that each lot matches their previous work. We keep retention samples to let them validate performance. The relationship builds on reliability, not just specification sheets.

    Applications We See Most Often

    In the bio/pharmaceutical world, requests for D-Arabinitol usually arrive from teams synthesizing chiral intermediates or running genetically engineered fermentations. The compound’s moderate solubility and minimal sweetness give it an edge where interference is a concern. Environmental and medical labs testing for fungal or bacterial identification use it as a signature substrate; positive detection of D-Arabinitol in a biological sample can point to select microbial metabolism.

    In food chemistry research, although D-Arabinitol isn’t used as a major sweetener, it sometimes serves as a marker for process validation, or as a calibrant. Here, our consistency and documented batch record support traceability. We document production methods from start to finish, keeping full traceability on every batch to back up results if anomalies arise years down the line.

    We also see increasing interest from material science teams investigating polyols for biodegradable polymers or new carrier materials. While D-Arabinitol won’t replace larger-volume alcohols for rigid foam production, it often finds a role in high-value, low-dose technical innovations where the cost is driven by performance, not bulk sweetness or bulking properties.

    Challenges in Production and Shipping

    Handling D-Arabinitol safely and efficiently never gets routine. Environmental exposure leads to caking, so product containment remains tight at every stage. Our workers inspect every container for humidity ingress before loading and sorting. Small oversights during drying translate directly to lumping, prompting investments in environment-controlled warehouses and rigid material handling systems. Each operator receives hands-on training for clean handling, detailed recordkeeping, and contamination checks, not because regulations say so, but because accumulated experience taught us that oversights create headaches for customers and wider supply chain holdups.

    Transportation brings its own lessons. Compared with bulkier or more robust products, D-Arabinitol’s crystalline texture demands thorough packaging. Extra lining, careful labeling, and clear customs documentation all reduce delays and product loss. Real-world issues—temperature swings, rough handling in transit, or mislabeling—have a way of surfacing. It’s not about blind adherence to protocol; staying close to the process and adjusting in response to true field data forms our real quality system.

    Regulatory and Safety Learnings On the Job

    While our daily output focuses on meeting technical specs, practical knowledge about D-Arabinitol safety and compliance has grown in the trenches. Each production run involves monitoring not just final output but also by-products, dust levels, and cleaning agent residues. Our QC lab runs microbial counts alongside purity assays, even though true sterility isn’t required for every batch. Most D-Arabinitol headed into food contact or pharmaceutical precursor chains follows tight contaminant controls based on direct client feedback and past audits.

    Decades in the business shape more than our paperwork. New regulations and client audits shaped a review of our documentation chains; we keep batch records and reference standards available for cross-checking. On occasion, a client needs proof of GMP-aligned production, and every time, our response improves through practice rather than memo-writing. We work alongside customers through their compliance bottlenecks, sharing process information frankly to enable their regulatory filings and customer audits.

    Improvement Never Stops: Upgrades and Insights

    We keep investing, both in technical know-how and plant hardware. Early on, fluctuations in raw material quality created ripples downstream; now, we check incoming feedstocks, not out of habit, but through lessons learned when a single problematic cargo nearly left three clients unable to file test results on schedule. Feedback loops between plant, lab, and client define our upgrades: drier air at the crystallizer, automated impurity screening at every shift, more reliable in-line temperature monitoring.

    Our staff has seen how even small changes—like adjusting filtering mesh or tweaking the rotary drier speed—alter the product’s look and handling. This kind of shop talk runs up and down the plant, outpacing memos or formal revision logs. Chemistry does not wait for documentation. For D-Arabinitol, every improvement is traceable to real feedback, whether it’s optimizing for clarity or cutting time in dissolution tanks on end-user lines. We measure success by how smoothly the powder pours and how often formulating chemists send thanks instead of questions.

    Lessons Learned Through Missteps and Solutions

    Not every lot leaves the plant perfect. A few years back, a routine shipment turned up with off-color. Investigation traced the issue back to a seemingly minor reagent change at one purification stage. Sharing root cause and corrective plan with affected clients took hours of candid conversation. That level of engagement became our standard—now, we proactively update clients when changes are made, drawing on history to head off confusion.

    D-Arabinitol rarely features in dramatic headlines, but consistent quality reduces rework, saves time in labs, and preserves trust in regulated industries where a single anomalous peak or failed fermentation batch costs hundreds of hours and significant financial losses. Each deviation or complaint weighs as heavily on production staff as it does on account managers or regulatory coordinators. We address root causes—whether in plant humidity, equipment calibration, or raw material sourcing—focusing less on blame and more on tangible, durable solutions. Over time, these efforts build reliable supply chains and personal relationships that last longer than any certificate or test result.

    Talking to Users, Building Trust

    Real trust grows slowly, batch by batch, and over many cycles of feedback. Longtime clients sometimes ask for advice on applications, not just supply. Years of working together on validation studies builds rapport that runs deeper than transactional business. We answer the phone when small-batch formulators call with solubility questions, talk through the quirks of D-Arabinitol compared to ribitol, share background on what worked and what didn’t in our own test reactors. That openness often leads to shared innovation—one client’s challenge becomes an opportunity for technical improvement at our plant.

    Fielding requests from researchers or technical buyers, we have noticed a demand for application notes, method validation, and full traceability—needs that trace directly to how thoroughly they have to support their own regulatory or developmental claims. Instead of hiding our process or ducking tough questions, we have made it routine to discuss limits, offer reference methods, and back statements with real production and performance data. In D-Arabinitol, trust is measured in fewer support calls and more direct problem-solving time.

    Looking Forward: Trends and Areas for Development

    While classic uses—chiral synthesis, fermentation, metabolic research—remain strong, we see hints of new demand from bio-environmental chemistry and specialty materials sectors. Users continue to push for ingredient clarity and traceability, challenging suppliers to provide granular background on both production and impurity profile. We see value in working directly with advanced analytical teams to map out our entire batch history. With technology speeds growing, even subtle changes in lot profile can ripple across research programs or production cycles.

    It’s clear now that serving these emerging needs means investing more in real time analytics—adopting advanced chromatographic and spectroscopic tools on our lines, backing each shipment with traceable, up-to-date batch folders. Many requests for technical data or supplier validation come from legal, regulatory, or risk management teams working alongside technical users. Meeting their need for transparency turns our attention back to training and empowering every operator, technician, and manager—not just to execute their step but to understand why it matters, and to communicate openly with those who use our D-Arabinitol worldwide.

    In Summary: Why D-Arabinitol Matters in Our Plant

    D-Arabinitol production teaches lessons in chemistry, logistics, and partnership every day. From raw material selection through finished packaging and global documentation, attention to purity, consistency, and usability defines our approach—by people who work the process and know the product firsthand. Our best batches deliver on more than a set of numbers. The value shows through in time saved, reliable test results, and customer loyalty over years of work. Every lesson learned, every process tweak, and every open discussion shapes our D-Arabinitol into something measurably dependable, batch by batch, year after year.